A slippery slope: On the origin, role and physiology of mucus☆

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Advanced Drug Delivery Reviews

• Publication date

  2017-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.addr.2017.10.014PMID 29108861
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cilia and Mucociliary Clearance.

  2017influential reference
• Anti-PEG antibodies alter the mobility and biodistribution of densely PEGylated nanoparticles in mucus.

  2016cited by this paper
• Cross-Comparison of Exome Analysis, Next-Generation Sequencing of Amplicons, and the iPLEX® ADME PGx Panel for Pharmacogenomic Profiling

  2016cited by this paper
• Inflammatory bowel disease: exploring gut pathophysiology for novel therapeutic targets.

  2016cited by this paper
• The Mucus Barrier to Inhaled Gene Therapy.

  2016cited by this paper
• Core 1- and core 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice

  2016cited by this paper
• Immunological aspects of intestinal mucus and mucins

  2016cited by this paper
• Mucoadhesive vs. mucopenetrating particulate drug delivery.

  2016cited by this paper
• Goblet cells of the conjunctiva: A review of recent findings.

  2016cited by this paper
• Nanoparticles coated with high molecular weight PEG penetrate mucus and provide uniform vaginal and colorectal distribution in vivo.

  2016cited by this paper
• Measurements of Deposition, Lung Surface Area and Lung Fluid for Simulation of Inhaled Compounds

  2016cited by this paper
• Role of Cytokine-Induced Glycosylation Changes in Regulating Cell Interactions and Cell Signaling in Inflammatory Diseases and Cancer

  2016cited by this paper
• A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility.

  2016cited by this paper
• Mechanistic modeling of ophthalmic drug delivery to the anterior chamber by eye drops and contact lenses.

  2016cited by this paper
• New developments in goblet cell mucus secretion and function

  2015cited by this paper
• Why Do People (Still) Go Blind from Glaucoma?

  2015cited by this paper
• Protective Factors of the Gastric and Duodenal Mucosa: An Overview

  2015cited by this paper
• Enhanced Trapping of HIV-1 by Human Cervicovaginal Mucus Is Associated with Lactobacillus crispatus-Dominant Microbiota

  2015cited by this paper
• Mucin glycan foraging in the human gut microbiome

  2015cited by this paper
• Topical Ocular Drug Delivery to the Back of the Eye by Mucus-Penetrating Particles.

  2015cited by this paper
• Steric and interactive barrier properties of intestinal mucus elucidated by particle diffusion and peptide permeation.

  2015cited by this paper
• Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses.

  2015cited by this paper
• Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo.

  2015cited by this paper
• Mucus as a barrier to drug delivery – understanding and mimicking the barrier properties.

  2015cited by this paper
• Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse.

  2015influential reference
• The Paradox of Artificial Sweeteners in Managing Obesity

  2015cited by this paper
• The role of sex hormones in immune protection of the female reproductive tract

  2015cited by this paper
• Animal Farm: Considerations in Animal Gastrointestinal Physiology and Relevance to Drug Delivery in Humans.

  2015cited by this paper
• Insights into the role of cervical mucus and vaginal pH in unexplained infertility

  2015cited by this paper
• Cystic fibrosis: an inherited disease affecting mucin-producing organs.

  2014cited by this paper
• Keratinization of the esophageal epithelium of domesticated mammals.

  2014cited by this paper
• Ocular Pharmacokinetics of a Novel Loteprednol Etabonate 0.4% Ophthalmic Formulation

  2014cited by this paper
• The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

  2014cited by this paper
• Enhancing the Buccal Mucosal Delivery of Peptide and Protein Therapeutics

  2014cited by this paper
• Enhanced Topical Delivery of a Novel Loteprednol Etabonate Ophthalmic Formulation

  2014cited by this paper
• Overcoming the pulmonary barrier: new insights to improve the efficiency of inhaled therapeutics

  2014cited by this paper
• Salivary Mucins Protect Surfaces from Colonization by Cariogenic Bacteria

  2014cited by this paper
• Cytokines in inflammatory bowel disease

  2014cited by this paper
• Expression analysis of the transmembrane mucin MUC20 in human corneal and conjunctival epithelia.

  2014cited by this paper
• Assembly of the Respiratory Mucin MUC5B

  2014cited by this paper
• Surface area of the digestive tract – revisited

  2014cited by this paper
• Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis

  2014cited by this paper
• Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus

  2014influential reference
• Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches.

