Asymmetric synthesis of 3-substituted isoindolinones: application to the total synthesis of (+)-lennoxamine.

An anionic chiral auxiliary mediated asymmetric alkylation of carbamate 2 provides 3-substituted isoindolinones 4 in high ee. This methodology was used in the first asymmetric synthesis of (+)-lennoxamine.

• Publication year

  2005

• Venue

  Organic Letters

• Publication date

  2005-01-06

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/OL047824WPMID 15624986
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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