A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Journal of Biological Chemistry

• Publication date

  1993-08-05

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  PMID 8344894
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Synthesis of the sequential polypeptide poly[Cys(Acm)-Ser-Phe-Glu-Glu] as a model for hydrolytic enzymes.

  2009cited by this paper
• Solid-phase peptide synthesis using mild base cleavage of N alpha-fluorenylmethyloxycarbonylamino acids, exemplified by a synthesis of dihydrosomatostatin.

  2009cited by this paper
• Oral zinc supplementation in Down's syndrome: restoration of thymic endocrine activity and of some immune defects.

  2008cited by this paper
• The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19.

  1993cited by this paper
• Purification of factor XIa inhibitor from human platelets.

  1992cited by this paper
• Human brain beta A4 amyloid protein precursor of Alzheimer's disease: purification and partial characterization.

  1992cited by this paper
• Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor.

  1992cited by this paper
• An abnormality of plasma amyloid protein precursor in Alzheimer's disease

  1992cited by this paper
• Zinc, a neurotoxin to cultured neurons, contaminates cycad flour prepared by traditional guamanian methods

  1992cited by this paper
• Dimerization of human growth hormone by zinc.

  1991cited by this paper
• Structural biology of zinc.

  1991cited by this paper
• The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein.

  1991cited by this paper
• Identification, secretion, and neural expression of APPL, a Drosophila protein similar to human amyloid protein precursor

  1990cited by this paper
• The amyloid precursor protein of Alzheimer's disease is released by human platelets.

  1990cited by this paper
• Trace element imbalances in isolated subcellular fractions of Alzheimer's disease brains.

  1990cited by this paper
• Metals and the Liver in Alzheimer's Disease An Investigation of Hepatic Zinc, Copper, Cadmium, and Metallothionein

  1990cited by this paper
• Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease.

  1989cited by this paper
• Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

  1989cited by this paper
• A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor.

  1989cited by this paper
• Modification of neuronal cell adhesion affects the genetic expression of the A4 amyloid peptide precursor.

  1989cited by this paper
• Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

  1988cited by this paper
• Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation

  1988cited by this paper
• A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

  1988cited by this paper
• Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

  1988cited by this paper
• A close ultrastructural relationship between sulfated proteoglycans and AA amyloid fibrils.

  1987cited by this paper
• Amyloid of neurofibrillary tangles of Guamanian parkinsonism-dementia and Alzheimer disease share identical amino acid sequence.

  1987cited by this paper
• The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

  1987cited by this paper
• Amyloid plaque core protein in Alzheimer disease and Down syndrome.

  1985cited by this paper
• Serotonin binds specifically and saturably to an actin-like protein isolated from rat brain synaptosomes.

  1984cited by this paper
• Cerebrospinal fluid trace element content in dementia

  1983cited by this paper
• Selective binding of zinc ions to heparin rather than to other glycosaminoglycans.

  1981cited by this paper
• Role of zinc in insulin biosynthesis

  1980cited by this paper
• Platelet Metal Levels in Normal Subjects Determined by Atomic Absorption Spectrophotometry

  1978cited by this paper
• Acetamidomethyl. A novel thiol protecting group for cysteine.

  1972cited by this paper

• Zinc and copper effect mechanical cell adhesion properties of the amyloid precursor protein

  2024cites this paper
• Recent Advances in Targeting Transition Metals (Copper, Iron, and Zinc) in Alzheimer’s Disease

  2024cites this paper
• Targeting Metals in Alzheimer’s Disease: An Update

  2024cites this paper
• The amyloid cascade hypothesis: an updated critical review.

  2023cites this paper
• Differential expression of SLC30A10 and RAGE in mouse pups by early life lead exposure.

  2023cites this paper
• Exposure of metal toxicity in Alzheimer’s disease: An extensive review

  2022cites this paper
• Structural Determinant of β-Amyloid Formation: From Transmembrane Protein Dimerization to β-Amyloid Aggregates

  2022cites this paper
• The amyloid precursor protein is a conserved Wnt receptor

  2021cites this paper
• The molecular and cellular basis of copper dysregulation and its relationship with human pathologies

  2021cites this paper
• The essential elements of Alzheimer’s disease

  2020cites this paper
• Targeting Metal Homeostasis as a Therapeutic Strategy for Alzheimer’s Disease

  2020influential citation
• Extracellular Amyloid Deposits in Alzheimer’s and Creutzfeldt–Jakob Disease: Similar Behavior of Different Proteins?

  2020cites this paper
• “What Doesn’t Kill You Makes You Stronger”: Future Applications of Amyloid Aggregates in Biomedicine

  2020cites this paper
• Genetic and Epigenetic Etiology Underlying Autism Spectrum Disorder

  2020cites this paper
• Peroxidase activity of heme bound amyloid β peptides associated with Alzheimer's disease.

