Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Clinical Cancer Research

• Publication date

  1999-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 10537357
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells

  1998cited by this paper
• Prognostic applications of the epidermal growth factor receptor and its ligand, transforming growth factor-alpha.

  1998cited by this paper
• Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts.

  1998cited by this paper
• Phase I study of anti-epidermal growth factor receptor (anti-EGFR) antibody C225 in combination with irradiation in patients with advanced squamous cell carcinoma of the head and neck (SCCHN)

  1998cited by this paper
• Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival.

  1998cited by this paper
• Levels of TGF-α and EGFR Protein in Head and Neck Squamous Cell Carcinoma and Patient Survival

  1998cited by this paper
• Potential indicators of radiosensitivity in squamous cell carcinoma of the head and neck.

  1997cited by this paper
• The Klaas Breur Lecture. Radiation, hypoxia and genetic stimulation: implications for future therapies.

  1997cited by this paper
• Epidermal growth factor receptor family and chemosensitization.

  1997influential reference
• Cell cycle regulation in irradiated and nonirradiated cells.

  1997cited by this paper
• EGF receptor phosphorylation is affected by ionizing radiation.

  1997cited by this paper
• A transgenic mouse model with cyclin D1 overexpression results in cell cycle, epidermal growth factor receptor, and p53 abnormalities.

  1997cited by this paper
• Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation

  1997cited by this paper
• Radiation-induced autophosphorylation of epidermal growth factor receptor in human malignant mammary and squamous epithelial cells.

  1996cited by this paper
• The effect of ionizing radiation on signal transduction: antibodies to EGF receptor sensitize A431 cells to radiation.

  1996influential reference
• 273The breur lecture: Radiation, hypoxia and genetic stimulation: Implications for future therapies

  1996cited by this paper
• Aberrant expression of p53 or the epidermal growth factor receptor is frequent in early bronchial neoplasia and coexpression precedes squamous cell carcinoma development.

  1995cited by this paper
• Epidermal growth factor-related peptides and their receptors in human malignancies.

  1995cited by this paper
• Increased resistance to cytotoxic agents in ZR75B human breast cancer cells transfected with epidermal growth factor receptor.

  1995cited by this paper
• Role of reoxygenation in induction of enhancement of tumor radioresponse by paclitaxel.

  1995cited by this paper
• Immunofluorometric analysis of p53 protein and prostate-specific antigen in breast tumours and their association with other prognostic indicators.

  1995cited by this paper
• Effect of epidermal growth factor on the growth and radiation sensitivity of human breast cancer cells in vitro.

  1994influential reference
• Is tumor cell radiation resistance correlated with metastatic ability?

  1994cited by this paper
• Apoptosis. Its significance in cancer and cancer Therapy

  1994cited by this paper
• The interaction of epidermal growth factor and radiation in human head and neck squamous cell carcinoma cell lines with vastly different radiosensitivities.

  1994cited by this paper
• Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells.

  1994cited by this paper
• Prognostic significance of transforming growth factor-alpha in human esophageal carcinoma. Implication for the autocrine proliferation.

  1993cited by this paper
• Heterogeneity in the development of apoptosis in irradiated murine tumours of different histologies.

  1993cited by this paper
• Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death.

  1993cited by this paper
• Prognostic significance of transforming growth factor‐α in human esophageal carcinoma implication for the autocrine proliferation

  1993cited by this paper
• Development of apoptosis in irradiated murine tumors as a function of time and dose.

  1993cited by this paper
• p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.

  1993cited by this paper
• Significance of epidermal growth factor receptor in advanced ovarian cancer.

  1992cited by this paper
• Social controls on cell survival and cell death

  1992cited by this paper
• Cell cycle dependence of epidermal growth factor induced radiosensitization.

  1992cited by this paper
• The clinical significance of epidermal growth factor receptor (EGF-R) in human breast cancer: a review on 5232 patients.

  1992cited by this paper
• Growth suppression of human breast cancer cells by the introduction of a wild-type p53 gene.

  1991cited by this paper
• Participation of p53 protein in the cellular response to DNA damage.

  1991cited by this paper
• Apoptosis in irradiated murine tumors.

  1991cited by this paper
• Differences in EGF related radiosensitisation of human squamous carcinoma cells with high and low numbers of EGF receptors.

  1991cited by this paper
• A monoclonal antibody against the c-erbB-2 protein enhances the cytotoxicity of cis-diamminedichloroplatinum against human breast and ovarian tumor cell lines.

  1991cited by this paper
• The epidermal growth factor receptor and the prognosis of bladder cancer

  1990cited by this paper
• Signal transduction through the EGF receptor transfected in IL-3-dependent hematopoietic cells.

