Myc activates telomerase.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Genes & Development

• Publication date

  1998-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/GAD.12.12.1769PMID 9637678PMCID PMC316904
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Extension of life-span by introduction of telomerase into normal human cells.

  1998cited by this paper
• Telomerase activity, cell proliferation, and cancer.

  1998cited by this paper
• hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization.

  1997cited by this paper
• Control of telomere length by the human telomeric protein TRF1

  1997cited by this paper
• Transactivation of Prothymosin α and c-mycPromoters by Human Papillomavirus Type 16 E6 Protein

  1997cited by this paper
• Telomerase activity in human endometrium.

  1997cited by this paper
• Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

  1997cited by this paper
• Telomere dynamics and telomerase activity in in vitro immortalised human cells.

  1997cited by this paper
• Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

  1997cited by this paper
• A survey of telomerase activity in human cancer.

  1997cited by this paper
• Myc target genes.

  1997cited by this paper
• Control of telomere length by the human telomeric protein TRF1

  1997cited by this paper
• Multiple pathways for the regulation of telomerase activity.

  1997cited by this paper
• Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

  1997cited by this paper
• Telomerase catalytic subunit homologs from fission yeast and human.

  1997cited by this paper
• Transactivation of prothymosin alpha and c-myc promoters by human papillomavirus type 16 E6 protein.

  1997cited by this paper
• Human telomerase contains evolutionarily conserved catalytic and structural subunits.

  1997cited by this paper
• Telomerase activation by the E6 gene product of human papillomavirus type 16

  1996influential reference
• Telomerase activity in human germline and embryonic tissues and cells.

  1996cited by this paper
• Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines

  1996cited by this paper
• Telomerase activity in human cancer.

  1996cited by this paper
• Spontaneous in vitro immortalization of breast epithelial cells from a patient with Li-Fraumeni syndrome

  1995cited by this paper
• A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

  1995cited by this paper
• Correlating telomerase activity levels with human neuroblastoma outcomes

  1995cited by this paper
• Origins of G1 arrest in senescent human fibroblasts

  1995cited by this paper
• Telomerase activity in normal and malignant hematopoietic cells.

  1995cited by this paper
• Specific association of human telomerase activity with immortal cells and cancer.

  1994cited by this paper
• Overexpression of plasminogen activator inhibitor type‐1 in senescent fibroblasts from normal subjects and those with Werner syndrome

  1994cited by this paper
• Telomerase activity in human ovarian carcinoma.

  1994cited by this paper
• TLC1: template RNA component of Saccharomyces cerevisiae telomerase.

  1994cited by this paper
• E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts.

  1993cited by this paper
• Temporal relationships between induced changes in c-myc mRNA abundance, proliferation, and differentiation in HL60 cells.

  1992cited by this paper
• Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

  1992cited by this paper
• Telomere loss: mitotic clock or genetic time bomb?

  1991cited by this paper
• Telomeres shorten during ageing of human fibroblasts

  1990cited by this paper
• Telomere reduction in human colorectal carcinoma and with ageing

  1990cited by this paper
• Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line.

  1990cited by this paper
• Immunocytochemical study of ras and myc proto-oncogene polypeptide expression in the human menstrual cycle.

  1989cited by this paper
• Antibodies: A Laboratory Manual

  1988cited by this paper
• Mitogenic activation of normal T cells leads to increased initiation of transcription in the c-myc locus.

  1988cited by this paper
• myc oncogenes: activation and amplification.

  1987cited by this paper
• Induction of c-myc expression in human B lymphocytes by B-cell growth factor and anti-immunoglobulin.

  1986cited by this paper
• A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon.

  1973cited by this paper
• Origin of Concatemeric T7DNA

  1972cited by this paper
• Origin of concatemeric T7 DNA.

  1972cited by this paper
• Sugar and Disease

  1972cited by this paper

• Metastasis and chemoresistance in breast cancer: Crucial function of ZEB1/2 proteins.

  2025cites this paper
• Activation of Kv11.1 potassium channel suppresses non-small cell lung cancer growth by promoting c-Myc degradation

  2025cites this paper
• Aurora B inhibition induces polyploidy and mitotic catastrophe in HER2-amplified breast cancer: Telomere shortening as a potential anticancer mechanism of AZD1152-HQPA.

  2025cites this paper
• Telomeres and telomerase in mesothelioma: Pathophysiology, biomarkers and emerging therapeutic strategies (Review)

  2025cites this paper
• Comparison of primary and passaged tumor cell cultures and their application in personalized medicine

  2024cites this paper
• Molecular Prospective on Malignant Transformation of Mesenchymal Stem Cells: An Issue in Cell Therapy

  2024cites this paper
• Exploring Myc puzzle: Insights into cancer, stem cell biology, and PPI networks.

