Cyclic guanosine 3':5'-monophosphate in Escherichia coli and Bacillus lichenformis.

Abstract Cyclic guanosine 3' : 5'-monophosphate (cyclic GMP) has been found in extracts of Escherichia coli K-12 and Bacillus licheniformis A-5. In E. coli, the intracellular concentrations of cyclic GMP, which range from 3 to 35 nm, are approximately 2 orders of magnitude lower than those of cyclic adenosine 3' : 5'-monophosphate (cyclic AMP), and undergo alterations during experimentally altered physiological states that are generally in a direction opposite to those that occur in cyclic AMP. Highest levels of cyclic GMP are present during the early phase of logarithmic growth in glucose-containing media and significantly lower levels are found when cells approach the stationary phase of growth, when proliferation ceases, or when a slower rate of growth is maintained in the presence of succinate instead of glucose as the carbon source. In B. licheniformis extracts, cyclic AMP was not detected. Cyclic GMP concentrations in B. licheniformis, which are approximately 6 nm in exponentially proliferating cells grown with glucose, decrease progressively to minimal levels when growth ceases or when glucose is replaced by glutamate which supports a slower rate of growth. A high level of cyclic GMP reappears in sporulating cells.

• Publication year

  1974

• Venue

  Journal of Biological Chemistry

• Publication date

  1974-07-10

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/s0021-9258(19)42522-2PMID 4368547
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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