Calcium ions effectively enhance the effect of antisense peptide nucleic acids conjugated to cationic tat and oligoarginine peptides.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Chemistry and Biology

• Publication date

  2005-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.CHEMBIOL.2005.06.009PMID 16125104
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intracellular uptake and inhibition of gene expression by PNAs and PNA-peptide conjugates.

  2004cited by this paper
• Pathway for polyarginine entry into mammalian cells.

  2004cited by this paper
• Delivery of antisense peptide nucleic acids (PNAs) to the cytosol by disulphide conjugation to a lipophilic cation

  2004cited by this paper
• Cellular uptake of antisense morpholino oligomers conjugated to arginine-rich peptides.

  2004cited by this paper
• Uptake of analogs of penetratin, Tat(48-60) and oligoarginine in live cells.

  2003influential reference
• Cell-penetrating Peptides

  2003influential reference
• Inhibition of the translocated c-myc in Burkitt's lymphoma by a PNA complementary to the E mu enhancer.

  2003cited by this paper
• Novel binding and efficient cellular uptake of guanidine-based peptide nucleic acids (GPNA).

  2003cited by this paper
• Synthesis and properties of ester-linked peptide nucleic acid prodrug conjugates.

  2003cited by this paper
• Cell-Dependent Differential Cellular Uptake of PNA, Peptides, and PNA-Peptide Conjugates

  2002cited by this paper
• Histone H1-mediated transfection: role of calcium in the cellular uptake and intracellular fate of H1-DNA complexes.

  2002cited by this paper
• Targeting peptide nucleic acid (PNA) oligomers to mitochondria within cells by conjugation to lipophilic cations: implications for mitochondrial DNA replication, expression and disease.

  2001cited by this paper
• Inhibition of promyelocytic leukemia (PML)/retinoic acid receptor-alpha and PML expression in acute promyelocytic leukemia cells by anti-PML peptide nucleic acid.

  2001cited by this paper
• Inhibition of gene expression inside cells by peptide nucleic acids: effect of mRNA target sequence, mismatched bases, and PNA length.

  2001cited by this paper
• Enhanced plasmid DNA transfection with lysosomotropic agents in cultured fibroblasts.

  2001cited by this paper
• Polyarginine enters cells more efficiently than other polycationic homopolymers.

  2000cited by this paper
• Cellular uptake of adamantyl conjugated peptide nucleic acids.

  1999cited by this paper
• Antisense Pharmacodynamics: Critical Issues in the Transport and Delivery of Antisense Oligonucleotides

  1999cited by this paper
• Calcium ions as efficient cofactor of polycation-mediated gene transfer.

  1999cited by this paper
• PEPTIDE NUCLEIC ACIDS (PNAS) WITH A FUNCTIONAL BACKBONE

  1998cited by this paper
• Up-regulation of luciferase gene expression with antisense oligonucleotides: implications and applications in functional assay development.

  1998cited by this paper
• A peptide nucleic acid (PNA) is more rapidly internalized in cultured neurons when coupled to a retro-inverso delivery peptide. The antisense activity depresses the target mRNA and protein in magnocellular oxytocin neurons.

  1998cited by this paper
• Acid nuclear extracts as mediators of gene transfer and expression.

  1998cited by this paper
• Fluorescein-conjugated lysine monomers for solid phase synthesis of fluorescent peptides and PNA oligomers.

  1997cited by this paper
• Peptide Nucleic Acids (PNAs) Containing Thymine Monomers Derived from Chiral Amino Acids: Hybridization and Solubility Properties of D‐Lysine PNA

  1996cited by this paper
• Solid‐Phase synthesis of peptide nucleic acids

  1995cited by this paper
• Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide.

  1991cited by this paper

• Endocytic highways: Navigating macropinocytosis and other endocytic routes for precision drug delivery.

