Translational regulation of glutathione peroxidase 4 expression through guanine-rich sequence-binding factor 1 is essential for embryonic brain development.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Genes & Development

• Publication date

  2008-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/gad.466308PMID 18593884PMCID PMC2492670
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tea epigallocatechin-3-gallate increases 8-isoprostane level and induces caudal regression in developing rat embryos.

  2007cited by this paper
• Role for glutathione peroxidase-4 in brain development and neuronal apoptosis: specific induction of enzyme expression in reactive astrocytes following brain injury.

  2007cited by this paper
• Members of the Heterogeneous Nuclear Ribonucleoprotein H Family Activate Splicing of an HIV-1 Splicing Substrate by Promoting Formation of ATP-dependent Spliceosomal Complexes*

  2007cited by this paper
• Specific trans-acting proteins interact with auxiliary RNA polyadenylation elements in the COX-2 3'-UTR.

  2007cited by this paper
• Expression and regulation of antioxidant enzymes in the developing limb support a function of ROS in interdigital cell death.

  2006cited by this paper
• Translational Control of Collagen Prolyl 4-Hydroxylase-α(I) Gene Expression under Hypoxia*

  2006cited by this paper
• Translational control of collagen prolyl 4-hydroxylase-alpha(I) gene expression under hypoxia.

  2006cited by this paper
• The Role of Phospholipid Hydroperoxide Glutathione Peroxidase Isoforms in Murine Embryogenesis*

  2006cited by this paper
• Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity

  2006cited by this paper
• Dissecting Wnt/β-catenin signaling during gastrulation using RNA interference in mouse embryos

  2005cited by this paper
• A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain

  2005cited by this paper
• The RNA recognition motif, a plastic RNA‐binding platform to regulate post‐transcriptional gene expression

  2005cited by this paper
• Drosophila cup is an eIF4E binding protein that associates with Bruno and regulates oskar mRNA translation in oogenesis.

  2004cited by this paper
• A systems view of mRNP biology.

  2004cited by this paper
• cAMP-response element modulator-tau activates a distinct promoter element for the expression of the phospholipid hydroperoxide/sperm nucleus glutathione peroxidase gene.

  2004cited by this paper
• Elongator interactions with nascent mRNA revealed by RNA immunoprecipitation.

  2004cited by this paper
• Early neural cell death: dying to become neurons.

  2004cited by this paper
• Regulation of Expression of the Phospholipid Hydroperoxide/Sperm Nucleus Glutathione Peroxidase Gene

  2003cited by this paper
• Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene.

  2003cited by this paper
• Functional characterization of cis- and trans-regulatory elements involved in expression of phospholipid hydroperoxide glutathione peroxidase.

  2003cited by this paper
• Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells.

  2003cited by this paper
• Distinct Promoters Determine Alternative Transcription of gpx-4 into Phospholipid-Hydroperoxide Glutathione Peroxidase Variants*

  2003cited by this paper
• The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults.

  2003influential reference
• 3’UTRs of Glutathione Peroxidases Differentially Affect Selenium-Dependent mRNA Stability and Selenocysteine Incorporation Efficiency

  2003cited by this paper
• Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants.

  2003cited by this paper
• Differential Splicing of the Phospholipid Hydroperoxide Glutathione Peroxidase Gene in Diploid and Haploid Male Germ Cells in the Rat1

  2003cited by this paper
• Bicoid associates with the 5'-cap-bound complex of caudal mRNA and represses translation.

  2002cited by this paper
• Identification of Target Messenger RNA Substrates for the Murine Deleted in Azoospermia-Like RNA-Binding Protein1

  2002influential reference
• Regulation of enzymatic lipid peroxidation: the interplay of peroxidizing and peroxide reducing enzymes.

  2002cited by this paper
• Diclofenac-induced embryotoxicity is associated with increased embryonic 8-isoprostaglandin F2alpha level in rat whole embryo culture.

  2002cited by this paper
• Phospholipid-hydroperoxide glutathione peroxidase in sperm.

  2002cited by this paper
• Enzymatic and immunochemical evaluation of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in testes and epididymal spermatozoa of rats of different ages.

  2002cited by this paper
• Selective Translation of Eukaryotic mRNAs: Functional Molecular Analysis of GRSF-1, a Positive Regulator of Influenza Virus Protein Synthesis

  2002cited by this paper
• Analyzing mRNA-protein complexes using a yeast three-hybrid system.

  2002cited by this paper
• Role of HuD and other RNA‐binding proteins in neural development and plasticity

  2002cited by this paper
• Suppression of 15-lipoxygenase synthesis by hnRNP E1 is dependent on repetitive nature of LOX mRNA 3'-UTR control element DICE.

  2002cited by this paper
• Identification of a specific sperm nuclei selenoenzyme necessary for protamine thiol cross‐linking during sperm maturation

  2001cited by this paper
• Nonsense-mediated decay of mRNA for the selenoprotein phospholipid hydroperoxide glutathione peroxidase is detectable in cultured cells but masked or inhibited in rat tissues.

  2001cited by this paper
• Overexpression of PHGPx inhibits hydroperoxide-induced oxidation, NFkappaB activation and apoptosis and affects oxLDL-mediated proliferation of rabbit aortic smooth muscle cells.

  2000cited by this paper
• A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs

  2000cited by this paper
• Regulation of eukaryotic protein synthesis: selective influenza viral mRNA translation is mediated by the cellular RNA-binding protein GRSF-1.

  1999cited by this paper
• Tissue-specific functions of individual glutathione peroxidases.

  1999cited by this paper
• Murine phospholipid hydroperoxide glutathione peroxidase: cDNA sequence, tissue expression, and mapping

  1999cited by this paper
• Dual function of the selenoprotein PHGPx during sperm maturation.

  1999cited by this paper
• Cloning and sequencing of the mouse cDNA encoding a phospholipid hydroperoxide glutathione peroxidase.

  1997cited by this paper
• Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.

  1997influential reference
• Translational repressor bruno plays multiple roles in development and is widely conserved.

  1997cited by this paper
• The Selenoenzyme Phospholipid Hydroperoxide Glutathione Peroxidase Controls the Activity of the 15-Lipoxygenase with Complex Substrates and Preserves the Specificity of the Oxygenation Products (*)

  1996cited by this paper
• GRSF-1: a poly(A)+ mRNA binding protein which interacts with a conserved G-rich element.

  1994cited by this paper
• Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors.

  1993cited by this paper
• Enzymatic reduction of phospholipid and cholesterol hydroperoxides in artificial bilayers and lipoproteins.

  1990cited by this paper
• Morphogenesis and quantification of the development of post-implantation mouse embryos.

  1990cited by this paper
• The role of selenium peroxidases in the protection against oxidative damage of membranes.

  1987influential reference

• GRSF1 Protects Against Heart Failure by Maintaining BCAA Homeostasis.

  2026cites this paper
• Ferroptosis and Metabolic Dysregulation: Emerging Chemical Targets in Cancer and Infection

  2025cites this paper
• Antioxidant proteins can be potential targets in ameliorating ferroptosis in diabetic cardiomyopathy: a literature review

  2025cites this paper
• RNA G-quadruplexes control mitochondria-localized mRNA translation and energy metabolism

  2025cites this paper
• The Role of tRNA-Derived Small RNAs (tsRNAs) in Regulating Cell Death of Cardiovascular Diseases

  2025cites this paper
• Double-edged sword effect of GPX4 in skin homeostasis and diseases

  2025cites this paper
• The Role of Glutathione Peroxidase 4 in Neuronal Ferroptosis and Its Therapeutic Potential in Ischemic and Hemorrhagic Stroke.

  2024cites this paper
• Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy

  2024cites this paper
• STUB1-mediated ubiquitination and degradation of NSUN2 promotes hepatocyte ferroptosis by decreasing m5C methylation of Gpx4 mRNA.

  2024cites this paper
• Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications

  2024cites this paper
• The role of ferroptosis in central nervous system damage diseases

  2024cites this paper
• Mechanism of Dendrobium Nobile Polysaccharide Inhibition of Ferroptosis in Rats with Spinal Cord Injury.

  2024cites this paper
• Ferroptosis in health and disease

  2024cites this paper
• HIF-1 induced tiRNA-Lys-CTT-003 is protective against cisplatin induced ferroptosis of renal tubular cells in mouse AKI model.

  2024cites this paper
• New horizons for the role of selenium on cognitive function: advances and challenges

  2024cites this paper
• GPX4 in cell death, autophagy, and disease

  2023cites this paper
• Ferroptosis and its modulators: A raising target for cancer and Alzheimer's disease.

  2023cites this paper
• GRSF1 antagonizes age-associated hypercoagulability via modulation of fibrinogen mRNA stability

  2023cites this paper
• Anti-aging Factor GRSF1 Attenuates Cerebral Ischemia-Reperfusion Injury in Mice by Inhibiting GPX4-Mediated Ferroptosis

  2023cites this paper
• Guanine-rich RNA sequence binding factor 1 regulates neuronal ferroptosis after spinal cord injury in rats via the GPX4 signaling pathway.

  2023influential citation
• Cryostress induces fragmentation and alters the abundance of sperm transcripts associated with fertilizing competence and reproductive processes in buffalo

  2023cites this paper
• The HNRNPF/H RNA binding proteins and disease

  2023cites this paper
• GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment.