  1988cited by this paper
• Macrophage content of murine sarcomas and carcinomas: associations with tumor growth parameters and tumor radiocurability.

  1987cited by this paper
• Effect of the radiosensitizer misonidazole and the radioprotector diethyldithiocarbamate on spontaneous metastasis formation of murine tumors.

  1986cited by this paper
• Immunological resistance to pulmonary metastases in C3Hf-Bu mice bearing syngeneic fibrosarcoma of different sizes.

  1974cited by this paper
• Statistical Method in Biological Assay

  1966cited by this paper

• Cetuximab in Locoregionally Advanced Head and Neck Cancer: A Real-World Case Series

  2025cites this paper
• Hippo signaling pathway in cervical cancer: insights into mechanisms and therapeutic potential

  2025cites this paper
• DAHANCA19: A randomized phase III study of primary curative (chemo)-radiotherapy and the EGFR-inhibitor zalutumumab for squamous cell carcinoma of the head and neck.

  2025cites this paper
• Overcoming Resistance to Standard-of-Care Therapies for Head and Neck Squamous Cell Carcinomas

  2024cites this paper
• Differences in Radiosensitivity According to EGFR Mutation Status in Non-Small Cell Lung Cancer: A Clinical and In Vitro Study

  2023cites this paper
• The prognostic ability of radiotherapy of different colorectal cancer histological subtypes and tumor sites

  2023cites this paper
• Effects of EGFR driver mutations on pathologic regression in resectable locally advanced non-small cell lung cancer treated with neoadjuvant chemoradiation and completion surgery

  2023cites this paper
• Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer

  2023cites this paper
• Management of Oncogene Driven Locally Advanced Unresectable Non-small Cell Lung Cancer

  2023cites this paper
• Signature of seven cuproptosis-related lncRNAs as a novel biomarker to predict prognosis and therapeutic response in cervical cancer

  2022cites this paper
• Insights on the Dynamic Innovative Tumor Targeted-Nanoparticles-Based Drug Delivery Systems Activation Techniques

  2022cites this paper
• Association Between EGFR and ALK Mutation Status on Patient-Reported Symptoms After Palliative Radiation for Bone Pain in NSCLC

  2022cites this paper
• Polymorphisms in EGFR Gene Predict Clinical Outcome in Unresectable Non-Small Cell Lung Cancer Treated with Radiotherapy and Platinum-Based Chemoradiotherapy

  2021cites this paper
• Brain Metastasis Response to Stereotactic Radio Surgery: A Mathematical Approach

  2021cites this paper
• Liquid biopsy in NSCLC: a new challenge in radiation therapy

  2021cites this paper
• Combined EGFR1 and PARP1 Inhibition Enhances the Effect of Radiation in Head and Neck Squamous Cell Carcinoma Models

  2020cites this paper
• Celecoxib and Afatinib synergistic enhance radiotherapy sensitivity on human non-small cell lung cancer A549 cells

  2020cites this paper
• Phase 2 Study of Nimotuzumab in Combination With Concurrent Chemoradiotherapy in Patients With Locally Advanced Non-Small-Cell Lung Cancer.

  2020cites this paper
• Molecular biomarkers: multiple roles in radiotherapy

  2020cites this paper
• Cetuximab-Containing Combinations in Locally Advanced and Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

  2019cites this paper
• Nanoparticle Activation Methods in Cancer Treatment

  2019cites this paper
• Chemotherapy and Biologic Therapy in Rectal Cancer: An Update

  2019cites this paper
• Stereotactic radiosurgery in the era of novel systemic therapy for lung cancer brain metastases

  2019cites this paper
• Synergistic In-Vitro Effects through Radiation and Blocking the Epidermal Growth Factor Receptor (EGFR) with the Monoclonal Antibody Cetuximab in Prostate Carcinoma Cell Line DU145

  2019cites this paper
• Dielectrophoretic analysis of treated cancer cells for rapid assessment of treatment efficacy

  2018cites this paper
• Human epidermal growth factor receptor 2 neu expression in head and neck squamous cell cancers and its clinicopathological correlation: Results from an Indian cancer center

  2018influential citation
• The Effect of Canertinib on Sensitivity of Cytotoxic Drugs in Tamoxifen-Resistant Breast Cancer Cells In Vitro

  2018cites this paper
• SRSF1 modulates PTPMT1 alternative splicing to regulate lung cancer cell radioresistance

  2018cites this paper
• Inhibition of NF‐κB improves sensitivity to irradiation and EGFR‐TKIs and decreases irradiation‐induced lung toxicity

  2018cites this paper
• The Prognostic Significance of the Expression Change of EGFR during Neoadjuvant Chemoradiotherapy in Patients with Rectal Carcinoma

  2018cites this paper
• Beneficial effects of anti-EGFR agents, Cetuximab or Nimotuzumab, in combination with concurrent chemoradiotherapy in advanced nasopharyngeal carcinoma.