  2013cited by this paper
• Contact lenses as a platform for ocular drug delivery

  2013cited by this paper
• The gastrointestinal mucus system in health and disease

  2013cited by this paper
• In-vitro permeability of neutral polystyrene particles via buccal mucosa.

  2013cited by this paper
• Vaginal pH and Microbicidal Lactic Acid When Lactobacilli Dominate the Microbiota

  2013cited by this paper
• Enhanced vaginal drug delivery through the use of hypotonic formulations that induce fluid uptake.

  2013cited by this paper
• Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

  2013influential reference
• Differential Binding of IgG and IgA to Mucus of the Female Reproductive Tract

  2013influential reference
• Nasal Physiology and Pathophysiology of Nasal Disorders

  2013influential reference
• Food, physiology and drug delivery.

  2013cited by this paper
• Cellular and molecular biology of airway mucins.

  2013influential reference
• Mucous hypersecretion and relationship to cough.

  2013cited by this paper
• Ex vivo characterization of particle transport in mucus secretions coating freshly excised mucosal tissues.

  2013cited by this paper
• Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

  2013cited by this paper
• Nanoparticles formulations with enhanced mucosal penetration

  2013cited by this paper
• Spatial configuration and composition of charge modulates transport into a mucin hydrogel barrier.

  2013cited by this paper
• Mucosal Barrier in Ulcerative Colitis and Crohn's Disease

  2013cited by this paper
• Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin

  2012cited by this paper
• Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus

  2012cited by this paper
• A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia

  2012influential reference
• Mucus thickness in the gastrointestinal tract of laboratory animals

  2012cited by this paper
• Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype

  2012cited by this paper
• Secreted and Membrane-Bound Mucins and Idiopathic Peptic Ulcer Disease

  2012cited by this paper
• Necropsy and Histology

  2012cited by this paper
• Mucins

  2012cited by this paper
• Dextran Sodium Sulfate (DSS) Induces Colitis in Mice by Forming Nano-Lipocomplexes with Medium-Chain-Length Fatty Acids in the Colon

  2012cited by this paper
• Fast Renewal of the Distal Colonic Mucus Layers by the Surface Goblet Cells as Measured by In Vivo Labeling of Mucin Glycoproteins

  2012cited by this paper
• Microbial degradation of complex carbohydrates in the gut

  2012cited by this paper
• Human cervicovaginal mucus contains an activity that hinders HIV-1 movement

  2012cited by this paper
• The Microbiota of the Gut in Preschool Children With Normal and Excessive Body Weight

  2012cited by this paper
• Mucus Penetrating Nanoparticles: Biophysical Tool and Method of Drug and Gene Delivery

  2012cited by this paper
• Lifting the Veil of Morality: Choice Blindness and Attitude Reversals on a Self-Transforming Survey

  2012cited by this paper
• The Airway Epithelium: Soldier in the Fight against Respiratory Viruses

  2011cited by this paper
• Keeping Bacteria at a Distance

  2011cited by this paper
• Does sex matter? The influence of gender on gastrointestinal physiology and drug delivery.

  2011cited by this paper
• Physiology and pathophysiology of respiratory mucosa of the nose and the paranasal sinuses

  2011cited by this paper
• Muc17 protects intestinal epithelial cells from enteroinvasive E. coli infection by promoting epithelial barrier integrity.

  2011cited by this paper
• Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice.

  2011cited by this paper
• Surgery of the turbinates and “empty nose” syndrome

  2011cited by this paper
• Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice

  2011cited by this paper
• Interaction between otorhinolaryngology and orthodontics: correlation between the nasopharyngeal airway and the craniofacial complex

  2011cited by this paper
• Altered O‐glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation

  2011cited by this paper
• Mucoadhesive platforms for targeted delivery to the colon.

  2011influential reference
• At the crossroads of vaginal health and disease, the genome sequence of Lactobacillus iners AB-1

  2010cited by this paper
• Paneth cells and innate mucosal immunity

  2010cited by this paper
• Safety and Efficacy of Erythropoietin in Traumatic Brain Injury Patients: A Pilot Randomized Trial

  2010cited by this paper
• Bacteria Penetrate the Inner Mucus Layer before Inflammation in the Dextran Sulfate Colitis Model

  2010cited by this paper
• Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging

  2010cited by this paper
• Vaginal microbiome of reproductive-age women

  2010cited by this paper
• Cultured Human Airway Epithelial Cells (Calu-3): A Model of Human Respiratory Function, Structure, and Inflammatory Responses

  2010cited by this paper
• Advances in mucous cell metaplasia: a plug for mucus as a therapeutic focus in chronic airway disease.

