Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Oncogene

• Publication date

  1999-02-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1202669PMID 10022128
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Myc activates telomerase.

  1998influential reference
• Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas

  1998cited by this paper
• Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells

  1998cited by this paper
• Extension of life-span by introduction of telomerase into normal human cells.

  1998cited by this paper
• Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation

  1998cited by this paper
• Tankyrase, a poly(ADP-ribose) polymerase at human telomeres.

  1998cited by this paper
• Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span.

  1998cited by this paper
• Telomerase catalytic subunit homologs from fission yeast and human.

  1997influential reference
• Myc target genes.

  1997cited by this paper
• hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization.

  1997influential reference
• Control of telomere length by the human telomeric protein TRF1

  1997cited by this paper
• Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.

  1997influential reference
• Human telomerase contains evolutionarily conserved catalytic and structural subunits.

  1997cited by this paper
• Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

  1997influential reference
• Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition

  1997cited by this paper
• Myc represses the growth arrest gene gadd45

  1997cited by this paper
• Myc represses transcription of the growth arrest gene gas1.

  1997cited by this paper
• Telomerase activity in human leukemic cell lines is inhibited by antisense pentadecadeoxynucleotides targeted against c-myc mRNA.

  1997cited by this paper
• Control of telomere length by the human telomeric protein TRF1

  1997cited by this paper
• Cdc25 cell-cycle phosphatase as a target of c-myc

  1996cited by this paper
• Myc‐Max heterodimers activate a DEAD box gene and interact with multiple E box‐related sites in vivo.

  1996cited by this paper
• Telomerase activation by the E6 gene product of human papillomavirus type 16

  1996cited by this paper
• Mechanism of telomerase induction during T cell activation.

  1996cited by this paper
• Correlating telomerase activity levels with human neuroblastoma outcomes

  1995influential reference
• A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins.

  1995cited by this paper
• Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?

  1995cited by this paper
• Specific association of human telomerase activity with immortal cells and cancer.

  1994cited by this paper
• c-Myc induces the expression and activity of ornithine decarboxylase.

  1993cited by this paper
• The ornithine decarboxylase gene is a transcriptional target of c-Myc.

  1993cited by this paper
• Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

  1992cited by this paper
• MYB and MYC in the cell cycle.

  1991cited by this paper
• The MYC protein activates transcription of the alpha‐prothymosin gene.

  1991cited by this paper
• Telomeres shorten during ageing of human fibroblasts

  1990cited by this paper
• Telomere reduction in human colorectal carcinoma and with ageing

  1990cited by this paper
• Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

  1989cited by this paper
• Expression of a transfected human c-myconcogene inhibits differentiation of a mouse erythroleukaemia cell line

  1986influential reference
• Sequential expression of protooncogenes during lectin-stimulated mitogenesis of normal human lymphocytes.

  1986cited by this paper
• Expression of c-myc changes during differentiation of mouse erythroleukaemia cells

  1984cited by this paper
• Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

  1983cited by this paper

• Telomere length as a predictor of therapy response and survival in patients diagnosed with ovarian carcinoma

  2024cites this paper
• Telomere Reprogramming and Cellular Metabolism: Is There a Link?

  2024cites this paper
• Iron-(Fe3+)-Dependent Reactivation of Telomerase Drives Colorectal Cancers

  2024cites this paper
• Lectins as a promising therapeutic agent for breast cancer: A review

  2024cites this paper
• Recent advances in anti-tumor therapeutic approaches for the universally active transcriptional factor c-MYC

  2024cites this paper
• InTERTwined: how TERT promoter mutations impact BRAFV600E-driven thyroid cancers.

  2023cites this paper
• Telomerase reactivation induces progression of mouse BrafV600E-driven thyroid cancers without telomere lengthening

  2023cites this paper
• NIPSNAP1 directs dual mechanisms to restrain senescence in cancer cells

  2023cites this paper
• Targeting telomerase utilizing zeolitic imidazole frameworks as non-viral gene delivery agents across different cancer cell types.

  2023cites this paper
• Telomerase upregulation induces progression of mouse BrafV600E-driven thyroid cancers and triggers non-telomeric effects.

  2023cites this paper
• TERT Promoter Mutations Frequency Across Race, Sex, and Cancer Type

  2023cites this paper
• Strategies for immortalisation of amnion‐derived mesenchymal and epithelial cells

  2022cites this paper
• How Do Telomere Abnormalities Regulate the Biology of Neuroblastoma?

