An Overview of the Mechanisms of Microcystin-LR Genotoxicity and Potential Carcinogenicity.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Mini-Reviews in Medical Chemistry

• Publication date

  2016-08-31

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.2174/1389557516666160308141549PMID 26951459
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of chronic exposure to microcystin-LR on hepatocyte mitochondrial DNA replication in mice.

  2015cited by this paper
• Toxicopathology Induced by Microcystins and Nodularin: A Histopathological Review

  2015cited by this paper
• Role of nitric oxide in the genotoxic response to chronic microcystin-LR exposure in human-hamster hybrid cells.

  2015cited by this paper
• An overview of the toxic effect of potential human carcinogen Microcystin-LR on testis

  2015cited by this paper
• Alteration in the Expression of Cytochrome P450s (CYP1A1, CYP2E1, and CYP3A11) in the Liver of Mouse Induced by Microcystin-LR

  2015cited by this paper
• Genotoxicity of Microcystin-LR in In Vitro and In Vivo Experimental Models

  2014cited by this paper
• Epidemiology of Cancers in Serbia and Possible Connection with Cyanobacterial Blooms

  2014cited by this paper
• Abstract 18473: Oxidative Stress Improves Coronary Endothelial Function Through Activation of the Pro-Survival Kinase AMPK

  2013cited by this paper
• Combined exposure to 3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone and microsytin-LR increases genotoxicity in Chinese hamster ovary cells through oxidative stress.

  2013cited by this paper
• Assessment of the mutagenic potential of cyanobacterial extracts and pure cyanotoxins.

  2013cited by this paper
• Epidemiology of Primary Liver Cancer in Serbia and Possible Connection With Cyanobacterial Blooms

  2013cited by this paper
• Diverse action of acrylamide on cytochrome P450 and glutathione S-transferase isozyme activities, mRNA levels and protein levels in human hepatocarcinoma cells

  2012cited by this paper
• DNA - Cyanobacterial Hepatotoxins Microcystin-LR and Nodularin Interaction: Electrochemical Evaluation

  2012cited by this paper
• Alterations in microRNA expression linked to microcystin-LR-induced tumorigenicity in human WRL-68 Cells.

  2012cited by this paper
• Genomic profiling of microRNAs and proteomics reveals an early molecular alteration associated with tumorigenesis induced by MC-LR in mice.

  2012cited by this paper
• Genotoxicity and potential carcinogenicity of cyanobacterial toxins - a review.

  2011cited by this paper
• The Water Environment: Algal Toxins And Health

  2011cited by this paper
• Microcystin-LR Induces Apoptosis via NF-κB/iNOS Pathway in INS-1 Cells

  2011cited by this paper
• Microcystin-LR induced DNA damage in human peripheral blood lymphocytes.

  2011cited by this paper
• Molecular Aspects of Microcystin-induced Hepatotoxicity and Hepatocarcinogenesis

  2010cited by this paper
• Differential oxidative stress responses to pure Microcystin-LR and Microcystin-containing and non-containing cyanobacterial crude extracts on Caco-2 cells.

  2010cited by this paper
• Evaluation of genotoxic potential of neurotoxin anatoxin-a with the use of umuC test.

  2010cited by this paper
• Cyanobacterial extracts and microcystin-LR are inactive in the micronucleus assay in vivo and in vitro.

  2010cited by this paper
• DNA-electrochemical biosensors: AFM surface characterisation and application to detection of in situ oxidative damage to DNA.

  2010cited by this paper
• In vivo study on the effects of microcystin extracts on the expression profiles of proto-oncogenes (c-fos, c-jun and c-myc) in liver, kidney and testis of male Wistar rats injected i.v. with toxins.

