Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Nature Structural & Molecular Biology

• Publication date

  2018-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/s41594-018-0050-8PMID 29610493
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks

  2018cited by this paper
• Phosphorylation of the FUS low‐complexity domain disrupts phase separation, aggregation, and toxicity

  2017cited by this paper
• Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains.

  2017cited by this paper
• Structural Studies of Amyloid Proteins at the Molecular Level.

  2017cited by this paper
• Atomic resolution structures from fragmented protein crystals by the cryoEM method MicroED

  2017cited by this paper
• The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril

  2017cited by this paper
• Decoding ALS: from genes to mechanism

  2016cited by this paper
• Hypo- and Hyper-Assembly Diseases of RNA-Protein Complexes.

  2016cited by this paper
• Getting Access to Low-Complexity Domain Modifications.

  2016cited by this paper
• The activities of amyloids from a structural perspective

  2016cited by this paper
• Phase Separation: Linking Cellular Compartmentalization to Disease.

  2016cited by this paper
• Principles and Properties of Stress Granules.

  2016cited by this paper
• The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules.

  2016cited by this paper
• Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease

  2016cited by this paper
• Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization.

  2015cited by this paper
• ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

  2015cited by this paper
• A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.

  2015cited by this paper
• The amyloid state and its association with protein misfolding diseases

  2014cited by this paper
• FUS is Phosphorylated by DNA-PK and Accumulates in the Cytoplasm after DNA Damage

  2014cited by this paper
• Structure-based design of functional amyloid materials.

  2014cited by this paper
• Phosphorylation-regulated binding of RNA polymerase II to fibrous polymers of low-complexity domains.

  2013cited by this paper
• Stress granules as crucibles of ALS pathogenesis

  2013cited by this paper
• Altered ribostasis: RNA-protein granules in degenerative disorders.

  2013cited by this paper
• Designed amyloid fibers as materials for selective carbon dioxide capture

  2013cited by this paper
• The amyloid state of proteins in human diseases.

  2012cited by this paper
• Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels.

  2012cited by this paper
• Phase Transitions in the Assembly of Multi-Valent Signaling Proteins

  2012cited by this paper
• Cell-free formation of RNA granules: bound RNAs identify features and components of cellular assemblies.

  2012cited by this paper
• Towards automated crystallographic structure refinement with phenix.refine

  2012cited by this paper
• Accumulation of insoluble forms of FUS protein correlates with toxicity in Drosophila.

  2012cited by this paper
• RNA-binding proteins with prion-like domains in ALS and FTLD-U

  2011cited by this paper
• Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS

  2011cited by this paper
• Features and development of Coot

  2010cited by this paper
• RNA granules: post-transcriptional and epigenetic modulators of gene expression

  2009cited by this paper
• Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

  2009cited by this paper
• Mutations in FUS cause FALS and SALS in French and French Canadian populations

  2009cited by this paper
• Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells

  2008cited by this paper
• Identification and characterization of FUS/TLS as a new target of ATM.

  2008cited by this paper
• Phaser crystallographic software

  2007cited by this paper
• Atomic structures of amyloid cross-beta spines reveal varied steric zippers.

  2007cited by this paper
• Structure of the cross-beta spine of amyloid-like fibrils.

  2005cited by this paper

• Formation of soy protein amyloid fibrils-tannic acid complexes: structure remodeling of fibrils and enhanced antioxidant properties

  2026cites this paper
• Targeting fused in sarcoma (FUS): a novel antisense strategy for treating idiopathic pulmonary fibrosis

  2026cites this paper
• Breaking β-sheets in FUS prion-like domain preserves phase separation and function but prevents aggregation and toxicity

  2026cites this paper
• The Many Lives of a Single Sequence: Functional Plasticity Through Amyloid Polymorphism.

  2026cites this paper
• Fluorescence imaging of FUS biomolecular condensates: From assembly regulation to pathological transition

  2026cites this paper
• Multistage Phase Programming in Fibrillated Peptide Coacervates.

  2026cites this paper
• Allosteric modulation of TIA-1 phase separation by double serine phosphorylation

  2025cites this paper
• Functional Biomaterials Derived from Protein Liquid–Liquid Phase Separation and Liquid‐to‐Solid Transition

  2025cites this paper
• Green tea polyphenol EGCG acts differentially on end-stage amyloid polymorphs of α-synuclein formed in different polyol osmolytes.

  2025cites this paper
• Structural basis for T-cell intracellular antigen-1 amyloid fibril formation revealed by cryo-electron microscopy

  2025cites this paper
• Charged mutations in the FUS low-complexity domain modulate condensate ageing kinetics

  2025cites this paper
• Compartment engineering in yeast: a path to increased biochemical production

  2025cites this paper
• Applications of MicroED in structural biology and structure-based drug discovery.

