Galectins Control mTOR in Response to Endomembrane Damage.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Molecules and Cells

• Publication date

  2018-04-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.molcel.2018.03.009PMID 29625033PMCID PMC5911935
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Autophagy balances inflammation in innate immunity

  2018cited by this paper
• mTOR Signaling in Growth, Metabolism, and Disease.

  2017cited by this paper
• Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

  2017cited by this paper
• AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance.

  2017cited by this paper
• Dynamics of mTORC1 activation in response to amino acids

  2016cited by this paper
• TFEB at a glance

  2016cited by this paper
• Spatially resolved proteomic mapping in living cells with the engineered peroxidase APEX2

  2016cited by this paper
• TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis.

  2016cited by this paper
• A guide to immunometabolism for immunologists

  2016cited by this paper
• Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles

  2016cited by this paper
• Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

  2016cited by this paper
• The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

  2015cited by this paper
• Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay

  2015cited by this paper
• Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

  2015cited by this paper
• ATM Functions at the Peroxisome to Induce Pexophagy in Response to ROS

  2015cited by this paper
• Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

  2015cited by this paper
• Evolving mechanistic insights into galectin functions.

  2015cited by this paper
• Regulation of endoplasmic reticulum turnover by selective autophagy

  2015cited by this paper
• Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.

  2014cited by this paper
• SLC38A9 is a component of the lysosomal amino acid-sensing machinery that controls mTORC1

  2014cited by this paper
• The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism.

  2014cited by this paper
• Directed evolution of APEX2 for electron microscopy and proteomics

  2014cited by this paper
• Proteomic mapping of the human mitochondrial intermembrane space in live cells via ratiometric APEX tagging.

  2014cited by this paper
• NBR1 acts as an autophagy receptor for peroxisomes

  2013cited by this paper
• Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin

  2013cited by this paper
• Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging

  2013cited by this paper
• Where is mTOR and what is it doing there?

  2013cited by this paper
• Autophagy in infection, inflammation and immunity

  2013cited by this paper
• Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages.

  2012cited by this paper
• Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.

  2012cited by this paper
• mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

  2011cited by this paper
• AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

  2011cited by this paper
• Galectin-8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

  2011cited by this paper
• The role of Atg proteins in autophagosome formation.

  2011cited by this paper
• Selective autophagy mediated by autophagic adapter proteins

  2011cited by this paper
• Tim3 binding to galectin-9 stimulates antimicrobial immunity

  2010cited by this paper
• Innate immune lectins kill bacteria expressing blood group antigen

  2010cited by this paper
• Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

  2010cited by this paper
• TAK1 activates AMPK‐dependent cytoprotective autophagy in TRAIL‐treated epithelial cells

  2009cited by this paper
• The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

  2008cited by this paper
• Regulation of TORC1 by Rag GTPases in nutrient response

  2008cited by this paper
• AMPK phosphorylation of raptor mediates a metabolic checkpoint.

  2008cited by this paper
• Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

  2008cited by this paper
• PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.

  2007cited by this paper
• Rheb binds and regulates the mTOR kinase.

  2005cited by this paper
• Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

  2005cited by this paper
• Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.

  2005cited by this paper
• The LKB1 tumor suppressor negatively regulates mTOR signaling.

  2004cited by this paper
• Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages.

  2004cited by this paper
• A model for random sampling and estimation of relative protein abundance in shotgun proteomics.

  2004cited by this paper
• Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

  2003cited by this paper
• Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.

  2003cited by this paper
• Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.

  2003cited by this paper
• Use of glycyl-L-phenylalanine 2-naphthylamide, a lysosome-disrupting cathepsin C substrate, to distinguish between lysosomes and prelysosomal endocytic vacuoles.

  1994cited by this paper
• Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells.

  1990cited by this paper

• Lysosomes as hubs of metabolic sensing and cellular homeostasis.

  2026cites this paper
• A novel SO2 probe inhibits lysophagy induced by Senecavirus A infection by promoting LAMP1 Cys375 sulfenylation

  2026cites this paper
• TGFB-inducible VASN (vasorin) promotes lysosomal acidification.

  2026cites this paper
• Membrane atg8ylation and autophagy in protection against Mycobacterium tuberculosis.

  2026cites this paper
• Selective Autophagy in Kidney Diseases: The Tip of the Iceberg

  2025cites this paper
• Maintenance and Decline of Neuronal Lysosomal Function in Aging

  2025cites this paper
• ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains

  2025cites this paper
• Regulation of nanoparticle exocytosis direction via receptors transfer: A novel strategy to enhance therapeutic efficacy of semaglutide.

  2025cites this paper
• mRNA-Based FRET-FLIM Imaging Platform for Quantifying Lipid Nanoparticle Endosomal Escape and Membrane Damage.

  2025cites this paper
• Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens

  2025cites this paper
• VPS18 contributes to phagosome membrane integrity in Mycobacterium tuberculosis–infected macrophages

  2025cites this paper
• Regulatory Mechanisms and Therapeutic Implications of Lysosomal Dysfunction in Alzheimer's Disease

  2025cites this paper
• Sense, plug and seal: Proteins as both rapid responders and constitutive barriers supporting organelle compartmentalization.

