The Runt domain identifies a new family of heteromeric transcriptional regulators.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Trends in Genetics

• Publication date

  1993-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0168-9525(93)90026-EPMID 8273148
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene.

  1993cited by this paper
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• The t(8;21) translocation in acute myeloid leukemia results in production of an AML1‐MTG8 fusion transcript.

  1993cited by this paper
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• Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha.

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• Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia.

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• Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1.

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• Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

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• Differential Expression of Subspecies of Polyomavirus and Murine Leukemia Virus Enhancer Core Binding Protein, PEBP2, in Various Hematopoietic Cells

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• Leukaemia/Drosophila homology

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• Consistent disruption of the AML1 gene occurs within a single intron in the t(8;21) chromosomal translocation.

  1992cited by this paper
• Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers.

  1992cited by this paper
• The Drosophila segmentation gene runt has an extended cis-regulatory region that is required for vital expression at other stages of development.

  1992cited by this paper
• Indistinguishable nuclear factor binding to functional core sites of the T-cell receptor delta and murine leukemia virus enhancers.

  1992cited by this paper
• Expression and function of the Drosophila gene runt in early stages of neural development.

  1991cited by this paper
• Convergence of Ets- and notch-related structural motifs in a heteromeric DNA binding complex.

  1991cited by this paper
• The Drosophila segmentation gene runt acts as a position-specific numerator element necessary for the uniform expression of the sex-determining gene Sex-lethal.

  1991cited by this paper
• The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system.

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