The retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cell line as a model for Alzheimer's disease-like tau phosphorylation.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2004-07-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.BBRC.2004.05.075PMID 15184080
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease

  2014cited by this paper
• Tau protein phosphorylation as a therapeutic target in Alzheimer's disease.

  2002cited by this paper
• Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK‐3β

  2002cited by this paper
• A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

  2002cited by this paper
• BDNF‐mediated signal transduction is modulated by GSK3β and mood stabilizing agents

  2002cited by this paper
• Role of c-Jun N-terminal kinase in apoptosis.

  2001cited by this paper
• SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

  2001cited by this paper
• Hyperphosphorylation of tau is mediated by ERK activation during anticancer drug‐induced apoptosis in neuroblastoma cells

  2001cited by this paper
• Activation and redistribution of c‐Jun N‐terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease

  2001cited by this paper
• Selective expression of JNK isoforms and stress-specific JNK activity in different neural cell lines.

  2000cited by this paper
• Sequential Treatment of SH‐SY5Y Cells with Retinoic Acid and Brain‐Derived Neurotrophic Factor Gives Rise to Fully Differentiated, Neurotrophic Factor‐Dependent, Human Neuron‐Like Cells

  2000cited by this paper
• Brain-derived neurotrophic factor-induced phosphorylation of neurofilament-H subunit in primary cultures of embryo rat cortical neurons.

  2000cited by this paper
• Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain.

  1999cited by this paper
• Lithium Inhibits Neurite Growth and Tau Protein Kinase I/Glycogen Synthase Kinase‐3β‐Dependent Phosphorylation of Juvenile Tau in Cultured Hippocampal Neurons

  1999cited by this paper
• Extracellular‐Regulated Kinases and Phosphatidylinositol 3‐Kinase Are Involved in Brain‐Derived Neurotrophic Factor‐Mediated Survival and neuritogenesis of the Neuroblastoma Cell Line SH‐SY5Y

  1999cited by this paper
• Distribution of Active Glycogen Synthase Kinase 3β (GSK-3β) in Brains Staged for Alzheimer Disease Neurofibrillary Changes

  1999cited by this paper
• Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes.

  1999cited by this paper
• Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

  1999cited by this paper
• Ras‐Signaling Pathways: Positive and Negative Regulation of Tau Expression in PC12 Cells

  1998cited by this paper
• Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration.

  1998cited by this paper
• The phosphorylation of tau: a critical stage in neurodevelopment and neurodegenerative processes.

  1997cited by this paper
• Stress‐Activated Protein Kinase/c‐Jun N‐Terminal Kinase Phosphorylates τ Protein

  1997cited by this paper
• Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau.

  1997cited by this paper
• Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

  1997cited by this paper
• Distribution, Levels, and Activity of Glycogen Synthase Kinase‐3 in the Alzheimer Disease Brain

  1997cited by this paper
• A molecular mechanism for the effect of lithium on development.

  1996cited by this paper
• Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3β and cyclin-dependent kinase 5, a component of TPK II

  1996cited by this paper
• Distribution of the phosphorylated microtubule-associated protein tau in developing cortical neurons.

  1994cited by this paper
• Induction of TrkB by retinoic acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells. Eukaryotic Signal Transduction Group.

  1993cited by this paper
• Developmental Changes in τ Phosphorylation: Fetal τ Is Transiently Phosphorylated in a Manner Similar to Paired Helical Filament‐τ Characteristic of Alzheimer's Disease

  1993cited by this paper
• Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization.

  1990cited by this paper
• Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

  1986cited by this paper
• Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

  1986cited by this paper

• Xmu-mp-1 attenuates streptozotocin-induced neurotoxicity in SH-SY5Y cells: potential role of Hippo pathway modulation

  2026cites this paper
• Functional Expression of NMDA Receptors in SH-SY5Y Neuroblastoma Cells Following Long-Term RA/BDNF-Induced Differentiation

  2025cites this paper
• Knockdown of POLG Mimics the Neuronal Pathology of Polymerase-γ Spectrum Disorders in Human Neurons

  2025cites this paper
• Measurement of cell electrical signal by dual-probe atomic force microscopy.

