Identification of a 45-kDa protein at the protein import site of the yeast mitochondrial inner membrane.

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1992-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/PNAS.89.24.11930PMID 1465421PMCID PMC50671
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mapping of the protein import machinery in the mitochondrial outer membrane by crosslinking of translocation intermediates

  1992cited by this paper
• Mitochondrial proteins essential for viability mediate protein import into yeast mitochondria

  1991cited by this paper
• Sequential action of mitochondrial chaperones in protein import into the matrix.

  1991cited by this paper
• The identification of proteins in the proximity of signal-anchor sequences during their targeting to and insertion into the membrane of the ER

  1991cited by this paper
• Import of precursor proteins into yeast submitochondrial particles.

  1991cited by this paper
• Mitochondrial preproteins en route from the outer membrane to the inner membrane are exposed to the intermembrane space

  1991cited by this paper
• Protein import into the yeast mitochondrial matrix. A new translocation intermediate between the two mitochondrial membranes.

  1991cited by this paper
• Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex

  1991cited by this paper
• Protein import into mitochondria: two systems acting in tandem?

  1991cited by this paper
• A precursor protein partly translocated into yeast mitochondria is bound to a 70 kd mitochondrial stress protein.

  1990cited by this paper
• Identification of a mitochondrial receptor complex required for recognition and membrane insertion of precursor proteins

  1990cited by this paper
• A yeast mitochondrial outer membrane protein essential for protein import and cell viability

  1990cited by this paper
• Protein sorting to mitochondria: evolutionary conservations of folding and assembly.

  1990cited by this paper
• Citrate synthase encoded by the CIT2 gene of Saccharomyces cerevisiae is peroxisomal

  1990cited by this paper
• Protein translocation across the endoplasmic reticulum membrane: identification by photocross-linking of a 39-kD integral membrane glycoprotein as part of a putative translocation tunnel

  1989cited by this paper
• A 42K outer-membrane protein is a component of the yeast mitochondrial protein import site

  1989cited by this paper
• Disrupted yeast mitochondria can import precursor proteins directly through their inner membrane

  1989cited by this paper
• A chimeric mitochondrial precursor protein with internal disulfide bridges blocks import of authentic precursors into mitochondria and allows quantitation of import sites

  1988cited by this paper
• Mitochondrial protein import: involvement of the mature part of a cleavable precursor protein in the binding to receptor sites.

  1987cited by this paper
• The amino‐terminal region of an imported mitochondrial precursor polypeptide can direct cytoplasmic dihydrofolate reductase into the mitochondrial matrix.

  1984cited by this paper
• Immunochemical identification of membrane proteins after sodium dodecyl sulfate-polyacrylamide gel electrophoresis.

  1983cited by this paper
• Import of proteins into mitochondria. Cytochrome b2 and cytochrome c peroxidase are located in the intermembrane space of yeast mitochondria.

  1982cited by this paper
• Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum

  1982cited by this paper

• FUNDAMENTALS OF PROTEIN-PROTEIN INTERACTIONS AND THEIR METHODS OF CHARACTERIZATION

  2022cites this paper
• Mapping protein interactions in the active TOM-TIM23 supercomplex

  2021cites this paper
• ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.

  2021cites this paper
• Cancer-Related Increases and Decreases in Calcium Signaling at the Endoplasmic Reticulum-Mitochondria Interface (MAMs).

  2020cites this paper
• How to get to the other side of the mitochondrial inner membrane – the protein import motor

  2020cites this paper
• From TOM to the TIM23 complex – handing over of a precursor

  2020cites this paper
• Is a New Component of the Tim 54 p-Tim 22 p Translocon in the Mitochondrial Inner Membrane

  2019cites this paper
• Alterations in Ca2+ Signalling via ER-Mitochondria Contact Site Remodelling in Cancer.

  2017cites this paper
• Dual interaction of scaffold protein Tim44 of mitochondrial import motor with channel-forming translocase subunit Tim23

  2017cites this paper
• An antimicrobial origin of transit peptides accounts for early endosymbiotic events

  2016cites this paper
• The evolution and function of co-chaperones in mitochondria.

  2015cites this paper
• Dissertation zur Erlangung des Doktorgrades der Fakultät für Chemie und Pharmazie der Ludwig-Maximilians-Universität München Functional characterization of MCJ in the protein import into human mitochondria

  2014cites this paper
• Multiple interactions of components mediating preprotein translocation across the inner mitochondrial membrane 1996

  2013cites this paper
• Mortalin - a multipotent chaperone regulating cellular processes ranging from viral infection to neurodegeneration.

  2013cites this paper
• Mortalin, Apoptosis, and Neurodegeneration

  2012cites this paper
• UNIVERSIDADE FEDERAL DE SANTA MARIA CENTRO CIÊNCIAS NATURAIS E EXATAS PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS BIOLÓGICAS: BIOQUIMICA TOXICOLÓGICA

  2012cites this paper
• Structural insight into the mitochondrial protein import system.

