PLK4: a link between centriole biogenesis and cancer

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Expert opinion on therapeutic targets

• Publication date

  2018-01-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1080/14728222.2018.1410140PMID 29171762
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton.

  2017cited by this paper
• Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals.

  2017cited by this paper
• The polo-like kinase 4 gene (PLK4) is overexpressed in pediatric medulloblastoma

  2017cited by this paper
• PLK4 phosphorylation of CP110 is required for efficient centriole assembly

  2017cited by this paper
• Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1

  2017cited by this paper
• Centrosome Amplification and Cancer: A Question of Sufficiency.

  2017cited by this paper
• A functional screening of the kinome identifies the Polo‐like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain

  2017cited by this paper
• Maternal common variant rs2305957 spanning PLK4 is associated with blastocyst formation and early recurrent miscarriage.

  2017cited by this paper
• A non‐canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation

  2016cited by this paper
• Expression of Polo-Like Kinase 4(PLK4) in Breast Cancer and Its Response to Taxane-Based Neoadjuvant Chemotherapy

  2016cited by this paper
• KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number

  2016cited by this paper
• Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors

  2016cited by this paper
• Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts

  2016cited by this paper
• Targeting Mitosis in Cancer: Emerging Strategies.

  2015influential reference
• PLK4 Is Essential for Meiotic Resumption in Mouse Oocytes1

  2015cited by this paper
• Reversible centriole depletion with an inhibitor of Polo-like kinase 4

  2015cited by this paper
• The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.

  2015cited by this paper
• Drug discovery using spirooxindole cores: Success and Challenges [corrected].

  2015cited by this paper
• Binding of STIL to Plk4 activates kinase activity to promote centriole assembly

  2015cited by this paper
• The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.

  2015cited by this paper
• The E3 ubiquitin ligase Mib1 regulates Plk4 and centriole biogenesis

  2015cited by this paper
• Autoinhibition and relief mechanism for Polo-like kinase 4

  2015influential reference
• Loss of KLF14 triggers centrosome amplification and tumorigenesis

  2015cited by this paper
• The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor agent.

  2015cited by this paper
• Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis

  2015cited by this paper
• Plk4-dependent phosphorylation of STIL is required for centriole duplication

  2015influential reference
• The deregulated promoter methylation of the Polo-like kinases as a potential biomarker in hematological malignancies

  2015cited by this paper
• Chronic centrosome amplification without tumorigenesis

  2015cited by this paper
• Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse

  2015cited by this paper
• STIL binding to Polo-box 3 of PLK4 regulates centriole duplication

  2015influential reference
• The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond

  2015cited by this paper
• Common variants spanning PLK4 are associated with mitotic-origin aneuploidy in human embryos

  2015cited by this paper
• Polo-like kinases: structural variations lead to multiple functions

  2014cited by this paper
• E2F Activators Signal and Maintain Centrosome Amplification in Breast Cancer Cells

  2014cited by this paper
• Polo-like kinase 4 inhibition: a strategy for cancer therapy?

  2014cited by this paper
• Polo-Like Kinases (Plks), a Key Regulator of Cell Cycle and New Potential Target for Cancer Therapy

  2014cited by this paper
• Oncogene-like induction of cellular invasion from centrosome amplification

  2014cited by this paper
• Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole

  2014influential reference
• Mutation in PLK4, encoding a master regulator of centriole formation, defines a novel locus for primordial dwarfism

  2014cited by this paper
• Nek2 and Plk4: prognostic markers, drivers of breast tumorigenesis and drug resistance.

  2014cited by this paper
• Polo-like kinase 4 at the nexus of epigenetic modifications and the DNA damage signaling network

  2014influential reference
• Plk4 Phosphorylates Ana2 to Trigger Sas6 Recruitment and Procentriole Formation

  2014cited by this paper
• p53-Dependent and Cell Specific Epigenetic Regulation of the Polo-like kinases under Oxidative Stress

  2014cited by this paper
• Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent.

  2014influential reference
• Molecular Basis for Unidirectional Scaffold Switching of Human Plk4 in Centriole Biogenesis

  2014cited by this paper
• Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy

  2014cited by this paper
• PLK4 overexpression and its effect on centrosome regulation and chromosome stability in human gastric cancer

  2014cited by this paper
• A novel role for Plk4 in regulating cell spreading and motility

  2014cited by this paper
• SAPK pathways and p53 cooperatively regulate PLK4 activity and centrosome integrity under stress

  2013influential reference
• The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents.