  2024cites this paper
• Recent advances in anti-tumor therapeutic approaches for the universally active transcriptional factor c-MYC

  2024cites this paper
• Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression

  2024cites this paper
• The SIRT1-c-Myc axis in regulation of stem cells

  2023cites this paper
• Interactions between the DNA Damage Response and the Telomere Complex in Carcinogenesis: A Hypothesis

  2023cites this paper
• Telomeres: Dysfunction, Maintenance, Aging and Cancer

  2023cites this paper
• Combining old and new concepts in targeting telomerase for cancer therapy: transient, immediate, complete and combinatory attack (TICCA)

  2023cites this paper
• Ethacrynic Acid: A Promising Candidate for Drug Repurposing as an Anticancer Agent

  2023cites this paper
• Strategies for immortalisation of amnion‐derived mesenchymal and epithelial cells

  2022cites this paper
• Establishment methods and research progress of livestock and poultry immortalized cell lines: A review

  2022cites this paper
• Telomerase: a good target in hepatocellular carcinoma? An overview of relevant preclinical data

  2022cites this paper
• Bioinformatics network analyses of growth differentiation factor 11

  2022cites this paper
• Identification of human MHC-I HPV18 E6/E7-specific CD8 + T cell epitopes and generation of an HPV18 E6/E7-expressing adenosquamous carcinoma in HLA-A2 transgenic mice

  2022cites this paper
• Connecting telomere maintenance and regulation to the developmental origin and differentiation states of neuroblastoma tumor cells

  2022cites this paper
• The Molecular Interplay between Human Oncoviruses and Telomerase in Cancer Development

  2022influential citation
• Generation and characterization of genome-modified chondrocyte-like cells from the zebra finch cell line immortalized by c-MYC expression

  2022cites this paper
• A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle

  2022cites this paper
• Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation

  2021cites this paper
• The regulatory function of tandem repeat VNTR2‐1 in hTERT gene involves basic Helix–loop–helix family transcription factors

  2021cites this paper
• Engineering L7Ae for RNA-Only Delivery Kill Switch Targeting CMS2 Type Colorectal Cancer Cells.

  2021cites this paper
• Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation

  2021cites this paper
• Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7–Expressing Carcinoma in the Cervicovaginal Tract

  2021cites this paper
• Telomeres: history, health, and hallmarks of aging.

  2021cites this paper
• Prognostic Alternative Splicing Signatures in Esophageal Carcinoma

  2021cites this paper
• The telomere complex and the origin of the cancer stem cell

  2021cites this paper
• Ovarian Telomerase and Female Fertility

  2021cites this paper
• Telomere Signaling and Maintenance Pathways in Spermatozoa of Infertile Men Treated With Antioxidants: An in silico Approach Using Bioinformatic Analysis

  2021cites this paper
• Inferring Telomerase Enzymatic Activity from Expression Data

  2020cites this paper
• Impact of Ovarian Aging in Reproduction: From Telomeres and Mice Models to Ovarian Rejuvenation

  2020cites this paper
• Poly(U) binding splicing factor 60 promotes renal cell carcinoma growth by transcriptionally upregulating telomerase reverse transcriptase

  2020cites this paper
• Role of DNA Methylation and CpG Sites in the Viral Telomerase RNA Promoter during Gallid Herpesvirus 2 Pathogenesis

  2020cites this paper
• The cellular senescence unification model and telomerase therapy: To treat all age-related diseases

  2020cites this paper
• Telomere-related Markers for Cancer

  2020cites this paper
• Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target

  2020cites this paper
• Telomeres and Telomerase in the Development of Liver Cancer

  2020cites this paper
• Thrombospondin-1 in Maladaptive Aging Responses: A Concept Whose Time Has Come.

  2020cites this paper
• Bioinformatics Network Analyses of Growth Differentiation Factor 11 Anti-aging Study

  2020cites this paper
• Wnts and the hallmarks of cancer

  2020cites this paper
• c‐Myc promotes lymphatic metastasis of pancreatic neuroendocrine tumor through VEGFC upregulation

  2020cites this paper
• Telomerase reverse transcriptase promoter mutations in thyroid carcinomas: implications in precision oncology—a narrative review

  2020cites this paper
• A multiscale agent-based model of ductal carcinoma in situ

  2019cites this paper
• Targeting of MKRNI for identifying cancer treatment agents

  2019cites this paper
• Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players

  2019cites this paper
• Effects of Telomerase Activation

  2019cites this paper
• DNA demethylation with 5-aza-2'-deoxycytidine induces the senescence-associated secretory phenotype in the immortal fish cell line, EPC.

  2019cites this paper
• The Quest for Immortality: Introducing Metadichol® a Novel Telomerase Activator

  2019cites this paper
• MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer

  2018cites this paper
• ZEB1 stimulates breast cancer growth by up-regulating hTERT expression.

  2018cites this paper
• Chaperones and Their Role in Telomerase Ribonucleoprotein Biogenesis and Telomere Maintenance

  2018cites this paper
• O-GlcNAcylation: key regulator of glycolytic pathways

  2018cites this paper
• Deducing Immortality

  2018cites this paper
• Induction of apoptosis via proteasome inhibition in leukemia/lymphoma cells by two potent piperidones

  2018cites this paper
• Understanding Ductal Carcinoma In Situ Invasion using a Multiscale Agent-Based Model*

  2018cites this paper
• Molecular Pathology of High-Grade Prostatic Intraepithelial Neoplasia: Challenges and Opportunities.

