Clinical Significance and Biological Role of HuR in Head and Neck Carcinomas

Background Hu-antigen R (HuR) is a posttranscriptional regulator of several target mRNAs, implicated in carcinogenesis. This review aims to present the current evidence regarding the biological role and potential clinical significance of HuR in head and neck carcinomas. Methods The existing literature concerning HuR expression and function in head and neck carcinomas is critically presented and summarised. Results HuR is expressed in the majority of the examined samples, showing higher cytoplasmic levels in malignant or premalignant cases. Moreover, HuR modulates several genes implicated in biological processes important for malignant transformation, growth, and invasiveness. HuR seems to be an adverse prognosticator in patients with OSCCs, whereas a correlation with a more aggressive phenotype is reported in several types of carcinomas. Conclusions A consistent role of HuR in the carcinogenesis and progression of head and neck carcinomas is suggested; nevertheless, further studies are warranted to expand the present information.

• Publication year

  2018

• Venue

  Disease Markers

• Publication date

  2018-01-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1155/2018/4020937PMID 29619127PMCID 5829322
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Update from the 4th Edition of the World Health Organization of Head and Neck Tumours: Tumours of the Oral Cavity and Mobile Tongue

  2017cited by this paper
• Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Oropharynx

  2017cited by this paper
• Update from the 4th Edition of the World Health Organization of Head and Neck Tumours: Tumours of the Oral Cavity and Mobile Tongue

  2017cited by this paper
• Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumors of the Nasal Cavity, Paranasal Sinuses and Skull Base

  2017cited by this paper
• Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: What Is New in the 2017 WHO Blue Book for Tumors and Tumor-Like Lesions of the Neck and Lymph Nodes

  2017cited by this paper
• Update From The 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Nasopharynx

  2017cited by this paper
• Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: What is New in the 2017 WHO Blue Book for Tumours of the Hypopharynx, Larynx, Trachea and Parapharyngeal Space

  2017cited by this paper
• Identification of tumorigenesis-related mRNAs associated with RNA-binding protein HuR in thyroid cancer cells

  2016influential reference
• Current Evidence and Future Perspectives on HuR and Breast Cancer Development, Prognosis, and Treatment

  2016cited by this paper
• HuR and podoplanin expression is associated with a high risk of malignant transformation in patients with oral preneoplastic lesions

  2016cited by this paper
• Clinical Significance of Hu-Antigen Receptor (HuR) and Cyclooxygenase-2 (COX-2) Expression in Human Malignant and Benign Thyroid Lesions

  2015influential reference
• Cytoplasmic expression of HuR may be a valuable diagnostic tool for determining the potential for malignant transformation of oral verrucous borderline lesions [an abstract of entire text]

  2015influential reference
• HuR and Ago2 Bind the Internal Ribosome Entry Site of Enterovirus 71 and Promote Virus Translation and Replication

  2015cited by this paper
• Clinical significance of HuR expression in human malignancy

  2014cited by this paper
• Cancer statistics, 2014

  2014cited by this paper
• Cytoplasmic HuR expression: Correlation with cellular inhibitors of apoptosis protein‐2 expression and clinicopathologic factors in oral squamous cell carcinoma cells

  2014influential reference
• Cytoplasmic expression of HuR may be a valuable diagnostic tool for determining the potential for malignant transformation of oral verrucous borderline lesions

  2014cited by this paper
• HuR Regulates Alternative Splicing of the TRA2β Gene in Human Colon Cancer Cells under Oxidative Stress

  2014cited by this paper
• Adaptive and maladaptive expression of the mRNA regulatory protein HuR.

  2013cited by this paper
• Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs

  2013cited by this paper
• HuR controls mitochondrial morphology through the regulation of BclxL translation

  2013cited by this paper
• Landes Highlights

  2013cited by this paper
• Significance of molecular markers in survival prediction of oral squamous cell carcinoma

  2012influential reference
• Kalopanaxsaponin A inhibits the invasion of human oral squamous cell carcinoma by reducing metalloproteinase-9 mRNA stability and protein trafficking.

  2012influential reference
• Including the p53 ELAV-like protein-binding site in vector cassettes enhances transgene expression in rat submandibular gland.

  2012influential reference
• Versatility of RNA-Binding Proteins in Cancer

  2012cited by this paper
• Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis.

  2012cited by this paper
• HuR keeps an angiogenic switch on by stabilising mRNA of VEGF and COX-2 in tumour endothelium

  2011cited by this paper
• The RNA-binding protein HuR stabilizes survivin mRNA in human oesophageal epithelial cells.

  2011influential reference
• Biology of Cox-2: an application in cancer therapeutics.

  2011cited by this paper
• The RNA-Binding Protein HuR Promotes Glioma Growth and Treatment Resistance

  2011cited by this paper
• Caspase-mediated Cleavage of RNA-binding Protein HuR Regulates c-Myc Protein Expression after Hypoxic Stress*

  2011influential reference
• High-constitutive HuR phosphorylation at Ser 318 by PKC{delta} propagates tumor relevant functions in colon carcinoma cells.

