Improving metabolome coverage and data quality: advancing metabolomics and lipidomics for biomarker discovery.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Chemical Communications

• Publication date

  2018-06-19

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1039/c8cc02592dPMID 29888773
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Application of mass spectrometry-based metabolomics approaches for food 1 safety, quality and traceability.

  2020cited by this paper
• Adding a new separation dimension to MS and LC-MS: What is the utility of ion mobility spectrometry?

  2018cited by this paper
• Integrating bioinformatics approaches for a comprehensive interpretation of metabolomics datasets.

  2018cited by this paper
• Evaluating lipid mediator structural complexity using ion mobility spectrometry combined with mass spectrometry.

  2018cited by this paper
• Globotriaosylsphingosine (Lyso-Gb3) as a biomarker for cardiac variant (N215S) Fabry disease

  2018cited by this paper
• Objective Metabolomics Research.

  2018cited by this paper
• Two complementary reversed-phase separations for comprehensive coverage of the semipolar and nonpolar metabolome

  2018cited by this paper
• Advances in Solid Phase Microextraction and Perspective on Future Directions.

  2018cited by this paper
• Mass spectrometry in untargeted liquid chromatography/mass spectrometry metabolomics: Electrospray ionisation parameters and global coverage of the metabolome.

  2018cited by this paper
• Improving negative liquid chromatography/electrospray ionization mass spectrometry lipidomic analysis of human plasma using acetic acid as a mobile-phase additive.

  2018cited by this paper
• Long-Term Stability of Human Plasma Metabolites during Storage at -80 °C.

  2018cited by this paper
• The combination of four analytical methods to explore skeletal muscle metabolomics: Better coverage of metabolic pathways or a marketing argument?

  2018cited by this paper
• Liquid chromatography - high resolution mass spectrometry method for monitoring of 17 mycotoxins in human plasma for exposure studies.

  2018cited by this paper
• Annotation: A Computational Solution for Streamlining Metabolomics Analysis.

  2018cited by this paper
• METLIN: A Technology Platform for Identifying Knowns and Unknowns.

  2018cited by this paper
• Quality assurance procedures for mass spectrometry untargeted metabolomics. a review

  2018cited by this paper
• A review of nanoscale LC-ESI for metabolomics and its potential to enhance the metabolome coverage.

  2018cited by this paper
• Isotope-labeling derivatization with 3-nitrophenylhydrazine for LC/multiple-reaction monitoring-mass-spectrometry-based quantitation of carnitines in dried blood spots.

  2018cited by this paper
• Strategies to assess and optimize stability of endogenous amines during cerebrospinal fluid sampling

  2018cited by this paper
• LipidQC: Method Validation Tool for Visual Comparison to SRM 1950 Using NIST Interlaboratory Comparison Exercise Lipid Consensus Mean Estimate Values.

  2017cited by this paper
• Metabolomic analysis of oxidative stress: Superoxide dismutase mutation and paraquat induced stress in Drosophila melanogaster

  2017cited by this paper
• In vivo microsampling to capture the elusive exposome

  2017cited by this paper
• Off-line mixed-mode liquid chromatography coupled with reversed phase high performance liquid chromatography-high resolution mass spectrometry to improve coverage in lipidomics analysis.

  2017cited by this paper
• Analytes related to erythrocyte metabolism are reliable biomarkers for preanalytical error due to delayed plasma processing in metabolomics studies.

  2017cited by this paper
• Tuning Metabolome Coverage in Reversed Phase LC-MS Metabolomics of MeOH Extracted Samples Using the Reconstitution Solvent Composition.

  2017cited by this paper
• Assessment of metabolic phenotypic variability in children’s urine using 1H NMR spectroscopy

  2017cited by this paper
• NMR metabolomics highlights sphingosine kinase‐1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells

  2017cited by this paper
• Interlaboratory Reproducibility of a Targeted Metabolomics Platform for Analysis of Human Serum and Plasma.

  2017cited by this paper
• HMDB 4.0: the human metabolome database for 2018

  2017cited by this paper
• Validating Quantitative Untargeted Lipidomics Across Nine Liquid Chromatography-High-Resolution Mass Spectrometry Platforms.