  2020cites this paper
• Multifunctional roles of zinc in Alzheimer's disease.

  2020cites this paper
• Copper and zinc ions govern the trans‐directed dimerization of APP family members in multiple ways

  2019cites this paper
• Metal Toxicity Links to Alzheimer's Disease and Neuroinflammation.

  2019cites this paper
• The 5th International Conference on Molecular Neurodegeneration: Overlapping Pathologies and Common Mechanisms

  2019cites this paper
• Redox active metals in neurodegenerative diseases

  2019cites this paper
• Copper imbalance in Alzheimer’s disease: Convergence of the chemistry and the clinic

  2019cites this paper
• Intrinsically disordered proteins in various hypotheses on the pathogenesis of Alzheimer's and Parkinson's diseases.

  2019cites this paper
• Cu and Zn interactions with Aβ peptides: consequence of coordination on aggregation and formation of neurotoxic soluble Aβ oligomers.

  2019cites this paper
• The Role of Trace Metals in Alzheimer’s Disease

  2019cites this paper
• Effects of amyloid pl-42 investigated by in vivo single-unit electrophysiology: Ionotropic glutamate receptors and neuroprotection Ph.D. Thesis

  2018cites this paper
• The mechanism of action of clioquinol for the treatment of Alzheimer's disease

  2018cites this paper
• The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system

  2017cites this paper
• Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production*

  2017cites this paper
• Biometals and Alzheimer’s Disease

  2017cites this paper
• Alzheimer’s disease: How metal ions define β-amyloid function

  2017cites this paper
• Physiological role of amyloid precursor protein during neural development

  2017cites this paper
• Metal ions influx is a double edged sword for the pathogenesis of Alzheimer's disease.

  2017cites this paper
• Alzheimer’s disease: as it was in the beginning

  2017cites this paper
• Targeting Transition Metals for Neuroprotection in Alzheimer’s Disease

  2017cites this paper
• Protein Phosphorylation is a Key Mechanism in Alzheimer’s Disease

  2017cites this paper
• The Metalloprotease Meprin β Is an Alternative β-Secretase of APP

  2017cites this paper
• Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments

  2017cites this paper
• Zinc Signal in Brain Diseases

  2017cites this paper
• Metallomic Biomarkers in Cerebrospinal fluid and Serum in patients with Parkinson’s disease in Indian population

  2016cites this paper
• An overview on therapeutics attenuating amyloid β level in Alzheimer's disease: targeting neurotransmission, inflammation, oxidative stress and enhanced cholesterol levels.

  2016cites this paper
• Alzheimer's disease due to loss of function: A new synthesis of the available data.

  2016cites this paper
• Implication du domaine intracellulaire du précurseur de la protéine amyloïde dans la modulation de la plasticité synaptique

  2016cites this paper
• Inhibitors of the Hydrolytic Enzyme Dimethylarginine Dimethylaminohydrolase (DDAH): Discovery, Synthesis and Development

  2016cites this paper
• Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease

  2016cites this paper
• Investigating novel interaction partners of amyloid precursor protein: the mechanistic target of rapamycin and pikyve complex

  2016cites this paper
• Characterization of Mn(II) ion binding to the amyloid-β peptide in Alzheimer's disease.

  2016cites this paper
• Some Biochemical Markers in Patients with Alzheimer’s Disease

  2016influential citation
• Amyloid precursor‐like protein 1 (APLP1) exhibits stronger zinc‐dependent neuronal adhesion than amyloid precursor protein and APLP2

  2016cites this paper
• Synthesis of a Fluorinated 8-hydroxyquinoline Derivative to Explore the Metal Hypothesis of Alzheimer's Disease

  2016influential citation
• The Role of metals and Aβ in excitotoxicity and Alzheimer’s disease

  2015cites this paper
• The human β-amyloid precursor protein: biomolecular and epigenetic aspects

  2015cites this paper
• Modulation of Alzheimer's amyloid β peptide self-assembly : Insights into molecular mechanisms of peptide aggregation associated with Alzheimer's disease

  2015cites this paper
• Combined deletions of amyloid precursor protein and amyloid precursor-like protein 2 reveal different effects on mouse brain metal homeostasis.

  2014cites this paper
• Amyloid Precursor Protein Dimerization and Synaptogenic Function Depend on Copper Binding to the Growth Factor-Like Domain

  2014cites this paper
• Novel Zinc-binding Site in the E2 Domain Regulates Amyloid Precursor-like Protein 1 (APLP1) Oligomerization*

  2014cites this paper
• Heparin induced dimerization of APP is primarily mediated by E1 and regulated by its acidic domain.

