Hydrogen peroxide relaxes porcine coronary arteries by stimulating BKCachannel activity.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  American Journal of Physiology. Heart and Circulatory Physiology

• Publication date

  1998-10-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1152/ajpheart.1998.275.4.H1283PMID 9746477
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Redox Modulation of hslo Ca2+-Activated K+ Channels

  1997cited by this paper
• Redox Modulation of hslo Ca 21 -Activated K 1 Channels

  1997cited by this paper
• Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes.

  1997cited by this paper
• Modulation of the ER Ca2+ channel BCC1 from tendrils of Bryonia dioica by divalent cations, protons and H2O2

  1997influential reference
• Hydrogen peroxide activates glibenclamide-sensitive K+ channels in LLC-PK1 cells.

  1997cited by this paper
• Estrogen relaxation of coronary artery smooth muscle is mediated by nitric oxide and cGMP.

  1997cited by this paper
• Mechanisms of bradykinin-induced cerebral vasodilatation in rats. Evidence that reactive oxygen species activate K+ channels.

  1997cited by this paper
• Mechanisms of cerebral vasodilation by superoxide, hydrogen peroxide, and peroxynitrite.

  1996cited by this paper
• H2O2 modulates twitch tension and increases Po of Ca2+ release channel in frog skeletal muscle.

  1996cited by this paper
• Somatostatin stimulates BKCa channels in rat pituitary tumor cells through lipoxygenase metabolites of arachidonic acid.

  1996cited by this paper
• K+ currents in human coronary artery vascular smooth muscle cells.

  1996cited by this paper
• Effects of H2O2 on membrane potential and [Ca2+]i of cultured rat arterial smooth muscle cells.

  1995cited by this paper
• Hydrogen peroxide activation of cytosolic phospholipase A2 in vascular smooth muscle cells.

  1995influential reference
• Hydrogen peroxide-and fetal bovine serum-induced DNA synthesis in vascular smooth muscle cells: positive and negative regulation by protein kinase C isoforms.

  1995cited by this paper
• Hydrogen peroxide contracts human airways in vitro: role of epithelium.

  1995cited by this paper
• The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels

  1995cited by this paper
• H2O2‐induced chloride currents are indicative of an endogenous Na(+)‐Ca2+ exchange mechanism in Xenopus oocytes.

  1995influential reference
• Down-regulation of protein kinase C attenuates the oxidant hydrogen peroxide-mediated activation of phospholipase A2 in pulmonary vascular smooth muscle cells.

  1995cited by this paper
• Estrogen relaxes coronary arteries by opening BKCa channels through a cGMP-dependent mechanism.

  1995influential reference
• Different modulation of Ca-activated K channels by the intracellular redox potential in pulmonary and ear arterial smooth muscle cells of the rabbit

  1995cited by this paper
• Hydrogen peroxide hyperpolarizes rat CA1 pyramidal neurons by inducing an increase in potassium conductance.

  1995cited by this paper
• Tetrahydrobiopterin and dysfunction of endothelial nitric oxide synthase in coronary arteries.

  1995cited by this paper
• H2O2 induced hyperpolarization of pancreatic B-cells

  1994cited by this paper
• Potassium-channel activation in response to low doses of gamma-irradiation involves reactive oxygen intermediates in nonexcitatory cells.

  1993cited by this paper
• Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release: role of protein kinase C.

  1993cited by this paper
• In vivo visualization of oxidative changes in microvessels during neutrophil activation.

  1993cited by this paper
• Role of protein kinase C in oxidant — mediated activation of phospholipase A2 in rabbit pulmonary arterial smooth muscle cells

  1993cited by this paper
• Modulation of K+ channels by hydrogen peroxide.

  1992cited by this paper
• Mechanism of H2O2-induced modulation of airway smooth muscle.

  1992cited by this paper
• Ion channels of vascular smooth muscle cells and endothelial cells

  1991cited by this paper
• Regulation of fast inactivation of cloned mammalian IK(A) channels by cysteine oxidation

  1991cited by this paper
• Hydrogen peroxide: an endogenous smooth muscle cell hyperpolarizing factor.

  1991cited by this paper
• Reactive oxygen species alter contractile properties of pulmonary arterial smooth muscle.

  1990cited by this paper
• Hydrogen peroxide-induced potentiation of contractile responses in isolated rat airways.

  1990cited by this paper
• Effect of hydrogen peroxide on guinea‐pig tracheal smooth muscle in vitro: role of cyclo‐oxygenase and airway epithelium

  1989cited by this paper
• Up- and down-modulation of single K+ channel function by distinct second messengers.

  1988cited by this paper
• Hydrogen peroxide elicits pulmonary arterial relaxation and guanylate cyclase activation.

  1987cited by this paper
• Effects of hydrogen peroxide on cardiac function and post-ischaemic functional recovery in the isolated 'working' rat heart.

  1982cited by this paper
• Hydrogen peroxide contracts airway smooth muscle: a possible endogenous mechanism.

  1981cited by this paper
• Hydrogen peroxide: beneficial effects in rabbits following acute coronary occlusion.

  1978cited by this paper

• Study on peripheral antinociception induced by hydrogen peroxide (H2O2): characterization and mechanisms

  2024cites this paper
• Redox Regulation of K+ Channel: Role of Thioredoxin

  2024cites this paper
• Basal NAD(H) redox state permits hydrogen peroxide‐induced mesenteric artery dilatation

  2023cites this paper
• Effects of Pharmacological Inhibitors of NADPH Oxidase on Myogenic Contractility and Evoked Vasoactive Responses in Rat Resistance Arteries

  2022cites this paper
• Aging-Induced Impairment of Vascular Function: Mitochondrial Redox Contributions and Physiological/Clinical Implications

  2021cites this paper
• Cardiovascular Responses During Sepsis.

  2021cites this paper
• Coronary and cerebral metabolism - blood flow coupling and pulmonary alveolar ventilation - blood flow coupling may be disabled during carbon monoxide poisoning.

  2020cites this paper
• Mechanisms underlying suppression of noradrenaline-induced contraction by prolonged treatment with advanced glycation end-products in organ-cultured rat carotid artery

  2020cites this paper
• Nitric oxide donors as potential drugs for the treatment of vascular diseases due to endothelium dysfunction.

  2020cites this paper
• Ischemic Heart Disease and Heart Failure: Role of Coronary Ion Channels

  2020cites this paper
• Apelin Inhibits an Endothelium-Derived Hyperpolarizing Factor-Like Pathway in Rat Cerebral Arteries.

  2020cites this paper
• Myocardial Ischemia and Diabetes Mellitus: Role of Oxidative Stress in the Connection between Cardiac Metabolism and Coronary Blood Flow

  2019cites this paper
• Effect of Oxidative Stress on the Estrogen-NOS-NO-KCa Channel Pathway in Uteroplacental Dysfunction: Its Implication in Pregnancy Complications

  2019cites this paper
• Low-dose doxycycline inhibits hydrogen peroxide-induced oxidative stress, MMP-2 up-regulation and contractile dysfunction in human saphenous vein grafts

  2019cites this paper
• An investigation of the effects of haem on the activity of rat arterial large-conductance Ca2+-activated K+ (BKCa) channels

  2019cites this paper
• Catalase blockade reduces the pressor response to central cholinergic activation.

  2019cites this paper
• Erectile dysfunction and the biochemical/molecular/ regulation of human penile arteries

  2019cites this paper
• