Generation of germline-competent induced pluripotent stem cells

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Nature

• Publication date

  2007-07-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nature05934PMID 17554338
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Generation of germline-competent induced pluripotent stem cells

  2008influential reference
• GENERATION OF GERMLINECOMPETENT INDUCED PLURIPOTENT STEM CELLS

  2007influential reference
• Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

  2006cited by this paper
• Nuclear reprogramming and pluripotency

  2006cited by this paper
• Nanog promotes transfer of pluripotency after cell fusion

  2006cited by this paper
• LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism

  2005cited by this paper
• Transcriptional Regulation of Nanog by OCT4 and SOX2*

  2005cited by this paper
• Octamer and Sox Elements Are Required for Transcriptional cis Regulation of Nanog Gene Expression

  2005cited by this paper
• Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4.

  2005cited by this paper
• Derivation of embryonic germ cells and male gametes from embryonic stem cells

  2004cited by this paper
• The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells.

  2003cited by this paper
• Engineering the mouse genome with bacterial artificial chromosomes to create multipurpose alleles

  2003cited by this paper
• Fbx15 Is a Novel Target of Oct3/4 but Is Dispensable for Embryonic Stem Cell Self-Renewal and Mouse Development

  2003cited by this paper
• Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.

  2003cited by this paper
• Erasure of methylation imprinting of Igf2r during mouse primordial germ‐cell development

  2003cited by this paper
• The Writ-1 (in&l) Proto-Oncogene Is Required for Development of a Large Region of the Mouse Brain

  2003cited by this paper
• Multipotent cell lineages in early mouse development depend on SOX2 function.

  2003cited by this paper
• Erasing genomic imprinting memory in mouse clone embryos produced from day 11.5 primordial germ cells.

  2002cited by this paper
• A Novel Dnmt3a Isoform Produced from an Alternative Promoter Localizes to Euchromatin and Its Expression Correlates with Activede Novo Methylation*

  2002cited by this paper
• The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms

  2002cited by this paper
• Recombineering: a powerful new tool for mouse functional genomics

  2001cited by this paper
• The H19 methylation imprint is erased and re-established differentially on the parental alleles during male germ cell development.

  2000cited by this paper
• Plat-E: an efficient and stable system for transient packaging of retroviruses

  2000cited by this paper
• Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

  2000cited by this paper
• Retroviral Expression in Embryonic Stem Cells and Hematopoietic Stem Cells

  2000cited by this paper
• Developmental potential of mouse primordial germ cells.

  1999cited by this paper
• Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4.

  1998cited by this paper
• Embryonic stem cell lines derived from human blastocysts.

  1998cited by this paper
• Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals.

  1996cited by this paper
• Mouse embryonic germ (EG) cell lines: transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igf2r) gene compared with embryonic stem (ES) cell lines.

  1994cited by this paper
• The ontogeny of allele‐specific methylation associated with imprinted genes in the mouse.

  1993cited by this paper

• Application and progress of induced pluripotent stem in chronic wound healing: a narrative review

  2026cites this paper
• Comparative Analysis of Induced Pancreatic Stem Cells Generated with Different Factors.

  2026cites this paper
• Non-invasive ovulation tracking enables genetic engineering in wild rodents.

  2026cites this paper
• Human pluripotent stem cell-derived innate and adaptive immune cells for cancer immunotherapy.

  2026cites this paper
• Modeling mammalian meiosis with pluripotent stem cells: progress and challenges

  2026cites this paper
• The characterization and effect of Nanog on OSKM factors in large yellow croaker (Larimichthys crocea)

  2026cites this paper
• Induced Pluripotent Stem Cells (iPSCs) as a Regenerative Strategy for Parkinson's Disease: Opportunities and Challenges.