  2017cited by this paper
• Plant Metabolomics: Maximizing Metabolome Coverage by Optimizing Mobile Phase Additives for Nontargeted Mass Spectrometry in Positive and Negative Electrospray Ionization Mode.

  2017cited by this paper
• A review of blood sample handling and pre‐processing for metabolomics studies

  2017cited by this paper
• Mass spectrometric based approaches in urine metabolomics and biomarker discovery.

  2017cited by this paper
• Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950–Metabolites in Frozen Human Plasma[S]

  2017cited by this paper
• Ion mobility spectrometry combined with ultra performance liquid chromatography/mass spectrometry for metabolic phenotyping of urine: Effects of column length, gradient duration and ion mobility spectrometry on metabolite detection

  2017cited by this paper
• Development of High-Performance Chemical Isotope Labeling LC-MS for Profiling the Carbonyl Submetabolome.

  2017cited by this paper
• Expanding Lipidome Coverage Using LC-MS/MS Data-Dependent Acquisition with Automated Exclusion List Generation

  2017cited by this paper
• Recent advances in expanding the coverage of the lipidome

  2017cited by this paper
• LILY-lipidome isotope labeling of yeast: in vivo synthesis of 13C labeled reference lipids for quantification by mass spectrometry.

  2017cited by this paper
• High throughput solid phase microextraction: A new alternative for analysis of cellular lipidome?

  2017cited by this paper
• Systems-Level Annotation of a Metabolomics Data Set Reduces 25 000 Features to Fewer than 1000 Unique Metabolites.

  2017cited by this paper
• Power Analysis and Sample Size Determination in Metabolic Phenotyping.

  2016cited by this paper
• Isotope-coded ESI-enhancing derivatization reagents for differential analysis, quantification and profiling of metabolites in biological samples by LC/MS: A review.

  2016cited by this paper
• Intensive determination of storage condition effects on human plasma metabolomics

  2016cited by this paper
• 'Nothing of chemistry disappears in biology': the Top 30 damage-prone endogenous metabolites.

  2016cited by this paper
• Capturing Plant Metabolome with Direct-Immersion in Vivo Solid Phase Microextraction of Plant Tissues.

  2016cited by this paper
• Metabolomics enables precision medicine: “A White Paper, Community Perspective”

  2016cited by this paper
• Overlap in serum metabolic profiles between non-related diseases: Implications for LC-MS metabolomics biomarker discovery.

  2016cited by this paper
• Analysis of human plasma metabolites across different liquid chromatography/mass spectrometry platforms: Cross-platform transferable chemical signatures.

  2016cited by this paper
• Metabolomics: beyond biomarkers and towards mechanisms

  2016cited by this paper
• Training in metabolomics research. II. Processing and statistical analysis of metabolomics data, metabolite identification, pathway analysis, applications of metabolomics and its future.

  2016cited by this paper
• The use of mass spectrometry for analysing metabolite biomarkers in epidemiology: methodological and statistical considerations for application to large numbers of biological samples

  2016cited by this paper
• Circadian Metabolism: From Mechanisms to Metabolomics and Medicine.

  2016cited by this paper
• Benzoyl chloride derivatization with liquid chromatography-mass spectrometry for targeted metabolomics of neurochemicals in biological samples.

  2016cited by this paper
• Pitfalls in the analysis of the physiological antioxidant glutathione (GSH) and its disulfide (GSSG) in biological samples: An elephant in the room.

  2016cited by this paper
• Metabolomics: Small molecules, single cells

  2016cited by this paper
• Emerging applications of metabolomics in drug discovery and precision medicine

  2016cited by this paper
• The Emerging Role of Metabolomics in the Diagnosis and Prognosis of Cardiovascular Disease.

  2016cited by this paper
• Data analysis strategies for targeted and untargeted LC-MS metabolomic studies: Overview and workflow

  2016cited by this paper
• On the outside looking in: redefining the role of analytical chemistry in the biosciences.

  2016cited by this paper
• Mass spectral databases for LC/MS- and GC/MS-based metabolomics: state of the field and future prospects

  2016cited by this paper
• Interlaboratory analytical comparison of fatty acid concentrations in serum or plasma.

