Progressive retinal degeneration in transgenic mice with overexpression of endothelin-1 in vascular endothelial cells.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Investigative Ophthalmology and Visual Science

• Publication date

  2012-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1167/iovs.12-9999PMID 22729434
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Selective Over-Expression of Endothelin-1 in Endothelial Cells Exacerbates Inner Retinal Edema and Neuronal Death in Ischemic Retina

  2011cited by this paper
• Glaucoma.

  2011cited by this paper
• Renovascular hypertension causes cerebral vascular remodeling

  2011cited by this paper
• Lycium Barbarum Polysaccharides Reduce Neuronal Damage, Blood-Retinal Barrier Disruption and Oxidative Stress in Retinal Ischemia/Reperfusion Injury

  2011cited by this paper
• [Is normal-tension glaucoma different from primary open-angle glaucoma].

  2011cited by this paper
• Optic neuropathy due to microbead-induced elevated intraocular pressure in the mouse.

  2011cited by this paper
• Systemic vascular dysregulation and retrobulbar hemodynamics in normal-tension glaucoma.

  2011cited by this paper
• Age-Related Retinopathy in NRF2-Deficient Mice

  2011cited by this paper
• Transgenic Mice Over-Expressing ET-1 in the Endothelial Cells Develop Systemic Hypertension with Altered Vascular Reactivity

  2011cited by this paper
• Loss of retinal function in aged DBA/2J mice - New insights into retinal neurodegeneration.

  2010cited by this paper
• Mutant WDR36 directly affects axon growth of retinal ganglion cells leading to progressive retinal degeneration in mice

  2010cited by this paper
• The role of endothelin-1 and its receptors in optic nerve head astrocyte proliferation

  2010cited by this paper
• Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice

  2010cited by this paper
• Chronic whole-body hypoxia induces intussusceptive angiogenesis and microvascular remodeling in the mouse retina.

  2010cited by this paper
• Foveal cone photoreceptor involvement in primary open-angle glaucoma

  2010cited by this paper
• Color Doppler imaging and plasma levels of endothelin-1 in low-tension glaucoma.

  2009cited by this paper
• Effect of lutein on retinal neurons and oxidative stress in a model of acute retinal ischemia/reperfusion.

  2009cited by this paper
• Blood-brain barrier: ageing and microvascular disease--systematic review and meta-analysis.

  2009cited by this paper
• Intussusceptive angiogenesis and its role in vascular morphogenesis, patterning, and remodeling

  2009cited by this paper
• Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1 promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle cerebral artery occlusion.

  2009cited by this paper
• Targeted Overexpression of Endothelin-1 in Astrocytes Leads to More Severe Cytotoxic Brain Edema and Higher Mortality

  2009cited by this paper
• Hyperglycemia accelerates impairment of vasodilator responses to acetylcholine of retinal blood vessels in rats.

  2009cited by this paper
• Increase in endothelin B receptor expression in optic nerve astrocytes in endothelin-1 induced chronic experimental optic neuropathy.

  2009cited by this paper
• Normal-tension glaucoma: is it different from primary open-angle glaucoma?

  2008cited by this paper
• Blocking LINGO-1 function promotes retinal ganglion cell survival following ocular hypertension and optic nerve transection.

  2008cited by this paper
• Role of the ETB receptor in retinal ganglion cell death in glaucoma.

  2008cited by this paper
• Aging‐related changes in astrocytes in the rat retina: imbalance between cell proliferation and cell death reduces astrocyte availability

  2008cited by this paper
• Strain-specific differences in the effects of cyclosporin A and FK506 on the survival and regeneration of axotomized retinal ganglion cells in adult rats.

  2007cited by this paper
• Does the blood-brain barrier play a role in Glaucoma?

  2007cited by this paper
• What is the link between vascular dysregulation and glaucoma?

  2007cited by this paper
• Gene deletion and pharmacological inhibition of aldose reductase protect against retinal ischemic injury.

  2007cited by this paper
• Effects of Kallidinogenase on Ischemic Changes Induced by Repeated Intravitreal Injections of Endothelin-1 in Rabbit Retina

  2007cited by this paper
• The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma.

  2007cited by this paper
• Effects of acute delivery of endothelin-1 on retinal ganglion cell loss in the rat.

  2006cited by this paper
• Correlation Between Intraocular Pressure, Central Corneal Thickness, Stage of Glaucoma, and Demographic Patient Data: Prospective Analysis of Biophysical Parameters in Tertiary Glaucoma Practice Populations

  2006cited by this paper
• Intravitreal injection of endothelin-1 caused optic nerve damage following to ocular hypoperfusion in rabbits.

  2006cited by this paper
• Endothelin-1 impairs retrograde axonal transport and leads to axonal injury in rat optic nerve.

  2006cited by this paper
• Endothelin-1 and endothelin receptors in light-induced retinal degeneration.

  2005cited by this paper
• Aldose reductase deficiency prevents diabetes-induced blood-retinal barrier breakdown, apoptosis, and glial reactivation in the retina of db/db mice.

  2005cited by this paper
• Endothelin-1 Overexpression Leads to Further Water Accumulation and Brain Edema after Middle Cerebral Artery Occlusion via Aquaporin 4 Expression in Astrocytic End-Feet

  2005cited by this paper
• Endothelial Cell-specific Over-expression of Endothelin- 1 Leads to More Severe Cerebral Damage following Transient Middle Cerebral Artery Occlusion

  2004cited by this paper
• The prevalence of primary open-angle glaucoma in Japanese: the Tajimi Study.

  2004cited by this paper
• Model of endothelin-1-induced chronic optic neuropathy in rat.

  2004cited by this paper
• Increased plasma endothelin-1 levels in patients with progressive open angle glaucoma

  2004cited by this paper
• Glaucoma: ocular Alzheimer's disease?