  2023cites this paper
• The role of selenoproteins in neurodevelopment and neurological function: Implications in autism spectrum disorder

  2023cites this paper
• COVID-19 Causes Ferroptosis and Oxidative Stress in Human Endothelial Cells

  2023cites this paper
• Prospects for Anti-Tumor Mechanism and Potential Clinical Application Based on Glutathione Peroxidase 4 Mediated Ferroptosis

  2023cites this paper
• Effects of Rapamycin on the Expression of Redox Enzymes in Aortic Vascular Smooth Muscle Cells from Marfan Syndrome Mice

  2022cites this paper
• Geniposide Possesses the Protective Effect on Myocardial Injury by Inhibiting Oxidative Stress and Ferroptosis via Activation of the Grsf1/GPx4 Axis

  2022cites this paper
• Ferroptosis-related genes involved in animal reproduction: An Overview.

  2022cites this paper
• GPX4 deficiency-dependent phospholipid peroxidation drives motor deficits of ALS

  2022cites this paper
• The RNA-binding protein fragile-X mental retardation autosomal 1 (FXR1) modulates glioma cells sensitivity to temozolomide by regulating ferroptosis.

  2022cites this paper
• Male guanine-rich RNA sequence binding factor 1 knockout mice (Grsf1−/−) gain less body weight during adolescence and adulthood

  2022influential citation
• Glucose-6-Phosphate Dehydrogenase, Redox Homeostasis and Embryogenesis

  2022cites this paper
• Host adaptive mutations in the 2009 H1N1 pandemic influenza A virus PA gene regulate translation efficiency of viral mRNAs via GRSF1

  2022cites this paper
• Inhibition of SND1 overcomes chemoresistance in bladder cancer cells by promoting ferroptosis

  2022cites this paper
• Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA

  2021cites this paper
• Expression regulation, protein chemistry and functional biology of the guanine-rich sequence binding factor 1 (GRSF1).

  2021cites this paper
• Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX With Its Interactors at the Nucleoid and RNA Granule

  2021cites this paper
• GRSF1 promotes tumorigenesis and EMT-mediated metastasis through PI3K/AKT pathway in gastric cancer.

  2021cites this paper
• GRSF1 deficiency in skeletal muscle reduces endurance in aged mice

  2021cites this paper
• Ferroptosis: mechanisms, biology and role in disease

  2021cites this paper
• Identifying lncRNA–miRNA–mRNA networks to investigate Alzheimer’s disease pathogenesis and therapy strategy

  2020cites this paper
• Identification of the COMM-domain containing protein 1 as specific binding partner for the guanine-rich RNA sequence binding factor 1.

  2020cites this paper
• RETRACTED ARTICLE: GRSF1-mediated MIR-G-1 promotes malignant behavior and nuclear autophagy by directly upregulating TMED5 and LMNB1 in cervical cancer cells

  2019cites this paper
• Ferroptosis and Brain Injury

  2019cites this paper
• Guanine-rich RNA binding protein GRSF1 inhibits myoblast differentiation through repressing mitochondrial ROS production.

  2019cites this paper
• GRSF1 is an age-related regulator of senescence

  2019cites this paper
• RETRACTED ARTICLE: A novel miRNA identified in GRSF1 complex drives the metastasis via the PIK3R3/AKT/NF-κB and TIMP3/MMP9 pathways in cervical cancer cells

  2019cites this paper
• Evaluation of in vitro embryotoxicity tests for Chinese herbal medicines.

  2019cites this paper
• Early-life selenium status and cognitive development

  2018cites this paper
• Regulation of gene silencing: From microRNA biogenesis to post-translational modifications of TNRC6 complexes

  2018cites this paper
• Functional characterization of naturally occurring genetic variations of the human guanine-rich RNA sequence binding factor 1 (GRSF1).

  2018cites this paper
• Morphology-Based Whole Embryo Culture for Developmental Toxicity of Drugs.

  2018cites this paper
• Comprehensive identification of proteins binding to RNA G-quadruplex motifs in the 5' UTR of tumor-associated mRNAs.

  2018cites this paper
• RNA Binding Proteins and Regulation of mRNA Translation in Erythropoiesis

  2018influential citation
• Selenium‐sensitive miRNA‐181a‐5p targeting SBP2 regulates selenoproteins expression in cartilage

  2018cites this paper
• Does mitochondrial DNA evolution in metazoa drive the origin of new mitochondrial proteins?

  2018cites this paper
• Functional characterization of isolated RNA-binding domains of the GRSF1 protein.

  2017cites this paper
• Delineating hierarchy of selenotranscriptome expression and their response to selenium status in chicken central nervous system.

  2017influential citation
• Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications.