  2025cites this paper
• Resveratrol Analogs Ameliorate Mitochondrial Impairment and Insulin Resistance in a Streptozotocin-Induced In Vitro Model of Alzheimer’s Disease

  2025cites this paper
• Secretomic changes of amyloid beta peptides on Alzheimer’s disease related proteins in differentiated human SH-SY5Y neuroblastoma cells

  2024cites this paper
• RETRACTED: In Vitro Neuroprotective Effect Evaluation of Donepezil‐Loaded PLGA Nanoparticles‐Embedded PVA/PEG Nanofibers on SH‐SY5Y Cells and AP‐APP Plasmid Related Alzheimer Cell Line Model

  2024cites this paper
• Stemness and Cell Cycle Regulators and Their Modulation by Retinoic Acid in Ewing Sarcoma

  2024cites this paper
• Exploring differentiation-dependent responses to 532 nm green laser photobiomodulation in SHSY5Y neuroblastoma cells

  2024cites this paper
• The ameliorative potential of metformin against aluminum‐induced neurotoxicity: Insights from in vitro studies

  2024cites this paper
• Interaction Between Aging-Related Elastin-Derived Peptide (VGVAPG) and Sirtuin 2 and its Impact on Functions of Human Neuron Cells in an In Vitro Model

  2024cites this paper
• Unraveling the neuroprotective mechanisms of naltrexone against aluminum-induced neurotoxicity

  2024cites this paper
• Exploring Neuronal Differentiation Profiles in SH-SY5Y Cells through Magnetic Levitation Analysis

  2024cites this paper
• Arc-Mediated Synaptic Plasticity Regulates Cognitive Function in a Migraine Mouse Model

  2023cites this paper
• Antioxidant dihydrolipolic acid protects against in vitro aluminum‐induced toxicity

  2023cites this paper
• Cellular Lipidome Changes during Retinoic Acid (RA)-Induced Differentiation in SH-SY5Y Cells: A Comprehensive In Vitro Model for Assessing Neurotoxicity of Contaminants

  2023cites this paper
• Hydroxytyrosol–Donepezil Hybrids Play a Protective Role in an In Vitro Induced Alzheimer’s Disease Model and in Neuronal Differentiated Human SH-SY5Y Neuroblastoma Cells

  2023cites this paper
• Evaluation of the Neuroprotective Effect of Organic Selenium Compounds: An in Vitro Model of Alzheimer’s Disease

  2023cites this paper
• Evaluation of possible neuroprotective effects of virgin coconut oil on aluminum‐induced neurotoxicity in an in vitro Alzheimer's disease model

  2023cites this paper
• Neuroprotective effects of Geranium Robertianum L. Aqueous extract on the cellular Parkinson's disease model.

  2023cites this paper
• The comparison of biological effects of bacterial and synthetic melanins in neuroblastoma cells.

  2022cites this paper
• Optogenetically Engineered Neurons Differentiated from Human SH-SY5Y Cells Survived and Expressed ChR2 in 3D Hydrogel

  2022cites this paper
• Quercetin Increases Mitochondrial Biogenesis and Reduces Free Radicals in Neuronal SH-SY5Y Cells

  2022cites this paper
• Design, synthesis, and biological evaluation of new thalidomide-donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation.

  2022cites this paper
• Advancements and future directions in research of the roles of insulin in amyloid diseases.

  2021cites this paper
• Boron-based hybrids as novel scaffolds for the development of drugs with neuroprotective properties.

  2021cites this paper
• In vitro Neuroprotective Potential and Lipidomics Study of Olive Leaves Extracts Enriched in Triterpenoids

  2021cites this paper
• The apolipoprotein receptor LRP3 compromises APP levels

  2021cites this paper
• Long-term culture of SH-SY5Y neuroblastoma cells in the absence of neurotrophins: A novel model of neuronal ageing

  2021influential citation
• Emphasizing roles of BDNF promoters and inducers in Alzheimer's disease for improving impaired cognition and memory

  2021cites this paper
• In-Silico and In-Vitro Evaluation of Antibacterial, Cytotoxic, and Apoptotic Activity and Structure of Modified CM11 Peptide

  2021cites this paper
• Cross contamination meets misclassification: Awakening of CHP‐100 from sleeping beauty sleep—A reviewed model for Ewing's sarcoma

  2021cites this paper
• Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates

  2021cites this paper
• In-Silico and In-Vitro Evaluation of Antibacterial, Cytotoxic, and Apoptotic Activity and Structure of Modified CM11 Peptide

  2021cites this paper
• Neuroprotective Effect of Epalrestat on Hydrogen Peroxide-Induced Neurodegeneration in SH-SY5Y Cellular Model

  2021cites this paper
• The effect of caspase-9 in the differentiation of SH-SY5Y cells.

