IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Journal of Immunology

• Publication date

  2018-01-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.1701538PMID 29321274PMCID PMC6483084
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• ZBP1: Innate Sensor Regulating Cell Death and Inflammation.

  2017cited by this paper
• The host microRNA miR-301a blocks the IRF1-mediated neuronal innate immune response to Japanese encephalitis virus infection

  2017cited by this paper
• Regulation and functions of NLRP3 inflammasome during influenza virus infection

  2017cited by this paper
• Gasdermins: Effectors of Pyroptosis.

  2017cited by this paper
• Mechanisms governing inflammasome activation, assembly and pyroptosis induction

  2017cited by this paper
• ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death

  2017cited by this paper
• Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition

  2017cited by this paper
• Interferon Regulatory Factor 1 Protects against Chikungunya Virus-Induced Immunopathology by Restricting Infection in Muscle Cells

  2017cited by this paper
• ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways.

  2016cited by this paper
• ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways

  2016cited by this paper
• RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus.

  2016cited by this paper
• DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.

  2016cited by this paper
• RIPK1 inhibits ZBP1-driven necroptosis during development

  2016cited by this paper
• RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

  2016cited by this paper
• Converging roles of caspases in inflammasome activation, cell death and innate immunity

  2015cited by this paper
• Disease-Promoting Effects of Type I Interferons in Viral, Bacterial, and Coinfections

  2015cited by this paper
• The transcription factor IRF1 and guanylate-binding proteins target AIM2 inflammasome activation by Francisella infection

  2015cited by this paper
• Cellular inhibitor of apoptosis protein cIAP2 protects against pulmonary tissue necrosis during influenza virus infection to promote host survival.

  2014cited by this paper
• Pathogenic potential of interferon αβ in acute influenza infection

  2014cited by this paper
• EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production.

  2014cited by this paper
• Tick-Borne Flaviviruses Antagonize Both IRF-1 and Type I IFN Signaling To Inhibit Dendritic Cell Function

  2014cited by this paper
• Interferon Regulatory Factor 1 Restricts Gammaherpesvirus Replication in Primary Immune Cells

  2014cited by this paper
• Interferon Regulatory Factor-1 Protects from Fatal Neurotropic Infection with Vesicular Stomatitis Virus by Specific Inhibition of Viral Replication in Neurons

  2014cited by this paper
• Interferon Regulatory Factor 1 Polymorphisms Previously Associated with Reduced HIV Susceptibility Have No Effect on HIV Disease Progression

  2013cited by this paper
• Compromised respiratory function in lethal influenza infection is characterized by the depletion of type I alveolar epithelial cells beyond threshold levels.

  2013cited by this paper
• Macrophage-expressed IFN-β Contributes to Apoptotic Alveolar Epithelial Cell Injury in Severe Influenza Virus Pneumonia

  2013cited by this paper
• A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection.

  2013cited by this paper
• The IRF family transcription factors at the interface of innate and adaptive immune responses.

  2013influential reference
• Respiratory virus–induced EGFR activation suppresses IRF1-dependent interferon λ and antiviral defense in airway epithelium

  2013cited by this paper
• Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells

  2013cited by this paper
• Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase.

  2012cited by this paper
• Interferon Regulatory Factor-1 (IRF-1) Shapes Both Innate and CD8+ T Cell Immune Responses against West Nile Virus Infection

  2011cited by this paper
• DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF‐κB

  2009cited by this paper
• The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1.

  2009cited by this paper
• The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.

  2009cited by this paper
• Inflammasome recognition of influenza virus is essential for adaptive immune responses

  2009cited by this paper
• TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

  2008cited by this paper
• The pathology of influenza virus infections.

  2008cited by this paper
• DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

  2007cited by this paper
• Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus

  2006cited by this paper
• Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA*>

  2006cited by this paper
• Repression of Interferon Regulatory Factor 1 by Hepatitis C Virus Core Protein Results in Inhibition of Antiviral and Immunomodulatory Genes

  2006cited by this paper
• Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

  2003cited by this paper
• Interferon regulatory factor-1, interferon-beta, and reovirus-induced myocarditis.

