Phytochemical Ginkgolide B Attenuates Amyloid-β1-42 Induced Oxidative Damage and Altered Cellular Responses in Human Neuroblastoma SH-SY5Y Cells

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Journal of Alzheimer's Disease

• Publication date

  2017-02-20

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.3233/JAD-161086PMID 28234255
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?

  2017cited by this paper
• Indian Herbs and their Therapeutic Potential against Alzheimer's Disease and Other Neurological Disorders

  2017cited by this paper
• Characterization of Differentiated SH-SY5Y as Neuronal Screening Model Reveals Increased Oxidative Vulnerability

  2016cited by this paper
• Ginsenoside Re protects methamphetamine‐induced mitochondrial burdens and proapoptosis via genetic inhibition of protein kinase C δ in human neuroblastoma dopaminergic SH‐SY5Y cell lines

  2015cited by this paper
• Ginkgolide B Inhibits JAM-A, Cx43, and VE-Cadherin Expression and Reduces Monocyte Transmigration in Oxidized LDL-Stimulated Human Umbilical Vein Endothelial Cells

  2015cited by this paper
• Centella asiatica extract protects against amyloid β1–40-induced neurotoxicity in neuronal cells by activating the antioxidative defence system

  2015cited by this paper
• Double-Edged Roles of Nitric Oxide Signaling on APP Processing and Amyloid-β Production In Vitro: Preliminary Evidence from Sodium Nitroprusside

  2015cited by this paper
• Ginkgolide B revamps neuroprotective role of apurinic/apyrimidinic endonuclease 1 and mitochondrial oxidative phosphorylation against Aβ25–35‐induced neurotoxicity in human neuroblastoma cells

  2015cited by this paper
• Oxidative Stress Events and Neuronal Dysfunction in Alzheimer’s Disease: Focus on APE1/Ref-1-Mediated Survival Strategies

  2015cited by this paper
• Magnesium Lithospermate B Protects Neurons Against Amyloid β (1–42)-Induced Neurotoxicity Through the NF-κB Pathway

  2015cited by this paper
• Protective Effects of Lycium barbarum Polysaccharide on 6-OHDA-Induced Apoptosis in PC12 Cells through the ROS-NO Pathway

  2014cited by this paper
• NAD attenuates oxidative DNA damages induced by amyloid beta-peptide in primary rat cortical neurons

  2014cited by this paper
• Ginkgolide B prevents cathepsin-mediated cell death following cerebral ischemia/reperfusion injury

  2014cited by this paper
• Nucleic acid oxidation: an early feature of Alzheimer's disease

  2014cited by this paper
• Watermelon (Citrullus lanatus (Thunb.) Matsum. and Nakai) Juice Modulates Oxidative Damage Induced by Low Dose X-Ray in Mice

  2014cited by this paper
• Ginkgolide B preconditioning on astrocytes promotes neuronal survival in ischemic injury via up-regulating erythropoietin secretion.

  2013cited by this paper
• Protective Effects of Hydroxysafflor Yellow A on β-Amyloid-Induced Neurotoxicity in PC12 Cells

  2013cited by this paper
• Ginkgolide B Reduces LOX-1 Expression by Inhibiting Akt Phosphorylation and Increasing Sirt1 Expression in Oxidized LDL-Stimulated Human Umbilical Vein Endothelial Cells

  2013cited by this paper
• Intracellular Localization of Amyloid-β Peptide in SH-SY5Y Neuroblastoma Cells

  2013cited by this paper
• Amyloid β-Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression

  2013cited by this paper
• Pretreatment of SH‐SY5Y cells with dicaffeoylquinic acids attenuates the reduced expression of nicotinic receptors, elevated level of oxidative stress and enhanced apoptosis caused by β‐amyloid peptide

  2013cited by this paper
• ROS and Brain Diseases: The Good, the Bad, and the Ugly

  2013cited by this paper
• The Earliest Stage of Cognitive Impairment in Transition From Normal Aging to Alzheimer Disease Is Marked by Prominent RNA Oxidation in Vulnerable Neurons

  2012cited by this paper
• Differential effects of α-tocopherol and N-acetyl-cysteine on advanced glycation end product-induced oxidative damage and neurite degeneration in SH-SY5Y cells.