  2018cites this paper
• Medical Treatment Options for Patients with Epidermal Growth Factor Receptor Mutation-Positive Non-Small Cell Lung Cancer Suffering from Brain Metastases and/or Leptomeningeal Disease

  2018cites this paper
• Final Report of a Phase I Trial of Olaparib with Cetuximab and Radiation for Heavy Smoker Patients with Locally Advanced Head and Neck Cancer

  2018cites this paper
• Locally Advanced Non-small Cell Lung Cancer and Targeted Therapy

  2017cites this paper
• Radiation Biology for Radiation Oncologists

  2017cites this paper
• Mechanism of action of Tarloxotinib, a hypoxia-activated pan-HER inhibitor: Potential for targeting wild-type EGFR in non-small cell lung cancer

  2017cites this paper
• Systemic therapy of brain metastases: non-small cell lung cancer, breast cancer, and melanoma.

  2017cites this paper
• Combined irradiation and targeted therapy or immune checkpoint blockade in brain metastases: toxicities and efficacy

  2017cites this paper
• Improving anti-EGFR therapy in HNSCC by targeting the growth factor receptor co-activation network

  2017cites this paper
• Long-term results and recurrence patterns from SCOPE-1: a phase II/III randomised trial of definitive chemoradiotherapy +/− cetuximab in oesophageal cancer

  2017cites this paper
• Receptor Tyrosine Kinases as Targets for Enhancing Tumor Radiosensitivity

  2017cites this paper
• Quelle est la meilleure séquence thérapeutique pour les CBNPC non-opérables ?

  2017cites this paper
• Inactivation of EGFR/AKT signaling enhances TSA-induced ovarian cancer cell differentiation.

  2017cites this paper
• The prognostic significance of epidermal growth factor receptor expression in patients with anal carcinoma.

  2016cites this paper
• Brain metastases from non-small cell lung cancer : radiation therapy in the era of targeted therapies

  2016cites this paper
• Targeted Therapies for the Treatment of Brain Metastases in Solid Tumors

  2016cites this paper
• Drug Combinations in Preoperative Chemoradiation for Rectal Cancer.

  2016cites this paper
• Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of central nervous system metastases from non-small cell lung cancer: the present and the future.

  2016cites this paper
• Modulation of Oxidative Stress Influences Tumor Response to Therapy.

  2016cites this paper
• Novel molecular imaging methods for cancer detection : more than meets the eye

  2016cites this paper
• [Radiotherapy and targeted therapy/immunotherapy].

  2016cites this paper
• Brain Metastases from NSCLC: Radiation Therapy in the Era of Targeted Therapies

  2016cites this paper
• Novel Treatment Strategies for Brain Metastases in Non-small-cell Lung Cancer

  2016cites this paper
• Molecular Targeting of Growth Factor Receptor Signaling in Radiation Oncology.

  2016cites this paper
• Cranial irradiation in patients with EGFR-mutant non-small cell lung cancer brain metastases.

  2016cites this paper
• Gene Therapy for Lung Cancer.

  2016cites this paper
• A copper chelate induces apoptosis and overcomes multidrug resistance in T-cell acute lymphoblastic leukemia through redox imbalance and inhibition of EGFR/PI3K/Akt expression.

  2016cites this paper
• EGFR monoclonal antibodies in locally advanced head and neck squamous cell carcinoma: What is their current role?

  2016cites this paper
• Pharmacologic Management of Advanced Cervical Cancer: Antiangiogenesis Therapy and Immunotherapeutic Considerations

  2015cites this paper
• Quantitative mRNA expression analysis of selected genes in patients with early-stage hypothyroidism induced by treatment with iodine-131.

  2015cites this paper
• The kinase inhibitor D11 induces caspase-mediated cell death in cancer cells resistant to chemotherapeutic treatment

  2015cites this paper
• Considerations on the management of EGF receptor-TKIs for brain metastases in EGFR-mutant lung carcinoma patients

  2015cites this paper
• Photochemical internalization of recombinant toxins targeting EGFR and HER2 for treatment of aggressive and resistant cancers

  2015cites this paper
• Effects of Black Seed on Lung Cancer/in Vitro Study

  2015cites this paper
• Design of an EGFR-targeting toxin for photochemical delivery: in vitro and in vivo selectivity and efficacy

  2015cites this paper
• Synthetic Sickness with Molecularly Targeted Agents Against the EGFR Pathway

  2015cites this paper
• Targeting EGFR-PI3K-AKT-mTOR signaling enhances radiosensitivity in head and neck squamous cell carcinoma

  2015cites this paper
• EGFR targeted therapies and radiation: Optimizing efficacy by appropriate drug scheduling and patient selection.