  2016cited by this paper
• Trimethylation Enhancement Using (13)C-Diazomethane ((13)C-TrEnDi): Increased Sensitivity and Selectivity of Phosphatidylethanolamine, Phosphatidylcholine, and Phosphatidylserine Lipids Derived from Complex Biological Samples.

  2016cited by this paper
• Tartrate inhibition of prostatic acid phosphatase improves seminal fluid metabolite stability

  2016cited by this paper
• Enhanced Lipidome Coverage in Shotgun Analyses by using Gas-Phase Fractionation

  2016cited by this paper
• Systematic Assessment of Seven Solvent and Solid-Phase Extraction Methods for Metabolomics Analysis of Human Plasma by LC-MS

  2016cited by this paper
• Evaluation of coverage, retention patterns, and selectivity of seven liquid chromatographic methods for metabolomics

  2016cited by this paper
• Training in metabolomics research. II. Processing and statistical analysis of metabolomics data, metabolite identification, pathway analysis, applications of metabolomics and its future.

  2016cited by this paper
• Chemical Isotope Labeling LC-MS for High Coverage and Quantitative Profiling of the Hydroxyl Submetabolome in Metabolomics.

  2016cited by this paper
• Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy

  2016cited by this paper
• Mapping the Human Platelet Lipidome Reveals Cytosolic Phospholipase A2 as a Regulator of Mitochondrial Bioenergetics during Activation

  2016cited by this paper
• Discovering and validating between-subject variations in plasma lipids in healthy subjects

  2016cited by this paper
• Training in metabolomics research. I. Designing the experiment, collecting and extracting samples and generating metabolomics data.

  2016cited by this paper
• Citrus tristeza virus infection in sweet orange trees and a mandarin × tangor cross alters low molecular weight metabolites assessed using gas chromatography mass spectrometry (GC/MS)

  2016cited by this paper
• The emerging roles of lipids in circadian control.

  2015cited by this paper
• An isotope-labeled chemical derivatization method for the quantitation of short-chain fatty acids in human feces by liquid chromatography-tandem mass spectrometry.

  2015cited by this paper
• Optimizing the lipidomics workflow for clinical studies—practical considerations

  2015cited by this paper
• Complementing reversed-phase selectivity with porous graphitized carbon to increase the metabolome coverage in an on-line two-dimensional LC-MS setup for metabolomics

  2015cited by this paper
• Nanoflow LC-MS for High-Performance Chemical Isotope Labeling Quantitative Metabolomics.

  2015cited by this paper
• Improved data-dependent acquisition for untargeted metabolomics using gas-phase fractionation with staggered mass range.

  2015cited by this paper
• Data standards can boost metabolomics research, and if there is a will, there is a way

  2015cited by this paper
• Stability of energy metabolites—An often overlooked issue in metabolomics studies: A review

  2015cited by this paper
• In vivo solid phase microextraction sampling of human saliva for non-invasive and on-site monitoring.

  2015cited by this paper
• Effects of pre-analytical processes on blood samples used in metabolomics studies

  2015cited by this paper
• DnsID in MyCompoundID for rapid identification of dansylated amine- and phenol-containing metabolites in LC-MS-based metabolomics.

  2015cited by this paper
• In vivo solid-phase microextraction liquid chromatography-tandem mass spectrometry for monitoring blood eicosanoids time profile after lipopolysaccharide-induced inflammation in Sprague-Dawley rats.

  2015cited by this paper
• Optimized Analytical Procedures for the Untargeted Metabolomic Profiling of Human Urine and Plasma by Combining Hydrophilic Interaction (HILIC) and Reverse-Phase Liquid Chromatography (RPLC)–Mass Spectrometry*

  2015cited by this paper
• Metabolic fingerprinting reveals a novel candidate biomarker for prednisolone treatment in cattle

  2015cited by this paper
• Quality markers addressing preanalytical variations of blood and plasma processing identified by broad and targeted metabolite profiling.

  2014cited by this paper
• Can we trust untargeted metabolomics? Results of the metabo-ring initiative, a large-scale, multi-instrument inter-laboratory study

  2014cited by this paper
• Current practice of liquid chromatography-mass spectrometry in metabolomics and metabonomics.

  2014cited by this paper
• Design and analysis of metabolomics studies in epidemiologic research: a primer on -omic technologies.

  2014cited by this paper
• Comprehensive analysis of lipids in biological systems by liquid chromatography-mass spectrometry.