  2021cites this paper
• Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation

  2021cites this paper
• Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes

  2021cites this paper
• Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation

  2021cites this paper
• Multiple ETS Factors Participate in the Transcriptional Control of TERT Mutant Promoter in Thyroid Cancers

  2021cites this paper
• Aloe emodin inhibits telomerase activity in breast cancer cells: transcriptional and enzymological mechanism

  2020cites this paper
• Role of DNA Methylation and CpG Sites in the Viral Telomerase RNA Promoter during Gallid Herpesvirus 2 Pathogenesis

  2020cites this paper
• Assessment of telomerase as drug target in breast cancer

  2020cites this paper
• Regulation of human telomerase in homeostasis and disease

  2020cites this paper
• Inferring Telomerase Enzymatic Activity from Expression Data

  2020cites this paper
• Pt(II) and Au(III) complexes containing Schiff-base ligands: A promising source for antitumor treatment.

  2020cites this paper
• Telomeres and Telomerase in the Development of Liver Cancer

  2020cites this paper
• TERT promotor region rearrangements analyzed in high-risk neuroblastomas by FISH method and whole genome sequencing

  2020cites this paper
• Assessment of telomerase as drug target in breast cancer

  2020cites this paper
• Centromere and telomere dynamics in humans

  2020cites this paper
• c‐Myc controls the fate of neural progenitor cells during cerebral cortex development

  2020cites this paper
• Telomeres in Liver Cancer

  2020cites this paper
• Discriminating association of a common telomerase reverse transcriptase promoter polymorphism with telomere parameters in non-small cell lung cancer with or without epidermal growth factor receptor mutation.

  2019cites this paper
• Non-canonical Roles of Telomerase: Unraveling the Imbroglio

  2019cites this paper
• Expression of hTERT in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma – an Immunohistochemical Analysis

  2019cites this paper
• The Bromodomain Inhibitor JQ1 Enhances the Responses to All-trans Retinoic Acid in HL-60 and MV4-11 Leukemia Cells

  2018cites this paper
• MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer

  2018cites this paper
• Chaperones and Their Role in Telomerase Ribonucleoprotein Biogenesis and Telomere Maintenance

  2018cites this paper
• PINX1 and TERT Are Required for TNF-α–Induced Airway Smooth Muscle Chemokine Gene Expression

  2018cites this paper
• Genoprotective Effects of Thai Royal Jelly against Doxorubicin in Human Lymphocytes in Vitro

  2018cites this paper
• Cancer telomeres and white crows.

  2018cites this paper
• Structure and biological properties of five Pt(II) complexes as potential anticancer agents.

  2018cites this paper
• Study of telomerase reverse transcriptase and uterine-ovarian-specific genes expression in the endometrial tissue of ovariectomized female Sprague-Dawley rats.

  2018cites this paper
• Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in mice dependent on c‐Myc expression

  2017cites this paper
• Transdifferentiation in Turritopsis dohrnii (Immortal Jellyfish): Model System for Regeneration, Cellular Plasticity and Aging

  2017cites this paper
• Indole-3-carbinol induces apoptosis of chronic myelogenous leukemia cells through suppression of STAT5 and Akt signaling pathways

  2017cites this paper
• TERT biology and function in cancer: beyond immortalisation.

  2017cites this paper
• Hallmarks of glycosylation in cancer

  2016cites this paper
• Telomeres and telomerase in head and neck squamous cell carcinoma: from pathogenesis to clinical implications

  2016cites this paper
• New prospects for targeting telomerase beyond the telomere

  2016cites this paper
• Urinary Phthalates and Leukocyte Telomere Length: An Analysis of NHANES 1999–2002

  2016cites this paper
• Telomere biology including TERT rearrangements in neuroblastoma: a useful indicator for surgical treatments.

  2016cites this paper
• Telomerase in hematologic malignancies

  2016cites this paper
• ELL targets c-Myc for proteasomal degradation and suppresses tumour growth

  2016influential citation
• PinX1: structure, regulation and its functions in cancer

  2016cites this paper
• Functional Studies of the Human Telomerase Holoenzyme

  2016cites this paper
• Targeting Myc-driven tumours - BETing on ATR

  2016cites this paper
• An interaction proteomics survey of transcription factor binding at recurrent TERT promoter mutations

  2016cites this paper
• Polo-like Kinase 1 (Plk1) Up-regulates Telomerase Activity by Affecting Human Telomerase Reverse Transcriptase (hTERT) Stability*

  2015cites this paper
• Human telomerase inhibitors from microbial source

  2015cites this paper
• Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis.

