β1 integrin targeting potentiates antiangiogenic therapy and inhibits the growth of bevacizumab-resistant glioblastoma.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Cancer Research

• Publication date

  2013-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-13-0011PMID 23644530PMCID PMC4040366
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gene Expression Profile Identifies Tyrosine Kinase c-Met as a Targetable Mediator of Antiangiogenic Therapy Resistance

  2013cited by this paper
• Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma.

  2012cited by this paper
• Integrins in tumor angiogenesis and lymphangiogenesis.

  2012cited by this paper
• The tumor microenvironment modulates tamoxifen resistance in breast cancer: a role for soluble stromal factors and fibronectin through β1 integrin

  2012cited by this paper
• Integrin α5β1 plays a critical role in resistance to temozolomide by interfering with the p53 pathway in high-grade glioma.

  2012cited by this paper
• Microarray Analysis Verifies Two Distinct Phenotypes of Glioblastomas Resistant to Antiangiogenic Therapy

  2012cited by this paper
• The hypoxia-associated factor switches cells from HIF-1α- to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion.

  2011cited by this paper
• Glioblastoma angiogenesis and tumor cell invasiveness are differentially regulated by β8 integrin.

  2011cited by this paper
• β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib

  2011cited by this paper
• Is surgery at progression a prognostic marker for improved 6-month progression-free survival or overall survival for patients with recurrent glioblastoma?

  2011cited by this paper
• Acidic stress promotes a glioma stem cell phenotype

  2011influential reference
• Knockdown of the β1 integrin subunit reduces primary tumor growth and inhibits pancreatic cancer metastasis

  2011cited by this paper
• Integrins in cancer: biological implications and therapeutic opportunities

  2010cited by this paper
• Integrins in cancer: biological implications and therapeutic opportunities

  2010cited by this paper
• Therapy and prophylaxis of brain metastases

  2010cited by this paper
• Tumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and mice

  2010cited by this paper
• Mechanisms of resistance to antiangiogenesis therapy.

  2010cited by this paper
• The Vascular Basement Membrane as “Soil” in Brain Metastasis

  2009influential reference
• Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma.

  2009cited by this paper
• Beta1-integrin circumvents the antiproliferative effects of trastuzumab in human epidermal growth factor receptor-2-positive breast cancer.

  2009cited by this paper
• Environment-mediated drug resistance: a major contributor to minimal residual disease

  2009cited by this paper
• Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts.

  2008cited by this paper
• Combination therapy of an anticancer drug with the FNIII14 peptide of fibronectin effectively overcomes cell adhesion-mediated drug resistance of acute myelogenous leukemia

  2008cited by this paper
• Quantification of integrin receptor agonism by fluorescence lifetime imaging

  2008cited by this paper
• Cilengitide: an integrin-targeting arginine–glycine–aspartic acid peptide with promising activity for glioblastoma multiforme

  2008cited by this paper
• Modes of resistance to anti-angiogenic therapy

  2008cited by this paper
• Cilengitide: an integrin-targeting arginine-glycine-aspartic acid peptide with promising activity for glioblastoma multiforme.

  2008cited by this paper
• In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro

  2007cited by this paper
• Phase II Trial of Bevacizumab and Irinotecan in Recurrent Malignant Glioma

  2007cited by this paper
• Analysis of integrin dynamics by fluorescence recovery after photobleaching.

  2007cited by this paper
• beta1 integrin as a molecular therapeutic target

  2007cited by this paper
• Changes in laminin isoforms associated with brain tumor invasion and angiogenesis.

  2006cited by this paper
• Integrins: Molecular targets in cancer therapy

  2006cited by this paper
• Migration of Perilesional Microglia after Focal Brain Injury and Modulation by CC Chemokine Receptor 5: An In Situ Time-Lapse Confocal Imaging Study

  2005cited by this paper
• Molecular aspects of epithelial cell plasticity: implications for local tumor invasion and metastasis.

  2004cited by this paper
• Association between laminin‐8 and glial tumor grade, recurrence, and patient survival

  2004cited by this paper
• High Expression of Integrin β1 and p53 is a Greater Poor Prognostic Factor Than Clinical Stage in Small-Cell Lung Cancer

  2004cited by this paper
• Antiangiogenic Therapy of Cerebral Melanoma Metastases Results in Sustained Tumor Progression via Vessel Co-Option

  2004cited by this paper
• Role of the tumor microenvironment in mediating de novo resistance to drugs and physiological mediators of cell death

  2003cited by this paper
• Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide.

  2002cited by this paper
• Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells

  2001cited by this paper
• Integrin-Mediated Drug Resistance in Multiple Myeloma

  2000cited by this paper
• Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin.