  2002cited by this paper
• Review: Activities of IRF-1

  2002cited by this paper
• Alpha/Beta Interferons Potentiate Virus-Induced Apoptosis through Activation of the FADD/Caspase-8 Death Signaling Pathway

  2000cited by this paper
• Cloning of DLM-1, a novel gene that is up-regulated in activated macrophages, using RNA differential display.

  1999cited by this paper
• Involvement of the IRF-1 transcription factor in antiviral responses to interferons.

  1994cited by this paper

• PANoptosis as a Potential Therapeutic Target in Drug-Induced Liver Injury: A Narrative Review

  2026cites this paper
• The IRF transcription factor family in type I interferon-mediated antiviral immunity and associated diseases

  2026cites this paper
• Orchestrating immunopathology: the spectrum of programmed cell death pathways co-opted by influenza a virus in pulmonary immunity

  2026cites this paper
• The mtDNA-ZBP1 axis in alzheimer's disease: Mechanisms, pathogenesis, and therapeutic implications.

  2025cites this paper
• PANoptosis: A new perspective on the pathogenesis of cardiovascular diseases

  2025cites this paper
• Advances in Pseudomonas aeruginosa-Induced Programmed Cell Death and Potential Targeted Treatment Strategies

  2025cites this paper
• Z-DNA-binding protein 1-mediated programmed cell death: Mechanisms and therapeutic implications

  2025cites this paper
• PANoptosis: Potential Therapeutic Prospects in Alzheimer's Disease

  2025cites this paper
• Total glucosides of paeony ameliorates lupus nephritis by suppressing ZBP1-mediated PANoptosis in podocytes.

  2025cites this paper
• PANoptosis in neurological disorders: mechanisms, implications, and therapeutic potential

  2025cites this paper
• Transcriptional characterization of sepsis in a LPS porcine model

  2025cites this paper
• Research advances of PANoptosis in gastrointestinal tumors.

  2025cites this paper
• Targeting programmed cell death pathways in gastric cancer: a focus on pyroptosis, apoptosis, necroptosis and PANoptosis.

  2025cites this paper
• PANoptosis: a potential target of atherosclerotic cardiovascular disease

  2025cites this paper
• KLX ameliorates liver cancer progression by mediating ZBP1 transcription and ubiquitination and increasing ZBP1-induced PANoptosis

  2025cites this paper
• Unravelling the Role of PANoptosis in Liver Diseases: Mechanisms and Therapeutic Implications

  2025cites this paper
• The critical role of the ZBP1-NINJ1 axis and IRF1/IRF9 in ethanol-induced cell death, PANoptosis, and alcohol-associated liver disease

  2025cites this paper
• Inflammasome Activation by RNA Respiratory Viruses: Mechanisms, Viral Manipulation, and Therapeutic Insights

  2025cites this paper
• Exploring gene expression, alternative splicing events and RNA-binding proteins changes in PBMC from patients with hyperuricemia.

  2025cites this paper
• lncRNA CARINH regulates expression and function of innate immune transcription factor IRF1 in macrophages

  2025cites this paper
• PANoptosis in intestinal epithelium: its significance in inflammatory bowel disease and a potential novel therapeutic target for natural products

  2025cites this paper
• Interferon regulatory factor 1 promotes pyroptosis and inflammation in mouse sepsis-induced cardiomyopathy.

  2025cites this paper
• Identification of an IRF-ZBP1-caspase-8-NINJ1 axis in driving PANoptosis and pathology during alcohol-associated liver disease.

  2025cites this paper
• Cytosolic DNA sensors in neurodegenerative diseases: from physiological defenders to pathological culprits

  2024cites this paper
• Role of Interferon Regulatory Factor 1 in acute and chronic virus infections.

  2024cites this paper
• Integrating bioinformatics and experimental validation to Investigate IRF1 as a novel biomarker for nucleus pulposus cells necroptosis in intervertebral disc degeneration

  2024cites this paper
• The Potential Therapeutic Prospect of PANoptosis in Heart Failure

  2024cites this paper
• Mechanistic Insights into Influenza A Virus-Induced Cell Death and Emerging Treatment Strategies

  2024cites this paper
• Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair.