  2025cites this paper
• Comparing cell penetration of biotherapeutics across human cell lines

  2024cites this paper
• In vivo interference of pea aphid endosymbiont Buchnera groEL gene by synthetic peptide nucleic acids

  2024cites this paper
• Application of Cell Penetrating Peptides as a Promising Drug Carrier to Combat Viral Infections

  2023cites this paper
• Synthetic Peptide Nucleic Acids in Action: In Vivo Interference of the groEL Gene from Pea Aphid Endosymbiont Buchnera aphidicola

  2023cites this paper
• 2′-O-(N-(Aminoethyl)carbamoyl)methyl Modification Allows for Lower Phosphorothioate Content in Splice-Switching Oligonucleotides with Retained Activity

  2022cites this paper
• Evolution of complexity in non-viral oligonucleotide delivery systems: from gymnotic delivery through bioconjugates to biomimetic nanoparticles

  2022cites this paper
• Explorations into Peptide Nucleic Acid Contrast Agents as Emerging Scaffolds for Breakthrough Solutions in Medical Imaging and Diagnosis

  2021cites this paper
• Novel peptide (RATH) mediated delivery of peptide nucleic acids for antiviral interventions

  2021cites this paper
• Camptothecin Nanoprodrug Possessing Dual Responsiveness to Endolysosomal pH and Cytosolic Redox for Amplified Cytotoxic Potency.

  2021cites this paper
• Cellular uptake of 2‐aminopyridine‐modified peptide nucleic acids conjugated with cell‐penetrating peptides

  2021cites this paper
• In Vitro Cellular Delivery of Peptide Nucleic Acid (PNA).

  2020cites this paper
• Calcium-Mediated In Vitro Transfection Technique of Oligonucleotides with Broad Chemical Modification Compatibility.

  2020cites this paper
• Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair

  2020cites this paper
• Photoinduced Endosomal Escape Mechanism: A View from Photochemical Internalization Mediated by CPP-Photosensitizer Conjugates

  2020cites this paper
• Cell Penetrating Peptides, Novel Vectors for Gene Therapy

  2020cites this paper
• A Short Chemically Modified dsRNA-Binding PNA (dbPNA) Inhibits Influenza Viral Replication by Targeting Viral RNA Panhandle Structure.

  2019cites this paper
• Cooperative Cellular Uptake and Activity of Octaarginine Antisense Peptide Nucleic Acid (PNA) Conjugates

  2019cites this paper
• Advances in Nanoparticle-based Delivery of Next Generation Peptide Nucleic Acids.

  2019cites this paper
• A CRISPR/Cas9 based polymeric nanoparticles to treat/inhibit microbial infections.

  2019cites this paper
• Platforms for delivery of macromolecules to sites of DNA double-strand break repair

  2019cites this paper
• Cell-Penetrating Peptides for Mitochondrial Targeting

  2018cites this paper
• Overcoming Endosomal Entrapment in Drug Delivery.

  2018cites this paper
• Effective photo-enhancement of cellular activity of fluorophore-octaarginine antisense PNA conjugates correlates with singlet oxygen formation, endosomal escape and chromophore lipophilicity

  2018cites this paper
• Histidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1

  2018cites this paper
• Polymeric micelleplexes for improved photothermal endosomal escape and delivery of siRNA

  2018cites this paper
• 
Therapeutic Peptide Nucleic Acids: Principles, Limitations, and Opportunities


  2017cites this paper
• Complexes of cell-penetrating peptides with oligonucleotides : Structure, binding and translocation in lipid membranes

  2017cites this paper
• Distinct effects of endosomal escape and inhibition of endosomal trafficking on gene delivery via electrotransfection

  2017cites this paper
• All-atom MD indicates ion-dependent behavior of therapeutic DNA polymer.

  2017cites this paper
• Calcium Phosphate Nanoparticles Cytocompatibility Versus Cytotoxicity: A Serendipitous Paradox.

  2017cites this paper
• An Amphipathic trans‐Acting Phosphorothioate DNA Element Delivers Uncharged PNA and PMO Nucleic Acid Sequences in Mammalian Cells

  2016cites this paper
• Perfluoroalkylchain conjugation as a new tactic for enhancing cell permeability of peptide nucleic acids (PNAs) via reducing the nanoparticle size.

  2016cites this paper
• Biological Properties of a 3',3″-Bis-Peptide-siRNA Conjugate in Vitro and in Vivo.