  2015cites this paper
• Targeting Notch to overcome radiation resistance

  2015cites this paper
• RNA interference for epidermal growth factor receptor enhances the radiosensitivity of esophageal squamous cell carcinoma cell line Eca109.

  2015cites this paper
• Cancer bronchique non à petites cellules localement avancé : quand et comment intégrer chimiothérapie et radiothérapie ?

  2015cites this paper
• Targeted Therapy for Brain Metastases in EGFR-Mutated and ALK-Rearranged Non–Small-Cell Lung Cancer

  2015cites this paper
• Možnosti inhibice receptoru pro epidermální růstový faktor u karcinomu anu

  2015cites this paper
• Syddansk Universitet The kinase inhibitor D 11 induces caspase-mediated cell death in cancer cells resistant to chemotherapeutic treatment

  2015cites this paper
• Adding Erlotinib to Chemoradiation Improves Overall Survival but not Progression-Free Survival in Stage III Non-Small-Cell Lung Cancer

  2015cites this paper
• Linking the History of Radiation Biology to the Hallmarks of Cancer

  2014cites this paper
• A prospective randomised controlled trial of concurrent chemoradiation versus concurrent chemoradiation along with gefitinib in locally advanced squamous cell carcinoma of head and neck

  2014influential citation
• EGFR ligands and DNA repair genes: genomic predictors of complete response after capecitabine-based chemoradiotherapy in locally advanced rectal cancer

  2014cites this paper
• [The combination of neoadjuvant chemoradiotherapy and epidermal growth factor receptor inhibitors in the treatment of rectal adenocarcinoma].

  2014cites this paper
• Combining targeted agents and hypo- and hyper-fractionated radiotherapy in NSCLC.

  2014cites this paper
• SAFETY AND ANTITUMOR ACTIVITY OF GEFITINIB: AN OVERVIEW

  2014cites this paper
• Neoadjuvantní chemoradioterapie karcinomu rekta v kombinaci s inhibitory receptoru pro růstový epidermální faktor Th e Combination of Neoadjuvant Chemoradiotherapy and Epidermal Growth Factor Receptor Inhibitors in the Treatment of Rectal Adenocarcinoma

  2014cites this paper
• effec-Beyond angiogenesis blockade: targeted therapy for advanced cervical cancer

  2014cites this paper
• Beyond angiogenesis blockade: targeted therapy for advanced cervical cancer

  2014cites this paper
• Der Einfluss des Stammzellmarkers ALDH und des EGFR-PI3 Kinase-Akt Signalwegs auf die Strahlenresistenz humaner Tumorzelllinien

  2014cites this paper
• Schedule-dependent interactions between perifosine and radiotherapy in prostate cancer

  2013cites this paper
• Integration of targeted therapy in the management of locally advanced, unresectable non-small-cell lung cancer

  2013cites this paper
• The status of targeted agents in the setting of neoadjuvant radiation therapy in locally advanced rectal cancers.

  2013cites this paper
• Clinical perspectives of cancer stem cell research in radiation oncology.

  2013cites this paper
• Locoregional recurrence in patients with HER2 positive breast cancer.

  2013cites this paper
• EGFR mutation status and brain metastases in non-small cell lung cancer: an understudied problem

  2013cites this paper
• Radiation-induced dimer formation of EGFR: implications for the radiosensitizing effect of cetuximab.

  2013cites this paper
• Current concepts in clinical radiation oncology

  2013cites this paper
• Phase II trial of erlotinib plus concurrent whole-brain radiation therapy for patients with brain metastases from non-small-cell lung cancer.

  2013cites this paper
• Lessons Learned from Radiation Oncology Clinical Trials

  2013influential citation
• Molecular biomarkers as predictors of response to neoadjuvant chemoradiation therapy in rectal cancer

  2013cites this paper
• The Role of Molecular Diagnostics in Cancer Diagnosis and Treatment

  2012cites this paper
• The impact of timing of EGFR and IGF-1R inhibition for sensitizing head and neck cancer to radiation.

  2012cites this paper
• The Current State of Targeted Agents in Rectal Cancer

  2012cites this paper
• Nimotuzumab increases chemosensitivity of human lung adenocarcinoma cell lines to docetaxel.

  2012cites this paper