  2011cited by this paper
• Nitric Oxide-Sensitive Guanylyl Cyclase Is Differentially Regulated by Nuclear and Non-Nuclear Estrogen Pathways in Anterior Pituitary Gland

  2011cited by this paper
• Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability.

  2011cited by this paper
• Assembly and Initial Characterization of a Panel of 85 Genomically Validated Cell Lines from Diverse Head and Neck Tumor Sites

  2011cited by this paper
• Association between expression of embryonic lethal abnormal vision‐like protein HuR and cyclooxygenase‐2 in oral squamous cell carcinoma

  2011influential reference
• Association between expression of embryonic lethal abnormal vision-like protein HuR and cyclooxygenase-2 in oral squamous cell carcinoma.

  2011cited by this paper
• COX-2 as a target for cancer chemotherapy

  2010cited by this paper
• The RNA binding protein HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and estrogen receptor positive breast cancer

  2010cited by this paper
• HuR Knockdown Changes the Oncogenic Potential of Oral Cancer Cells

  2010influential reference
• MicroRNA-125a represses cell growth by targeting HuR in breast cancer

  2009cited by this paper
• Cell cycle, CDKs and cancer: a changing paradigm

  2009cited by this paper
• Regulation of non-AU-rich element containing c-fms proto-oncogene expression by HuR in breast cancer

  2009cited by this paper
• HuR is exported to the cytoplasm in oral cancer cells in a different manner from that of normal cells

  2009influential reference
• Regulation of Bcl-2 Expression by HuR in HL60 Leukemia Cells and A431 Carcinoma Cells

  2009cited by this paper
• The Elav-like protein HuR exerts translational control of viral internal ribosome entry sites.

  2009cited by this paper
• p38 Mitogen-Activated Protein Kinase- and HuR-Dependent Stabilization of p21Cip1 mRNA Mediates the G1/S Checkpoint

  2009cited by this paper
• Matrix metalloproteinase (MMP)-1, -9 and -13 as prognostic factors in salivary gland cancer

  2008cited by this paper
• Hu Antigen R (HuR) Functions as an Alternative Pre-mRNA Splicing Regulator of Fas Apoptosis-promoting Receptor on Exon Definition*

  2008cited by this paper
• Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells

  2008cited by this paper
• RNA-binding protein HuR interacts with thrombomodulin 5'untranslated region and represses internal ribosome entry site-mediated translation under IL-1 beta treatment.

  2008cited by this paper
• Nuclear HuR accumulation through phosphorylation by Cdk1.

  2008cited by this paper
• Diverse molecular functions of Hu proteins

  2008cited by this paper
• miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels

  2008cited by this paper
• Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2 expression.

  2008cited by this paper
• Expression of HuR Is Associated With Increased Cyclooxygenase-2 Expression in Uterine Cervical Carcinoma

  2007cited by this paper
• Protein Kinase Cα-dependent Phosphorylation of the mRNA-stabilizing Factor HuR: Implications for Posttranscriptional Regulation of Cyclooxygenase-2

  2007cited by this paper
• Association of p53 gene alterations with the expression of antiapoptotic survivin splice variants in breast cancer

  2007cited by this paper
• Posttranscriptional Orchestration of an Anti-Apoptotic Program by HuR

  2007cited by this paper
• Cytoplasmic HuR over‐expression is associated with increased cyclooxygenase‐2 expression in laryngeal squamous cell carcinomas

  2007influential reference
• Hu Proteins Regulate Polyadenylation by Blocking Sites Containing U-rich Sequences*

  2007cited by this paper
• Overexpression of cyclooxygenase-2 correlates with cytoplasmic HuR expression in salivary mucoepidermoid carcinoma but not in pleomorphic adenoma.

  2007influential reference
• Requirement of MMP-3 in anchorage-independent growth of oral squamous cell carcinomas.

  2007cited by this paper
• Cdk1 is sufficient to drive the mammalian cell cycle

  2007cited by this paper
• Post-transcriptional control of the MCT-1-associated protein DENR/DRP by RNA-binding protein AUF1.

  2007cited by this paper
• High gene expression of matrix metalloproteinase-7 is associated with early stages of oral cancer.

  2007cited by this paper
• Cyclooxygenase-2 Is an Independent Prognostic Factor in Gastric Cancer and Its Expression Is Regulated by the Messenger RNA Stability Factor HuR

  2005cited by this paper
• HuR as a negative posttranscriptional modulator in inflammation.

  2005cited by this paper
• HuR: Post-Transcriptional Paths to Malignancy

  2005cited by this paper
• Adenovirus E4orf6 targets pp32/LANP to control the fate of ARE-containing mRNAs by perturbing the CRM1-dependent mechanism

  2005cited by this paper
• The ELAV RNA-stability factor HuR binds the 5′-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation

  2005cited by this paper
• Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs

  2004cited by this paper
• Post‐transcriptional regulation in cancer

  2004cited by this paper
• Tissue Distribution of AU-rich mRNA-binding Proteins Involved in Regulation of mRNA Decay*

  2004cited by this paper
• Overexpression of the Embryonic-Lethal Abnormal Vision-like Protein HuR in Ovarian Carcinoma Is a Prognostic Factor and Is Associated with Increased Cyclooxygenase 2 Expression

  2004cited by this paper
• Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR.

