Prevalence, incidence, indication, and choice of antidepressants in patients with and without chronic kidney disease: a matched cohort study in UK Clinical Practice Research Datalink

People with chronic kidney disease (CKD) have an increased prevalence of depression, anxiety, and neuropathic pain. We examined prevalence, incidence, indication for, and choice of antidepressants among patients with and without CKD.

• Publication year

  2017

• Venue

  Pharmacoepidemiology and Drug Safety

• Publication date

  2017-04-11

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/pds.4212PMID 28397412PMCID 5516188
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Validity of estimated prevalence of decreased kidney function and renal replacement therapy from primary care electronic health records compared with national survey and registry data in the United Kingdom

  2017cited by this paper
• Prevalence, incidence, indication, and choice of antidepressants in patients with and without chronic kidney disease: a matched cohort study in UK Clinical Practice Research Datalink

  2017cited by this paper
• Timeliness in chronic kidney disease and albuminuria identification: a retrospective cohort study

  2015cited by this paper
• Risk for chronic kidney disease increases with obesity: Health Survey for England 2010

  2015cited by this paper
• National Institute for Health and Care Excellence.

  2015cited by this paper
• Changes in rates of recorded depression in English primary care 2003-2013: Time trend analyses of effects of the economic recession, and the GP contract quality outcomes framework (QOF).

  2015cited by this paper
• Chronic pain and analgesic use in CKD: implications for patient safety.

  2015cited by this paper
• Data Resource Profile: Clinical Practice Research Datalink (CPRD)

  2015cited by this paper
• Predicting risk of upper gastrointestinal bleed and intracranial bleed with anticoagulants: cohort study to derive and validate the QBleed scores

  2014cited by this paper
• Assessment and management

  2014cited by this paper
• Antidepressant prescribing in five European countries: application of common definitions to assess the prevalence, clinical observations, and methodological implications

  2014cited by this paper
• Evidence of prescription of antidepressants for non-psychiatric conditions in primary care: an analysis of guidelines and systematic reviews

  2013cited by this paper
• Prevalence of depression in chronic kidney disease: systematic review and meta-analysis of observational studies.

  2013cited by this paper
• Association of depression and anxiety with reduced quality of life in patients with predialysis chronic kidney disease

  2013cited by this paper
• Chronic kidney disease: global dimension and perspectives

  2013cited by this paper
• Stroke and bleeding in atrial fibrillation with chronic kidney disease.

  2012cited by this paper
• Trends in prescriptions and costs of drugs for mental disorders in England, 1998-2010.

  2012cited by this paper
• Antidepressants for depression in stage 3-5 chronic kidney disease: a systematic review of pharmacokinetics, efficacy and safety with recommendations by European Renal Best Practice (ERBP).

  2012cited by this paper
• Factors associated with depressive symptoms and use of antidepressant medications among participants in the Chronic Renal Insufficiency Cohort (CRIC) and Hispanic-CRIC Studies.

  2012cited by this paper
• A practical approach to the treatment of depression in patients with chronic kidney disease and end-stage renal disease.

  2012cited by this paper
• Association of depression and antidepressant use with mortality in a large cohort of patients with nondialysis-dependent CKD.

  2012cited by this paper
• Recent Trends in the Incidence of Anxiety Diagnoses and Symptoms in Primary Care

  2012cited by this paper
• Commonality between depression and heart failure.

  2012cited by this paper
• Derivation and validation of updated QFracture algorithm to predict risk of osteoporotic fracture in primary care in the United Kingdom: prospective open cohort study

  2012cited by this paper
• Prevalence and factors associated with off-label antidepressant prescriptions for insomnia

  2011cited by this paper
• Antidepressants for depression in physically ill people.

  2010cited by this paper
• National Ambulatory Medical Care Survey: 2007 summary.

  2010cited by this paper
• A new equation to estimate glomerular filtration rate.

  2009cited by this paper
• Recent trends in the incidence of recorded depression in primary care

  2009cited by this paper
• Indications for antidepressant drug prescribing in general practice in the Netherlands.

  2007cited by this paper
• Pain, sleep disturbance, and quality of life in patients with chronic kidney disease.

  2007cited by this paper
• The search for new off-label indications for antidepressant, antianxiety, antipsychotic and anticonvulsant drugs.

  2006cited by this paper
• The exclusion of patients with chronic kidney disease from clinical trials in coronary artery disease.