  2013cited by this paper
• Polo-like kinase 4 transcription is activated via CRE and NRF1 elements, repressed by DREAM through CDE/CHR sites and deregulated by HPV E7 protein

  2013cited by this paper
• Spindle Formation in the Mouse Embryo Requires Plk4 in the Absence of Centrioles

  2013cited by this paper
• NFκB regulates expression of Polo-like kinase 4

  2013cited by this paper
• Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response

  2013cited by this paper
• Regulation of autophosphorylation controls PLK4 self-destruction and centriole number.

  2013cited by this paper
• Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152

  2013cited by this paper
• Centrosome amplification causes microcephaly

  2013cited by this paper
• Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication

  2013cited by this paper
• CAND1 promotes PLK4-mediated centriole overduplication and is frequently disrupted in prostate cancer.

  2012influential reference
• The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development

  2012cited by this paper
• GF-15, a novel inhibitor of centrosomal clustering, suppresses tumor cell growth in vitro and in vivo.

  2012cited by this paper
• The structure of the plk4 cryptic polo box reveals two tandem polo boxes required for centriole duplication.

  2012cited by this paper
• Downregulation of Polo-Like Kinase 4 in Hepatocellular Carcinoma Associates with Poor Prognosis

  2012influential reference
• Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes

  2012cited by this paper
• Supernumerary centrosomes nucleate extra cilia and compromise primary cilium signaling.

  2012cited by this paper
• 3D-structured illumination microscopy provides novel insight into architecture of human centrosomes

  2012cited by this paper
• The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle.

  2012cited by this paper
• SCF ubiquitin ligases in the maintenance of genome stability.

  2012cited by this paper
• Structural Basis of the 9-Fold Symmetry of Centrioles

  2011cited by this paper
• The SCF–FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication

  2011cited by this paper
• CDK11p58 Is Required for Centriole Duplication and Plk4 Recruitment to Mitotic Centrosomes

  2011cited by this paper
• Abstract LB-215: Inhibition of Polo-like kinase 4 as an anti-cancer strategy

  2011cited by this paper
• Aberrant methylation of Polo-like kinase CpG islands in Plk4 heterozygous mice

  2011cited by this paper
• Structures of SAS-6 Suggest Its Organization in Centrioles

  2011cited by this paper
• Functional evolution of Polo-like kinases

  2011influential reference
• The HPV-16 E7 oncoprotein induces centriole multiplication through deregulation of Polo-like kinase 4 expression

  2011cited by this paper
• Plk5, a Polo Box Domain-Only Protein with Specific Roles in Neuron Differentiation and Glioblastoma Suppression

  2011cited by this paper
• From Plk1 to Plk5

  2011cited by this paper
• Genomic instability and cancer: lessons learned from human papillomaviruses.

  2011cited by this paper
• Oncogenic and tumor suppressive roles of polo‐like kinases in human hepatocellular carcinoma

  2010cited by this paper
• Autophosphorylation of Polo-like Kinase 4 and Its Role in Centriole Duplication

  2010cited by this paper
• Centriole duplication

  2010cited by this paper
• Plk4 is required for cytokinesis and maintenance of chromosomal stability

  2010influential reference
• Regulated protein kinases and phosphatases in cell cycle decisions.

  2010cited by this paper
• Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability

  2010cited by this paper
• Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy

  2010cited by this paper
• Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

  2010cited by this paper
• Stepwise evolution of the centriole-assembly pathway

  2010cited by this paper
• Polo-like kinase 4: the odd one out of the family

  2010influential reference
• When mutants gain new powers: news from the mutant p53 field

  2009cited by this paper
• Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation

  2009cited by this paper
• Predicting protein-protein interactions in Arabidopsis thaliana through integration of orthology, gene ontology and co-expression

  2009cited by this paper
• hPOC5 is a centrin-binding protein required for assembly of full-length centrioles

  2009cited by this paper
• Primary Cilia and Signaling Pathways in Mammalian Development, Health and Disease

  2009cited by this paper
• Centrosome abnormalities during a Chlamydia trachomatis infection are caused by dysregulation of the normal duplication pathway

  2009cited by this paper
• A Mechanism Linking Extra Centrosomes to Chromosomal Instability

  2009cited by this paper
• The SCF/Slimb ubiquitin ligase limits centrosome amplification through degradation of SAK/PLK4.

