Dynamic modulation of ANO1/TMEM16A HCO3− permeability by Ca2+/calmodulin

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2012-12-17

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1073/pnas.1211594110PMID 23248295PMCID PMC3538232
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion.

  2012influential reference
• Rescue of ΔF508-CFTR trafficking via a GRASP-dependent unconventional secretion pathway.

  2011cited by this paper
• Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop

  2011cited by this paper
• Calmodulin‐dependent activation of the epithelial calcium‐dependent chloride channel TMEM16A

  2011cited by this paper
• Role of epithelial HCO3⁻ transport in mucin secretion: lessons from cystic fibrosis.

  2010cited by this paper
• Dynamic regulation of CFTR bicarbonate permeability by [Cl-]i and its role in pancreatic bicarbonate secretion.

  2010influential reference
• Exocytosis, dependent on Ca2+ release from Ca2+ stores, is regulated by Ca2+ microdomains

  2010cited by this paper
• Tmem16A Encodes the Ca2+-activated Cl− Channel in Mouse Submandibular Salivary Gland Acinar Cells*

  2010cited by this paper
• TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cells*

  2010cited by this paper
• Calcium concentration jumps reveal dynamic ion selectivity of calcium‐activated chloride currents in mouse olfactory sensory neurons and TMEM16b‐transfected HEK 293T cells

  2010cited by this paper
• Continuous analysis of parotid saliva during resting and short-duration simulated chewing.

  2009cited by this paper
• ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification

  2009cited by this paper
• Regulation of TMEM16A Chloride Channel Properties by Alternative Splicing*

  2009cited by this paper
• CFTR Functions as a Bicarbonate Channel in Pancreatic Duct Cells

  2009cited by this paper
• Expression cloning of TMEM16A as a calcium-activated chloride channel subunit.

  2008cited by this paper
• Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosis

  2008cited by this paper
• TMEM16A confers receptor-activated calcium-dependent chloride conductance

  2008influential reference
• PIP2 is a necessary cofactor for ion channel function: how and why?

  2008cited by this paper
• TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

  2008cited by this paper
• Calcium-activated chloride channels.

  2005influential reference
• Release currents of IP(3) receptor channel clusters and concentration profiles.

  2004cited by this paper
• Involvement of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm

  2003cited by this paper
• Bimodal Control of a Ca 2 Ϩ -activated Cl Ϫ Channel by Different Ca 2 Ϩ Signals Key Words: Ion Channels @bullet Electrophysiology @bullet Ion Channel Gating @bullet Calcium Signaling @bullet Ion Transport

  2000cited by this paper
• Anion Permeation in Ca2+-Activated Cl− Channels

  2000cited by this paper
• Bimodal Control of a Ca2+-Activated Cl− Channel by Different Ca2+ Signals

  2000cited by this paper
• HCO3− Transport in a Mathematical Model of the Pancreatic Ductal Epithelium

  2000cited by this paper
• Cystic Fibrosis Transmembrane Conductance Regulator: Physical Basis for Lyotropic Anion Selectivity Patterns

  1999cited by this paper
• Cystic Fibrosis Transmembrane Conductance Regulator

  1999cited by this paper
• Polarized Expression of Ca2+ Channels in Pancreatic and Salivary Gland Cells

  1997cited by this paper
• Optimized δ expansion for relativistic nuclear models

  1997cited by this paper
• Sequence motifs for calmodulin recognition

  1997influential reference
• Kinetic and pharmacological properties of the calcium-activated chloride-current in macrovascular endothelial cells.

  1997cited by this paper
• Pre-formation of the semi-open conformation by the apo-calmodulin C-terminal domain and implications for binding IQ-motifs

  1996cited by this paper
• Diverse essential functions revealed by complementing yeast calmodulin mutants.

  1994cited by this paper
• Regulation of cytoplasmic pH in rat sublingual mucous acini at rest and during muscarinic stimulation

  1992cited by this paper
• The EF-hand family of calcium-modulated proteins.

  1989cited by this paper
• Calcium‐dependent chloride currents in isolated cells from rat lacrimal glands.

  1986cited by this paper
• Solubilization of particulate proteins and nonelectrolytes by chaotropic agents.

