Lithium Inhibits Neurite Growth and Tau Protein Kinase I/Glycogen Synthase Kinase‐3β‐Dependent Phosphorylation of Juvenile Tau in Cultured Hippocampal Neurons

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Journal of Neurochemistry

• Publication date

  1999-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1046/j.1471-4159.1999.02073.xPMID 10537067
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium.

  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
• Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

  1997influential reference
• Lithium Reduces Tau Phosphorylation by Inhibition of Glycogen Synthase Kinase-3*

  1997influential reference
• Analysis of the Signaling Activities of Localization Mutants of β-Catenin during Axis Specification in Xenopus

  1997cited by this paper
• Alzheimer-like Changes in Microtubule-associated Protein Tau Induced by Sulfated Glycosaminoglycans

  1997cited by this paper
• Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells.

  1996influential reference
• A molecular mechanism for the effect of lithium on development.

  1996cited by this paper
• Proline-directed and Non-proline-directed Phosphorylation of PHF-tau (*)

  1995cited by this paper
• Involvement of τ Protein Kinase I in Paired Helical Filament‐Like Phosphorylation of the Juvenile τ in Rat Brain

  1995cited by this paper
• A novel tau‐tubulin kinase from bovine brain

  1995cited by this paper
• Involvement of tau protein kinase I in paired helical filament-like phosphorylation of the juvenile tau in rat brain.

  1995cited by this paper
• Analysis of phosphorylation of tau with antibodies specific for phosphorylation sites.

  1995cited by this paper
• Localization and Developmental Changes of τ Protein Kinase I/Glycogen Synthase Kinase‐3β in Rat Brain

  1994cited by this paper
• wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo.

  1994cited by this paper
• Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein.

  1994influential reference
• τ Protein Kinase II Is Involved in the Regulation of the Normal Phosphorylation State of τ Protein

  1993influential reference
• A cdc2‐related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline‐directed protein kinase associated with microtubule

  1993influential reference
• Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

  1993cited by this paper
• Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments.

  1993cited by this paper
• Drosophila shaggy kinase and rat glycogen synthase kinase-3 have conserved activities and act downstream of Notch

  1993cited by this paper
• Tau protein kinase II is involved in the regulation of the normal phosphorylation state of tau protein.

  1993cited by this paper
• Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments

  1993cited by this paper
• Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments.

  1992cited by this paper
• Fetal-type phosphorylation of the tau in paired helical filaments.

  1992cited by this paper
• Tau protein kinase I converts normal tau protein into A68-like component of paired helical filaments.

  1992cited by this paper
• Lithium chloride alters cytoskeletal organization in growing, but not mature, cultured chick sensory neurons

  1991cited by this paper
• Abnormal phosphorylation of the microtubule-associated protein? (tau) in Alzheimer cytoskeletal pathology

  1987influential reference
• Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

  1986cited by this paper
• Lithium ion inhibits nerve growth factor-induced neurite outgrowth and phosphorylation of nerve growth factor-modulated microtubule-associated proteins

  1985cited by this paper
• An improved method to determine cell viability by simultaneous staining with fluorescein diacetate-propidium iodide.

  1985cited by this paper

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• Lithium: a therapeutic option in Alzheimer's disease and its prodromal stages?

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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
• Inositol depletion, GSK3 inhibition and bipolar disorder.

  2016cites this paper
• Comparison of Human Induced Pluripotent Stem Cell-Derived Neurons and Rat Primary Cortical Neurons as In Vitro Models of Neurite Outgrowth

  2016cites this paper
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  2016cites this paper
• The development of biomarkers to reduce attrition rate in drug discovery focused on oncology and central nervous system

  2016cites this paper
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  2015cites this paper
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  2015cites this paper
• Neuroprotective effects of lithium: implications for the treatment of Alzheimer's disease and related neurodegenerative disorders.

  2014cites this paper
• Glycogen Synthase Kinase 3 Beta (GSK3β) at the Tip of Neuronal Development and Regeneration

  2014cites this paper
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  2013cites this paper
• Lithium and neuroprotection: translational evidence and implications for the treatment of neuropsychiatric disorders

  2013cites this paper
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  2013cites this paper
• The Role of Glycogen Synthase Kinase 3 Beta in Neuroinflammation and Pain.

  2013cites this paper
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  2012cites this paper
• Neurite outgrowth and differentiation of rat cortex progenitor cells are sensitive to lithium chloride at non-cytotoxic exposures.

  2012cites this paper
• Psychopharmacological neuroprotection in neurodegenerative diseases, part III: criteria-based assessment: a report of the ANPA committee on research.

  2011cites this paper
• GSK-3 in Neurodegenerative Diseases

  2011influential citation
• Psychopharmacological Neuroprotection in Neurodegenerative Diseases, Part III: Criteria-Based Assessment: A Report of the ANPA Committee on Research

  2011cites this paper
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• Developmental neurotoxicity testing in vitro: models for assessing chemical effects on neurite outgrowth.

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  2005cites this paper
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• The development of potent and selective bisarylmaleimide GSK3 inhibitors.

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• Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies

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• Lithium therapy and cerebrospinal fluid biomarker levels in Alzheimer's disease

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• Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo.

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• On the horizon: pathways for drug development in Alzheimer's disease.

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  2004cites this paper
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  2003cites this paper
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  2003influential citation
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  2002cites this paper
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  2002cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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