Endothelial-Mesenchymal Transition in Regenerative Medicine

Endothelial-mesenchymal transition (EndMT) is a fundamental cellular mechanism that regulates embryonic development and diseases such as cancer and fibrosis. Recent developments in biomedical research have shown remarkable potential to harness the EndMT process for tissue engineering and regeneration. As an alternative to traditional or artificial stem cell therapies, EndMT may represent a safe method for engineering new tissues to treat degenerative diseases by mimicking a process that occurs in nature. This review discusses the signaling mechanisms and therapeutic inhibitors of EndMT, as well as the role of EndMT in development, disease, acquiring stem cell properties and generating connective tissues, and its potential as a novel mechanism for tissue regeneration.

• Publication year

  2016

• Venue

  Stem Cells International

• Publication date

  2016-04-07

• Fields of study

  Biology, Medicine, Engineering

• Identifiers
  DOI 10.1155/2016/6962801PMID 27143978PMCID 4838799
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2014cited by this paper
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• Bmp signaling represses Vegfa to promote outflow tract cushion development

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  2013cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2008cited by this paper
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  2019influential citation
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