  1969cited by this paper
• Excretion of sodium, potassium, chloride and carbon dioxide in human parotid saliva.

  1954cited by this paper
• Volumen und Hydratationswärme der Ionen

  1920cited by this paper
• Exocytosis , dependent on Ca 2 + release from Ca 2 + stores , is regulated by Ca 2 + microdomains

  year unknowncited by this paper

• Conformational changes upon pore blocker removal reveal conductive states of TMEM16A

  2026cites this paper
• Transmembrane protein 16A in the digestive diseases: A review of its physiology, pharmacology, and therapeutic opportunities.

  2025cites this paper
• [Transmembrane protein 16A--a new target for the treatment of airway inflammatory diseases].

  2025cites this paper
• Host Microenvironment Reprogramming by Saccharides Overcomes Lung Barriers for mRNA Therapeutics

  2025cites this paper
• Human induced pluripotent stem cells for in vitro modeling of impaired mucociliary clearance in cystic fibrosis lung disease

  2025cites this paper
• Phenotypic diversity of cystic fibrosis:pathogenesis and modifying factors

  2025cites this paper
• TMEM16 proteins: Ca2+-activated chloride channels and phospholipid scramblases as potential drug targets (Review)

  2024cites this paper
• Regulation of Branchial Anoctamin 1 Expression in Freshwater- and Seawater-Acclimated Japanese Medaka, Oryzias latipes.

  2024cites this paper
• Ca2+/calmodulin signaling in organismal aging and cellular senescence: Impact on human diseases.

  2024cites this paper
• The Tmem16a chloride channel is required for mucin maturation after secretion from goblet-like cells in the Xenopus tropicalis tadpole skin

  2024cites this paper
• Structural Basis and Molecular Mechanisms of Cl– Transmembrane Transport in Cardiomyocytes

  2024cites this paper
• The anoctamins: Structure and function.

  2024cites this paper
• Major depression-related factor NEGR1 controls salivary secretion in mouse submandibular glands

  2023cites this paper
• Distinct modulation of calcium-activated chloride channel TMEM16A by a novel drug-binding site

  2023cites this paper
• Regulation of ErbB Receptors by the Ca2+ Sensor Protein Calmodulin in Cancer

  2023cites this paper
• Intestinal mucus components and secretion mechanisms: what we do and do not know

  2023cites this paper
• Amelioration of SARS-CoV-2 infection by ANO6 phospholipid scramblase inhibition

  2022cites this paper
• Sodium/hydrogen‐exchanger‐2 modulates colonocyte lineage differentiation

  2022cites this paper
• Polymodal Control of TMEM16x Channels and Scramblases

  2022cites this paper
• TMEM16A (ANO1) as a therapeutic target in cystic fibrosis.

  2022cites this paper
• Role of ANO1 in tumors and tumor immunity

  2022cites this paper
• Analysis of a cell niche with proliferative potential at the roof of the aqueduct of Sylvius.

  2022cites this paper
• The pharmacology of the TMEM16A channel: therapeutic opportunities.

  2022cites this paper
• A Mathematical Model of Salivary Gland Duct Cells

  2022cites this paper
• Structure and Function of Calcium-Activated Chloride Channels and Phospholipid Scramblases in the TMEM16 Family.

  2022cites this paper
• Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction

  2022cites this paper
• Ion Channels, Transporters, and Sensors Interact with the Acidic Tumor Microenvironment to Modify Cancer Progression.

  2021cites this paper
• TMEM16A/ANO1: Current Strategies and Novel Drug Approaches for Cystic Fibrosis

  2021cites this paper
• Calmodulin-Dependent Regulation of Overexpressed but Not Endogenous TMEM16A Expressed in Airway Epithelial Cells

  2021cites this paper
• Molecular mechanisms of activation and regulation of ANO1-Encoded Ca2+-Activated Cl- channels

  2021cites this paper
• Anion and Cation Permeability of the Mouse TMEM16F Calcium-Activated Channel

  2021cites this paper
• Inflammatory cytokines TNFα and IL-17 enhance the efficacy of cystic fibrosis transmembrane conductance regulator modulators.