  2021cites this paper
• Carbon Quantum Dots for Treatment of Amyloid Disorders.

  2021cites this paper
• Current Approaches and Tools Used in Drug Development against Parkinson’s Disease

  2021cites this paper
• Heat-treated human platelet pellet lysate modulates microglia activation, favors wound healing and promotes neuronal differentiation in vitro

  2020cites this paper
• Inhibitory Effects of Raw-Extract Centella asiatica (RECA) on Acetylcholinesterase, Inflammations, and Oxidative Stress Activities via In Vitro and In Vivo

  2020cites this paper
• Brain-derived neurotropic factor (BDNF) promotes molecular polarization and differentiation of immature neuroblastoma cells into definitive neurons.

  2020cites this paper
• Histidyl-Proline Diketopiperazine Isomers as Multipotent Anti-Alzheimer Drug Candidates

  2020cites this paper
• Molecular toxicological mechanisms of new psychoactive substances "in vitro"

  2020cites this paper
• An FTIR Microspectroscopy Ratiometric Approach for Monitoring X-ray Irradiation Effects on SH-SY5Y Human Neuroblastoma Cells

  2020cites this paper
• Combination therapy with cilostazol, aripiprazole, and donepezil protects neuronal cells from β-amyloid neurotoxicity through synergistically enhanced SIRT1 expression

  2020cites this paper
• Kars region of Turkey: The role of computerized temporal tomography in diagnosis of tympanosclerosis

  2020cites this paper
• Oxidative stress conditions result in trapping of PHF-core tau (297-391) intermediates

  2020cites this paper
• Human VGF-Derived Antidepressant Neuropeptide TLQP62 Promotes SH-SY5Y Neurite Outgrowth

  2020cites this paper
• Dynamics of Internalization and Intracellular Interaction of Tau Antibodies and Human Pathological Tau Protein in a Human Neuron-Like Model

  2020cites this paper
• Studies of Anticancer Activity of Beta-carotene, Alpha-tocopherol and Ascorbic acid in SH-SY5Y Neuroblastoma Cells

  2019cites this paper
• Multifunctional Nanobiohybrid Material Composed of Ag@Bi2Se3/RNA Three-Way Junction/miRNA/Retinoic Acid for Neuroblastoma Differentiation.

  2019cites this paper
• Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models

  2019cites this paper
• A Proteomic Analysis of Mitochondrial Complex III Inhibition in SH-SY5Y Human Neuroblastoma Cell Line

  2019cites this paper
• Evaluation of antioxidant activity of caffeic acid phenethyl ester loaded block copolymer micelles

  2019cites this paper
• Insulin-Mediated Changes in Tau Hyperphosphorylation and Autophagy in a Drosophila Model of Tauopathy and Neuroblastoma Cells

  2019cites this paper
• Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease

  2018influential citation
• Ligand-cascading nano-delivery devices to enable multiscale targeting of anti-neurodegenerative therapeutics

  2018cites this paper
• Hydroxylated Single-Walled Carbon Nanotubes Inhibit Aβ42 Fibrillogenesis, Disaggregate Mature Fibrils, and Protect against Aβ42-Induced Cytotoxicity.

  2018cites this paper
• Tyrosinase-Treated Hydroxytyrosol-Enriched Olive Vegetation Waste with Increased Antioxidant Activity Promotes Autophagy and Inhibits the Inflammatory Response in Human THP-1 Monocytes.

  2018cites this paper
• Mechanisms of carnosine-induced activation of neuronal cells

  2018cites this paper
• miR-9 Upregulation Integrates Post-ischemic Neuronal Survival and Regeneration In Vitro

  2018cites this paper
• Characterization of alginate/chitosan-based nanoparticles and mathematical modeling of their SpBMP-9 release inducing neuronal differentiation of human SH-SY5Y cells.