  2025cites this paper
• Galectin-3 facilitates Helicobacter pylori-induced apoptosis independently of sensing lysosomal damage.

  2025cites this paper
• Gal3‐CaN‐Smurf1 Complex Sequestrates FLCN‐FNIPs to Facilitate TFEB Activation in Response to Endomembrane Damage

  2025cites this paper
• Targeting p70S6K1 Inhibits Glycated Albumin-Induced Triple-Negative Breast Cancer Cell Invasion and Overexpression of Galectin-3, a Potential Prognostic Marker in Diabetic Patients with Invasive Breast Cancer

  2025cites this paper
• Processing bodies promote lysosomal quality control and cell survival during recovery from lysosomal damage

  2025cites this paper
• Mycobacterium tuberculosis phagosome Ca2+ leakage triggers multimembrane ATG8/LC3 lipidation to restrict damage in human macrophages

  2025cites this paper
• Lysosomal quality control Review

  2025cites this paper
• Intracellular and extracellular activities of V-domain Ig-containing suppressor of T cell activation (VISTA) modulated by immunosuppressive factors of tumour microenvironment.

  2025cites this paper
• Cell-associated galectin 9 interacts with cytotoxic T cells confers resistance to tumor killing in nasopharyngeal carcinoma through autophagy activation

  2025cites this paper
• Dissecting the specificity of sugar code recognition - Unleashing the biomedical potential of galectins by protein engineering.

  2025cites this paper
• The TECPR1:ATG5-ATG12 complex conjugates LC3/ATG8 to damaged lysosomes that expose luminal glycans in response to osmotic imbalance

  2025cites this paper
• Chronic lysosome damage boosts interferon responses to Palbociclib dependent upon the mitochondrion

  2025cites this paper
• Lysosomal Repair in Health and Disease

  2025cites this paper
• NLRX1 mediated impaired microglial phagocytosis of NETs in cerebral ischemia and reperfusion injury

  2025cites this paper
• Astrocytes mobilize a broader repertoire of lysosomal repair mechanisms than neurons

  2025cites this paper
• Galectin-9 treatment is cytotoxic for B cell lymphoma by disrupting autophagy

  2025cites this paper
• Lysosomes’ fallback strategies: more than just survival or death

  2025cites this paper
• Impairment of lysosomal quality control in Huntington disease

  2025cites this paper
• Galectins in Inflammatory Skin Diseases: Mechanisms and Therapeutic Potential.

  2025cites this paper
• Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response

  2025cites this paper
• STING-induced noncanonical autophagy regulates endolysosomal homeostasis

  2025cites this paper
• The Sugar-coated truth of alcohol-associated liver disease: Galectins as multi-faceted regulators of Alcohol-induced liver injury.

  2025cites this paper
• Processing bodies promote lysosomal quality control and cell survival during recovery from lysosomal damage

  2025cites this paper
• A role for CASM in the repair of damaged Golgi architecture

  2025cites this paper
• ATG16L1 controls mammalian vacuolar proton ATPase.

  2025cites this paper
• Cellular homeostatic responses to lysosomal damage.

  2025cites this paper
• Molecular mechanisms of the lysosomal damage response and its roles in aging and disease.

  2025cites this paper
• Non-coding RNAs regulate autophagy in kidney disease: friend or foe?

  2025cites this paper
• Gouty inflammation: genetic mechanisms towards flare therapy

  2025cites this paper
• Alveolar macrophage endosomal-lysosomal system: potential therapeutic targets for COVID-19

  2025cites this paper
• Galectin-9 activates microglial asparagine endopeptidase and promotes α-synuclein pathology in Parkinson's disease.

  2025cites this paper
• ESCRT III-mediated lysosomal repair improve renal tubular cell injury in cisplatin-induced AKI

  2025cites this paper
• Evolution and function of galectins in Xenopus laevis: Comparison with mammals and new perspectives

  2025cites this paper
• Lysosomal membrane homeostasis and its importance in physiology and disease

  2025cites this paper
• Methods to Determine Lysosomal AMPK Activation.

  2025cites this paper
• Programmed cell revival from imminent cell death enhances tissue repair and regeneration

  2025cites this paper
• SLC38A9 is directly involved in Tat-induced endolysosome dysfunction and senescence in astrocytes

  2025cites this paper
• Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function

  2025cites this paper
• RpH-ILV: Probe for lysosomal pH and acute LLOMe-induced membrane permeabilization in cell lines and Drosophila

  2025cites this paper
• Galectins as Drivers of Host-Pathogen Dynamics in Mycobacterium tuberculosis Infection.

  2025cites this paper
• Intracellular galectin interactions in health and disease

  2024cites this paper
• Lysosomes in the immunometabolic reprogramming of immune cells in atherosclerosis

  2024cites this paper
• Neuronal constitutive endolysosomal perforations enable α-synuclein aggregation by internalized PFFs

  2024influential citation
• The di-leucine motif in the host defense peptide LL-37 is essential for initiation of autophagy in human macrophages.

