Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A

F. Lotti,A. Jarrar,R. Pai,M. Hitomi,J. Lathia,A. Mace,G. Gantt,K. Sukhdeo,J. Devecchio,A. Vasanji,P. Leahy,A. Hjelmeland,M. Kalady,J. Rich

Published 2013 in Journal of Experimental Medicine

ABSTRACT

Chemotherapy stimulates cancer-associated fibroblasts to secrete interleukin-17A to provide maintenance cues to support the growth of colorectal cancer-initiating cells.

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