  2012cited by this paper
• Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases.

  2012cited by this paper
• Mitochondrial effects of Ginkgo biloba extract

  2012cited by this paper
• Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons

  2012cited by this paper
• Proteomic study of amyloid beta (25–35) peptide exposure to neuronal cells: Impact on APE1/Ref‐1's protein–protein interaction

  2012cited by this paper
• Attenuation of Aβ-induced neurotoxicity by thymoquinone via inhibition of mitochondrial dysfunction and oxidative stress

  2012cited by this paper
• Stimulation of DNA repair in Saccharomyces cerevisiae by Ginkgo biloba leaf extract.

  2011cited by this paper
• Antioxidant activity and toxicity profile of total triterpenes isolated from Ganoderma lucidum (Fr.) P. Karst occurring in South India.

  2011cited by this paper
• NADPH oxidase inhibition ameliorates Trypanosoma cruzi‐induced myocarditis during Chagas disease

  2011cited by this paper
• Deficiency of the Copper Chaperone for Superoxide Dismutase Increases Amyloid-β Production

  2010cited by this paper
• Oxidative damage to RNA: mechanisms, consequences, and diseases

  2010cited by this paper
• Amyloid oligomers: formation and toxicity of Aβ oligomers

  2010cited by this paper
• Naturally occurring phytochemicals for the prevention of Alzheimer’s disease

  2010cited by this paper
• Free radical induced oxidative damage to DNA: relation to brain aging and neurological disorders.

  2009cited by this paper
• Protective effects of Ginkgo biloba extract (EGb761) and its constituents quercetin and ginkgolide B against beta-amyloid peptide-induced toxicity in SH-SY5Y cells.

  2009cited by this paper
• Intracellular amyloid beta interacts with SOD1 and impairs the enzymatic activity of SOD1: implications for the pathogenesis of amyotrophic lateral sclerosis

  2009cited by this paper
• Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death

  2009cited by this paper
• Regulation of GAP-43 at serine 41 acts as a switch to modulate both intrinsic and extrinsic behaviors of growing neurons, via altered membrane distribution.

  2009cited by this paper
• Nucleic acid oxidation in Alzheimer disease.

  2008cited by this paper
• Mitochondrial DNA repair in aging and disease.

  2008cited by this paper
• Benefits from Dietary Polyphenols for Brain Aging and Alzheimer’s Disease

  2008cited by this paper
• Methods to detect nitric oxide and its metabolites in biological samples.

  2007cited by this paper
• Effect of Resveratrol on Antioxidant Enzyme Activities in the Brain of Healthy Rat

  2007cited by this paper
• Oxidative stress alters neuronal RNA- and protein-synthesis: Implications for neural viability

  2007cited by this paper
• N VIVO PROTECTION BY THE XANTHATE TRICYCLODECAN-9-YL-ANTHOGENATE AGAINST AMYLOID-PEPTIDE ( 1 – 42 )-INDUCED XIDATIVE STRESS

  2006cited by this paper
• In vivo protection by the xanthate tricyclodecan-9-yl-xanthogenate against amyloid beta-peptide (1-42)-induced oxidative stress.

  2006cited by this paper
• Research on the measurement of the SOD activity via pyrogallol auto-oxidation

  2006cited by this paper
• Nonrandom AP site distribution in highly proliferative cells

  2006cited by this paper
• Curcumin protects mouse brain from oxidative stress caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

  2006cited by this paper
• Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method

  2006cited by this paper
• Oxidative stress induced by beta-amyloid peptide(1-42) is involved in the altered composition of cellular membrane lipids and the decreased expression of nicotinic receptors in human SH-SY5Y neuroblastoma cells.

  2005cited by this paper
• Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes.

