Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Experimental Cell Research

• Publication date

  2003-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0014-4827(03)00140-XPMID 12799193
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Overexpression of c-Myc Alters G1/S Arrest following Ionizing Radiation

  2002cited by this paper
• Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair

  2002cited by this paper
• Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

  2001cited by this paper
• Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential.

  2001cited by this paper
• Pathways governing G1/S transition and their response to DNA damage

  2001cited by this paper
• Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions.

  2001cited by this paper
• Distinct Functional Domains of Nibrin Mediate Mre11 Binding, Focus Formation, and Nuclear Localization

  2001cited by this paper
• The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity.

  2001cited by this paper
• An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

  2001cited by this paper
• Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit.

  2001cited by this paper
• Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

  2000cited by this paper
• Ectopic Human Telomerase Catalytic Subunit Expression Maintains Telomere Length But Is Not Sufficient for CD8+ T Lymphocyte Immortalization1

  2000cited by this paper
• Human Keratinocytes That Express hTERT and Also Bypass a p16INK4a-Enforced Mechanism That Limits Life Span Become Immortal yet Retain Normal Growth and Differentiation Characteristics

  2000cited by this paper
• Long-term cultured IL-2-dependent T cell lines demonstrate p16(INK4a) overexpression, normal pRb/p53, and upregulation of cyclins E or D2.

  2000cited by this paper
• Cancer: New link in a web of human genes

  2000cited by this paper
• Immortalization of Human CD8+ T Cell Clones by Ectopic Expression of Telomerase Reverse Transcriptase1

  2000cited by this paper
• Cell biology: Risky immortalization by telomerase

  2000cited by this paper
• Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres.

  2000cited by this paper
• Ovarian cancer cells that coexpress endogenous Rb and p16 are insensitive to overexpression of functional p16 protein

  2000cited by this paper
• NBS1 and TRF1 Colocalize at Promyelocytic Leukemia Bodies during Late S/G2 Phases in Immortalized Telomerase-negative Cells

  2000cited by this paper
• The Forkhead-associated Domain of NBS1 Is Essential for Nuclear Foci Formation after Irradiation but Not Essential for hRAD50·hMRE11·NBS1 Complex DNA Repair Activity*

  2000cited by this paper
• Loss of functional pRB is not a ubiquitous feature of B-cell malignancies

  1999cited by this paper
• Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation

  1999cited by this paper
• Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex.

  1999cited by this paper
• Wild-type p53 can induce p21 and apoptosis in neuroblastoma cells but the DNA damage-induced G1 checkpoint function is attenuated.

  1999cited by this paper
• Gene amplification and overexpression of CDK4 in sporadic breast carcinomas is associated with high tumor cell proliferation.

  1999cited by this paper
• Nijmegen breakage syndrome: consequences of defective DNA double strand break repair

  1999cited by this paper
• The mammalian Mre11-Rad50-nbs1 protein complex: integration of functions in the cellular DNA-damage response.

  1999cited by this paper
• Direct activation of TERT transcription by c-MYC

  1999cited by this paper
• Control of Replicative Life Span in Human Cells: Barriers to Clonal Expansion Intermediate Between M1 Senescence and M2 Crisis

  1999cited by this paper
• Reconsideration of senescence, immortalization and telomere maintenance of Epstein-Barr virus-transformed human B-lymphoblastoid cell lines.

  1999cited by this paper
• Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells

  1998cited by this paper
• Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome.

  1998cited by this paper
• The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.

  1998cited by this paper
• Disruption of the cyclin D/cyclin-dependent kinase/INK4/retinoblastoma protein regulatory pathway in human neuroblastoma.

  1998cited by this paper
• Changes in telomerase activity and telomere length during human T lymphocyte senescence.

  1997cited by this paper
• hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks

  1997cited by this paper
• The gene for the ataxia-telangiectasia variant, Nijmegen breakage syndrome, maps to a 1-cM interval on chromosome 8q21.

  1997cited by this paper
• Genetic mapping using microcell-mediated chromosome transfer suggests a locus for Nijmegen breakage syndrome at chromosome 8q21-24.

  1997cited by this paper
• Early supernatants of mitogen-stimulated mononuclear cells promote long-term IL-2-dependent growth of human T lymphocytes.

