Synthesis and Structure − Activity Relationship Studies of Novel Dual Inhibitors of Soluble Epoxide Hydrolase and 5 ‐ Lipoxygenase

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Not labeled

• Identifiers

  No identifiers available.

• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health.

  2013cited by this paper
• Molecular characterization of EP6--a novel imidazo[1,2-a]pyridine based direct 5-lipoxygenase inhibitor.

  2012cited by this paper
• Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors.

  2012cited by this paper
• Epoxides and soluble epoxide hydrolase in cardiovascular physiology.

  2012cited by this paper
• Complementary Screening Techniques Yielded Fragments that Inhibit the Phosphatase Activity of Soluble Epoxide Hydrolase

  2011cited by this paper
• Synthesis and Structure−Activity Relationship Studies of Urea-Containing Pyrazoles as Dual Inhibitors of Cyclooxygenase-2 and Soluble Epoxide Hydrolase

  2011cited by this paper
• 5-Lipoxygenase inhibitors: a review of recent developments and patents

  2010cited by this paper
• Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs.

  2010cited by this paper
• Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model.

  2010cited by this paper
• Soluble epoxide hydrolase inhibitors: a patent review

  2010cited by this paper
• Inhibition of the Soluble Epoxide Hydrolase Promotes Albuminuria in Mice with Progressive Renal Disease

  2010cited by this paper
• Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase.

  2010cited by this paper
• Inhibition of arachidonic acid metabolism and its implication on cell proliferation and tumour-angiogenesis.

  2009cited by this paper
• Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1

  2008cited by this paper
• The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5‐lipoxygenase products

  2007cited by this paper
• 5-Lipoxygenase: regulation of expression and enzyme activity.

  2007cited by this paper
• Designed Multiple Ligands. An Emerging Drug Discovery Paradigm

  2006cited by this paper
• From magic bullets to designed multiple ligands.

  2004cited by this paper
• Metal ion recognition. Selective interaction of silver(I) with tri-linked N2S2-donor macrocycles and their single-ring analogues

  2002cited by this paper
• Secondary amides of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase.

  2000cited by this paper
• Synthesis of Imidazo[1,2-a] annulated Pyridines, Pyrazines and Pyrimidines by a Novel Three-Component Condensation

  1998cited by this paper
• The Use of 5‐Lipoxygenase Inhibitors and Leukotriene Receptor Antagonists in the Treatment of Chronic Asthma

  1997cited by this paper
• Sequential induction of 5-lipoxygenase gene expression and activity in Mono Mac 6 cells by transforming growth factor beta and 1,25-dihydroxyvitamin D3.

  1995cited by this paper
• Effect of chronic 5-lipoxygenase inhibition on airway hyperresponsiveness in asthmatic subjects.

  1995cited by this paper
• Pharmacological profile of a new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase.

  1994cited by this paper
• The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products

  1981cited by this paper

• Strategies for developing dual-targeted soluble epoxide hydrolase inhibitors.

  2025cites this paper
• Molecular hybridization: a powerful tool for multitarget drug discovery

  2024cites this paper
• Generation of multimillion chemical space based on the parallel Groebke–Blackburn–Bienaymé reaction

  2024cites this paper
• N-alkylamides from Litsea cubeba (Lour.) Pers. with potential anti-inflammatory activity

  2023cites this paper
• Soluble epoxide hydrolase inhibitors: an overview and patent review from the last decade

  2022cites this paper
• Novel 5-Nitrofuran-Tagged Imidazo-Fused Azines and Azoles Amenable by the Groebke–Blackburn–Bienaymé Multicomponent Reaction: Activity Profile against ESKAPE Pathogens and Mycobacteria

  2022cites this paper
• Quinazoline-4(3H)-one-7-carboxamide Derivatives as Human Soluble Epoxide Hydrolase Inhibitors with Developable 5-Lipoxygenase Activating Protein Inhibition

  2022cites this paper
• Design, synthesis and mechanistic study of novel diarylpyrazole derivatives as anti-inflammatory agents with reduced cardiovascular side effects.

  2021cites this paper
• Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative

  2021cites this paper
• Recent Applications of Multicomponent Reactions Toward Heterocyclic Drug Discovery

  2021cites this paper
• Discovery of Soluble Epoxide Hydrolase Inhibitors from Chemical Synthesis and Natural Products.

  2020cites this paper
• Small Molecule Soluble Epoxide Hydrolase Inhibitors in Multitarget and Combination Therapies for Inflammation and Cancer

  2020cites this paper
• The Groebke-Blackburn-Bienaymé Reaction.

  2019cites this paper
• Development of multitarget agents possessing soluble epoxide hydrolase inhibitory activity.

  2019cites this paper
• Two‐pronged approach to anti‐inflammatory therapy through the modulation of the arachidonic acid cascade

  2018cites this paper
• Synthesis of substituted fluorobenzimidazoles as inhibitors of 5‐lipoxygenase and soluble epoxide hydrolase for anti‐inflammatory activity

  2018cites this paper
• Synthesis, Biological Evaluation and Structure–Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors

  2018cites this paper
• Synthesis of a NbO Type Homochiral Cu(II) Metal-Organic Framework: Ferroelectric Behavior and Heterogeneous Catalysis of Three-Component Coupling and Pechmann Reactions.

  2017cites this paper
• Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening

  2017cites this paper
• Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase

  2017cites this paper
• Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase

  2016cites this paper
• Design and synthesis of fused soluble epoxide hydrolase/peroxisome proliferator-activated receptor modulators

  2016cites this paper
• Introducing ferrocene into imidazo[1,2-a]pyridine by Groebke three-component-reaction for scavenging radicals and inhibiting DNA oxidation

  2015cites this paper
• Cytochrome P450 epoxygenase pathway of polyunsaturated fatty acid metabolism.

  2015cites this paper
• In vitro inhibitory effects of ethanol extract of Danshen (Salvia miltiorrhiza) and its components on the catalytic activity of soluble epoxide hydrolase.

  2015cites this paper
• The 2014 Bernard B. Brodie Award Lecture—Epoxide Hydrolases: Drug Metabolism to Therapeutics for Chronic Pain

  2015cites this paper
• The Pharmacology of the Cytochrome P 450 Epoxygenase / Soluble Epoxide Hydrolase Axis in the Vasculature and Cardiovascular Disease

  2014cites this paper
• Inhibitors of the arachidonic acid cascade: interfering with multiple pathways.

  2014cites this paper
• PHARMREV007781 1106..1140

  2014cites this paper
• Functionalization of Imidazo[1,2‐a]pyridines by Means of Metal‐Catalyzed Cross‐Coupling Reactions

  2014cites this paper
• One-pot copper nanoparticle-catalyzed synthesis of imidazo[1,2-a]pyridines under solvent-free conditions

  2014cites this paper
• The Pharmacology of the Cytochrome P450 Epoxygenase/Soluble Epoxide Hydrolase Axis in the Vasculature and Cardiovascular Disease

  2014cites this paper
• Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase.

  2014cites this paper
• Cu–Mn spinel oxide catalyzed synthesis of imidazo[1,2-a]pyridines through domino three-component coupling and 5-exo-dig cyclization in water

  2013cites this paper
• Exploring the chemical space of multitarget ligands using aligned self-organizing maps.

  2013cites this paper