  2009cited by this paper
• In vivo genotoxic potential of microcystin‐LR: A cyanobacterial toxin, investigated both by the unscheduled DNA synthesis (UDS) and the comet assays after intravenous administration

  2009cited by this paper
• Regulation of c-fos, c-jun and c-myc Gene Expression by Angiotensin II in Primary Cultured Rat Astrocytes: Role of ERK1/2 MAP Kinases

  2008cited by this paper
• Different sensitivities of human colon adenocarcinoma (CaCo-2), astrocytoma (IPDDC-A2) and lymphoblastoid (NCNC) cell lines to microcystin-LR induced reactive oxygen species and DNA damage.

  2008cited by this paper
• Patterns of microcystin-LR induced alteration of the expression of genes involved in response to DNA damage and apoptosis.

  2008cited by this paper
• Human Health Risk Assessment Related to Cyanotoxins Exposure

  2008cited by this paper
• In vivo DNA damage induced by the cyanotoxin microcystin-LR: comparison of intra-peritoneal and oral administrations by use of the comet assay.

  2008cited by this paper
• Toxins of cyanobacteria.

  2007cited by this paper
• Evaluation of extracellular products and mutagenicity in cyanobacteria cultures separated from a eutrophic reservoir.

  2007cited by this paper
• Hepatic Gene Expression Changes in Mice Associated with Prolonged Sublethal Microcystin Exposure

  2007cited by this paper
• Effects of microcystin-LR on mouse lungs.

  2007cited by this paper
• Subchronic exposure of rats to sublethal dose of microcystin-YR induces DNA damage in multiple organs

  2007cited by this paper
• Biomonitoring of cyanobacterial blooms in Polish water reservoir and the cytotoxicity and genotoxicity of selected cyanobacterial extracts.

  2007cited by this paper
• Toxicogenomic evaluation of microcystin-LR treated with ultrasonic irradiation.

  2007cited by this paper
• Involvement of reactive oxygen species in Microcystin-LR-induced cytogenotoxicity

  2007cited by this paper
• Activity and gene expression profile of certain antioxidant enzymes to microcystin-LR induced oxidative stress in mice.

  2006cited by this paper
• Inhibition of nucleotide excision repair (NER) by microcystin-LR in CHO-K1 cells.

  2006cited by this paper
• The repair of gamma-radiation-induced DNA damage is inhibited by microcystin-LR, the PP1 and PP2A phosphatase inhibitor.

  2006cited by this paper
• Evaluating genotoxicity associated with microcystin‐LR and its risk to source water safety in Meiliang Bay, Taihu Lake

  2006cited by this paper
• Cytokinesis-block micronucleus assay evolves into a "cytome" assay of chromosomal instability, mitotic dysfunction and cell death.

  2006cited by this paper
• Microcystin-induced 8-hydroxydeoxyguanosine in DNA and its reduction by melatonin, vitamin C, and vitamin E in mice

  2006cited by this paper
• Cyanobacterial toxins--occurrence, biosynthesis and impact on human affairs.

  2006cited by this paper
• Toxic effects of Microcystis cell extracts on the reproductive system of male mice.

  2006cited by this paper
• Effects of microcystins over short- and long-term memory and oxidative stress generation in hippocampus of rats.

  2006cited by this paper
• Alteration of intracellular GSH levels and its role in microcystin-LR-induced DNA damage in human hepatoma HepG2 cells.

  2006cited by this paper
• Microcystin-LR is not Mutagenic in vivo in the λ/lacZ Transgenic Mouse (MutaTMMouse)

  2006cited by this paper
• Age-dependent effects on biochemical variables and toxicity induced by cyclic peptide toxin microcystin-LR in mice.

  2005cited by this paper
• Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis.

  2005cited by this paper
• Genotoxic potential of Microcystin‐LR and nodularin in vitro in primary cultured rat hepatocytes and in vivo in rat liver

  2005cited by this paper
• Expression of the tumor necrosis factorα gene and early response genes by nodularin, a liver tumor promoter, in primary cultured rat hepatocytes

  2005cited by this paper
• Toxic Cyanobacteria in Water : A guide to their public health consequences , monitoring and management

  2005cited by this paper
• Antioxidant enzyme activity and lipid peroxidation in liver and kidney of rats exposed to microcystin-LR administered intraperitoneally.