  2005cited by this paper
• Oxidative DNA damage and disease: induction, repair and significance.

  2004cited by this paper
• Curcumin has potent anti‐amyloidogenic effects for Alzheimer's β‐amyloid fibrils in vitro

  2004cited by this paper
• The retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cell line as a model for Alzheimer's disease-like tau phosphorylation.

  2004cited by this paper
• Amyloid β-induced Changes in Nitric Oxide Production and Mitochondrial Activity Lead to Apoptosis*

  2004cited by this paper
• Free radicals and aging.

  2004cited by this paper
• Pathways towards and away from Alzheimer's disease

  2004cited by this paper
• Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease.

  2004cited by this paper
• Neuroprotective effects of Ginkgo biloba extract

  2003cited by this paper
• Protein carbonyl groups as biomarkers of oxidative stress.

  2003cited by this paper
• Neuroprotective Effects of Bilobalide, a Component of Ginkgo biloba Extract (EGb 761®) in Global Brain Ischemia and in Excitotoxicity-induced Neuronal Death

  2003cited by this paper
• Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death.

  2003cited by this paper
• Amyloid β-peptide (1-42)-induced Oxidative Stress and Neurotoxicity: Implications for Neurodegeneration in Alzheimer's Disease Brain. A Review

  2002cited by this paper
• Comparison of two methods used to analyse lipid peroxidation from Vaccinium myrtillus (L.) during snow removal, reacclimation and cold acclimation.

  2001cited by this paper
• Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide.

  2001cited by this paper
• Antioxidant compounds EGB-761 and BN-520 21 attenuate heat shock protein (HSP 72 kD) response, edema and cell changes following hyperthermic brain injury

  2000cited by this paper
• The Ginkgo biloba Extract (EGb 761) Protects and Rescues Hippocampal Cells Against Nitric Oxide‐Induced Toxicity

  2000cited by this paper
• beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease.

  1999cited by this paper
• Glutathione depletion and neuronal cell death: the role of reactive oxygen intermediates and mitochondrial function.

  1999cited by this paper
• RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease

  1999cited by this paper
• Amyloid-beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release.

  1998cited by this paper
• Amyloid-β peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release

  1998cited by this paper
• Mechanisms of neurotoxicity associated with amyloid beta deposition and the role of free radicals in the pathogenesis of Alzheimer's disease: a critical appraisal.

  1997cited by this paper
• Protein Oxidation in Aging, Disease, and Oxidative Stress*

  1997cited by this paper
• Free radicals and aging

  1994cited by this paper
• Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

  1994cited by this paper

• A Cross-sectional In Vitro Study on the Synergistic Neuroprotective Effects of Phytochemicals Ferulic Acid and Ginkgolide B against Amyloid Beta-induced Oxidative Stress and Modulation of Multifunctional Enzyme APE1/Ref-1 in Human Neuroblastoma SH-SY5Y Cells

  2025influential citation
• Cell culture research in aging and Alzheimer's disease: The strategic use/reuse of untreated controls and savings people's tax dollars

  2025cites this paper
• Rationale and design of Shuxuening Injection in the Treatment With Intravenous Thrombolysis in Patients With Ischemic Stroke (SHINY): A multicenter randomized trial

  2025cites this paper
• Ginkgolide B as a biopsychosocial treatment salvages repeated restraint stress-induced amygdalar anomalies in mice

  2024cites this paper
• Activation of multifunctional DNA repair APE1/Ref-1 enzyme by the dietary phytochemical Ferulic acid protects human neuroblastoma SH-SY5Y cells against Aβ(25-35)-Induced oxidative stress and inflammatory responses.