  1996cited by this paper
• Cyclin E, a redundant cyclin in breast cancer.

  1996cited by this paper
• Nijmegen breakage syndrome.

  1996cited by this paper
• Early supernatants of mitogen-stimulated mononuclear cells promote long-term IL-2-dependent growth of human T lymphocytes.

  1996cited by this paper
• Mechanism of telomerase induction during T cell activation.

  1996cited by this paper
• Overexpression of cyclin D2 in chronic B-cell malignancies.

  1995cited by this paper
• Immunohistochemical detection of the cyclin-dependent kinase inhibitor 2/multiple tumor suppressor gene 1 (CDKN2/MTS1) product p16INK4A in archival human solid tumors: correlation with retinoblastoma protein expression.

  1995cited by this paper
• Eleven Polish patients with microcephaly, immunodeficiency, and chromosomal instability: the Nijmegen breakage syndrome.

  1995cited by this paper
• Absence of radiation-induced G1 arrest in two closely related human lymphoblast cell lines that differ in p53 status

  1995cited by this paper
• Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines.

  1995cited by this paper
• Telomere shortening in renal cell carcinoma.

  1994cited by this paper
• CDK4 amplification is an alternative mechanism to p16 gene homozygous deletion in glioma cell lines.

  1994cited by this paper
• Characterization of clone-specific rearrangement T-cell receptor gamma-chain genes in lymphomas and leukemias by the polymerase chain reaction and DNA sequencing.

  1994cited by this paper
• Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

  1992cited by this paper
• A role for both RB and p53 in the regulation of human cellular senescence.

  1991cited by this paper
• Long-term growth of human WGA-activated T-lymphocytes without feeder cells.

  1989cited by this paper
• A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis.

  1983cited by this paper

• Telomere attrition and dysfunction: a potential trigger of the progeroid phenotype in nijmegen breakage syndrome

  2020cites this paper
• Nijmegen Breakage Syndrome (NBS) is a Telomeropathy: Analysis of Telomere Length in NBS Homo- and Heterozygotes and Humanized Nbs Mice

  2019cites this paper
• Immortalization of T-Cells Is Accompanied by Gradual Changes in CpG Methylation Resulting in a Profile Resembling a Subset of T-Cell Leukemias123

  2014cites this paper
• The Role of Nibrin in Doxorubicin-Induced Apoptosis and Cell Senescence in Nijmegen Breakage Syndrome Patients Lymphocytes

  2014cites this paper
• Nijmegen breakage syndrome fibroblasts expressing the C-terminal truncated NBNp70 protein undergo p38/MK2-dependent premature senescence

  2014cites this paper
• Telomerase and primary T cells: biology and immortalization for adoptive immunotherapy.

  2011cites this paper
• Signalling pathways in renal cell carcinoma with a focus on telomerase regulation

  2010cites this paper
• Telomerase upregulation is a postcrisis event during senescence bypass and immortalization of two Nijmegen breakage syndrome T cell cultures

  2010cites this paper
• Spontaneously immortalized T lymphocytes from Nijmegen Breakage Syndrome patients display phenotypes typical for lymphoma cells.

  2008cites this paper
• Critical Involvement of the ATM-Dependent DNA Damage Response in the Apoptotic Demise of HIV-1-Elicited Syncytia

  2008cites this paper
• Extreme variation in apoptosis capacity amongst lymphoid cells of Nijmegen breakage syndrome patients.

  2008cites this paper
• Untersuchungen zur Apoptoseinduktion in lymphoblastoiden Zellen von Patienten mit Nijmegen-Breakage-Syndrom

  2006cites this paper
• The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control

  2006cites this paper
• The role of interleukin-2 receptor alpha in cancer.

  2005cites this paper
• NBS1 knockdown by small interfering RNA increases ionizing radiation mutagenesis and telomere association in human cells.

  2005cites this paper
• Familial (inherited) leukemia, lymphoma, and myeloma: an overview.

  2004cites this paper
• Spontaneously immortalized human T lymphocytes develop gain of chromosomal region 2p13–24 as an early and common genetic event

  2004influential citation
• Anti-Aging Medicine LiteratureWatch

  2003cites this paper