  2014cites this paper
• Disruption of zinc homeostasis and the pathogenesis of senile dementia.

  2014cites this paper
• Zinc: The Metal of Life.

  2014cites this paper
• The structural biology of the amyloid precursor protein APP – a complex puzzle reveals its multi-domain architecture

  2014cites this paper
• Metals and cholesterol: two sides of the same coin in Alzheimer’s disease pathology

  2014cites this paper
• The N‐terminal fragment of the β‐amyloid precursor protein of Alzheimer's disease (N‐APP) binds to phosphoinositide‐rich domains on the surface of hippocampal neurons

  2014cites this paper
• Oral Zinc Reduces Amyloid Burden in Tg2576 Mice

  2014cites this paper
• The Effects That Dietary Manipulations of Zinc and Copper Have on Nest Building, Zinc Transporter and Glial Fibrillary Acidic Protein Expression in a Transgenic Mouse Model of Alzheimer’s Disease

  2014cites this paper
• Biometals and Their Therapeutic Implications in Alzheimer’s Disease

  2014cites this paper
• Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease

  2014cites this paper
• Modulation of tau phosphorylation by environmental copper

  2014cites this paper
• Spatial memory deficits in a mouse model of late-onset Alzheimer’s disease are caused by zinc supplementation and correlate with amyloid-beta levels

  2014influential citation
• Werner coordination chemistry and neurodegeneration.

  2013cites this paper
• Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts

  2013cites this paper
• Zinc and Neurodegenerative Diseases

  2013cites this paper
• Altered Expression of ZnT10 in Alzheimer's Disease Brain

  2013influential citation
• The interaction between the neural cell adhesion molecule L1 and β-amyloid peptide : potential relevance in Alzheimer’s disease

  2013cites this paper
• Surface plasmon resonance imaging of amyloid-β aggregation kinetics in the presence of epigallocatechin gallate and metals.

  2013cites this paper
• Altered Expression of ZnT 10 in Alzheimer ’ s Disease Brain

  2013influential citation
• Metal dyshomeostasis and oxidative stress in Alzheimer's disease.

  2013cites this paper
• Importance and management of micronutrient deficiencies in patients with Alzheimer’s disease

  2013cites this paper
• Chapter 21 Zinc and Neurodegenerative Diseases

  2013cites this paper
• The Structural Study of Copper-binding Peptides: Implication in the Aggregation of Amyloid-β Peptides

  2013cites this paper
• Metallostasis in Alzheimer's disease.

  2013cites this paper
• Structural features of the KPI domain control APP dimerization, trafficking, and processing

  2012cites this paper
• Functions of Aβ, sAPPα and sAPPβ : similarities and differences

  2012cites this paper
• Brain zinc metabolism and Alzheimer’s disease

  2012cites this paper
• A potential role for zinc alterations in the pathogenesis of Alzheimer's disease

  2012cites this paper
• Brain zinc metabolism and Alzheimer's disease

  2012cites this paper
• Coordination of zinc ions to the key proteins of neurodegenerative diseases: Aβ, APP, α-synuclein and PrP

  2012cites this paper
• Synthesis, characterization and potential applications of multifunctional PEO-PPOPEO- magnetic drug delivery system.

  2012cites this paper
• Bioinorganic chemistry of Alzheimer's disease.

  2012cites this paper
• Different types of γ-secretes complexes and their effect on substrate processing

  2012cites this paper
• Studies on the use of glycosaminoglycans for the treatment of Alzheimer's Disease

  2012cites this paper
• The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases

  2012cites this paper
• Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-β precursor protein dimerization.

  2012cites this paper
• Affinity of copper and zinc ions to proteins and peptides related to neurodegenerative conditions (Aβ, APP, α-synuclein, PrP)

  2012cites this paper
• The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization.

  2012cites this paper
• The amyloid precursor protein and its homologues: structural and functional aspects of native and pathogenic oligomerization.

  2012cites this paper
• Characterisation of the zinc transporter ZnT10 and its role in cellular homeostasis in healthy and Alzheimer's disease brain

  2012cites this paper
• Clioquinol Reduces Zinc Accumulation in Neuritic Plaques and Inhibits the Amyloidogenic Pathway in AβPP/PS1 Transgenic Mouse Brain

  2012cites this paper
• Studies on the use of glycosaminoglycans for the treatment of Alzheimer ’ s disease

  2012cites this paper
• Metal binding dictates conformation and function of the amyloid precursor protein (APP) E2 domain.

  2012cites this paper
• The role of metallobiology and amyloid‐β peptides in Alzheimer’s disease

  2012cites this paper
• Interactions of α-Synuclein with Metal Ions: New Insights into the Structural Biology and Bioinorganic Chemistry of Parkinson’s Disease

  2012cites this paper