  2024cites this paper
• Ginkgolic acid inhibited Tau phosphorylation and improved cognitive ability through the SUMO-1/GSK3β pathway in Aβ-Induced Alzheimer’s disease model rats

  2024cites this paper
• Role of Cytoskeletal Elements in Regulation of Synaptic Functions: Implications Toward Alzheimer’s Disease and Phytochemicals-Based Interventions

  2024cites this paper
• Implications of organophosphate pesticides on brain cells and their contribution toward progression of Alzheimer's disease

  2024cites this paper
• Therapeutic potential and microRNA regulating properties of phytochemicals in Alzheimer’s disease

  2024cites this paper
• Mechanisms of ferroptosis in Alzheimer's disease and therapeutic effects of natural plant products: A review.

  2023cites this paper
• Edaravone combined with Shuxuening versus edaravone alone in the treatment of acute cerebral infarction: A systematic review and meta-analysis

  2023cites this paper
• Plant-Derived Bioactive Compounds in the Management of Neurodegenerative Disorders: Challenges, Future Directions and Molecular Mechanisms Involved in Neuroprotection

  2023cites this paper
• The Role of Iron Metabolism, Lipid Metabolism, and Redox Homeostasis in Alzheimer’s Disease: from the Perspective of Ferroptosis

  2023cites this paper
• Current Advances in Mitochondrial Targeted Interventions in Alzheimer’s Disease

  2023cites this paper
• Perfluorocarbon Nanoparticles Incorporating Ginkgolide B: Artificial O2 Carriers with Antioxidant Activity and Antithrombotic Effect

  2023cites this paper
• Correlative study on heavy metal-induced oxidative stress and hypertension among the rural population of Malwa Region of Punjab, India

  2022cites this paper
• Identification of metabolites of Ginkgolide B in vivo and in vitro using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry.

  2022cites this paper
• Gliadin induced oxidative stress and altered cellular responses in human intestinal cells: An in‐vitro study to understand the cross‐talk between the transcription factor Nrf‐2 and multifunctional APE1 enzyme

  2022cites this paper
• Can We Use Ginkgo biloba Extract to Treat Alzheimer’s Disease? Lessons from Preclinical and Clinical Studies

  2022cites this paper
• Ginkgolides and bilobalide for treatment of Alzheimer's disease and COVID-19: potential mechanisms of action.

  2022cites this paper
• Pharmacokinetics of Ginkgolide B Lyophilized Nanoparticles Following Intravenous Injection in Rats by Using LC-MS/MS.

  2022cites this paper
• A cross-sectional study to correlate antioxidant enzymes, oxidative stress and inflammation with prevalence of hypertension.

  2022cites this paper
• Promising Therapeutic Candidate for Myocardial Ischemia/Reperfusion Injury: What Are the Possible Mechanisms and Roles of Phytochemicals?

  2022cites this paper
• Curcumin Resuscitate Gliadin Induced Oxidative Damage And Altered Cellular Responses In Human Intestinal Cells Via Cross-Talk Between The Transcription Factor Nrf-2 And Multifunctional Protein APE1

  2021cites this paper
• Neuroprotective effects of Ginkgolide B in focal cerebral ischemia through selective activation of prostaglandin E2 receptor EP4 and the downstream transactivation of epidermal growth factor receptor

  2021cites this paper
• Design, synthesis, biological evaluation of 3,5-diaryl-4,5-dihydro-1H-pyrazole carbaldehydes as non-purine xanthine oxidase inhibitors: Tracing the anticancer mechanism via xanthine oxidase inhibition.

  2021cites this paper
• Study on Mechanism of Ginkgo biloba L. Leaves for the Treatment of Neurodegenerative Diseases Based on Network Pharmacology

  2021cites this paper
• WITHDRAWN: Assessment and Validation of Globodera pallida as a Novel In Vivo Model for Studying Alzheimer's Disease

  2021cites this paper
• Ginkgolide B-mediated therapeutic effects on perioperative neurocognitive dysfunction are associated with the inhibition of iNOS-mediated production of NO

  2021cites this paper
• Ginkgolide B protects against cognitive impairment in senescence-accelerated P8 mice by mitigating oxidative stress, inflammation and ferroptosis.