  2000cited by this paper
• Regulation of Angiogenesis in Vivo by Ligation of Integrin α5β1 with the Central Cell-Binding Domain of Fibronectin

  2000cited by this paper
• Adhesion to fibronectin via β1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR)

  2000cited by this paper
• Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo

  1999cited by this paper
• Alpha v beta 1 is a receptor for vitronectin and fibrinogen, and acts with alpha 5 beta 1 to mediate spreading on fibronectin.

  1995cited by this paper
• Convection-enhanced distribution of large molecules in gray matter during interstitial drug infusion.

  1995cited by this paper

• ESM1 SUMOylation mediates bevacizumab resistance in ovarian cancer through ITGB1-FAK-driven angiogenesis.

  2026cites this paper
• ITGB1 Regulates Triple-Negative Breast Cancer Development by Modulating the Tumor Microenvironment.

  2026cites this paper
• Targeting angiogenesis in cancer therapy: lessons learned and paths forward.

  2025cites this paper
• Gamma-synuclein drives bevacizumab resistance in colorectal cancer via VEGFR2 activation and angiogenesis.

  2025cites this paper
• Identification of dynamic network biomarker ITGB1 for erlotinib pre-resistance using single-cell differential covariance entropy

  2025cites this paper
• Targeting focal adhesion kinase inhibits cell migration and non-angiogenic vascularization in malignant breast cancer

  2025cites this paper
• Integrins as Key Mediators of Metastasis

  2025cites this paper
• Accessing the vasculature in cancer: revising an old hallmark.

  2024cites this paper
• A new perspective on antiangiogenic antibody drug resistance: Biomarkers, mechanisms, and strategies in malignancies

  2024cites this paper
• Postoperative radiotherapy with docetaxel versus cisplatin for high-risk oral squamous cell carcinoma: a randomized phase II trial with exploratory analysis of ITGB1 as a potential predictive biomarker

  2024cites this paper
• Targeting drug resistance in glioblastoma (Review)

  2024cites this paper
• Understanding the Role of Endothelial Cells in Glioblastoma: Mechanisms and Novel Treatments

  2024cites this paper
• Identification of the biological functions and chemo-therapeutic responses of ITGB superfamily in ovarian cancer

  2024cites this paper
• Mechanisms of angiogenesis in tumour

  2024cites this paper
• Prognostic Role of Invasion-Related Extracellular Matrix Molecules in Diffusely Infiltrating Grade 2 and 3 Astrocytomas

  2024cites this paper
• Exploring Extracellular Vesicle Surface Protein Markers Produced by Glioblastoma Tumors: A Characterization Study Using In Vitro 3D Patient-Derived Cultures

  2024cites this paper
• Integrinβ-1 in disorders and cancers: molecular mechanisms and therapeutic targets

  2024cites this paper
• HIF-1A as a prognostic biomarker related to invasion, migration and immunosuppression of cervical cancer

  2024cites this paper
• The Inhibition of Vessel Co-Option as an Emerging Strategy for Cancer Therapy

  2024cites this paper
• THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancer

  2024cites this paper
• The Breast Cancer Single-Cell Atlas: Defining cellular heterogeneity within model cell lines and primary tumors to inform disease subtype, stemness, and treatment options

  2023cites this paper
• Novel Systemic Approaches for the Management of Meningiomas: Immunotherapy and Targeted Therapies.

  2023cites this paper
• Redox signaling in drug-tolerant persister cells as an emerging therapeutic target

  2023cites this paper
• Glial Cell Adhesion Molecule (GlialCAM) Determines Proliferative versus Invasive Cell States in Glioblastoma

  2023cites this paper
• Targeting fatty acid oxidation via Acyl-CoA binding protein hinders glioblastoma invasion

  2023cites this paper
• A novel navigated doxorubicin delivery formulation to breast cancer therapy

  2022cites this paper
• High beta integrin expression is differentially associated with worsened pancreatic ductal adenocarcinoma outcomes.

  2022cites this paper
• Combination of Quercetin or/and siRNA-loaded DDAB-mPEG-PCL hybrid nanoparticles reverse resistance to Regorafenib in colon cancer cells

  2022cites this paper
• A Signaling Crosstalk Links SNAIL to the 37/67 kDa Laminin-1 Receptor Ribosomal Protein SA and Regulates the Acquisition of a Cancer Stem Cell Molecular Signature in U87 Glioblastoma Neurospheres

  2022cites this paper
• Medical Device Advances in the Treatment of Glioblastoma

  2022cites this paper
• An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family

  2022influential citation
• HepaCAM Suppresses Glioblastoma Stem Cell Invasion in the Brain

  2022cites this paper
• Integrin β1 in Pancreatic Cancer: Expressions, Functions, and Clinical Implications

  2022cites this paper
• Nanotherapeutic treatment of the invasive glioblastoma tumor microenvironment.