  2011cites this paper
• Direct Interaction of Mitochondrial Targeting Presequences with Purified Components of the TIM23 Protein Complex*

  2011cites this paper
• Understanding the molecular mechanism of protein translocation across the mitochondrial inner membrane: still a long way to go.

  2011cites this paper
• The many faces of the mitochondrial TIM23 complex.

  2010cites this paper
• New insights into the mechanism of precursor protein insertion into the mitochondrial membranes.

  2008cites this paper
• 15 - The Role of the TIM23 Complex and Its Associated Motor Complex in Mitochondrial Protein Import

  2007cites this paper
• UvA-DARE ( Digital Academic Repository ) Protein import into yeast mitochondria

  2007cites this paper
• Association of the Tim14·Tim16 Subcomplex with the TIM23 Translocase Is Crucial for Function of the Mitochondrial Protein Import Motor*

  2007cites this paper
• The evolution and function of co-chaperones in mitochondria

  2007cites this paper
• neue Komponenten der TIM22 Präproteintranslokase von Mitochondrien

  2004cites this paper
• Import of Proteins into Mitochondria

  2004cites this paper
• Regulated interactions of mtHsp70 with Tim44 at the translocon in the mitochondrial inner membrane

  2004cites this paper
• Regulated Cycling of Mitochondrial Hsp70 at the Protein Import Channel

  2003cites this paper
• Probing the membrane topology of a subunit of the mitochondrial protein translocase, Tim44, with biotin maleimide.

  2002cites this paper
• Protein import into and across the mitochondrial inner membrane: role of the TIM23 and TIM22 translocons.

  2002cites this paper
• Molecular chaperones as essential mediators of mitochondrial biogenesis.

  2002cites this paper
• The protein import motor of mitochondria

  2002cites this paper
• Untersuchungen zur Charakterisierung der Zusammensetzung, Biogenese und des Mechanismus der Proteintranslokase der mitochondrialen Außenmembran von Neurospora crassa

  2002cites this paper
• Translocation and Insertion of Precursor Proteins into Isolated Outer Membranes of Mitochondria

  2002cites this paper
• Translocation of Proteins into Mitochondria

  2002cites this paper
• Mitochondrial protein import machinery and targeting information

  2002cites this paper
• Protein Translocation into Mitochondria

  2001cites this paper
• The Mitochondrial Import Machinery for Preproteins

  2001cites this paper
• Transport of proteins into mitochondria.

  2001cites this paper
• Analysis of the Association of Proteins with Membranes

  2000cites this paper
• Protein translocation pathways of the mitochondrion

  2000cites this paper
• Two Intermembrane Space Tim Complexes Interact with Different Domains of Tim23p during Its Import into Mitochondria

  2000cites this paper
• Tim18p is a new component of the Tim54p-Tim22p translocon in the mitochondrial inner membrane.

  2000cites this paper
• Biogenesis of the yeast frataxin homolog Yfh1p. Tim44-dependent transfer to mtHsp70 facilitates folding of newly imported proteins in mitochondria.

  2000cites this paper
• The Protein Import Machinery of the Mitochondrial Membranes

  2000cites this paper
• Use and Applications of Subtractive Antibody Screening

  2000cites this paper
• MCC and PSC, the Putative Protein Import Channels of Mitochondria

  2000cites this paper
• Funktionelle Charakterisierung des Imports des ADP/ATP-Carriers über die TIM22-Translokase der mitochondrialen Innenmembran

  2000cites this paper
• Mechanisms of mitochondrial protein import.

  2000influential citation
• The Lipopolysaccharide-activated Toll-like Receptor (TLR)-4 Induces Synthesis of the Closely Related Receptor TLR-2 in Adipocytes*

  2000cites this paper
• Mechanisms of protein translocation into mitochondria.

  1999cites this paper
• Predominant expression of the mitochondrial dicarboxylate carrier in white adipose tissue.

  1999cites this paper
• The TIM17·23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix

  1999cites this paper
• A Multisubunit Complex of Outer and Inner Mitochondrial Membrane Protein Translocases Stabilized in Vivo by Translocation Intermediates*

  1999cites this paper
• The preprotein translocase of the mitochondrial inner membrane: function and evolution.

  1999cites this paper
• The J-related Segment of Tim44 Is Essential for Cell Viability: A Mutant Tim44 Remains in the Mitochondrial Import Site, but Inefficiently Recruits mtHsp70 and Impairs Protein Translocation

  1999cites this paper
• Characterization of the initial steps of precursor import into rat liver mitoplasts.

  1998cites this paper
• Characterization of mammalian translocase of inner mitochondrial membrane (Tim44) isolated from diabetic newborn mouse kidney.

