Mitochondrial DNA Depletion in Respiratory Chain–Deficient Parkinson Disease Neurons

A. Grünewald,K. Rygiel,Philippa D. Hepplewhite,C. Morris,M. Picard,D. Turnbull

Published 2016 in Annals of Neurology

ABSTRACT

To determine the extent of respiratory chain abnormalities and investigate the contribution of mtDNA to the loss of respiratory chain complexes (CI–IV) in the substantia nigra (SN) of idiopathic Parkinson disease (IPD) patients at the single‐neuron level.

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