  2010cited by this paper
• Human buccal mucosa as an innovative site of drug delivery.

  2010cited by this paper
• High incidence of mortality and recurrent bleeding in patients with Helicobacter pylori-negative idiopathic bleeding ulcers.

  2009cited by this paper
• Cystic Fibrosis

  2009cited by this paper
• Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues.

  2009cited by this paper
• Cervical mucins carry α(1,2)fucosylated glycans that partly protect from experimental vaginal candidiasis

  2009cited by this paper
• Cystic fibrosis

  2009cited by this paper

• Mucins: Progress in Understanding Physiological Functions and Involvement in Pathological Processes and Prospects for Use (A Review)

  2025cites this paper
• Mobiluncus mulieris alters the transcriptomic profile of cervicovaginal epithelial cells, shedding light on molecular drivers of adverse reproductive outcomes

  2025cites this paper
• Engineered carbon dots for mucosal gene delivery.

  2025cites this paper
• Cervicovaginal microbiome alters transcriptomic and chromatin accessibility signatures across cervicovaginal epithelial barriers

  2025cites this paper
• Schistosomiasis: a neglected cause of infertility in females and males.

  2025cites this paper
• Alginate-based target specific bioadhesive drug delivery systems: a review

  2025cites this paper
• Cervicovaginal microbiome alters transcriptomic and epigenomic signatures across cervicovaginal epithelial barriers

  2025cites this paper
• Unique physiological and regulatory activity drives divergent toxin and non-toxin gene expression in rattlesnake accessory venom glands.

  2025cites this paper
• Advances in natural polysaccharide/protein-based bioadhesive formulations for the potential application in esophagus: A review.

  2025cites this paper
• Vaginal probiotics as therapeutic adjuncts for improving embryo transfer success rates: a systematic review and meta-analysis

  2025cites this paper
• Lactiplantibacillus plantarum CCFM8661 improves intestinal barrier function and regulates gut microbiota to alleviate enterotoxigenic Escherichia coli-induced diarrhea in mice

  2025cites this paper
• Cervicovaginal Microbiome: Physiology, Age-Related Changes, and Protective Role Against Human Papillomavirus Infection

  2025cites this paper
• Environmental factors drive bacterial degradation of gastrointestinal mucus

  2025cites this paper
• Overcoming the mucus barrier: Optimization design of carriers to enhance mucus permeability, targeting, and responsiveness.

  2025cites this paper
• Site-Specific Microparticle Inhalation Therapy: A New Approach to Nasopharyngeal Symptoms

  2025cites this paper
• Inhalable nanoparticle-based delivery systems for the treatment of pulmonary infections: Status quo and barrier-overcoming strategies

  2025cites this paper
• Efficacy of a Maillard-type conjugate of whey protein isolate with chitosan as a carrier for a liposomal form of a combination of curcumin and balanced amounts of n-3 and n-6 PUFAs. Part II. Carrier behaviour under simulated in vitro digestion

  2024cites this paper
• Deciphering mucin degrading ability and safety aspects of enterococcus strain from human feces

  2024cites this paper
• Key structural factors and intermolecular interactions underlying the formation, functional properties and behaviour in the gastrointestinal tract in vitro of the liposomal form of nutraceuticals coated with whey proteins and chitosan.

  2024cites this paper
• Microenvironment of the Lower Reproductive Tract: Focus on the Cervical Mucus Plug

  2024cites this paper
• Development of a canine artificial colonic mucus model for drug diffusion studies.

  2024cites this paper
• Nanotechnology for enhanced nose-to-brain drug delivery in treating neurological diseases.

  2024cites this paper
• Efficacy, Safety, and Tolerability of Nasal Wash in Patients with Upper Respiratory Tract Diseases

  2024cites this paper
• Preliminary Research on Invasive and Non-Invasive Methods for Identifying Estrus in Ewes

  2024cites this paper
• Nanomedicines for Pulmonary Drug Delivery: Overcoming Barriers in the Treatment of Respiratory Infections and Lung Cancer

  2024cites this paper
• Human milk oligosaccharides combine with Bifidobacterium longum to form the “golden shield” of the infant intestine: metabolic strategies, health effects, and mechanisms of action

  2024cites this paper
• Lateral Assessment of Mucomimetic Hydrogels to Evaluate Correlation between Microscopic and Macroscopic Properties.

  2024cites this paper
• Inter-societal Delphi Consensus on the topical nasal treatments in Italy

  2024cites this paper
• Lipid polymer hybrid nanoparticles against lung cancer and their application as inhalable formulation.