  2005cited by this paper
• Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR

  2005cited by this paper
• Induction of Apoptosis in Mouse Liver by Microcystin-LR

  2005cited by this paper
• Inhibition of protein phosphatases by microcystis and nodularin associated with hepatotoxicity

  2005cited by this paper
• Mitochondrial damage mediates genotoxicity of arsenic in mammalian cells.

  2005cited by this paper
• The effect of intraperitoneally administered microcystin-LR on the gastrointestinal tract of Balb/c mice.

  2004cited by this paper
• Microcystin-LR and nodularin induce intracellular glutathione alteration, reactive oxygen species production and lipid peroxidation in primary cultured rat hepatocytes.

  2004cited by this paper
• Genotoxicity of microcystin-LR in human lymphoblastoid TK6 cells.

  2004cited by this paper
• DNA repair and cancer: Lessons from mutant mouse models

  2004cited by this paper
• Detection by 32P-postlabelling of 8-oxo-7,8-dihydro-2'-deoxyguanosine in DNA as biomarker of microcystin-LR- and nodularin-induced DNA damage in vitro in primary cultured rat hepatocytes and in vivo in rat liver.

  2004cited by this paper
• The role of reactive oxygen species in microcystin-LR-induced DNA damage.

  2004cited by this paper
• Expression modulation of multiple cytokines in vivo by cyanobacteria blooms extract from Taihu Lake, China.

  2004cited by this paper
• DNA damage and repair in human peripheral blood lymphocytes following treatment with microcystin-LR.

  2004cited by this paper
• Microcystin‐LR and okadaic acid‐induced cellular effects: a dualistic response

  2004cited by this paper
• Microcystin-LR induces oxidative DNA damage in human hepatoma cell line HepG2.

  2003cited by this paper
• Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity.

  2003cited by this paper
• Effect of microcystin-LR and cyanobacterial extract from Polish reservoir of drinking water on cell cycle progression, mitotic spindle, and apoptosis in CHO-K1 cells.

  2003cited by this paper
• Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice.

  2003cited by this paper
• Oxidative DNA damage: assessment of the role in carcinogenesis, atherosclerosis, and acquired immunodeficiency syndrome.

  2002cited by this paper
• Renal injuries induced by chronic intoxication with microcystins.

  2002cited by this paper
• Genotoxicity of cyanobacterial extracts containing microcystins from Polish water reservoirs as determined by SOS chromotest and comet assay

  2002cited by this paper
• Relationship between microcystin in drinking water and colorectal cancer.

  2002cited by this paper
• Clinical importance of the cytochromes P450.

  2002cited by this paper
• Tumor Necrosis Factor-α Expression and Kupffer Cell Activation in Hepatotoxicity Caused by Microcystin-LR in Mice

  2001cited by this paper
• Protein Phosphatases Regulate DNA-dependent Protein Kinase Activity*

  2001cited by this paper
• Microcystins (cyanobacterial toxins) in drinking water enhance the growth of aberrant crypt foci in the mouse colon.

  2000cited by this paper
• Critical Role of Reactive Oxygen Species and Mitochondrial Permeability Transition in Microcystin‐Induced Rapid Apoptosis in Rat Hepatocytes

  2000cited by this paper
• Peroxynitrite: an endogenous oxidizing and nitrating agent

  1999cited by this paper
• Unique features of the okadaic acid activity class of tumor promoters

  1999cited by this paper
• Enhancement of glutathione S-transferase placental-form positive liver cell foci development by microcystin-LR in aflatoxin B1-initiated rats.

  1999cited by this paper
• Toxins affecting cell signalling and alteration of cytoskeletal structure.

  1999cited by this paper
• Bulky endogenous DNA modifications (I-compounds) -possible structural origins and functional implications.