  2006cited by this paper
• The relationship between time since registration and measured incidence rates in the General Practice Research Database

  2005cited by this paper
• Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.

  2004cited by this paper
• Sertraline treatment of major depression in patients with acute MI or unstable angina.

  2002cited by this paper
• K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification.

  2002cited by this paper
• The prevalence of comorbid depression in adults with diabetes: a meta-analysis.

  2001cited by this paper
• Use of prevalence and incidence measures to describe age-related prescribing of antidepressants with and without anticholinergic effects.

  2000cited by this paper
• Quality of life and psychosocial relationships in patients with chronic renal insufficiency.

  1998cited by this paper
• Transferring the costs of expensive treatments from secondary to primary care

  1995cited by this paper
• Evaluation of amitriptyline pharmacokinetics during peritoneal dialysis.

  1985cited by this paper
• Tricyclic antidepressants and delirium.

  1983cited by this paper
• Cardiotoxicity of amitriptyline.

  1972cited by this paper
• Cardiotoxicity of amitriptyline.

  1972cited by this paper
• Recognition and Management

  1971cited by this paper
• Infestation of the human brain with Coenurus cerebralis in human brain.

  1951cited by this paper

• Psychotropic medication use and risks of kidney injury and fall-related events: a propensity score–matched cohort study

  2026cites this paper
• The role of COPD and inhaled corticosteroids in major adverse cardiovascular events in cardiovascular-kidney-metabolic populations.

  2026cites this paper
• The Paradox of Care: Family Support and Its Complex Role in the Depression and Anxiety Comorbidity Among Older Adults With Chronic Kidney Disease

  2025cites this paper
• Stage at diagnosis and breast cancer-specific mortality in breast cancer patients treated with antidepressants, anxiolytics, and antipsychotics: a population-based cohort study from Northern Ireland

  2025cites this paper
• Mental Health Symptoms and Receipt of Mental Health Care Among US Adults Diagnosed With Kidney Disease

  2025cites this paper
• Depression in chronic kidney disease: particularities, specific mechanisms and therapeutic considerations, a narrative review.

  2025influential citation
• Drugs with a negative impact on cognitive functions (Part 2): drug classes to consider while prescribing in CKD patients

  2023influential citation
• Comparative Safety of Antidepressants in Adults with CKD

  2023cites this paper
• Metabolic Effects of Antidepressants: Results of a Randomized Study’s Interim Analysis

  2023cites this paper
• Kidney function and prescribed dose in middle‐aged and older patients starting selective serotonin reuptake inhibitors

  2022cites this paper
• Incidence of nonvalvular atrial fibrillation and oral anticoagulant prescribing in England, 2009 to 2019: A cohort study

  2022cites this paper
• Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle?

  2021cites this paper
• Multifaceted Sexual Dysfunction in Dialyzing Men and Women: Pathophysiology, Diagnostics, and Therapeutics

  2021cites this paper
• An analysis of antidepressant prescribing trends in England 2015–2019.

  2021cites this paper
• Chronic prescription of antidepressant medication in patients with chronic kidney disease with and without kidney replacement therapy compared with matched controls in the Dutch general population

  2021influential citation
• Atopic Eczema in Adulthood and Risk of Depression and Anxiety: A Population-Based Cohort Study

  2020cites this paper
• The association between chronic kidney disease and tuberculosis; a comparative cohort study in England

  2020cites this paper
• Relationship between Anxiety Score and Erythrocyte Sedimentation Rate (ESR) in Hemodialysis Patient

  2020cites this paper
• Analgesic Use in Patients With Advanced Chronic Kidney Disease: A Systematic Review and Meta-Analysis

  2020cites this paper
• Risk profile, quality of life and care of patients with moderate and advanced CKD: The French CKD-REIN Cohort Study

  2019cites this paper
• Neuropsychiatric Disorders in Chronic Kidney Disease

  2019cites this paper
• Associations between chronic kidney disease and mental health disorders and psychoactive drugs in the UK general population

  2018cites this paper
• Gastrointestinal bleeding risk of selective serotonin reuptake inhibitors by level of kidney function: A population‐based cohort study

  2018cites this paper
• Personalised approaches to antithrombotic therapies : insights from linked electronic health records

  2018cites this paper
• Prevalence, incidence, indication, and choice of antidepressants in patients with and without chronic kidney disease: a matched cohort study in UK Clinical Practice Research Datalink

  2017cites this paper