  2018cites this paper
• Investigation into the molecular mechanisms of congenital insensitivity to pain

  2018cites this paper
• The involvement of tau in nucleolar transcription and the stress response

  2018cites this paper
• A small peptide derived from BMP‐9 can increase the effect of bFGF and NGF on SH‐SY5Y cells differentiation

  2018cites this paper
• The Involvement of Aβ42 and Tau in Nucleolar and Protein Synthesis Machinery Dysfunction

  2018cites this paper
• In vitro protective effects of encapsulated quercetin in neuronal models of oxidative stress injury

  2017cites this paper
• Phytochemical Ginkgolide B Attenuates Amyloid-β1-42 Induced Oxidative Damage and Altered Cellular Responses in Human Neuroblastoma SH-SY5Y Cells

  2017cites this paper
• Peptides derived from the knuckle epitope of BMP-9 induce the cholinergic differentiation and inactivate GSk3beta in human SH-SY5Y neuroblastoma cells

  2017cites this paper
• Lead exposure and tau hyperphosphorylation: An in vitro study

  2017cites this paper
• Oscillating Magnet Array−Based Nanomagnetic Gene Transfection: A Valuable Tool for Molecular Neurobiology Studies

  2017cites this paper
• Retinol (Vitamin A) Increases α-Synuclein, β-Amyloid Peptide, Tau Phosphorylation and RAGE Content in Human SH-SY5Y Neuronal Cell Line

  2017cites this paper
• Impedance Monitoring of SH-SY5Y Cell Adhesion and Responses to As2O3 Treatment by Indium Tin Oxide Microelectrode Arrays

  2017cites this paper
• Mechanism underlying the effects of doxepin on β-amyloid -induced memory impairment in rats

  2017cites this paper
• Pomegranate ellagitannin-gut microbial-derived metabolites, urolithins, inhibit neuroinflammation in vitro

  2017cites this paper
• Transcriptomic Profiling Discloses Molecular and Cellular Events Related to Neuronal Differentiation in SH-SY5Y Neuroblastoma Cells

  2017cites this paper
• Study of SH-SY5Y Cancer Cell Response to Treatment with Polyphenol Extracts Using FT-IR Spectroscopy

  2017cites this paper
• Retracted: Effects of Di‐isononyl Phthalate on Neuropeptide Y Expression in Differentiating Human Neuronal Cells

  2017cites this paper
• Quantitative proteomic analysis identifies proteins and pathways related to neuronal development in differentiated SH-SY5Y neuroblastoma cells

  2017cites this paper
• Redox binding partners of the hBCAT proteins and their distribution and expression in control and disease human brains: Implications in protein folding in neurodegeneration

  2017cites this paper
• Development Of High-throughput 3d Neural Cell Culture Platforms For Modelling Parkinson’s Disease

  2017cites this paper
• Targeted nano-carriers to combat neurodegeneration

  2017cites this paper
• Phenotype-specific store-operated calcium entry and the differentiation response in neuroblastoma cells

  2016cites this paper
• Nuclear Tau and Its Potential Role in Alzheimer’s Disease

  2016cites this paper
• Anti‐GAPDH Autoantibodies as a Pathogenic Determinant and Potential Biomarker of Neuropsychiatric Diseases

  2016cites this paper
• Non-cytotoxic Concentration of Cisplatin Decreases Neuroplasticity-Related Proteins and Neurite Outgrowth Without Affecting the Expression of NGF in PC12 Cells

  2016cites this paper
• Clinacanthus nutans Extracts Modulate Epigenetic Link to Cytosolic Phospholipase A2 Expression in SH-SY5Y Cells and Primary Cortical Neurons

  2016cites this paper
• How does neuroprotective sAPPα initiate its signalling cascade

  2016cites this paper
• Investigating the function of CLU in Alzheimer's Disease in in vitro and in vivo models

  2016cites this paper
• Toxic Oligomeric Alpha-Synuclein Variants Present in Human Parkinson’s Disease Brains Are Differentially Generated in Mammalian Cell Models

  2015cites this paper
• Mechanisms and consequences of carnosine-induced activation of intestinal epithelial cells

  2015cites this paper
• Vitamin A and Cognitive Impairment

  2015cites this paper
• Retinoic acid increases glucocorticoid receptor phosphorylation via cyclin‐dependent kinase 5

  2015cites this paper
• HIV-1-Tat Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A Kinase*

  2015cites this paper
• Epigenetic Regulation of Cytosolic Phospholipase A2 in SH-SY5Y Human Neuroblastoma Cells

  2015cites this paper
• The unfolded protein response in the therapeutic effect of hydroxy-DHA against Alzheimer’s disease

  2015cites this paper
• Growth factor treatment to overcome Alzheimer's dysfunctional signaling.

  2015cites this paper
• Ciliary neurotrophic factor protects SH-SY5Y neuroblastoma cells against Aβ1-42-induced neurotoxicity via activating the JAK2/STAT3 axis.

  2015cites this paper
• Role of kynurenines and oxidative stress in the differentiation of SH-SY5Y cells

  2015cites this paper
• QIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers

  2015cites this paper