  2024cites this paper
• Machine learning of Raman spectra predicts drug release from polysaccharide coatings for targeted colonic delivery.

  2024cites this paper
• Green Solid Lipid Nanoparticles by Fatty Acid Coacervation: An Innovative Nasal Delivery Tool for Drugs Targeting Cerebrovascular and Neurological Diseases

  2024cites this paper
• Functional PEGylated bacteria reinforce the intestinal mucosal barrier by effective mucus-penetration.

  2024cites this paper
• Mucosa-penetrating liposomes for esophageal local drug delivery.

  2024cites this paper
• Vaginal microbes alter epithelial transcriptome and induce epigenomic modifications providing insight into mechanisms for susceptibility to adverse reproductive outcomes

  2024cites this paper
• Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D

  2024cites this paper
• Combination of PEGylation and Cationization on Phospholipid-Coated Cyclosporine Nanosuspensions for Enhanced Ocular Drug Delivery.

  2024cites this paper
• Tethering of soluble immune effectors to mucin and chitin reflects a convergent and dynamic role in gut immunity

  2024influential citation
• Natural products from plants and microorganisms: Novel therapeutics for chronic kidney disease via gut microbiota regulation

  2023cites this paper
• Liensinine alleviates mouse intestinal injury induced by sepsis through inhibition of oxidative stress, inflammation, and cell apoptosis.

  2023cites this paper
• The Effect of a Lipid Surface Coating on the Permeation of Upconverting Nanoparticles through a 3D Human Lung Epithelial Model

  2023cites this paper
• Vaginal microbes alter epithelial transcriptomic and epigenomic modifications providing insight into the molecular mechanisms for susceptibility to adverse reproductive outcomes

  2023cites this paper
• Therapeutic effect of yinchenhao decoction on cholelithiasis via mucin in the gallbladder and intestine.

  2023cites this paper
• Sensing Mucus Physiological Property In Situ by Wireless Millimeter‐Scale Soft Robots

  2023cites this paper
• Vaginal microecology and its role in human papillomavirus infection and human papillomavirus associated cervical lesions

  2023cites this paper
• Recent developments in dry powder inhalation (DPI) formulations for lung-targeted drug delivery

  2023cites this paper
• Rational design of oral delivery nanosystems for hypoglycemic peptides

  2023cites this paper
• Neuraminidase B controls neuraminidase A-dependent mucus production and

  2023cites this paper
• Treatment of allergic rhinitis in clinical practice.

  2023cites this paper
• Future Nanotechnology-Based Strategies for Improved Management of Helicobacter pylori Infection.

  2023cites this paper
• Extract of Sophorae flavescentis radix-Cnidii fructus couplet medicines treats vulvovaginal candidiasis by affecting the vaginal mucosal barrier.

  2023cites this paper
• Impact of Peptide Structure on Colonic Stability and Tissue Permeability

  2023cites this paper
• Recent progress of micro/nanomotors to overcome physiological barriers in the gastrointestinal tract.

  2023cites this paper
• Current status and advances in esophageal drug delivery technology: influence of physiological, pathophysiological and pharmaceutical factors

  2023cites this paper
• Modulation of engineered nanomaterial interactions with organ barriers for enhanced drug transport.

  2023cites this paper
• Genome-wide multi-omics analysis reveals the nutrient-dependent metabolic features of mucin-degrading gut bacteria

  2023cites this paper
• Chitosan-based (Captomucil® complex) medical device nasal spray for relieving symptoms in patients with rhinitis: a primary care study

  2023cites this paper
• Computational fluid dynamics modeling of aerosol particle transport through lung airway mucosa,

  2023influential citation
• Laryngopharyngeal Reflux and Eye: More Than a Hypothesis

  2023cites this paper
• Bacteria-Induced Colloidal Encapsulation for Probiotic Oral Delivery.

  2023cites this paper
• Anti-Inflammatories in the Treatment of Dry Eye Disease: A Review

  2023cites this paper
• Understanding mucus modulation behavior of chitosan oligomers and dextran sulfate combining light scattering and calorimetric observations.

  2023cites this paper
• Engineering drug delivery systems to overcome the vaginal mucosal barrier: Current understanding and research agenda of mucoadhesive formulations of vaginal delivery

  2022cites this paper
• Intestinal toxicity of micro- and nano-particles of foodborne titanium dioxide in juvenile mice: Disorders of gut microbiota-host co-metabolites and intestinal barrier damage.

  2022cites this paper
• Complexation between porcine gastric mucin (PGM) and lysozyme: Influence of heat treatment of lysozyme on the tribological properties.