  2021cites this paper
• Assessment and Validation of Globodera pallida as a Novel In Vivo Model for Studying Alzheimer’s Disease

  2021cites this paper
• Protective Effect of Ginkgolide B against Cognitive Impairment in Mice via Regulation of Gut Microbiota.

  2021cites this paper
• Nutrition, Physical Activity, and Other Lifestyle Factors in the Prevention of Cognitive Decline and Dementia

  2021cites this paper
• Isolation and Characterization of A2-EPTX-Nsm1a, a Secretory Phospholipase A2 from Malaysian Spitting Cobra (Naja sumatrana) Venom

  2021cites this paper
• Highly Stabilized Nanocrystals Delivering Ginkgolide B in Protecting against the Parkinson's Disease.

  2020cites this paper
• Lycopene protects neuroblastoma cells against oxidative damage via depression of ER stress.

  2020cites this paper
• Anti-aging Klotho Protects SH-SY5Y Cells Against Amyloid β1–42 Neurotoxicity: Involvement of Wnt1/pCREB/Nrf2/HO-1 Signaling

  2020cites this paper
• Current perspectives on the clinical implications of oxidative RNA damage in aging research: challenges and opportunities

  2020cites this paper
• New opportunities for the application of natural products based on nitric oxide modulation: From research to registered patents

  2020cites this paper
• Current perspectives on the clinical implications of oxidative RNA damage in aging research: challenges and opportunities

  2020cites this paper
• Ginkgolide B inhibits hydrogen peroxide-induced apoptosis and attenuates cytotoxicity via activating the PI3K/Akt/mTOR signaling pathway in H9c2 cells

  2020cites this paper
• Non-polyphenolic natural inhibitors of amyloid aggregation.

  2020cites this paper
• An Updated Review of Randomized Clinical Trials Testing the Improvement of Cognitive Function of Ginkgo biloba Extract in Healthy People and Alzheimer’s Patients

  2020cites this paper
• The Role of Vitamin D and Sunlight Incidence in Cancer.

  2019cites this paper
• Fucosterol exerts protection against amyloid β-induced neurotoxicity, reduces intracellular levels of amyloid β and enhances the mRNA expression of neuroglobin in amyloid β-induced SH-SY5Y cells.

  2019cites this paper
• The neuroprotective mechanisms of ginkgolides and bilobalide in cerebral ischemic injury: a literature review

  2019cites this paper
• Genistein protects against amyloid‐beta‐induced toxicity in SH‐SY5Y cells by regulation of Akt and Tau phosphorylation

  2019cites this paper
• Rebalancing metal dyshomeostasis for Alzheimer’s disease therapy

  2019cites this paper
• Activation of anti‐oxidant of curcumin pyrazole derivatives through preservation of mitochondria function and Nrf2 signaling pathway

  2019cites this paper
• Hydrogen peroxide-induced oxidative stress and its impact on innate immune responses in lung carcinoma A549 cells

  2018cites this paper
• Ferulic Acid: A Natural Antioxidant with Application Towards Neuroprotection Against Alzheimer’s Disease

  2018cites this paper
• Cardioprotection of Ginkgolide B on Myocardial Ischemia/Reperfusion-Induced Inflammatory Injury via Regulation of A20-NF-κB Pathway

  2018cites this paper
• Amyloid-Beta 1-42 Cross-Reactive Antibody Prevalent in Human Sera May Contribute to Intraneuronal Deposition of A-Beta-P-42

  2018cites this paper
• Diterpene ginkgolides meglumine injection protects against paraquat-induced lung injury and pulmonary fibrosis in rats.

  2018cites this paper
• Autophagy-ERK1/2-Involved Disinhibition of Hippocampal Neurons Contributes to the Pre-Synaptic Toxicity Induced by Aβ42 Exposure

  2017cites this paper
• Plants-Derived Neuroprotective Agents: Cutting the Cycle of Cell Death through Multiple Mechanisms

  2017cites this paper
• APE1 modulates cellular responses to organophosphate pesticide-induced oxidative damage in non-small cell lung carcinoma A549 cells

  2017cites this paper