  2004cited by this paper
• The RNA-binding Protein HuR Regulates the Expression of Cyclooxygenase-2*

  2003cited by this paper
• Cancer of the larynx.

  2003cited by this paper
• Cytoplasmic HuR expression correlates with poor outcome and with cyclooxygenase 2 expression in serous ovarian carcinoma.

  2003cited by this paper
• RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation

  2003cited by this paper
• Leptomycin B, an Inhibitor of the Nuclear Export Receptor CRM1, Inhibits COX-2 Expression*

  2003cited by this paper
• Identification of a novel AU-rich-element-binding protein which is related to AUF1.

  2002cited by this paper
• New functions for the matrix metalloproteinases in cancer progression

  2002cited by this paper
• ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR.

  2002cited by this paper
• Inhibition of distant caspase homologues by natural caspase inhibitors.

  2001cited by this paper
• Loss of HuR Is Linked to Reduced Expression of Proliferative Genes during Replicative Senescence

  2001cited by this paper
• HuR, a RNA stability factor, is expressed in malignant brain tumors and binds to adenine- and uridine-rich elements within the 3' untranslated regions of cytokine and angiogenic factor mRNAs.

  2001cited by this paper
• Extraction, Isolation and Characterisation of Antitumor Principle, α-Hederin, from the Seeds of Nigella sativa

  2001cited by this paper
• Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock.

  2001influential reference
• Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock.

  2001cited by this paper
• Kalopanaxsaponin A is a basic saponin structure for the anti-tumor activity of hederagenin monodesmosides.

  2001cited by this paper
• Protein Ligands to Hur Modulate Its Interaction with Target Mrnas in Vivo

  2000cited by this paper
• Post-transcriptional Control of Cyclooxygenase-2 Gene Expression

  2000cited by this paper
• The IAP family: endogenous caspase inhibitors with multiple biological activities

  2000cited by this paper
• Essential moiety for antimutagenic and cytotoxic activity of hederagenin monodesmosides and bisdesmosides isolated from the stem bark of Kalopanax pictus.

  2000cited by this paper
• HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation

  2000cited by this paper
• RNA stabilization by the AU‐rich element binding protein, HuR, an ELAV protein

  1998cited by this paper
• HNS, a nuclear-cytoplasmic shuttling sequence in HuR.

  1998cited by this paper
• Overexpression of HuR, a nuclear–cytoplasmic shuttling protein, increases the in vivo stability of ARE‐containing mRNAs

  1998cited by this paper

• An HuR mutant, HuR-V225I, identified in adult T-cell Leukemia/Lymphoma, alters the pro-apoptotic function of HuR

  2024cites this paper
• Molecular landscape of proliferative verrucous leukoplakia: a systematic review.

  2023cites this paper
• Relationship between HuR and tumor drug resistance

  2023cites this paper
• The RNA-Binding Protein SMN as a Novel Player in Laryngeal Squamous Cell Carcinoma

  2023cites this paper
• Role and mechanism of action of circular RNA and laryngeal cancer.

  2021cites this paper
• Quercetin Impairs HuR-Driven Progression and Migration of Triple Negative Breast Cancer (TNBC) Cells

  2021cites this paper
• Divulging the Critical Role of HuR in Pancreatic Cancer as a Therapeutic Target and a Means to Overcome Chemoresistance

  2021cites this paper
• CCAAT/enhancer binding protein (C/EBP) delta promotes the expression of PTX3 and macrophage phagocytosis during A. fumigatus infection

  2021cites this paper
• HuR as Therapeutic Target in Cancer: What the Future Holds.

  2021cites this paper
• HuR Protein in Hepatocellular Carcinoma: Implications in Development, Prognosis and Treatment

  2021cites this paper
• Targeting the HuR Oncogenic Role with a New Class of Cytoplasmic Dimerization Inhibitors

  2021cites this paper
• Silencing of HuR Inhibits Osteosarcoma Cell Epithelial-Mesenchymal Transition via AGO2 in Association With Long Non-Coding RNA XIST

  2021cites this paper
• circRNA circ‐CCND1 promotes the proliferation of laryngeal squamous cell carcinoma through elevating CCND1 expression via interacting with HuR and miR‐646

  2020cites this paper
• The Expression Patterns and Associated Clinical Parameters of Human Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2 and Transmembrane and Immunoglobulin Domain Containing 2 in Oral Squamous Cell Carcinoma

  2019cites this paper
• Analysis of eEF1Bγ interactome in the nuclear fraction of A549 human lung adenocarcinoma cells

  2019cites this paper