  1999cited by this paper
• Genotoxicity of microcystic cyanobacteria extract of a water source in China.

  1999cited by this paper
• Production of Nitric Oxide by Mitochondria*

  1998cited by this paper
• Mutagenicity of arsenic in mammalian cells: role of reactive oxygen species.

  1998cited by this paper
• Primary liver cancer: natural toxins and prevention in China.

  1998cited by this paper
• Freshwater cyanobacterium Microcystis aeruginosa (UTEX 2385) induced DNA damage in vivo and in vitro.

  1998cited by this paper
• Mutagenicity of microcystin-LR in human RSa cells.

  1998cited by this paper
• Studies on oxidative damage induced by cyanobacteria extract in primary cultured rat hepatocytes.

  1998cited by this paper
• Nucleotide Excision Repair in Mammalian Cells*

  1997cited by this paper
• Expression of the tumor necrosis factor alpha gene and early response genes by nodularin, a liver tumor promoter, in primary cultured rat hepatocytes.

  1997cited by this paper
• Neoplastic nodular formation in mouse liver induced by repeated intraperitoneal injections of microcystin-LR.

  1997cited by this paper
• Stability of microcystins from cyanobacteria--IV. Effect of chlorination on decomposition.

  1997cited by this paper
• Validation of the SOS/umu test using test results of 486 chemicals and comparison with the Ames test and carcinogenicity data.

  1996cited by this paper
• Differential sensitivity of normal and H-ras oncogene-transformed rat kidney epithelial cells to okadaic acid-induced apoptosis.

  1996cited by this paper

• A regional network for harmful algal blooms (HABs) monitoring in Latin America and the Caribbean, 2019–2023

  2026cites this paper
• Automation and miniaturization of solid-phase extraction for high-throughput analysis of cyanotoxins.

  2025cites this paper
• Microcystins in Different Water Sources Accountable for Health Risk in Egypt

  2025cites this paper
• Microplastics as vectors for microcystin-LR: Enhanced bioavailability, oxidative damage, and immune dysregulation in zebrafish spleen.

  2025cites this paper
• Novel Insights into Microcystin-LR Uptake, Accumulation, and Toxicity Mechanisms in Lettuce (Lactuca sativa L.) Using a Protoplast Model.

  2025cites this paper
• Functional Role of Protein Phosphatase-6 (PPP6c): Regulation of Expression and Modulation of Activity.

  2025cites this paper
• Algae blooms with resistance in fresh water: Potential interplay between Microcystis and antibiotic resistance genes.

  2024cites this paper
• The problem of algal bloom in the source of drinking water supply for the population

  2024cites this paper
• Microcystin-LR in drinking water: An emerging role of mitochondrial-induced epigenetic modifications and possible mitigation strategies

  2024cites this paper
• Microcystin levels in irrigation water and field-vegetable plants, and food safety risk assessment: A case study from Egypt.

  2024cites this paper
• Alleviation of microcystin-leucine arginine -induced hepatotoxicity: An updated overview.

  2024cites this paper
• Effect of pretreatment approach on the ELISA-based detection of cyanotoxins in water: Analysis and application.

  2023cites this paper
• A proteomic study on gastric impairment in rats caused by microcystin-LR.

  2023cites this paper
• First Polyphasic Study of Cheffia Reservoir (Algeria) Cyanobacteria Isolates Reveals Toxic Picocyanobacteria Genotype

  2023cites this paper
• Toxicity assessment of microcystin-leucine arginine in planarian Dugesia japonica.

  2023cites this paper
• Respiratory Tract Oncobiome in Lung Carcinogenesis: Where Are We Now?

  2023cites this paper
• The mechanisms of microcystin-LR-induced genotoxicity and neurotoxicity in fish and mammals: Bibliometric analysis and meta-analysis.