  2026cites this paper
• Synergetic pathways for Parkinson’s disease therapy: The intersection of exercise and stem cell science

  2026cites this paper
• Human Induced Pluripotent Stem Cells-Derived Reconstructed Epidermal Skin Model as an Alternative Model for Skin Irritation

  2025cites this paper
• LIN28-mediated gene regulatory loops synchronize transitions throughout organogenesis

  2025cites this paper
• Hair-follicle-associated pluripotent (HAP) stem-cell-sheet implantation accelerates cutaneous wound closure and suppresses scar formation in a mouse model

  2025cites this paper
• Revolutionary Approaches to Hair Regrowth: Follicle Neogenesis, Wnt/ß-Catenin Signaling, and Emerging Therapies

  2025influential citation
• Respiratory microphysiological system in respiratory research: recent advances and future prospects

  2025cites this paper
• Current Development of iPSC-Based Modeling in Neurodegenerative Diseases

  2025cites this paper
• Current Applications of Human Pluripotent Stem Cells in Neuroscience Research and Cell Transplantation Therapy for Neurological Disorders

  2025cites this paper
• The miR-290 and miR-302 clusters are essential for reprogramming of fibroblasts to induced pluripotent stem cells.

  2025cites this paper
• c-Myc inhibits macrophage antimycobacterial response in Mycobacterium tuberculosis infection

  2025cites this paper
• FLT3 inhibition upregulates OCT4/NANOG to promote maintenance and TKI resistance of FLT3-ITD+ acute myeloid leukemia

  2025cites this paper
• Mesenchymal stem cell therapy for end-stage liver disease: adversity and opportunity

  2025cites this paper
• Development and characterization of a cell line from the caudal fin of Schizothorax niger (Heckel, 1838) for in vitro toxicity testing.

  2025cites this paper
• Investigating the Expression and Role of N-Myc in Spermatogonial Stem Cells and Male Infertility.

  2025cites this paper
• Fat-derived neural stem cells promote nerve regeneration following peripheral nerve injury

  2025cites this paper
• Human-Induced Pluripotent Stem Cells (iPSCs) for Disease Modeling and Insulin Target Cell Regeneration in the Treatment of Insulin Resistance: A Review

  2025cites this paper
• Application potential of induced pluripotent stem cells in the research and treatment of autoimmune diseases (Review)

  2025cites this paper
• Induced Pluripotent Stem Cell-Based Cancer Immunotherapy: Strategies and Perspectives

  2025cites this paper
• Current biological, chemical and physical gene delivery approaches for producing induced pluripotent stem cells (iPSCs).

  2025cites this paper
• Spermatogonia: a unique stem cell orchestrating species-specific transition from pluripotency to sperm production.

  2025cites this paper
• Xenograft of bio-3D printed scaffold-free cartilage constructs derived from human iPSCs to regenerate articular cartilage in immunodeficient pigs

  2025cites this paper
• Bone Organoids: Bridging Natural Bone with Advanced Organoid Technologies.

  2025cites this paper
• Scattering reduced imaging of spheroids via refractive index estimation and shift-variant deconvolution

  2025cites this paper
• Exploring hippocampal dysfunction in schizophrenia with pluripotent stem cell models.

  2025cites this paper
• Interpretable XGBoost-SHAP machine learning model for identifying scientific breakthroughs

  2025cites this paper
• Hic2 fast-tracks iPS cell generation by suppressing KLF4-dependent epidermal detour

  2025cites this paper
• Inducible differentiation of buffalo (Bubalus bubalis) embryonic stem cells towards male and female germ cell-like lineages under ex vivo BMP4-mediated stimulation.

  2025cites this paper
• Advances in Induced Pluripotent Stem Cell Reprogramming and Its Application in Amyotrophic Lateral Sclerosis: A Review

  2025cites this paper
• Scaffold-free cell sheet therapies: clinical advances, global approval landscapes, and strategic directions to address regenerative medicine barriers

  2025cites this paper
• THE ROLE OF STEM CELLS IN INCURABLE DISEASES: A SYSTEMATIC REVIEW WITH META-ANALYSIS

  2025cites this paper
• Development of Standardized Methods and Analytical Tools.