  2024cites this paper
• The emerging role of PANoptosis in viral infections disease.

  2024cites this paper
• PANoptosis in autoimmune diseases interplay between apoptosis, necrosis, and pyroptosis

  2024cites this paper
• Suppression of ZBP1-mediated NLRP3 inflammasome by the tegument protein VP22 facilitates pseudorabies virus infection

  2024cites this paper
• The multiple roles of interferon regulatory factor family in health and disease

  2024cites this paper
• IRF1 and IL1A associated with PANoptosis serve as potential immune signatures for lung ischemia reperfusion injury following lung transplantation.

  2024cites this paper
• Influenza virus infection activates TAK1 to suppress RIPK3-independent apoptosis and RIPK1-dependent necroptosis

  2024cites this paper
• Host Innate Antiviral Response to Influenza A Virus Infection: From Viral Sensing to Antagonism and Escape

  2024cites this paper
• Elabela ameliorates neuronal pyroptosis and mitochondrial fission via APJ/ZBP1 signaling in ischemic stroke.

  2024cites this paper
• Z-DNA binding protein 1 orchestrates innate immunity and inflammatory cell death.

  2024cites this paper
• Commonly disrupted pathways in brain and kidney in a pig model of systemic endotoxemia

  2024cites this paper
• Water Extract of Portulaca Oleracea Inhibits PEDV Infection-Induced Pyrolysis by Caspase-1/GSDMD

  2023cites this paper
• Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment

  2023cites this paper
• ZBP1 and heatstroke

  2023cites this paper
• Innate immune inflammatory cell death: PANoptosis and PANoptosomes in host defense and disease

  2023cites this paper
• Coxsackievirus A6 Infection Causes Neurogenic Pathogenesis in a Neonatal Murine Model

  2023cites this paper
• IFNγ causes keratinocyte necroptosis in acute graft-versus-host disease.

  2023cites this paper
• Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

  2023cites this paper
• BPDE exposure promotes trophoblast cell pyroptosis and induces miscarriage by up-regulating lnc-HZ14/ZBP1/NLRP3 axis.

  2023cites this paper
• Recent advances in ZBP1-derived PANoptosis against viral infections

  2023cites this paper
• Zbp1 gene: a modulator of multiple aging hallmarks as potential therapeutic target for age-related diseases

  2023cites this paper
• NLRP12 drives PANoptosis in response to heme.

  2023cites this paper
• Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and NLRP12-PANoptosome activation and inflammatory cell death (PANoptosis)

  2023cites this paper
• Programmed Necrosis in Host Defense.

  2023cites this paper
• Pyroptosis: the dawn of a new era in endometrial cancer treatment

  2023cites this paper
• Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes.

  2023cites this paper
• PANoptosis in cancer, the triangle of cell death

  2023cites this paper
• Mechanisms of PANoptosis and relevant small-molecule compounds for fighting diseases

  2023cites this paper
• The IRF1/GBP5 axis promotes osteoarthritis progression by activating chondrocyte pyroptosis

  2023cites this paper
• Comprehensive Analysis of PANoptosis-Related Gene Signature of Ulcerative Colitis

  2023cites this paper
• Type III interferons induce pyroptosis in gut epithelial cells and delay tissue restitution upon acute intestinal injury

  2022cites this paper
• ZBP1-Mediated Necroptosis: Mechanisms and Therapeutic Implications

  2022cites this paper
• Programmed cell death: the pathways to severe COVID-19?