  2025cites this paper
• Sequence-encoded conformational biases shape self-assembly modes of intrinsically disordered proteins

  2025cites this paper
• Structural and Functional Versatility of the Amyloidogenic Non‐Amidated Variant of the Antimicrobial Peptide Citropin 1.3

  2025cites this paper
• In situ secondary structure imaging of protein phase separation and aggregation by hyperspectral stimulated Raman scattering microscopy

  2025cites this paper
• Integrating coarse-grained simulations and machine learning to uncover protein aging mechanisms.

  2025cites this paper
• Peptide-mediated liquid-liquid phase separation and biomolecular condensates.

  2025cites this paper
• Unambiguous assignment of kinked‐β sheets leads to insights into molecular grammar of reversibility in biomolecular condensates

  2025cites this paper
• Dual Hydrophilic‐Hydrophobic Core Architecture in Soy Glycinin Amyloid Fibrils Revealed by Cryo‐EM

  2025cites this paper
• Nanofilm Formed via Amyloid-Like Protein Aggregation for Interfacial Modification: Prospects in Food, Agricultural, and Beyond.

  2025cites this paper
• Molecular insights on the mechanism of α1-antitrypsin condensate formation and maturation

  2025cites this paper
• Visualizing liquid-liquid phase separation and protein aggregates

  2025cites this paper
• Liquid-liquid phase separation (LLPS) in skeletal muscle: A new frontier in muscle biology.

  2025cites this paper
• Full‐Length FUS Protein Condensates Adopt a Domain‐Preferential Spatial Architecture

  2025cites this paper
• Investigation of the Differences in Amyloid-Like Fibrils Derived from Wheat Gluten with Varying Structures under Typical Food Processing Conditions.

  2025cites this paper
• RNA-binding proteins in ALS and FTD: from pathogenic mechanisms to therapeutic insights

  2025cites this paper
• Decoding physical environment's role in protein phase transition.

  2025cites this paper
• Functional amyloid protein FXR1 is recruited into neuronal stress granules

  2025cites this paper
• Intrinsically Disordered Protein Coating for Oral Delivery of Peptide Drugs

  2025cites this paper
• Elucidating the reversible and irreversible self-assembly mechanisms of low-complexity aromatic-rich kinked peptides and steric zipper peptides.

  2024cites this paper
• A chaperone-like function of FUS ensures TAZ condensate dynamics and transcriptional activation

  2024cites this paper
• Protein aggregation and biomolecular condensation in hypoxic environments (Review)

  2024cites this paper
• Ensemble structure of the N-terminal domain (1–267) of FUS in a biomolecular condensate

  2024cites this paper
• Synergistic treatment of pH and ultrasound promotes the formation of insoluble soy protein hydrolysate nanofibrils.

  2024cites this paper
• Alternative low-populated conformations prompt phase transitions in polyalanine repeat expansions

  2024cites this paper
• Decoding phase separation of prion-like domains through data-driven scaling laws

  2024cites this paper
• Capturing the Conformational Heterogeneity of HSPB1 Chaperone Oligomers at Atomic Resolution

  2024cites this paper
• Amyloid-like Aggregation of Wheat Gluten and Its Components during Cooking: Mechanisms and Structural Characterization.

  2024cites this paper
• Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications

  2024cites this paper
• Homologous Peptide Foldamer Promotes FUS Aggregation and Triggers Cancer Cell Death.

  2024cites this paper
• De novo designed YK peptides forming reversible amyloid for synthetic protein condensates in mammalian cells

  2024influential citation
• A Few Charged Residues in Galectin‐3′s Folded and Disordered Regions Regulate Phase Separation

  2024cites this paper
• Recent advances in engineering synthetic biomolecular condensates.

  2024cites this paper
• Structural changes in hemoglobin and glycation.

  2024cites this paper
• An evolutionarily conserved mechanism controls reversible amyloids of pyruvate kinase via pH-sensing regions.

  2024cites this paper
• Spatiotemporal control of kinases and the biomolecular tools to trace activity

  2024cites this paper
• Engineered droplet-forming peptide as photocontrollable phase modulator for fused in sarcoma protein

  2024cites this paper
• Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation

  2024cites this paper
• A solid beta-sheet structure is formed at the surface of FUS droplets during aging

  2024influential citation
• Early Aggregation Mechanism of SOD128-38 Based on Force Field Parameter of 5-Cyano-Tryptophan

  2024cites this paper
• The interplay between biomolecular assembly and phase separation

  2024cites this paper
• TDP-43 Amyloid Fibril Formation via Phase Separation-Related and -Unrelated Pathways

  2024cites this paper
• Observation of the Liquid-Liquid Phase Separation of FUS-LC Using Vacuum-Ultraviolet Circular Dichroism Spectroscopy.