  2025cites this paper
• Human Induced Pluripotent Stem Cells: Directed Differentiation Methods and Applications in Brain Diseases

  2025cites this paper
• Supramolecular Additive Screening to Engineer Microfibrous Rafts for Expansion of Pluripotent Stem Cells in Dynamic Suspension

  2025cites this paper
• Advancement of 3D biofabrication in repairing and regeneration of cartilage defects

  2025cites this paper
• Advances in clinical translation of stem cell-based therapy in neurological diseases

  2025cites this paper
• p53-mediated regulation of epiblast cell numbers predicts reactivation during mouse embryonic diapause.

  2025cites this paper
• Characterization of DNA methylation profile of the entire CpG island spanning the 5' untranslated region to intron 1 of the Oct4/POU5F1 gene in bovine gametes, embryos, and somatic cells.

  2025cites this paper
• c-Myc Inhibits Macrophage Antimycobacterial Response in Mycobacterium tuberculosis Infection

  2025cites this paper
• Evolving functional hydrogel strategies for cartilage engineering: from fundamentals to functional regeneration

  2025cites this paper
• Efficient generation of germline chimeras in a non-rodent species using rabbit induced pluripotent stem cells

  2025cites this paper
• Chondrogenic Differentiation of Stem Cells for Cartilage Regeneration: Advances and Future Perspectives

  2025cites this paper
• Redefining cellular reprogramming with advanced genomic technologies

  2025cites this paper
• CRISPR screen reveals SOX2 as a critical regulator of CD133 and cellular stress response in glioblastoma

  2025cites this paper
• Erucamide regulates retinal neurovascular crosstalk

  2025cites this paper
• Emerging Strategies in Corneal Regeneration: The Role of Induced Pluripotent Stem Cell-Based Therapies.

  2025cites this paper
• Comprehensive insight into chicken germline cells: A review

  2025cites this paper
• Cell and tissue reprogramming: Unlocking a new era in medical drug discovery

  2025cites this paper
• Reprogramming of skin fibroblasts by 3D spheroid culture promotes peripheral nerve regeneration via the ID3/semaphorin7a pathway

  2025cites this paper
• The roles of cancer stem cell-derived secretory factors in shaping the immunosuppressive tumor microenvironment in hepatocellular carcinoma

  2024cites this paper
• An update on microfluidic multi-organ-on-a-chip systems for reproducing drug pharmacokinetics: the current state-of-the-art

  2024cites this paper
• Automated xeno-free chondrogenic differentiation from human embryonic stem cells: Enhancing efficiency and ensuring high-quality mass production

  2024cites this paper
• Efficacy of Engraftment and Safety of Human Umbilical Di-Chimeric Cell (HUDC) Therapy after Systemic Intraosseous Administration in an Experimental Model

  2024cites this paper
• Pre-clinical evaluation of clinically relevant iPS cell derived neuroepithelial stem cells as an off-the-shelf cell therapy for spinal cord injury

  2024cites this paper
• In vivo genome editing via CRISPR/Cas9-mediated homology-independent targeted integration for Bietti crystalline corneoretinal dystrophy treatment

  2024cites this paper
• Establishment of Transgene‐Free Porcine Induced Pluripotent Stem Cells

  2024cites this paper
• The current status of various preclinical therapeutic approaches for tendon repair

  2024cites this paper
• Reprogramming Glioblastoma Cells into Non-Cancerous Neuronal Cells as a Novel Anti-Cancer Strategy

  2024cites this paper
• The occurrence and development of induced pluripotent stem cells

  2024cites this paper
• Mesenchymal stem cells in craniofacial reconstruction: a comprehensive review.

  2024cites this paper
• Maternal methylosome protein 50 is essential for embryonic development in medaka Oryzias latipes.

  2024cites this paper
• Role of small molecules as drug candidates for reprogramming somatic cells into induced pluripotent stem cells: A comprehensive review

  2024cites this paper
• Unlocking the Potential of Induced Pluripotent Stem Cells in Revolutionizing Cancer Therapy.