  2009cited by this paper
• Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells.

  2009cited by this paper
• The SCFSlimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication

  2009cited by this paper
• Polo-like kinase 4 phosphorylates Chk2

  2009cited by this paper

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• Chromosomal Instability and Clonal Heterogeneity in Breast Cancer: From Mechanisms to Clinical Applications

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• Discovery of novel dual-targeting inhibitors against PLK1-PBD and PLK4-PB3: structure-guided pharmacophore modelling, virtual screening, molecular docking, molecular dynamics simulation, and biological evaluation

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• PLK4 reflects extrathyroidal invasion, high tumor stage and poor prognosis in papillary thyroid carcinoma patients.

  2024cites this paper
• FOXM1 Participates in Trophoblast Migration and Early Trophoblast Invasion: Potential Role in Blastocyst Implantation

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• Tumor polo-like kinase 4 protein expression reflects lymphovascular invasion, higher Federation of Gynecology and Obstetrics stage, and shortened survival in endometrial cancer patients who undergo surgical resection

  2024influential citation
• Insights into the Structural Regulation of Polo-Like Kinase Activity using AlphaFold

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• Plk4 regulates centriole duplication in the embryonic development of zebrafish.

  2024cites this paper
• QSAR, Molecular Docking, and Dynamics-Based Computational discovery of Potential PLK4 Inhibitors for tumor therapy

  2024cites this paper
• Pan-cancer analysis of polo-like kinase family genes reveals polo-like kinase 1 as a novel oncogene in kidney renal papillary cell carcinoma

  2024cites this paper
• Design of novel PLK4 inhibitors as TRIM37-amplified breast cancer drugs using 3D-QSAR, molecular docking, and molecular dynamics simulation methods

  2024cites this paper
• Polo-like kinase 4 inhibitor CFI-400945 inhibits carotid arterial neointima formation but increases atherosclerosis

  2023cites this paper
• Polo-Like Kinase 4 Correlates with Aggressive Tumor Characteristics, Shortened Disease-Free Survival and Overall Survival in Patients with Cutaneous Melanoma who Undergo Surgical Resection.

  2023cites this paper
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• Discovery of the First Potent, Selective, and In Vivo Efficacious Polo-like Kinase 4 Proteolysis Targeting Chimera Degrader for the Treatment of TRIM37-Amplified Breast Cancer.

  2023cites this paper
• STIL/AURKA axis promotes cell proliferation by influencing primary cilia formation in bladder cancer

  2023cites this paper
• The TT Genotype of the KIAA1524 rs2278911 Polymorphism Is Associated with Poor Prognosis in Multiple Myeloma

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  2023cites this paper
• Discovery of CZS-241: A Potent, Selective, and Orally Available Polo-Like Kinase 4 Inhibitor for the Treatment of Chronic Myeloid Leukemia.

  2023cites this paper
• Centrosomal protein 120 promotes centrosome amplification and gastric cancer progression via USP54-mediated deubiquitination of PLK4

  2022cites this paper
• Role of Hub Genes in the Occurrence and Development of Testicular Cancer Based on Bioinformatics

  2022cites this paper
• CK1 Is a Druggable Regulator of Microtubule Dynamics and Microtubule-Associated Processes

  2022cites this paper
• Design, synthesis, and biological evaluation of novel pyrazolo [3,4-d]pyrimidine derivatives as potent PLK4 inhibitors for the treatment of TRIM37-amplified breast cancer.

  2022cites this paper
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  2022cites this paper
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  2022cites this paper
• PLK4 is a key molecule in the formation of PGCCs and promotes invasion and migration of progeny cells derived from PGCCs

  2022cites this paper
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• Vibrational, spectroscopic, chemical reactivity, molecular docking and in vitro anticancer activity studies against A549 lung cancer cell lines of 5‐Bromo‐indole‐3‐carboxaldehyde

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• Anticancer effects of the PLK4 inhibitors CFI-400945 and centrinone in Ewing’s sarcoma cells

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  2019cites this paper
• Precision Revisited: Targeting Microcephaly Kinases in Brain Tumors

  2019influential citation
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  2019cites this paper
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  2019cites this paper
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