  2022cites this paper
• Regulated necrosis, a proinflammatory cell death, potentially counteracts pathogenic infections

  2022cites this paper
• PANoptosis: A Unique Innate Immune Inflammatory Cell Death Modality

  2022cites this paper
• Detecting DNA: An Overview of DNA Recognition by Inflammasomes and Protection against Bacterial Respiratory Infections

  2022cites this paper
• The evolution of regulated cell death pathways in animals and their evasion by pathogens

  2022cites this paper
• It’s All in the PAN: Crosstalk, Plasticity, Redundancies, Switches, and Interconnectedness Encompassed by PANoptosis Underlying the Totality of Cell Death-Associated Biological Effects

  2022influential citation
• AP-1 signaling pathway promotes pro-IL-1β transcription to facilitate NLRP3 inflammasome activation upon influenza A virus infection

  2022cites this paper
• ZBP1: A Powerful Innate Immune Sensor and Double-Edged Sword in Host Immunity

  2022cites this paper
• Programming inflammatory cell death for therapy.

  2021cites this paper
• Screening key genes and signaling pathways in COVID-19 infection and its associated complications by integrated bioinformatics analysis

  2021cites this paper
• Human Metapneumovirus Induces IRF1 via TANK-Binding Kinase 1 and Type I IFN

  2021influential citation
• An update on the regulatory mechanisms of NLRP3 inflammasome activation

  2021cites this paper
• Role of inflammasomes/pyroptosis and PANoptosis during fungal infection

  2021cites this paper
• Tolerogenic and immunogenic states of Langerhans cells are orchestrated by epidermal signals acting on a core maturation gene module

  2021cites this paper
• Bioinformatics analysis of expression profiling by high throughput sequencing for identification of potential key genes among SARS-CoV-2/COVID 19

  2021influential citation
• Herpes Simplex Virus and Pattern Recognition Receptors: An Arms Race

  2021cites this paper
• The Role of the Z-DNA Binding Domain in Innate Immunity and Stress Granules

  2021cites this paper
• Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses

  2021cites this paper
• Immunostimulatory Endogenous Nucleic Acids Perpetuate Interface Dermatitis—Translation of Pathogenic Fundamentals Into an In Vitro Model

  2021cites this paper
• Comparative Analysis of Six IRF Family Members in Alveolar Epithelial Cell-Intrinsic Antiviral Responses

  2021cites this paper
• Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice

  2021cites this paper
• Potential Molecular Mechanisms and Remdesivir Treatment for Acute Respiratory Syndrome Corona Virus 2 Infection/COVID 19 Through RNA Sequencing and Bioinformatics Analysis

  2021cites this paper
• CircRNA–miRNA networks in regulating bone disease

  2021cites this paper
• The IFN‐inducible GTPase IRGB10 regulates viral replication and inflammasome activation during influenza A virus infection in mice

  2021cites this paper
• Endogenous tRNA‐derived small RNA (tRF3‐Thr‐AGT) inhibits ZBP1/NLRP3 pathway‐mediated cell pyroptosis to attenuate acute pancreatitis (AP)

  2021cites this paper
• ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis.

  2021cites this paper
• PANoptosis in microbial infection

  2020cites this paper
• Toward targeting inflammasomes: insights into their regulation and activation

  2020cites this paper
• Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

  2020cites this paper
• Integrated bioinformatics analysis for the screening of hub genes and therapeutic drugs in severe acute respiratory syndrome corona virus 2 infection/COVID 19

  2020cites this paper
• Inflammasome Activation in Acute Lung Injury.

  2020cites this paper
• Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes

  2020cites this paper
• Detection of viruses by inflammasomes

  2020cites this paper
• COVID-19 cytokines and the hyperactive immune response: Synergism of TNF-α and IFN-γ in triggering inflammation, tissue damage, and death

  2020cites this paper
• Transcriptome analysis of duck embryo fibroblasts for the dynamic response to duck tembusu virus infection and dual regulation of apoptosis genes

  2020cites this paper
• The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)

  2020cites this paper
• Pattern Recognition Receptor Signaling and Innate Responses to Influenza A Viruses in the Mallard Duck, Compared to Humans and Chickens

  2020cites this paper
• An approximate solution of the interferon-dependent viral kinetics model of influenza.

  2020cites this paper
• Die Another Way: Interplay between Influenza A Virus, Inflammation and Cell Death

  2020cites this paper
• The involvement of regulated cell death forms in modulating the bacterial and viral pathogenesis

  2020cites this paper