Co-activation of multiple tightly-coupled calcium channels triggers spontaneous release of GABA

Voltage-activated Ca2+ channels (VACCs) mediate Ca2+ influx to trigger action potential–evoked neurotransmitter release, but the mechanism by which Ca2+ regulates spontaneous transmission is unclear. We found that VACCs are the major physiological triggers for spontaneous release at mouse neocortical inhibitory synapses. Moreover, despite the absence of a synchronizing action potential, we found that spontaneous fusion of a GABA-containing vesicle required the activation of multiple tightly coupled VACCs of variable type.

• Publication year

  2012

• Venue

  Nature Neuroscience

• Publication date

  2012-06-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nn.3162PMID 22842148PMCID 3431448
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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