  2021cites this paper
• Electrophysiological Properties of Endogenous Single Ca2+ Activated Cl− Channels Induced by Local Ca2+ Entry in HEK293

  2021cites this paper
• Bicarbonate ion transport by the electrogenic Na+/HCO3− cotransporter, NBCe1, is required for normal electrical slow‐wave activity in mouse small intestine

  2021cites this paper
• Airway Surface Liquid pH Regulation in Airway Epithelium Current Understandings and Gaps in Knowledge

  2021cites this paper
• Ca2+ Sensitivity of Anoctamin 6/TMEM16F Is Regulated by the Putative Ca2+-Binding Reservoir at the N-Terminal Domain

  2021cites this paper
• Anoctamin 2-chloride channels reduce simple spike activity and mediate inhibition at elevated calcium concentration in cerebellar Purkinje cells

  2021cites this paper
• The cyclic AMP signaling pathway in the rodent main olfactory system

  2021cites this paper
• Characterization of intracellular buffering power in human induced pluripotent stem cells and the loss of pluripotency is delayed by acidic stimulation and increase of NHE1 activity

  2020cites this paper
• Transport properties in CFTR−/− knockout piglets suggest normal airway surface liquid pH and enhanced amiloride-sensitive Na+ absorption

  2020cites this paper
• Novel Anti-Inflammatory Approaches for Cystic Fibrosis Lung Disease: Identification of Molecular Targets and Design of Innovative Therapies

  2020cites this paper
• OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions

  2020cites this paper
• TMEM16 Proteins (Anoctamins) in Epithelia

  2020cites this paper
• Channels and Transporters in Zymogen Granule Membranes and their Role in Granule Function: A Critical Assessment

  2020cites this paper
• Fundamentals of Bicarbonate Secretion in Epithelia

  2020cites this paper
• The Ca2+-activated chloride channel ANO1/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?

  2020cites this paper
• Measurement of Multi Ion Transport through Human Bronchial Epithelial Cell Line Provides an Insight into the Mechanism of Defective Water Transport in Cystic Fibrosis

  2020cites this paper
• TNFα and IL-17 alkalinize airway surface liquid through CFTR and pendrin

  2020cites this paper
• The Role of MicroRNA in the Airway Surface Liquid Homeostasis

  2020cites this paper
• Allosteric modulation of alternatively spliced Ca2+-activated Cl− channels TMEM16A by PI(4,5)P2 and CaMKII

  2020cites this paper
• Bicarbonate permeation through anion channels: its role in health and disease

  2020cites this paper
• Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A

  2019cites this paper
• Cleaved Cochlin Sequesters Pseudomonas aeruginosa and Activates Innate Immunity in the Inner Ear.

  2019cites this paper
• TMEM16A is indispensable for basal mucus secretion in airways and intestine

  2019cites this paper
• Approaches for unveiling the kinetic mechanisms of voltage gated ion channels in neurons

  2019cites this paper
• Characterisation and validation of ex vivo nasal epithelial cultures to investigate transmembrane protein 16A as a therapeutic avenue in cystic fibrosis

  2019cites this paper
• TMEM16A chloride channel does not drive mucus production

  2019cites this paper
• References

  2019cites this paper
• Regulation of CFTR Bicarbonate Channel Activity by WNK1: Implications for Pancreatitis and CFTR-Related Disorders

  2019cites this paper
• Endophilin A2 regulates calcium-activated chloride channel activity via selective autophagy-mediated TMEM16A degradation

  2019cites this paper
• The multifaceted role of TMEM16A in cancer.

  2019cites this paper
• A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic.

  2018cites this paper
• Importance of bicarbonate transport in pH control during amelogenesis - need for functional studies.

  2018cites this paper
• Ecology of sleeping: the microbial and arthropod associates of chimpanzee beds

  2018cites this paper
• Extracellular pH and lung infections in cystic fibrosis.

  2018cites this paper
• Slippery When Wet: Airway Surface Liquid Homeostasis and Mucus Hydration.

  2018cites this paper
• Recent advances in developing therapeutics for cystic fibrosis.