  2014cited by this paper
• A review of peripheral biomarkers in major depression: the potential of inflammatory and oxidative stress biomarkers.

  2014cited by this paper
• Molecular phenotyping of a UK population: defining the human serum metabolome

  2014cited by this paper
• Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects.

  2014cited by this paper
• Targeted Metabolomics Identifies Reliable and Stable Metabolites in Human Serum and Plasma Samples

  2014cited by this paper
• Credentialing Features: A Platform to Benchmark and Optimize Untargeted Metabolomic Methods

  2014cited by this paper
• Quantification of thiols and disulfides.

  2014cited by this paper
• Enhanced detection and identification in metabolomics by use of LC-MS/MS untargeted analysis in combination with gas-phase fractionation.

  2014cited by this paper

• Lithospermic acid, a novel KLK5 inhibitor, ameliorates rosacea by suppressing the TLR4/NF-κB signaling pathway and rectifying phenylalanine metabolism

  2026cites this paper
• Enhanced Structure-guided Molecular Networking Annotation Method for Untargeted Metabolomics Data from Orbitrap Astral Mass Spectrometer.

  2025cites this paper
• Corrigendum to “Simultaneous quantification and natural 13C abundance of fatty acids in breast cancer tissues and serum by GC-C-IRMS for tumor characterization”

  2025cites this paper
• Simultaneous quantification and natural 13C abundance of fatty acids in breast cancer tissues and serum by GC-C-IRMS for tumor characterization

  2025cites this paper
• Optimization of GC-MS run time for untargeted metabolomics: Trade-offs between speed, coverage, and repeatability.

  2025cites this paper
• Fuel stores and time of day account for variation in serum metabolomes of passerine migrants stopping over

  2024cites this paper
• Chemoselectivity Strategy Based on B-Label Integrated with Tailored COF for Targeted Metabolomic Analysis of Short-Chain Fatty Acids by UHPLC-MS/MS.

  2024cites this paper
• Challenges in the Metabolomics-Based Biomarker Validation Pipeline

  2024influential citation
• Enhancing Metabolome Annotation by Electron Impact Excitation of Ions from Organics-Molecular Networking.

  2024cites this paper
• Advancements in Mass Spectrometry-Based Targeted Metabolomics and Lipidomics: Implications for Clinical Research

  2024cites this paper
• Metabolomic insights into the multiple stress responses of metabolites in major oilseed crops.

  2024cites this paper
• Multi-Omics Analysis Identified Drug Repurposing Targets for Chronic Obstructive Pulmonary Disease

  2024cites this paper
• A multi-omics approach reveals the changes in the gut microbiome and metabolism of large yellow croaker (Larimichthys crocea) by dietary supplementation with Bacillus

  2024cites this paper
• Volatile/semi-volatile metabolites profiling in living vegetables via a novel covalent triazine framework based solid-phase microextraction fiber coupled with GC-QTOF-MS.

  2023cites this paper
• Model-driven insights into the effects of temperature on metabolism.

  2023cites this paper
• An epidemiological introduction to human metabolomic investigations.

  2023cites this paper
• A Solid-Phase Microextraction—Liquid Chromatography-Mass Spectrometry Method for Analyzing Serum Lipids in Psoriatic Disease

  2023cites this paper
• Association between abnormal plasma metabolism and brain atrophy in alcohol-dependent patients

  2022cites this paper
• Instrument-type effects on chemical isotope labeling LC-MS metabolome analysis: Quadrupole time-of-flight MS vs. Orbitrap MS.

  2022cites this paper
• Avian metabolomics

  2022cites this paper
• A multi omics approach unravels metagenomic and metabolic alterations of a probiotic in rainbow trout (Oncorhynchus mykiss)

  2021cites this paper
• Reviewing the metabolome coverage provided by LC-MS: Focus on sample preparation and chromatography-A tutorial.