  2024cites this paper
• Detection of biomagnetic signals from induced pluripotent stem cell-derived cardiomyocytes using deep learning with simulation data

  2024cites this paper
• H1FOO-DD promotes efficiency and uniformity in reprogramming to naive pluripotency

  2024cites this paper
• Molecular Mechanisms in the Design of Novel Targeted Therapies for Neurodegenerative Diseases

  2024cites this paper
• Hypoxia-induced immortalization of primary cells depends on Tfcp2L1 expression

  2024cites this paper
• Using Liver Organoids as Models to Study the Pathobiology of Rare Liver Diseases

  2024cites this paper
• Research Progress in Induced Pluripotent Stem Cell Neoplasia

  2024cites this paper
• Human-Induced Pluripotent Stem Cells in Plastic and Reconstructive Surgery

  2024cites this paper
• MCLand: A Python program for drawing emerging shapes of Waddington’s epigenetic landscape by Monte Carlo simulations

  2024cites this paper
• Bone-Regeneration Therapy Using Biodegradable Scaffolds: Calcium Phosphate Bioceramics and Biodegradable Polymers

  2024cites this paper
• Glial-restricted progenitor cells: a cure for diseased brain?

  2024cites this paper
• NK-cell cytotoxicity toward pluripotent stem cells and their neural progeny: impacts of activating and inhibitory receptors and KIR/HLA mismatch

  2024cites this paper
• Development of bioengineered 3D patient derived breast cancer organoid model focusing dynamic fibroblast–stem cell reciprocity

  2024cites this paper
• Transplantation of derivative retinal organoids from chemically induced pluripotent stem cells restored visual function

  2024cites this paper
• Breaking the mold: 3D cell cultures reshaping the future of cancer research

  2024cites this paper
• Nanoparticle-Bearing Chitosan Implants for in Situ Stem Cell Reprogramming

  2024cites this paper
• Role of Protein Tyrosine Phosphatases in Inflammatory Bowel Disease, Celiac Disease and Diabetes: Focus on the Intestinal Mucosa

  2024cites this paper
• Molecular Basis of Cell Reprogramming into iPSCs with Exogenous Transcription Factors.

  2024cites this paper
• Exosomes in skin photoaging: biological functions and therapeutic opportunity

  2024cites this paper
• Metabolic control of induced pluripotency

  2024cites this paper
• Direct reprogramming of hepatocytes into JAK/Stat-dependent LGR5+ liver cells able to initiate intrahepatic cholangiocarcinoma.

  2024cites this paper
• Inducing Pluripotency in Somatic Cells: Historical Perspective and Recent Advances

  2024cites this paper
• Differentiation of Human-induced Pluripotent Stem Cell-derived Dental Stem Cells through Epithelial–Mesenchymal Interaction

  2024cites this paper
• Understanding genomic medicine for thoracic aortic disease through the lens of induced pluripotent stem cells

  2024cites this paper
• Recent Progress in Retinal Pigment Epithelium Cell-Based Therapy for Retinal Disease

  2024cites this paper
• Stem Cells and Bone Tissue Engineering

  2024cites this paper
• Stem cell therapy for heart failure in the clinics: new perspectives in the era of precision medicine and artificial intelligence

  2024cites this paper
• Single-cell RNA sequencing reveals key regulators and differentiation trajectory of iPSC-derived cardiomyocytes

  2024cites this paper
• Research progress of cell treatment strategy in Parkinson's disease

  2024cites this paper
• Efficient Generation of Human Pluripotent Stem Cells from Frozen Cord Tissue via Chemical Reprogramming

  2024cites this paper
• Mechanically mediated cargo delivery to cells using microfluidic devices.

  2024cites this paper
• Effects of Clump Size on the Pluripotency and Proliferation in the Passaging Process of Mouse Induced Pluripotent Stem Cells

  2024cites this paper