  1998cites this paper
• Separation of structural and dynamic functions of the mitochondrial translocase: Tim44 is crucial for the inner membrane import sites in translocation of tightly folded domains, but not of loosely folded preproteins

  1998influential citation
• Specific Inhibitors of p38 Mitogen-activated Protein Kinase Block 3T3-L1 Adipogenesis*

  1998cites this paper
• Tim23p contains separate and distinct signals for targeting to mitochondria and insertion into the inner membrane.

  1998cites this paper
• The ATP-driven protein translocation-motor of mitochondria

  1998cites this paper
• Characterization of the Mitochondrial Inner Membrane Translocase Complex: the Tim23p Hydrophobic Domain Interacts with Tim17p but Not with Other Tim23p Molecules

  1998cites this paper
• The role of molecular chaperones in mitochondrial protein import and folding.

  1997cites this paper
• In vivo zippering of inner and outer mitochondrial membranes by a stable translocation intermediate.

  1997cites this paper
• Reconstitution of the protein insertion machinery of the mitochondrial inner membrane

  1997cites this paper
• N-terminal Hydrophobic Sorting Signals of Preproteins Confer Mitochondrial hsp70 Independence for Import into Mitochondria*

  1997cites this paper
• The Tim54p–Tim22p Complex Mediates Insertion of Proteins into the Mitochondrial Inner Membrane

  1997influential citation
• Multiple interactions of components mediating preprotein translocation across the inner mitochondrial membrane

  1997cites this paper
• Protein import into mitochondria.

  1997cites this paper
• Tim23, a Protein Import Component of the Mitochondrial Inner Membrane, Is Required for Normal Activity of the Multiple Conductance Channel, MCC

  1997cites this paper
• Mitochondrial preprotein translocase.

  1997cites this paper
• Molecular Chaperones and Mitochondrial Protein Folding

  1997cites this paper
• The Mitochondrial Protein Import Pathway: Are Precursors Imported through Membrane Channels?

  1997cites this paper
• Translocation of preproteins across the mitochondrial inner membrane: TIMs and HSP70

  1996cites this paper
• PROTEIN TARGETING AND TRANSLOCATION; A COMPARATIVE SURVEY

  1996cites this paper
• Translocation arrest of an intramitochondrial sorting signal next to Tim11 at the inner-membrane import site

  1996cites this paper
• The Mas20p and Mas70p subunits of the protein import receptor of yeast mitochondria interact via the tetratricopeptide repeat motif in Mas20p: evidence for a single hetero‐oligomeric receptor.

  1996cites this paper
• Influence of the Mature Portion of a Precursor Protein on the Mitochondrial Signal Sequence*

  1996cites this paper
• Protein Import Across the Inner Mitochondrial Membrane

  1996cites this paper
• Uniform nomenclature for the protein transport machinery of the mitochondrial membranes.

  1996cites this paper
• Internal targeting signal of the BCS1 protein: a novel mechanism of import into mitochondria.

  1996cites this paper
• Sorting of Proteins to the Mitochondrial Intermembrane Space

  1996cites this paper
• Chapter 33 Protein transport across the outer and inner membranes of mitochondria

  1996cites this paper
• Unraveling the Protein Translocation Machinery in the Mitochondrial Inner Membrane

  1996cites this paper
• Differential requirement for the mitochondrial Hsp70‐Tim44 complex in unfolding and translocation of preproteins.

  1996cites this paper
• Molecular Mechanisms of Protein Translocation into and Across the Mitochondrial Outer Membrane

  1996cites this paper
• Functional and physical interactions of components of the yeast mitochondrial inner-membrane import machinery (MIM).

  1995cites this paper
• The Yeast Mitochondrial Protein Import Receptor Mas20p Binds Precursor Proteins through Electrostatic Interaction with the Positively Charged Presequence (*)

  1995cites this paper
• An intact protein translocating machinery is required for mitochondrial import of a yeast cytoplasmic tRNA.

  1995cites this paper
• Genetic and biochemical dissection of the mitochondrial protein-import machinery

  1995cites this paper
• Mas37p, a novel receptor subunit for protein import into mitochondria

  1995cites this paper
• The MIM complex mediates preprotein translocation across the mitochondrial inner membrane and couples it to the mt-Hsp70/ATP driving system.

  1995cites this paper
• Protein-protein interactions: methods for detection and analysis

  1995cites this paper
• Identification of protein-receptor components required for the import of prealdehyde dehydrogenase into rat liver mitochondria.

  1995cites this paper
• Cyclophilin 20 is involved in mitochondrial protein folding in cooperation with molecular chaperones Hsp70 and Hsp60

  1995cites this paper
• Conservative sorting of F0‐ATPase subunit 9: export from matrix requires delta pH across inner membrane and matrix ATP.

  1995cites this paper
• Analysis of mitochondrial protein import pathway in Saccharomyces cerevisiae with translocation intermediates.

  1995cites this paper
• Molecular chaperones and intracellular protein translocation.

  1995cites this paper