  2016cites this paper
• Production and clinical development of nanoparticles for gene delivery

  2016cites this paper
• Membrane Oxidation Governed Direct Plasma Membrane Translocation of Cell-Penetrating Peptides in Live Cells: Mechanisms and Implications

  2016cites this paper
• Nanocarriers Conjugated with Cell Penetrating Peptides: New Trojan Horses by Modern Ulysses.

  2016cites this paper
• Delivery of cell-penetrating peptide-peptide nucleic acid conjugates by assembly on an oligonucleotide scaffold

  2015cites this paper
• Cellular Antisense Activity of PNA–Oligo(bicycloguanidinium) Conjugates Forming Self‐Assembled Nanoaggregates

  2015cites this paper
• Delivery of therapeutic oligonucleotides with cell penetrating peptides☆

  2015cites this paper
• Intracellular Delivery of Molecular Cargo Using Cell-Penetrating Peptides and the Combination Strategies

  2015cites this paper
• Short interfering RNA therapeutics: nanocarriers, prospects and limitations.

  2015cites this paper
• Composites of peptide nucleic acids with titanium dioxide nanoparticles. IV. Antiviral activity of nanocomposites containing DNA/PNA duplexes

  2015cites this paper
• Ca2+ enrichment in culture medium potentiates effect of oligonucleotides

  2015cites this paper
• Enhanced Peptide delivery into cells by using the synergistic effects of a cell-penetrating Peptide and a chemical drug to alter cell permeability.

  2015cites this paper
• Amphipathic trans-acting phosphorothioate DNA elements mediate the delivery of uncharged nucleic acid sequences in mammalian cells

  2015cites this paper
• PAMAM Dendrimer Conjugated with Cell‐penetrating Peptide‐derived Oligopeptides for Enhanced Cell Uptake and Gene Delivery

  2015cites this paper
• Oligonucleotide Complexes with Cell-Penetrating Peptides : Structure, Binding, Translocation and Flux in Lipid Membranes

  2014cites this paper
• Cell-penetrating peptide-mediated topical delivery of biomacromolecular drugs.

  2014cites this paper
• Cellular delivery of peptide nucleic acids (PNAs).

  2014cites this paper
• Enhanced splicing correction effect by an oligo-aspartic acid-PNA conjugate and cationic carrier complexes.

  2014cites this paper
• Delivery of Antisense Peptide Nucleic Acids to Cells by Conjugation with Small Arginine-Rich Cell-Penetrating Peptide (R/W)9

  2014cites this paper
• Internalisation cellulaire et activité biologique de PNA bloqueurs stériques de la traduction, conjugués au peptide (R/W)9

  2014cites this paper
• Calcium-crosslinked LABL-TAT complexes effectively target gene delivery to ICAM-1 expressing cells

  2014cites this paper
• Cell penetrating peptides: efficient vectors for delivery of nanoparticles, nanocarriers, therapeutic and diagnostic molecules.

  2014cites this paper
• Cell penetration: scope and limitations by the application of cell‐penetrating peptides

  2014cites this paper
• Enhancing nucleic acid delivery by photochemical internalization.

  2013cites this paper
• Influence of nanoparticle shape, size, and surface functionalization on cellular uptake.

  2013cites this paper
• Nanoparticle-Based Delivery of RNAi Therapeutics: Progress and Challenges

  2013cites this paper
• Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus

  2013cites this paper
• Therapeutic delivery using cell-penetrating peptides

  2013cites this paper
• NickFects – novel cell-penetrating peptides. Design and uptake mechanism

  2013cites this paper
• A novel cell-penetrating peptide TAT-A1 delivers siRNA into tumor cells selectively.

  2013cites this paper
• Light-induced mRNA transfection.

  2013cites this paper
• Alkali metal cations control over nucleophilic substitutions on aromatic fused pyrimidine-2,4-[1H,3H]-diones: towards new PNA monomers

  2012cites this paper
• Nanomolar cellular antisense activity of peptide nucleic acid (PNA) cholic acid ("umbrella") and cholesterol conjugates delivered by cationic lipids.