  2022cites this paper
• The complex relationship between integrins and oncolytic herpes Simplex Virus 1 in high-grade glioma therapeutics

  2022influential citation
• Chemotherapy as a regulator of extracellular matrix-cell communication: implications in therapy resistance.

  2022cites this paper
• Temozolomide-Acquired Resistance Is Associated with Modulation of the Integrin Repertoire in Glioblastoma, Impact of α5β1 Integrin

  2022cites this paper
• Interactions Between Anti-Angiogenic Therapy and Immunotherapy in Glioblastoma

  2022cites this paper
• Opportunities and Challenges of Nanoparticles in Digestive Tumours as Anti-Angiogenic Therapies

  2022cites this paper
• Integrin α10-Antibodies Reduce Glioblastoma Tumor Growth and Cell Migration

  2021cites this paper
• The Current State of Oncolytic Herpes Simplex Virus for Glioblastoma Treatment

  2021cites this paper
• Macrophage–stroma interactions in fibrosis: biochemical, biophysical, and cellular perspectives

  2021cites this paper
• Lamellipodin-RICTOR Signaling Mediates Glioblastoma Cell Invasion and Radiosensitivity Downstream of EGFR

  2021cites this paper
• The emerging roles of circular RNAs in vessel co-option and vasculogenic mimicry: clinical insights for anti-angiogenic therapy in cancers

  2021cites this paper
• Distinct Cell Adhesion Signature Defines Glioblastoma Myeloid-Derived Suppressor Cell Subsets

  2021influential citation
• α4β1 and αMβ2 Integrin Expression and Pro-Proliferative Properties of Eosinophil Subtypes in Asthma

  2021cites this paper
• Expression Analysis of α5 Integrin Subunit Reveals Its Upregulation as a Negative Prognostic Biomarker for Glioblastoma

  2021cites this paper
• Association between chronic periodontitis and the risk of Alzheimer’s disease: combination of text mining and GEO dataset

  2021cites this paper
• S1431927621012393jra 1192..1201

  2021cites this paper
• LncRNA SOCS2-AS1 promotes the progression of glioma via regulating ITGB1 expression.

  2021cites this paper
• P76RBE silencing inhibits ovarian cancer cell proliferation, migration, and invasion via suppressing the integrin β1/NF-κB pathway

  2021cites this paper
• OV_A_268426 1..27

  2021cites this paper
• Therapeutic Application of Brain-Specific Angiogenesis Inhibitor 1 for Cancer Therapy

  2021cites this paper
• ME2 Promotes Proneural–Mesenchymal Transition and Lipogenesis in Glioblastoma

  2021cites this paper
• Multiple strategies to improve the therapeutic efficacy of oncolytic herpes simplex virus in the treatment of glioblastoma.

  2021cites this paper
• ITGB1 enhances the Radioresistance of human Non-small Cell Lung Cancer Cells by modulating the DNA damage response and YAP1-induced Epithelial-mesenchymal Transition

  2021cites this paper
• Apoptosis induction by siRNA targeting integrin-β1 and regorafenib/DDAB-mPEG-PCL hybrid nanoparticles in regorafenib-resistant colon cancer cells.

  2021cites this paper
• Overview on the Different Patterns of Tumor Vascularization

  2021cites this paper
• Tanshinone IIA Suppresses Glioma Cell Proliferation, Migration and Invasion Both in vitro and in vivo Partially Through miR-16-5p/Talin-1 (TLN1) Axis

  2020cites this paper
• Involvement of Integrin-Activating Peptides Derived from Tenascin-C in Cancer Aggression and New Anticancer Strategy Using the Fibronectin-Derived Integrin-Inactivating Peptide

  2020cites this paper
• Endpoint in ovarian cancer xenograft model predicted by nighttime motion metrics

  2020cites this paper
• Dual inhibition of VEGF and PARP suppresses KRAS-mutant colorectal cancer

  2020cites this paper
• Clonal ZEB1-Driven Mesenchymal Transition Promotes Targetable Oncologic Antiangiogenic Therapy Resistance

  2020cites this paper
• Resistance Mechanisms to Anti-angiogenic Therapies in Cancer

  2020cites this paper
• Vascular co-option

  2020cites this paper
• Resistance to Anti-angiogenic Therapies: A Mechanism Depending on the Time of Exposure to the Drugs

  2020cites this paper
• Transforming growth factor-β mimics the key proteome properties of CD133- differentiated and CD133+ cancer stem cells in glioblastoma.