  2003cited by this paper
• A human prion protein peptide (PrP59–91) protects against copper neurotoxicity

  2003cited by this paper
• Twenty-four-hour pattern of mouse intraocular pressure.

  2003cited by this paper
• A human prion protein peptide (PrP59–91) protects against copper neurotoxicity

  2003cited by this paper
• Endothelin: is it a contributor to glaucoma pathophysiology?

  2002cited by this paper
• Human optic nerve head astrocytes as a target for endothelin-1.

  2002cited by this paper
• Migraine and tension headache in high-pressure and normal-pressure glaucoma.

  2000cited by this paper
• Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice.

  1998cited by this paper
• An Endothelin‐1‐Induced Model of Chronic Optic Nerve Ischemia in Rhesus Monkeys

  1996cited by this paper
• Association of endothelin-1 with normal tension glaucoma: clinical and fundamental studies.

  1995cited by this paper
• Circulatory defects of the optic disk and retina in ocular hypertension and high pressure open-angle glaucoma.

  1994cited by this paper
• Prevalence of glaucoma. The Beaver Dam Eye Study.

  1992cited by this paper
• The Beaver Dam Eye Study. Retinopathy in adults with newly discovered and previously diagnosed diabetes mellitus.

  1992cited by this paper
• Experimental glaucoma in the rhesus monkey.

  1974cited by this paper

• Rodent Models of Glaucoma: How Mice and Rats Can Help Human Vision Move Out of the Woods and Into the Light

  2025cites this paper
• Long-Term Effects on Retinal Structure and Function in a Mouse Endothelin-1 Model of Retinal Ganglion Cell Degeneration

  2023cites this paper
• Intraocular Adeno-Associated Virus-Mediated Transgene Endothelin-1 Delivery to the Rat Eye Induces Functional Changes Indicative of Retinal Ischemia—A Potential Chronic Glaucoma Model

  2023influential citation
• Neurovascular dysfunction in glaucoma.

  2023cites this paper
• Rodent genetically modified models of glaucoma.

  2023cites this paper
• Solving the New Puzzle(s) 2014-2022: Flammer Syndrome Probably Represents a Mild Endophenotype of Raynaud’s Phenomenon Mainly Associated with Ocular Disturbances and Also Due to Latent T. gondii Infection

  2023cites this paper
• Vascular derived endothelin receptor A controls endothelin-induced retinal ganglion cell death

  2022cites this paper
• Influence of Trace Elements on Neurodegenerative Diseases of The Eye—The Glaucoma Model

  2021cites this paper
• The characteristics of fundus microvascular alterations in the course of glaucoma: a narrative review

  2021cites this paper
• The Neurovascular Unit in Glaucomatous Neurodegeneration

  2020cites this paper
• [Modern view on normal-tension glaucoma].

  2020cites this paper
• Normal tension glaucoma: from the brain to the eye or the inverse?

  2019cites this paper
• The effects of endothelium‐specific CYP2J2 overexpression on the attenuation of retinal ganglion cell apoptosis in a glaucoma rat model

  2019cites this paper
• Normal-tension glaucoma: Pathogenesis and genetics

  2018cites this paper
• Enlarged Optic Nerve Axons and Reduced Visual Function in Mice with Defective Microfibrils

  2018cites this paper
• Calcium Dobesilate Prevents Neurodegeneration and Vascular Leakage in Experimental Diabetes

  2017cites this paper
• Animal Models of Glaucoma

  2016cites this paper
• Neuroprotection as a Therapeutic Target for Diabetic Retinopathy

  2016cites this paper
• An ex vivo gene therapy approach in X-linked retinoschisis

  2016cites this paper
• Modulation of the Progenitor Cell and Homeostatic Capacities of Müller Glia Cells in Retina : Focus on α2-Adrenergic and Endothelin Receptor Signaling Systems

  2016cites this paper
• 2 . Neurodegeneration in DR and the Role of VEGF

  2016cites this paper
• Endothelin B Receptors on Primary Chicken Müller Cells and the Human MIO-M1 Müller Cell Line Activate ERK Signaling via Transactivation of Epidermal Growth Factor Receptors

  2016cites this paper
• Cell based therapeutics for retinal degenerations

  2016cites this paper
• Severe ocular phenotypes in Rbp4-deficient mice in the C57BL/6 genetic background

  2016cites this paper
• Relation of Endothelin-1 with ophthalmologic blinding diseases

  2016cites this paper
• Retinal ganglion cell apoptotic pathway in glaucoma: Initiating and downstream mechanisms.

  2015cites this paper
• Non-Traditional Systemic Treatments for Diabetic Retinopathy: An
Evidence-Based Review

  2015cites this paper
• Cre recombinase-regulated Endothelin1 transgenic mouse lines: novel tools for analysis of embryonic and adult disorders.

  2015cites this paper
• Plate reader-based cell viability assays for glioprotection using primary rat optic nerve head astrocytes.

  2015cites this paper
• Color Doppler Imaging Analysis of Ocular Blood Flow Velocities in Normal Tension Glaucoma Patients: A Meta-Analysis

  2015cites this paper
• The current research status of normal tension glaucoma

  2014influential citation
• GENOMIC AND PROTEOMIC CHARACTERIZATION OF PHYSIOLOGICAL AND PATHOLOGICAL ANGIOGENESIS IN THE HUMAN EYE

  2014cites this paper
• Effects of low level laser treatment on the survival of axotomized retinal ganglion cells in adult Hamsters

  2014cites this paper
• Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives.

  2014cites this paper
• Functional and Molecular Characterization of Ex Vivo Cultured Epiretinal Membrane Cells from Human Proliferative Diabetic Retinopathy

  2013cites this paper