PTIP associates with Artemis to dictate DNA repair pathway choice

PARP inhibitors (PARPi) are being used in patients with BRCA1/2 mutations; however, doubly deficient BRCA1−/−53BP1−/− tumors become resistant to PARPis. 53BP1 and its known downstream effectors, PTIP and RIF1, lack enzymatic activities directly implicated in DNA repair. Wang et al. uncovered a nuclease, Artemis, as a PTIP-binding protein that trims DNA ends, promotes NHEJ, and directly competes with the HR repair pathway. Loss of Artemis restores PARPi resistance in BRCA1-deficient cells.

• Publication year

  2014

• Venue

  Genes & Development

• Publication date

  2014-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/gad.252478.114PMID 25512557PMCID 4265673
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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