Regulatory cross-talk determines the cellular levels of 53BP1 protein, a critical factor in DNA repair

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Journal of Biological Chemistry

• Publication date

  2017-03-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/jbc.M116.760645PMID 28255090PMCID PMC5392589
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice

  2016cited by this paper
• Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage

  2015influential reference
• MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5′ end-resection

  2015influential reference
• REV7 counteracts DNA double-strand break resection and affects PARP inhibition

  2015influential reference
• Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining

  2015cited by this paper
• PTIP associates with Artemis to dictate DNA repair pathway choice

  2014cited by this paper
• UbcH7 regulates 53BP1 stability and DSB repair

  2014cited by this paper
• 53BP1, BRCA1, and the Choice between Recombination and End Joining at DNA Double-Strand Breaks

  2014cited by this paper
• 53BP1 Regulates DSB Repair Using Rif1 to Control 5′ End Resection

  2013influential reference
• Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching

  2013influential reference
• BRCA1 loss activates cathepsin L–mediated degradation of 53BP1 in breast cancer cells

  2013cited by this paper
• The repair and signaling responses to DNA double-strand breaks.

  2013cited by this paper
• 53BP1 expression in sporadic and inherited ovarian carcinoma: Relationship to genetic status and clinical outcomes.

  2013cited by this paper
• RIF1 Counteracts BRCA1-mediated End Resection during DNA Repair*

  2013influential reference
• RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

  2013influential reference
• A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice.

  2013cited by this paper
• BRCA1 promoter hypermethylation, 53BP1 protein expression and PARP-1 activity as biomarkers of DNA repair deficit in breast cancer

  2013cited by this paper
• 53BP1 is a reader of the DNA damage-induced H2A Lys15 ubiquitin mark

  2013cited by this paper
• Autoregulatory mechanisms of phosphorylation of checkpoint kinase 1.

  2012cited by this paper
• Low p53 binding protein 1 (53BP1) expression is associated with increased local recurrence in breast cancer patients treated with breast-conserving surgery and radiotherapy.

  2012cited by this paper
• Inhibition of Cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas.

  2012cited by this paper
• TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes.

  2012cited by this paper
• Coupling Cellular Localization and Function of Checkpoint Kinase 1 (Chk1) in Checkpoints and Cell Viability*

  2012cited by this paper
• Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1

  2011cited by this paper
• A new pathway that regulates 53BP1 stability implicates Cathepsin L and vitamin D in DNA repair

  2011cited by this paper
• Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.

  2011cited by this paper
• DNA damage signaling in response to double-strand breaks during mitosis

  2010cited by this paper
• 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks.

  2010influential reference
• A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint

  2010cited by this paper
• 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

  2010cited by this paper
• Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7.

  2009cited by this paper
• The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress.

  2009cited by this paper
• Novel roles for A‐type lamins in telomere biology and the DNA damage response pathway

  2009cited by this paper
• A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency.

  2009cited by this paper
• RAD18 and Poly(ADP-Ribose) Polymerase Independently Suppress the Access of Nonhomologous End Joining to Double-Strand Breaks and Facilitate Homologous Recombination-Mediated Repair

  2007cited by this paper
• Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.

  2005cited by this paper
• Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage.

  2004cited by this paper
• A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation.

  2004cited by this paper
• Post-translational Modifications of Three Members of the Human MAP1LC3 Family and Detection of a Novel Type of Modification for MAP1LC3B*

  2003cited by this paper
• Kinetochore localisation of the DNA damage response component 53BP1 during mitosis.

  2002cited by this paper
• Recombinational repair and restart of damaged replication forks

  2002cited by this paper
• Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis

  2000cited by this paper
• LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

  2000cited by this paper

• UBE2L3 expression in human gastric cancer and its clinical significance

  2024cites this paper
• The dimeric deubiquitinase USP28 integrates 53BP1 and MYC functions to limit DNA damage

  2024cites this paper
• Lamin A/C facilitates DNA damage response by modulating ATM signaling and homologous recombination pathways

  2024cites this paper
• Incorporation of 53BP1 into phase-separated bodies in cancer cells during aberrant mitosis.

  2023cites this paper
• MYO10 regulates genome stability and cancer inflammation through mediating mitosis

  2023cites this paper
• Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

  2023cites this paper
• 53BP1: Keeping It under Control, Even at a Distance from DNA Damage

  2022cites this paper
• The role of prelamin A post-translational maturation in stress response and 53BP1 recruitment

  2022cites this paper
• Cathepsin L inhibition prevents the cleavage of multiple nuclear proteins upon lysis of quiescent human cells

  2022cites this paper
• Mechanism and Disease Association With a Ubiquitin Conjugating E2 Enzyme: UBE2L3

  2022cites this paper
• Mechanism Study on Radiosensitization Effect of Curcumin in Bladder Cancer Cells Regulated by Filamin A

  2022cites this paper
• MYO10 drives genomic instability and inflammation in cancer

  2021cites this paper
• Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy-mediated DNA damage mechanism

  2021cites this paper
• A Link between Replicative Stress, Lamin Proteins, and Inflammation

  2021cites this paper
• Nuclear envelope integrity, DNA replication, damage repair and genome stability

  2021influential citation
• UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation of Myofibrillar Actin and Myosin

  2021cites this paper
• ReviewUbiquitylation-Mediated Fine-Tuning of DNA Double-Strand Break RepairBarbara N Borsos

  2020cites this paper
• PRMT5 promotes DNA repair through methylation of 53BP1 and is regulated by Src-mediated phosphorylation

  2020cites this paper
• PRMT5 promotes DNA repair through methylation of 53BP1 and is regulated by Src-mediated phosphorylation

  2020cites this paper
• Ubiquitylation-Mediated Fine-Tuning of DNA Double-Strand Break Repair

  2020cites this paper
• A role of the 53BP1 protein in genome protection: structural and functional characteristics of 53BP1-dependent DNA repair

  2019cites this paper
• The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair

  2019cites this paper
• The functional importance of lamins, actin, myosin, spectrin and the LINC complex in DNA repair

  2019cites this paper
• 53BP1: A key player of DNA damage response with critical functions in cancer.

  2019cites this paper
• Dotting the eyes: mouse strain dependency of the lens epithelium to low dose radiation-induced DNA damage

  2018cites this paper
• Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells

  2018cites this paper
• How cells ensure correct repair of DNA double-strand breaks

  2018cites this paper
• NuMA is a negative regulator of 53BP1 in DNA double-strand break repair

  2017cites this paper