Model of endothelin-1-induced chronic optic neuropathy in rat.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Investigative Ophthalmology and Visual Science

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1167/IOVS.03-0687PMID 14691166
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1999cited by this paper
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  1999cited by this paper
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  1991cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1989cited by this paper
• Dextromethorphan protects retina against ischemic injury in vivo.

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  1988cited by this paper
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  1985cited by this paper
• Acute responses of rat retina after optic nerve ligation: a biochemical and histochemical study.

  1985cited by this paper
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  1984cited by this paper
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  1983cited by this paper
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  1983cited by this paper
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  1978cited by this paper
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  1977cited by this paper
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  1976cited by this paper
• Slow axonal protein transport and visual function following retinal and optic nerve ischemia.

  1975cited by this paper
• Pathogenesis of cupping of the optic disc.

  1974cited by this paper
• Experimental glaucoma in the rhesus monkey.

  1974cited by this paper
• Ocular and optic nerve blood flow at normal and increased intraocular pressures in monkeys (Macaca irus): a study with radioactively labelled microspheres including flow determinations in brain and some other tissues.

  1973cited by this paper

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