  2024cites this paper
• A new electrochemical method that mimics phosphorylation of the core tau peptide K18 enables kinetic and structural analysis of intermediates and assembly

  2023cites this paper
• Construction of multiphasic membraneless organelles towards spontaneous spatial segregation and directional flow of biochemical reactions

  2023cites this paper
• Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates

  2023cites this paper
• Strategies for Making High‐Performance Artificial Spider Silk Fibers

  2023cites this paper
• Location and Concentration of Aromatic‐Rich Segments Dictates the Percolating Inter‐Molecular Network and Viscoelastic Properties of Ageing Condensates

  2023cites this paper
• Protein amyloid aggregate: Structure and function

  2023cites this paper
• What can AlphaFold do for antimicrobial amyloids?

  2023influential citation
• Synthesis and functionalization of scalable and versatile 2D protein films via amyloid-like aggregation

  2023cites this paper
• Glutathionylation on RNA-binding proteins: a regulator of liquid‒liquid phase separation in the pathogenesis of amyotrophic lateral sclerosis

  2023cites this paper
• Responsive Smart Materials from Energy Transition of Biomolecular Structural Changes

  2023cites this paper
• Creating an amyloid 'kaleidoscope' using short iodinated peptides.

  2023cites this paper
• Benchmarking of force fields to characterize the intrinsically disordered R2-FUS-LC region

  2023influential citation
• Toward a high-resolution mechanism of intrinsically disordered protein self-assembly.

  2023cites this paper
• Rational design of phase separating peptides based on phase separating protein sequence of p53

  2023cites this paper
• Multidimensional Super-Resolution Microscopy Unveils Nanoscale Surface Aggregates in the Aging of FUS Condensates.

  2023cites this paper
• Ability of soy protein derived amyloid fibrils to stabilize aqueous two-phase system and effect of pH on the system

  2023cites this paper
• Rational design of functional amyloid fibrillar assemblies.

  2023cites this paper
• Multidimensional super-resolution microscopy unveils nanoscale surface aggregates in the aging of FUS condensates

  2023cites this paper
• Dissecting the Effect of ALS Mutation G335D on the Early Aggregation of the TDP-43 Amyloidogenic Core Peptide: Helix-to-β-Sheet Transition and Conformational Shift

  2023cites this paper
• A solid beta-sheet structure is formed at the surface of FUS liquid droplets during aging

  2023cites this paper
• Peptide self-assembly through liquid-liquid phase separation

  2023cites this paper
• A linker protein from a red-type pyrenoid phase separates with Rubisco via oligomerizing sticker motifs

  2023cites this paper
• Dissecting how ALS-associated D290V mutation enhances pathogenic aggregation of hnRNPA2286-291 peptides: Dynamics and conformational ensembles.

  2023cites this paper
• FUS fibrillation occurs through a nucleation-based process below the critical concentration required for liquid–liquid phase separation

  2023cites this paper
• Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils

  2023cites this paper
• Designed inhibitors to reduce amyloid virulence and cytotoxicity and combat neurodegenerative and infectious diseases.

  2023cites this paper
• Chirality induction and amplification in supramolecular systems exhibiting vibrational optical activity.

  2023cites this paper
• Modeling the Effects of Phosphorylation on Phase Separation of the FUS Low-Complexity Domain.

  2023cites this paper
• Molecular Investigations of Protein Aggregation in the Pathogenesis of Amyotrophic Lateral Sclerosis

  2022cites this paper
• Structural Mimicry in Microbial and Antimicrobial Amyloids.

  2022cites this paper
• Structural Remodeling Mechanism of the Toxic Amyloid Fibrillary Mediated by Epigallocatechin-3-gallate

  2022cites this paper
• Reordering of aromatic-rich segments in FUS protein inhibits ageing of FUS-RNA condensates

  2022cites this paper
• Formation of versus Recruitment to RNA-Rich Condensates: Controlling Effects Exerted by Peptide Side Chain Identity.

  2022cites this paper
• Phosphorylated and Phosphonated Low‐Complexity Protein Segments for Biomimetic Mineralization and Repair of Tooth Enamel

  2022cites this paper
• Insights into the Atomistic Mechanisms of Phosphorylation in Disrupting Liquid-Liquid Phase Separation and Aggregation of the FUS Low-Complexity Domain

  2022cites this paper
• Aging can transform single-component protein condensates into multiphase architectures

  2022cites this paper
• Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases

  2022cites this paper
• Predicting disordered regions driving phase separation of proteins under variable salt concentration

  2022cites this paper
• Benchmark of force fields to characterize the intrinsically disordered R2-FUS-LC region

  2022cites this paper
• Modulating liquid-liquid phase separation of FUS: mechanisms and strategies.

  2022cites this paper
• Different states and the associated fates of biomolecular condensates.

  2022cites this paper
• How art impacts my science

  2022cites this paper
• Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it

  2022influential citation
• Structure and Polymorphism of Amyloid and Amyloid-Like Aggregates

  2022cites this paper
• Emerging Implications of Phase Separation in Cancer

  2022cites this paper
• Time-Dependent Material Properties of Aging Biomolecular Condensates from Different Viscoelasticity Measurements in Molecular Dynamics Simulations

  2022cites this paper