  2023cites this paper
• Cyanobacterial Harmful Algal Bloom Toxin Microcystin and Increased Vibrio Occurrence as Climate-Change-Induced Biological Co-Stressors: Exposure and Disease Outcomes via Their Interaction with Gut–Liver–Brain Axis

  2023cites this paper
• Meta-analysis reveals cyanotoxins risk across African inland waters.

  2023cites this paper
• In Vitro Toxicity Evaluation of Cyanotoxins Cylindrospermopsin and Microcystin-LR on Human Kidney HEK293 Cells

  2022cites this paper
• The Glu69Asp Polymorphism of EME1 Gene is Associated with an Increased Risk of Hepatocellular Carcinoma in Guangxi Population, China

  2022cites this paper
• Toxic effects of a cyanobacterial strain on Chironomus riparius larvae in a multistress environment.

  2022cites this paper
• A review and assessment of cyanobacterial toxins as cardiovascular health hazards

  2022cites this paper
• Microcystin pollution in lakes and reservoirs: A nationwide meta-analysis and assessment in China.

  2022cites this paper
• Inonotus obliquus aqueous extract prevents histopathological alterations in liver induced by environmental toxicant Microcystin

  2022cites this paper
• The role of toxins: impact on human health and aquatic environments

  2022cites this paper
• Enviromental Risk Factors Associated with Primary Liver Cancer in Western Kenya: A Mini-review

  2021cites this paper
• Oral exposure to environmental cyanobacteria toxins: Implications for cancer risk.

  2021cites this paper
• Cytotoxic and Genotoxic Effects of Cyanobacterial and Algal Extracts—Microcystin and Retinoic Acid Content

  2021influential citation
• Selective removal of common cyanotoxins: a review

  2021cites this paper
• Effects of acute exposure to microcystins on hypothalamic-pituitary-adrenal (HPA), -gonad (HPG) and -thyroid (HPT) axes of female rats.

  2021cites this paper
• Laboratory analysis of cyanobacterial toxins and bioassays

  2021influential citation
• Oxygen-Generating Cyanobacteria Powered by Upconversion-Nanoparticles-Converted Near-Infrared Light for Ischemic Stroke Treatment.

  2021cites this paper
• Health risk assessment related to cyanotoxins exposure of a community living near Tri An Reservoir, Vietnam

  2021cites this paper
• Subcellular Alterations Induced by Cyanotoxins in Vascular Plants—A Review

  2021cites this paper
• Cyanotoxin genotoxicity: a review

  2021cites this paper
• Microcystin Toxicokinetics, Molecular Toxicology, and Pathophysiology in Preclinical Rodent Models and Humans

  2021cites this paper
• Promotion effect of microcystin-LR on liver tumor progression in krasV12 transgenic zebrafish following acute or subacute exposure.

  2021cites this paper
• Microcystin-LR, a Cyanobacterial Toxin, Induces DNA Strand Breaks Correlated with Changes in Specific Nuclease and Protease Activities in White Mustard (Sinapis alba) Seedlings

  2021cites this paper
• Alterations in Mediterranean mussel (Mytilus galloprovincialis) composition exposed to cyanotoxins as revealed by analytical pyrolysis

  2020cites this paper
• Cyanotoxins and their environmental health risk in marine and freshwaters of Saudi Arabia

  2020cites this paper
• Higher content of microcystin‐leucine‐arginine promotes the survival of intrahepatic cholangiocarcinoma cells via regulating SET resulting in the poorer prognosis of patients

  2020cites this paper
• Cylindrospermopsin-Microcystin-LR Combinations May Induce Genotoxic and Histopathological Damage in Rats

  2020cites this paper
• DNA damages induced by both endotoxin and exotoxin produced by cyanobacteria.

  2020cites this paper
• The cyanobacterial oligopeptides microginins induce DNA damage in the human hepatocellular carcinoma (HepG2) cell line.

  2020cites this paper
• Genotoxic Effects of Cylindrospermopsin, Microcystin-LR and Their Binary Mixture in Human Hepatocellular Carcinoma (HepG2) Cell Line

  2020cites this paper
• Can phytoplankton blooming be harmful to benthic organisms? The toxic influence of Anabaena sp. and Chlorella sp. on Chironomus riparius larvae.

