Frequent silencing of RUNX3 in esophageal squamous cell carcinomas is associated with radioresistance and poor prognosis

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Oncogene

• Publication date

  2007-08-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1210403PMID 17384682
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2001influential reference
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  2000influential reference
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