  2015cites this paper
• Human telomerase inhibitors from microbial source

  2015cites this paper
• Polychlorinated Biphenyls and Leukocyte Telomere Length: An Analysis of NHANES 1999–2002

  2015cites this paper
• TERT abrogate

  2015cites this paper
• Cancer-associated TERT promoter mutations abrogate telomerase silencing

  2015cites this paper
• Identification and characterization of pathogenetically relevant genes in mature aggressive B-cell lymphomas of childhood by a combination of genomic and functional analyses

  2015cites this paper
• Acidified bile acids increase hTERT expression via c-myc activation in human gastric cancer cells.

  2015cites this paper
• Plk1 upregulates telomerase activity by affecting hTERT stability

  2015influential citation
• Bmi-1: At the crossroads of physiological and pathological biology

  2015cites this paper
• Contribution of Sp1 to Telomerase Expression and Activity in Skin Keratinocytes Cultured With a Feeder Layer

  2015cites this paper
• Stabilization of G-quadruplex DNA, inhibition of telomerase activity, and tumor cell apoptosis by organoplatinum(II) complexes with oxoisoaporphine.

  2015cites this paper
• Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblastic leukemia cells

  2015cites this paper
• V-Myc Immortalizes Human Neural Stem Cells in the Absence of Pluripotency-Associated Traits

  2015cites this paper
• Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity.

  2015cites this paper
• Saccharomyces cerevisiae as a model for the study of extranuclear functions of mammalian telomerase

  2015cites this paper
• Regulation of viral and host genomes by high risk human papillomavirus E2 protein in association with cellular factors

  2015cites this paper
• Dual roles of c-Myc in the regulation of hTERT gene

  2014cites this paper
• Tumor Cell Development: A Role for Viruses and Telomerase Activity?

  2014cites this paper
• Potential Effect of Bovine Colostrum on Tongue Mucosa in Ovariectomized Rats

  2014cites this paper
• Telomerase reverse transcriptase promoter mutations in tumors originating from the adrenal gland and extra-adrenal paraganglia.

  2014cites this paper
• An agent-based model of cancer stem cell initiated avascular tumour growth and metastasis: the effect of seeding frequency and location

  2014cites this paper
• E2F1 acts as a negative feedback regulator of c-Myc‑induced hTERT transcription during tumorigenesis.

  2014cites this paper
• High‐risk human papillomavirus infection associated with telomere elongation in patients with esophageal squamous cell carcinoma with poor prognosis

  2014cites this paper
• WRAP 53 promotes cancer cell survival and is a potential target for cancer therapy

  2014cites this paper
• hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness

  2014cites this paper
• Consequences of telomerase inhibition and telomere dysfunction in BRCA1 mutant cancer cells

  2014cites this paper
• The 58-kda microspherule protein (MSP58) represses human telomerase reverse transcriptase (hTERT) gene expression and cell proliferation by interacting with telomerase transcriptional element-interacting factor (TEIF).

  2014cites this paper
• Oncogenic Pathways and Molecular Prognostics in Neuroblastoma

  2013cites this paper
• Core breast cancer-associated molecules: The Essence

  2013cites this paper
• Genetic Profiling: Searching for Novel Genetic Aberrations in Glioblastoma

  2013cites this paper
• Conditionally immortalized stem cell lines from human spinal cord retain regional identity and generate functional V2a interneurons and motorneurons

  2013cites this paper
• Telomerase: central regulator of all of the hallmarks of cancer.

  2013cites this paper
• snoRNPs Regulate Telomerase Activity in Neuroblastoma and Are Associated with Poor Prognosis.

  2013cites this paper
• Telomere biology and translational research.

  2013cites this paper
• The Effectiveness of Cucurbitacin B in BRCA1 Defective Breast Cancer Cells

  2013cites this paper
• CITED2 is a novel direct effector of peroxisome proliferator‐activated receptor γ in suppressing hepatocellular carcinoma cell growth

  2013cites this paper
• hTERT: another brick in the wall of cancer cells.

  2013cites this paper
• An unbiased in vivo screen reveals multiple transcription factors that control HPV E6-regulated hTERT in keratinocytes.

  2013cites this paper
• Mitochondrial localisation of hTERT protects against nuclear DNA damage and mitochondrial ROS production after endogenous and exogenous stress

  2013cites this paper
• The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype

  2013cites this paper
• Telomeres: Their Structure and Maintenance

  2013cites this paper
• The MAPK Pathway Signals Telomerase Modulation in Response to Isothiocyanate-Induced DNA Damage of Human Liver Cancer Cells

  2013cites this paper
• Chromatin dynamics at the hTERT promoter during transcriptional activation and repression by c-Myc and Mnt in Xenopus leavis oocytes.

  2013cites this paper