  2016cites this paper
• HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP

  2016cites this paper
• Sex-Specific Differences in Biological Effects and Metabolism of Selenium

  2016cites this paper
• EXPLORING THE ROLE OF ELEVATED LIPID PEROXIDATION AND GLUTATHIONE PEROXIDASE 4 IN METABOLIC SYNDROME AND CARDIAC REMODELING IN OBESITY

  2016cites this paper
• Association of U2AF35, U2AF65 and U2 snRNP with constitutively and alternatively spliced pre-mRNA

  2016cites this paper
• Regulated necrosis: disease relevance and therapeutic opportunities

  2016cites this paper
• miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively

  2015cites this paper
• Mimicking the Lipid Peroxidation Inhibitory Activity of Phospholipid Hydroperoxide Glutathione Peroxidase (GPx4) by Using Fatty Acid Conjugates of a Water-Soluble Selenolane

  2015cites this paper
• miR-346 Up-regulates Argonaute 2 (AGO2) Protein Expression to Augment the Activity of Other MicroRNAs (miRNAs) and Contributes to Cervical Cancer Cell Malignancy*

  2015cites this paper
• MECHANISTIC REGULATION OF SELENOPROTEIN MRNAS DURING SELENIUM DEFICIENCY

  2014cites this paper
• Selenium Action in Neuro-Oncology

  2014cites this paper
• Free Radicals and Embryo Development

  2014cites this paper
• Serotonin Receptor 6 Mediates Defective Brain Development in Monoamine Oxidase A-deficient Mouse Embryos

  2014cites this paper
• Grsf1-Induced Translation of the SNARE Protein Use1 Is Required for Expansion of the Erythroid Compartment

  2014cites this paper
• The Post-Transcriptional Regulation of Antioxidant Enzymes

  2013cites this paper
• Glutathione peroxidase 4 regulates autophagy and cell death during erythropoiesis

  2013cites this paper
• A study of glutathione peroxidase 4 function in human intestinal epithelial cells

  2013cites this paper
• Zur Interaktion von Genotyp und Ernährung bei Darmkrebs

  2013cites this paper
• The role of redox environment in neurogenic development.

  2013cites this paper
• Research resource: identification of novel coregulators specific for thyroid hormone receptor-β2.

  2013cites this paper
• The mitochondrial RNA-binding protein GRSF1 localizes to RNA granules and is required for posttranscriptional mitochondrial gene expression.

  2013cites this paper
• GRSF1 Regulates RNA Processing in Mitochondrial RNA Granules

  2013cites this paper
• Monoamine oxidases in development

  2013cites this paper
• Glutathione peroxidase 4 has a major role in protecting mitochondria from oxidative damage and maintaining oxidative phosphorylation complexes in gut epithelial cells.

  2012cites this paper
• A Complex Network of Factors with Overlapping Affinities Repress Splicing through Intronic Elements

  2012cites this paper
• Oxidative stress is involved in age-dependent spermatogenic damage of Immp2l mutant mice.

  2012cites this paper
• Dietary selenium and selenoprotein function

  2012cites this paper
• Molecular studies of the congenital malformation induced by Largehead Atractylodes Rhizome, the most commonly used Chinese medicine for threatened miscarriage.

  2012cites this paper
• The biology of the RNA binding protein guanine-rich sequence binding factor 1.

  2012cites this paper
• Zur Interaktion von Genotyp und Ernährung bei Darmkrebs: Selen- und Selenoprotein P-abhängige Tumorigenese im

  2012cites this paper
• Monoamine Oxidase A Expression Is Vital for Embryonic Brain Development by Modulating Developmental Apoptosis*

  2011cites this paper
• A genome-wide shRNA screen for new OxPhos related genes.

  2011cites this paper
• Glutathione Peroxidase 4 Is Required for Maturation of Photoreceptor Cells*

  2011cites this paper
• Magnetically enhanced nucleic acid delivery. Ten years of magnetofection—Progress and prospects

  2011cites this paper
• The Roles of Glutathione Peroxidases during Embryo Development

  2011influential citation
• From selenoprotein to endochondral ossification: a novel mechanism with microRNAs potential in bone related diseases?

  2011cites this paper
• Selenoproteins in Nervous System Development, Function and Degeneration

  2011cites this paper
• Selenoproteins in Cellular Redox Regulation and Signaling

  2011cites this paper
• Variations in Selenium Metabolism in Males and Females

  2011cites this paper
• Normal skin and hypertrophic scar fibroblasts differentially regulate collagen and fibronectin expression as well as mitochondrial membrane potential in response to basic fibroblast growth factor.

  2011cites this paper
• Delineating the Role of Glutathione Peroxidase 4 in Protecting Cells Against Lipid Hydroperoxide Damage and in Alzheimer's Disease

  2010cites this paper