Alzheimer’s Disease and Metal Contamination: Aspects on Genotoxicity

Alzheimer's Disease Pathogenesis: Core Concepts, Shifting Paradigms, and Therapeutic Targets, delivers the concepts embodied within its title. This exciting book presents the full array of theories about the causes of Alzheimer's, including fresh concepts that have gained ground among both professionals and the lay public. Acknowledged experts provide highly informative yet critical reviews of the factors that most likely contribute to Alzheimer's, including genetics, metabolic deficiencies, oxidative stress, and possibly environmental exposures. Evidence that Alzheimer's resembles a brain form of diabetes is discussed from different perspectives, ranging from disease mechanisms to therapeutics. This book is further energized by discussions of how neurotransmitter deficits, neuro-inflammation, and oxidative stress impair neuronal plasticity and contribute to Alzheimer's neurodegeneration. The diversity of topics presented in just the right depth will interest clinicians and researchers alike. This book inspires confidence that effective treatments could be developed based upon the expanding list of potential therapeutic targets. following:

• Publication year

  2011

• Venue

  Unknown venue

• Publication date

  2011-09-12

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.5772/17659
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Aluminum induces neurodegeneration and its toxicity arises from increased iron accumulation and reactive oxygen species (ROS) production.

  2012cited by this paper
• Toxicological Profile for Manganese

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  2011cited by this paper
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• International Labour Organization (ILO)

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• Genotoxic and cytotoxic effects induced by aluminum in the lymphocytes of the common carp (Cyprinus carpio).

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• Alzheimer's Disease Pathogenesis - Core Concepts, Shifting Paradigms and Therapeutic Targets

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• Manganese inhibits poly(ADP-ribosyl)ation in human cells: a possible mechanism behind manganese-induced toxicity?

  2010cited by this paper
• Metal Toxicity, Liver Disease and Neurodegeneration

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• Evaluation of Sinos River water genotoxicity using the comet assay in fish.

  2010cited by this paper
• Risk Assessment of an Essential Element: Manganese

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• Lead, Manganese, and Methylmercury as Risk Factors for Neurobehavioral Impairment in Advanced Age

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• Informed consent in experimentation involving mentally impaired persons: ethical issues.

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• The neurotoxicity of environmental aluminum is still an issue.

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• DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease

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• Specific Inhibition of NEIL-initiated Repair of Oxidized Base Damage in Human Genome by Copper and Iron

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• Impaired Spatial Learning and Unaltered Neurogenesis in a Transgenic Model of Alzheimers Disease After Oral Aluminum Exposure

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• Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

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• APLP1, Alzheimer's-like pathology and neurodegeneration in the frontal cortex of manganese-exposed non-human primates.

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• Iron elevations in the aging Parkinsonian brain: a consequence of impaired iron homeostasis?

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• Relevance of Iron Deposition in Deep Gray Matter Brain Structures to Cognitive and Motor Performance in Healthy Elderly Men and Women: Exploratory Findings

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• Aluminum induces chromosome aberrations, micronuclei, and cell cycle dysfunction in root cells of Vicia faba

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• Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus

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• Influence of orange juice in the levels and in the genotoxicity of iron and copper.

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• Metal exposure and Alzheimer's pathogenesis.

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• A comet assay study reveals that aluminium induces DNA damage and inhibits the repair of radiation-induced lesions in human peripheral blood lymphocytes.

  2006cited by this paper
• Aluminum complexing enhances amyloid protein penetration of bloodbrain barrier

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• Aluminum and Alzheimer's disease: A new look

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• Anticlastogenic effect of redistilled cow's urine distillate in human peripheral lymphocytes challenged with manganese dioxide and hexavalent chromium.

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• Manganese

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• Potential sources of increased iron in the substantia nigra of parkinsonian patients.

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• Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases.

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• Aluminum‐induced micronuclei and apoptosis in human peripheral‐blood lymphocytes treated during different phases of the cell cycle

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• Excessive iron accumulation in the brain: A possible potential risk of neurodegeneration in Parkinson's disease

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• Identification of a 250 kDa putative microtubule‐associated protein as bovine ferritin

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• Low-calcium, high-aluminum diet-induced motor neuron pathology in cynomolgus monkeys

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• Induction of Genomic Instability in TK6 Human Lymphoblasts Exposed to 137Cs γ Radiation: Comparison to the Induction by Exposure to Accelerated 56Fe Particles

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• Iron-overload induces oxidative DNA damage in the human colon carcinoma cell line HT29 clone 19A.

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• The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

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• Effects of AlCl3 on toad skin, human erythrocytes, and model cell membranes.

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• Amyloid-beta is an antioxidant for lipoproteins in cerebrospinal fluid and plasma.

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