  2012cites this paper
• Effects of hydroxyapatite nanoparticles on proliferation and apoptosis of human breast cancer cells (MCF-7)

  2012cites this paper
• Flavin Conjugates for Delivery of Peptide Nucleic Acids

  2012cites this paper
• Cell Penetrating Peptides in the Delivery of Biopharmaceuticals

  2012cites this paper
• Chiral Peptide Nucleic Acids with a Substituent in the N-(2-Aminoethy)glycine Backbone

  2012cites this paper
• Peptide-based cationic liposome-mediated gene delivery

  2012cites this paper
• Peptide vectors for the nonviral delivery of nucleic acids.

  2012cites this paper
• Biomineralization‐Based Virus Shell‐Engineering: Towards Neutralization Escape and Tropism Expansion

  2012cites this paper
• Cell-Penetrating Peptides

  2011cites this paper
• Cell-penetrating peptides : Uptake, stability and biological activity

  2011cites this paper
• Intracellular delivery of nanoparticles with CPPs.

  2011cites this paper
• Inhibition of Multidrug Resistance by SV40 Pseudovirion Delivery of an Antigene Peptide Nucleic Acid (PNA) in Cultured Cells

  2011cites this paper
• Chemical structure requirements and cellular targeting of microRNA-122 by peptide nucleic acids anti-miRs

  2011cites this paper
• A Novel Photosensitizer for Light-Controlled Gene Silencing

  2011cites this paper
• Peptide nucleic acid (PNA) cell penetrating peptide (CPP) conjugates as carriers for cellular delivery of antisense oligomers

  2011cites this paper
• Calcium condensed LABL-TAT complexes effectively target gene delivery to ICAM-1 expressing cells.

  2011cites this paper
• Enhanced cellular delivery of cell-penetrating peptide-peptide nucleic acid conjugates by photochemical internalization.

  2011cites this paper
• Improved cellular uptake of antisense peptide nucleic acids by conjugation to a cell-penetrating peptide and a lipid domain.

  2011cites this paper
• Efficiency of Cellular Delivery of Antisense Peptide Nucleic Acid by Electroporation Depends on Charge and Electroporation Geometry

  2011cites this paper
• IMRE MÄGER Characterization of cell-penetrating peptides: assessment of cellular internalization kinetics, mechanisms and bioactivity

  2011cites this paper
• Peptide nucleic acids with a structurally biased backbone. Updated review and emerging challenges.

  2011cites this paper
• Transduction of peptides and proteins into live cells by cell penetrating peptides

  2011influential citation
• Therapeutic delivery opportunities, obstacles and applications for cell-penetrating peptides.

  2011cites this paper
• NIKITA OSKOLKOV A novel strategy for peptide-mediated cellular delivery and induction of endosomal escape

  2011cites this paper
• Peptide Nucleic Acids (PNAs) as a Tool in Chemical Biology

  2011cites this paper
• Bioengineering of a TAT-conjugated Peptide to Modulate the Activity of Glycogen Synthase Kinase-3 in Adult and Embryonic Stem Cells

  2011cites this paper
• Polyelectrolyte-based Nanoparticles for Gene and Protein Delivery

  2011cites this paper
• Chemical Biology of Peptide Nucleic Acids (PNAs)

  2010cites this paper
• Cell‐Penetrating Peptides for Cytosolic Delivery of Biomacromolecules

  2010cites this paper
• Cellular delivery and antisense effects of peptide nucleic acid conjugated to polyethyleneimine via disulfide linkers.

  2010cites this paper
• A non-covalent strategy combining cationic lipids and CPPs to enhance the delivery of splice correcting oligonucleotides.

  2010cites this paper
• Enhanced internalization and endosomal escape of dual-functionalized poly(ethyleneimine)s polyplex with diphtheria toxin T and R domains.

  2010cites this paper
• Sequence-selective targeting of duplex DNA by peptide nucleic acids.

  2010cites this paper
• Gene targeting and expression modulation by peptide nucleic acids (PNA).

  2010cites this paper
• Intracellular transduction using cell-penetrating peptides.

  2010cites this paper