  2022cites this paper
• Application of Sol–Gels for Treatment of Gynaecological Conditions—Physiological Perspectives and Emerging Concepts in Intravaginal Drug Delivery

  2022cites this paper
• The Shape of the Nasal Cavity and Adaptations to Sniffing in the Dog (Canis familiaris) Compared to Other Domesticated Mammals: A Review Article

  2022cites this paper
• A guide to oral vaccination: Highlighting electrospraying as a promising manufacturing technique toward a successful oral vaccine development

  2022cites this paper
• Untangling Mucosal Drug Delivery: Engineering, Designing, and Testing Nanoparticles to Overcome the Mucus Barrier.

  2022cites this paper
• Correlations of Salivary and Blood Glucose Levels among Six Saliva Collection Methods

  2022cites this paper
• Non-Cellular Layers of the Respiratory Tract: Protection against Pathogens and Target for Drug Delivery

  2022cites this paper
• An improved, filtration-based process to purify functional mucins from mucosal tissues with high yields

  2022cites this paper
• Poly(lactic acid)-hyperbranched polyglycerol nanoparticles enhance bioadhesive treatment of esophageal disease and reduce systemic drug exposure.

  2022cites this paper
• Rod-like mesoporous silica nanoparticles facilitate oral drug delivery via enhanced permeation and retention effect in mucus

  2022cites this paper
• Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat

  2022cites this paper
• Recent advances on drug delivery applications of mucopenetrative/mucoadhesive particles: A review

  2022cites this paper
• Colon mucus in colorectal neoplasia and beyond

  2022cites this paper
• An experimental and theoretical approach to understand the interaction between particles and mucosal tissues

  2022cites this paper
• In vitro and ex vivo models for evaluating vaginal drug delivery systems.

  2022cites this paper
• Magnetically Driven Muco-Inert Janus Nanovehicles for Enhanced Mucus Penetration and Cellular Uptake

  2022cites this paper
• The effect of mucin on supersaturation of poorly water-soluble drugs with different crystallization behavior and in vitro-in vivo correlation

  2022cites this paper
• Bifidobacterium breve CCFM1078 Alleviates Collagen-Induced Arthritis in Rats via Modulating the Gut Microbiota and Repairing the Intestinal Barrier Damage.

  2022cites this paper
• Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics.

  2022influential citation
• Poly-β-hydroxybutyrate alleviated diarrhea and colitis via Lactobacillus johnsonii biofilm-mediated maturation of sulfomucin

  2022cites this paper
• Cervical MUC5B and MUC5AC are barriers to ascending pathogens during pregnancy.

  2022cites this paper
• Targeting strategies of oral nano-delivery systems for treating inflammatory bowel disease.

  2021cites this paper
• Impact of Anatomy and Physiology

  2021cites this paper
• Clinical translation of advanced colonic drug delivery technologies.

  2021cites this paper
• Cyclosporine A Nanosuspensions for Ophthalmic Delivery: A Comparative Study between Cationic Nanoparticles and Drug-Core Mucus Penetrating Nanoparticles.

  2021cites this paper
• Understanding the Interplay Between the Host Immune–Microbiome Interactions: A State of the Art Review

  2021cites this paper
• Computer Modeling of Aerosol Particle Transport through Lung Mucosa

  2021influential citation
• Essential contributions of food hydrocolloids and phospholipid liposomes to the formation of carriers for controlled delivery of biologically active substances via the gastrointestinal tract

  2021cites this paper
• MUC1 is an oncoprotein with a significant role in apoptosis (Review)

  2021cites this paper
• Forgotten but not gone: Particulate matter as contaminations of mucosal systems.

  2021cites this paper
• Mucosal drug delivery and 3D printing technologies: a focus on special patient populations.

  2021cites this paper
• From barriers to bridges; glycans in nonparenteral nanomedicines

  2021cites this paper
• Significance of Slippage and Electric Field in Mucociliary Transport of Biomagnetic Fluid

  2021cites this paper
• Ocular drug delivery to the anterior segment using nanocarriers: A mucoadhesive/mucopenetrative perspective.

  2021cites this paper
• Therapeutic effect of yinchenhao decoction on cholelithiasis via mucin from gallbladder-intestine

  2021cites this paper
• The role of KPI-121 0.25% in the treatment of dry eye disease: penetrating the mucus barrier to treat periodic flares

  2021cites this paper
• Biodegradable Electrospun Nanofibers: A New Approach For Rhinosinusitis Treatment.

  2021cites this paper