  2020cites this paper
• A mode of cell adhesion and migration facilitated by CD44-dependent microtentacles

  2020cites this paper
• A Chinese Herbal Formula Suppresses Colorectal Cancer Migration and Vasculogenic Mimicry Through ROS/HIF-1α/MMP2 Pathway in Hypoxic Microenvironment

  2020cites this paper
• Plaučių vėžio imunologiniai mechanizmai

  2020cites this paper
• Convection-Enhanced Delivery of a First-in-Class Anti-β1 Integrin Antibody for the Treatment of High-Grade Glioma Utilizing Real-Time Imaging

  2020influential citation
• Clinical Development of an Anti- β1 Integrin Antibody for the Treatment of High-Grade Glioma via Convection Enhanced Delivery

  2020cites this paper
• The role of eosinophilopoietins and integrins on eosinophils biology in asthma

  2020cites this paper
• Integrin-Src-YAP1 signaling mediates the melanoma acquired resistance to MAPK and PI3K/mTOR dual targeted therapy

  2020cites this paper
• Vascular co‐option and vasculogenic mimicry mediate resistance to antiangiogenic strategies

  2020cites this paper
• Cadherins, Selectins, and Integrins in CAM-DR in Leukemia

  2020cites this paper
• Tumor Microenvironment Conditions that Favor Vessel Co-option in Colorectal Cancer Liver Metastases: A Theoretical Model.

  2020cites this paper
• Vessel co-option and resistance to anti-angiogenic therapy

  2019cites this paper
• Vessel co-option in cancer

  2019cites this paper
• Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance.

  2019cites this paper
• Enhancing Therapeutic Efficacy of Oncolytic Herpes Simplex Virus-1 with Integrin β1 Blocking Antibody OS2966

  2019cites this paper
• Role of Integrins in Resistance to Therapies Targeting Growth Factor Receptors in Cancer

  2019influential citation
• Mechanisms behind Temsirolimus Resistance Causing Reactivated Growth and Invasive Behavior of Bladder Cancer Cells In Vitro

  2019cites this paper
• Autocrine Production of PDGF Stimulated by the Tenascin-C-Derived Peptide TNIIIA2 Induces Hyper-Proliferation in Glioblastoma Cells

  2019cites this paper
• A Monoclonal Antibody Against β1 Integrin Inhibits Proliferation and Increases Survival in an Orthotopic Model of High-Grade Meningioma

  2019cites this paper
• Rechallenging Recurrent Glioblastoma with Intra-Arterial Bevacizumab with Blood Brain Barrier Disruption Results in Radiographic Response: a Case Report.

  2019cites this paper
• Dissecting and rebuilding the glioblastoma microenvironment with engineered materials

  2019cites this paper
• Collective cancer invasion forms an integrin-dependent radioresistant niche

  2019cites this paper
• Extracellular matrix-cell interactions: Focus on therapeutic applications.

  2019cites this paper
• Tumor Progression–Pseudoprogression

  2019cites this paper
• Integrin β1 regulates the invasion and radioresistance of laryngeal cancer cells by targeting CD147

  2018cites this paper
• A 3D Topographical Model of Parenchymal Infiltration and Perivascular Invasion in Glioblastoma

  2018cites this paper
• β1-Integrin Impacts Rad51 Stability and DNA Double-Strand Break Repair by Homologous Recombination

  2018cites this paper
• NFκB activation in differentiating glioblastoma stem-like cells is promoted by hyaluronic acid signaling through TLR4

  2018cites this paper
• Resistance to Anti-Angiogenic Therapy in Cancer—Alterations to Anti-VEGF Pathway

  2018cites this paper
• SNRK (Sucrose Nonfermenting 1-Related Kinase) Promotes Angiogenesis In Vivo

  2018cites this paper
• Integrins in wound healing, fibrosis and tumor stroma: High potential targets for therapeutics and drug delivery

  2018cites this paper
• Whole exome sequencing identifies mTOR and KEAP1 as potential targets for radiosensitization of HNSCC cells refractory to EGFR and β1 integrin inhibition

  2018cites this paper
• Les cellules initiatrices de tumeurs à l'origine de l'hétérogénéité d'expression de l'intégrine α5β1 dans les glioblastomes

  2018cites this paper
• A novel xenograft model reveals invasive mesenchymal transition and ineffective angiogenic response during anti-angiogenic therapy resistance

  2018cites this paper