  2024cites this paper
• SMURF1 mediates damaged lysosomal homeostasis by ubiquitinating PPP3CB to promote the activation of TFEB

  2024cites this paper
• Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage

  2024cites this paper
• Lysosome quality control in health and neurodegenerative diseases

  2024influential citation
• LRRK2 and RAB8A regulate cell death after lysosomal damage in macrophages through cholesterol-related pathways.

  2024cites this paper
• Golgi pH homeostasis stabilizes the lysosomal membrane through N-glycosylation of membrane proteins

  2024cites this paper
• Autophagy accompanying the developmental process of male germline stem cells

  2024cites this paper
• Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function

  2024cites this paper
• The role of galectins in the regulation of autophagy and inflammasome in host immunity

  2024cites this paper
• Inhibitory immune checkpoints suppress the surveillance of senescent cells promoting their accumulation with aging and in age-related diseases

  2024cites this paper
• Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27.

  2024cites this paper
• The expression of Galectin‐9 correlates with mTOR and AMPK in murine colony‐forming erythroid progenitors

  2024cites this paper
• Innate immune responses and monocyte-derived phagocyte recruitment in protective immunity to pathogenic bacteria: insights from Legionella pneumophila.

  2024cites this paper
• PRRSV utilizes MALT1-regulated autophagy flux to switch virus spread and reserve

  2024cites this paper
• Mitochondria-lysosome-extracellular vesicles axis and nanotheranostics in neurodegenerative diseases.

  2024cites this paper
• A mechanism that transduces lysosomal damage signals to stress granule formation for cell survival

  2024influential citation
• Activation of the lysosomal damage response and selective autophagy: the coordinated actions of galectins, TRIM proteins, and CGAS-STING1 in providing immunity against Mycobacterium tuberculosis

  2024cites this paper
• PRKAA2, MTOR, and TFEB in the regulation of lysosomal damage response and autophagy

  2024cites this paper
• HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence

  2024cites this paper
• Dual inhibition of atypical PKC signaling and PI3K/Akt signaling dysregulates c-Myc to induce apoptosis in clear cell Renal Cell Carcinoma

  2024cites this paper
• Galectin-8 modulates human osteoclast activity partly through isoform-specific interactions

  2024cites this paper
• Galectins in epithelial-mesenchymal transition: roles and mechanisms contributing to tissue repair, fibrosis and cancer metastasis

  2024cites this paper
• Membrane atg8ylation in canonical and noncanonical autophagy.

  2024cites this paper
• Cell-autonomous targeting of arabinogalactan by host immune factors inhibits mycobacterial growth

  2024cites this paper
• Calcium signaling from damaged lysosomes induces cytoprotective stress granules

  2024influential citation
• Constitutive Endolysosomal Perforation in Neurons allows Induction of α-Synuclein Aggregation by Internalized Pre-Formed Fibrils

  2024cites this paper
• Galectin‐8 inhibition and functions in immune response and tumor biology

  2024cites this paper
• The TMEM192-mKeima probe specifically assays lysophagy and reveals its initial steps

  2023cites this paper
• Galectin-3 does not interact with RNA directly

  2023cites this paper
• Inducin Triggers LC3‐Lipidation and ESCRT‐Mediated Lysosomal Membrane Repair

  2023cites this paper
• Vps18 contributes to phagosome membrane integrity in Mycobacterium tuberculosis-infected macrophages

  2023influential citation
• Targeting intracellular galectins for cancer treatment

  2023cites this paper
• A galectin-9 involved in the microbial recognition and haemocyte autophagy in the Pacific oyster Crassostrea gigas.

  2023cites this paper
• Atg8ylation as a host-protective mechanism against Mycobacterium tuberculosis.

  2023cites this paper
• Human GBP1 Is Involved in the Repair of Damaged Phagosomes/Endolysosomes

  2023cites this paper
• TECPR1 provides E3-ligase like activity to the ATG5-ATG12 complex to conjugate LC3/ATG8 to damaged lysosomes

  2023cites this paper
• Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy

  2023cites this paper
• Eat, prey, love: Pathogen-mediated subversion of lysosomal biology.

  2023cites this paper
• The interrelation of galectins and autophagy.

  2023cites this paper
• Balancing lysosome abundance in health and disease

  2023cites this paper
• SMURF1 controls the PPP3/calcineurin complex and TFEB at a regulatory node for lysosomal biogenesis

  2023cites this paper
• Mammalian ATG8 proteins maintain autophagosomal membrane integrity through ESCRTs

  2023cites this paper
• Linear ubiquitination at damaged lysosomes induces local NF-κB activation and controls cell survival

  2023cites this paper
• ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion.

  2023cites this paper
• Therapeutic potential of autophagy in immunity and inflammation: current and future perspectives

  2023cites this paper