  2018cites this paper
• Low p16INK4a Expression in Early Passage Human Prostate Basal Epithelial Cells Enables Immortalization by Telomerase Expression Alone

  2017cites this paper
• A history of embryonic stem cell research: Concepts, laboratory work, and contexts

  2017cites this paper
• Direct HPV E6/Myc interactions induce histone modifications, Pol II phosphorylation, and hTERT promoter activation

  2017cites this paper
• Epigenetic silencing of miR-296 and miR-512 ensures hTERT dependent apoptosis protection and telomere maintenance in basal-type breast cancer cells

  2017cites this paper
• Functional dissection of breast cancer risk-associated TERT promoter variants

  2017cites this paper
• TERT promoter status and gene copy number gains: effect on TERT expression and association with prognosis in breast cancer

  2017cites this paper
• Telomerase Regulation from Beginning to the End

  2016cites this paper
• The role of telomeres and telomerase reverse transcriptase isoforms in pluripotency induction and maintenance

  2016cites this paper
• Stabilization of c-myc G-Quadruplex DNA, inhibition of telomerase activity, disruption of mitochondrial functions and tumor cell apoptosis by platinum(II) complex with 9-amino-oxoisoaporphine.

  2016cites this paper
• Regulation of the Telomerase Reverse Transcriptase Subunit through Epigenetic Mechanisms

  2016cites this paper
• One-step immortalization of primary human airway epithelial cells capable of oncogenic transformation

  2016cites this paper
• MUC1-C drives MYC in multiple myeloma.

  2016cites this paper
• Synthesis, crystal structure, cytotoxicity and action mechanism of Zn(II) and Mn(II) complexes with 4-([2,2′:6′,2′′-terpyridin]-4′-yl)-N,N-diethylaniline as a ligand

  2016cites this paper
• Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence

  2016cites this paper
• Hsp90-binding immunophilin FKBP52 modulates telomerase activity by promoting the cytoplasmic retrotransport of hTERT.

  2016cites this paper
• Alkyne-substituted diminazene as G-quadruplex binders with anticancer activities.

  2016cites this paper
• Hallmarks of glycosylation in cancer

  2016cites this paper
• LYMPHOID NEOPLASIA MUC 1-C drives MYC in multiple myeloma

  2016cites this paper
• Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas.

  2016cites this paper
• Effects of polychlorinated biphenyls (PCBs) on telomere maintenance in hematopoietic stem cells and progenitor cells

  2015cites this paper
• LymphomiRs: microRNAs with regulatory roles in lymphomas

  2015cites this paper
• Disruptive chemicals, senescence and immortality

  2015cites this paper
• ROLE OF TELOMERES IN CAUSING CANCER AND TARGETING TELOMERASE IN TREATMENT OF CANCER AS BETTER THAN CONVENTIONAL THERAPY

  2015cites this paper
• Identification and characterization of pathogenetically relevant genes in mature aggressive B-cell lymphomas of childhood by a combination of genomic and functional analyses

  2015cites this paper
• Disruptive chemicals, senescence and immortality.

  2015cites this paper
• Polo-like Kinase 1 (Plk1) Up-regulates Telomerase Activity by Affecting Human Telomerase Reverse Transcriptase (hTERT) Stability*

  2015cites this paper
• PinX1 serves as a potential prognostic indicator for clear cell renal cell carcinoma and inhibits its invasion and metastasis by suppressing MMP-2 via NF-κB-dependent transcription

  2015cites this paper
• Myc and cell cycle control.

  2015cites this paper
• Investigating telomerase regulation in human breast cancer cells: a search for telomerase repressor sequences localised to chromosome 3P

  2015cites this paper
• Plk1 upregulates telomerase activity by affecting hTERT stability

  2015influential citation
• Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity.

  2015cites this paper
• Akt-mediated phosphorylation increases the binding affinity of hTERT for importin α to promote nuclear translocation

  2015cites this paper
• Compositions, procedes, et utilisations associees a des fusions ntrk2-tert

  2015cites this paper
• Senescence in Oncogenesis: From Molecular Mechanisms to Therapeutic Opportunities

  2015cites this paper
• Contribution of Sp1 to Telomerase Expression and Activity in Skin Keratinocytes Cultured With a Feeder Layer

  2015cites this paper
• Neoplasia of the gastrointestinal tract

  2015cites this paper
• Therapeutic targeting of replicative immortality

  2015cites this paper
• Telomere biology: Rationale for diagnostics and therapeutics in cancer

  2015cites this paper
• Stabilization of G-quadruplex DNA, inhibition of telomerase activity, and tumor cell apoptosis by organoplatinum(II) complexes with oxoisoaporphine.

  2015cites this paper
• Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming

  2015cites this paper