  2021cites this paper
• Hexosylceramides and Glycerophosphatidylcholine GPC(36:1) Increase in Multi-Organ Dysfunction Syndrome Patients with Pediatric Intensive Care Unit Admission over 8-Day Hospitalization

  2021cites this paper
• Untargeted metabolomic analysis in cats with naturally occurring inflammatory bowel disease and alimentary small cell lymphoma

  2021cites this paper
• The Effects of Sampling and Storage Conditions on the Metabolite Profile of the Marine Sponge Geodia barretti

  2021cites this paper
• Ultra-high-performance liquid chromatography high-resolution mass spectrometry variants for metabolomics research

  2021cites this paper
• Use of Blood, Urine or Saliva-based Biomarkers in the Diagnosis of Active Pulmonary Tuberculosis-Sample Type Matters

  2021cites this paper
• Metabolomics Studies in Psoriatic Disease: A Review

  2021influential citation
• Dried Blood Spot (DBS) Methodology Study for Biomarker Discovery in Lysosomal Storage Disease (LSD)

  2021cites this paper
• Simultaneous 3-Nitrophenylhydrazine Derivatization Strategy of Carbonyl, Carboxyl and Phosphoryl Submetabolome for LC-MS/MS-Based Targeted Metabolomics with Improved Sensitivity and Coverage.

  2021cites this paper
• Characterizing Multidevice Capillary Vibrating Sharp-Edge Spray Ionization for In-Droplet Hydrogen/Deuterium Exchange to Enhance Compound Identification

  2021cites this paper
• DBS Methodology Study for Biomarker Discovery in LSD

  2021cites this paper
• A multi-omics approach unravels metagenomic and metabolic alterations of a probiotic and synbiotic additive in rainbow trout (Oncorhynchus mykiss)

  2021cites this paper
• State-of-the-art GC-MS approaches for probing central carbon metabolism

  2021cites this paper
• Simultaneous Analysis of the Metabolome and Lipidome Using Polarity Partition Two-Dimensional Liquid Chromatography-Mass Spectrometry.

  2021cites this paper
• Anion-exchange chromatography mass spectrometry provides extensive coverage of primary metabolic pathways revealing altered metabolism in IDH1 mutant cells

  2020cites this paper
• Biostimulants for Plant Growth and Mitigation of Abiotic Stresses: A Metabolomics Perspective

  2020cites this paper
• Pediatric Multi-Organ Dysfunction Syndrome: Analysis by an Untargeted “Shotgun” Lipidomic Approach Reveals Low-Abundance Plasma Phospholipids and Dynamic Recovery over 8-Day Period, a Single-Center Observational Study

  2020cites this paper
• Metabolic profile of fish muscle tissue changes with sampling method, storage strategy and time.

  2020cites this paper
• Metabolomic Approaches to Study Chemical Exposure-Related Metabolism Alterations in Mammalian Cell Cultures

  2020cites this paper
• Absolute Quantification of the Central Carbon Metabolome in Eight Commonly Applied Prokaryotic and Eukaryotic Model Systems

  2020cites this paper
• Metabolomics applied in the study of emerging arboviruses caused by Aedes aegypti mosquitoes: A review

  2020cites this paper
• An Optimized Dual Extraction Method for the Simultaneous and Accurate Analysis of Polar Metabolites and Lipids Carried out on Single Biological Samples

  2020cites this paper
• Advances in Liquid Chromatography–Mass Spectrometry-Based Lipidomics: A Look Ahead

  2020cites this paper
• Recent developments and applications of solid phase microextraction as a sample preparation approach for mass-spectrometry-based metabolomics and lipidomics

  2019cites this paper
• Monitoring of system conditioning after blank injections in untargeted UPLC-MS metabolomic analysis

  2019cites this paper
• Solid-phase microextraction: An appealing alternative for the determination of endogenous substances - A review.

  2019cites this paper
• Decoding the Metabolome and Lipidome of Child Malnutrition by Mass Spectrometric Techniques: Present Status and Future Perspectives.

  2019cites this paper
• Metabolomic Coverage of Chemical-Group-Submetabolome Analysis: Group Classification and 4-Channel Chemical Isotope Labeling LC-MS.

  2019cites this paper
• Enhancing coverage in LC–MS-based untargeted metabolomics by a new sample preparation procedure using mixed-mode solid-phase extraction and two derivatizations

  2019cites this paper
• Tools and resources for metabolomics research community: A 2017–2018 update

  2018cites this paper
• Analytical method development in liquid chromatography-mass spectrometry based metabolomics

  year unknowncites this paper