  2020cites this paper
• Microcystin-LR Does Not Alter Cell Survival and Intracellular Signaling in Human Bronchial Epithelial Cells

  2020cites this paper
• Low-dose microcystin-LR antagonizes aflatoxin B1 induced hepatocarcinogenesis through decreasing cytochrome P450 1A2 expression and aflatoxin B1-DNA adduct generation.

  2020cites this paper
• Photoelectrocatalytic degradation of microcystin-LR using a dimensionally stable anode and the assessment of detoxification

  2019cites this paper
• A Comparative Review of the Effect of Microcystin-LR on the Proteome

  2019influential citation
• Anabaenopeptins and cyanopeptolins induce systemic toxicity effects in a model organism the nematode Caenorhabditis elegans.

  2019cites this paper
• Toxicological Studies on Microcystin Produced by Microcystis aeruginosa : Assessment and Management

  2019cites this paper
• Effects of microcystins-LR on genotoxic responses in human intestinal epithelial cells (NCM460)

  2019cites this paper
• Oral Microcystin-LR Does Not Cause Hepatotoxicity in Pigs: Is the Risk of Microcystin-LR Overestimated?

  2019influential citation
• Oriented functionalization of magnetic beads with in vivo biotinylated nanobodies for rapid MALDI-TOF ultrasensitive quantitation of microcystins in biological samples.

  2019cites this paper
• In Vitro Mutagenic and Genotoxic Assessment of a Mixture of the Cyanotoxins Microcystin-LR and Cylindrospermopsin

  2019cites this paper
• The Occurrence and Potential Health Risk of Microcystins in Drinking Water of Rural Areas in China

  2019cites this paper
• A simple, supersensitive and highly selective electrochemical aptasensor for Microcystin-LR based on synergistic signal amplification strategy with graphene, DNase I enzyme and Au nanoparticles

  2019cites this paper
• Determination of microcystin-LR, employing aptasensors.

  2018cites this paper
• The dose makes the poison.

  2018cites this paper
• Microcystin-LR increases genotoxicity induced by aflatoxin B1 through oxidative stress and DNA base excision repair genes in human hepatic cell lines.

  2018cites this paper
• Influencing factors and health risk assessment of microcystins in the Yongjiang river (China) by Monte Carlo simulation

  2018cites this paper
• MATERIALS FOR THE SUBSTANTIATION OF HYGIENIC STANDARD OF MICROCYSTIN-LR IN WATER OF WATER OBJECTS

  2018cites this paper
• Genetic toxicity of water contaminated by microcystins collected during a cyanobacteria bloom.

  2018cites this paper
• Chronic Microcystin-LR Exposure Induces Hepatocarcinogenesis via Increased Gankyrin in Vitro and in Vivo

  2018cites this paper
• Analysis of Microcystins in Cyanobacterial Blooms from Freshwater Bodies in England

  2018cites this paper
• Serum microcystin levels positively linked with risk of hepatocellular carcinoma: A case‐control study in southwest China

  2017cites this paper
• Genotoxic potential of the binary mixture of cyanotoxins microcystin-LR and cylindrospermopsin.

  2017cites this paper
• Potential Use of Chemoprotectants against the Toxic Effects of Cyanotoxins: A Review

  2017cites this paper
• Proceedings of the 2017 National Toxicology Program Satellite Symposium

  2017cites this paper
• Toxicology of microcystins with reference to cases of human intoxications and epidemiological investigations of exposures to cyanobacteria and cyanotoxins

  2017cites this paper
• Assessment of the mutagenic and genotoxic activity of cyanobacterial toxin beta-N-methyl-amino-L-alanine in Salmonella typhimurium.

  2016cites this paper
• International Journal of Veterinary Medical Sciences

  year unknowncites this paper