  2018cites this paper
• Chloride Homeostasis in Neurons With Special Emphasis on the Olivocerebellar System: Differential Roles for Transporters and Channels

  2018cites this paper
• Identification of a Novel EF-Loop in the N-terminus of TRPM2 Channel Involved in Calcium Sensitivity

  2018cites this paper
• Functional roles of glutamic acid E143 and E705 residues in the N-terminus and transmembrane domain 7 of Anoctamin 1 in calcium and noxious heat sensing

  2018cites this paper
• Cystic Fibrosis of the Pancreas: The Role of CFTR Channel in the Regulation of Intracellular Ca2+ Signaling and Mitochondrial Function in the Exocrine Pancreas

  2018cites this paper
• Molecular, biophysical, and pharmacological properties of calcium‐activated chloride channels

  2018cites this paper
• New Insights on the Regulation of Ca2+‐Activated Chloride Channel TMEM16A

  2017influential citation
• Ion channels as targets to treat cystic fibrosis lung disease.

  2017cites this paper
• The association between the expression of PAR2 and TMEM16A and neuropathic pain

  2017cites this paper
• ANO9/TMEM16J promotes tumourigenesis via EGFR and is a novel therapeutic target for pancreatic cancer

  2017cites this paper
• MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology

  2017cites this paper
• EAVK segment "c" sequence confers Ca2+-dependent changes to the kinetics of full-length human Ano1.

  2017cites this paper
• Mechanisms of acid and base secretion: implications for airway host defense in cystic fibrosis

  2017cites this paper
• ANO1 as a Novel Drug Target

  2017cites this paper
• Mechanisms of ANO1 channel activation in sensory neurons

  2017influential citation
• Ca2+/Calmodulin-Dependent Protein Kinase II γ-Dependent Serine727 Phosphorylation Is Required for TMEM16A Ca2+-Activated Cl- Channel Regulation in Cerebrovascular Cells.

  2017cites this paper
• The role of Ca2+-activated Cl- current in tone generation in the rabbit corpus cavernosum.

  2017cites this paper
• Cell Physiology The role of Ca 2 (cid:2) -activated Cl (cid:3) current in tone generation in the rabbit corpus cavernosum

  2017cites this paper
• Oxidation of RyR2 Has a Biphasic Effect on the Threshold for Store Overload-Induced Calcium Release.

  2016cites this paper
• The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons

  2016cites this paper
• PKCα regulates TMEM16A-mediated Cl⁻ secretion in human biliary cells.

  2016cites this paper
• Role of Ca(2+) in the Stability and Function of TMEM16F and 16K.

  2016cites this paper
• Influence of intracellular Ca2+ and alternative splicing on the pharmacological profile of ANO1 channels.

  2016cites this paper
• Functions of ANO1/TMEM16A, Ca2+-activated Cl- channels in Regulation of Blood Pressure and Vascular Remodeling

  2016cites this paper
• Airway acidification initiates host defense abnormalities in cystic fibrosis mice

  2016cites this paper
• Ca2+-activated Cl- channel currents in mammary secretory cells from lactating mouse.

  2016cites this paper
• HCO3− Transport through Anoctamin/Transmembrane Protein ANO1/TMEM16A in Pancreatic Acinar Cells Regulates Luminal pH*

  2016cites this paper
• Calmodulin regulation of TMEM16A and 16B Ca2+-activated chloride channels

  2016influential citation
• Increased TMEM16A Involved in Alveolar Fluid Clearance After Lipopolysaccharide Stimulation

  2016cites this paper
• Negative News: Cl- and HCO3- in the Vascular Wall.

  2016cites this paper
• Pore dilatation increases the bicarbonate permeability of CFTR, ANO1 and glycine receptor anion channels

  2016cites this paper
• Régulation du canal chlorure ANO1 par les miARN et stratégie thérapeutique dans la mucoviscidose

  2016cites this paper
• A novel exon in the human Ca2+-activated Cl- channel Ano1 imparts greater sensitivity to intracellular Ca2.

  2015cites this paper
• Upregulation of TMEM16A Protein in Bronchial Epithelial Cells by Bacterial Pyocyanin

  2015cites this paper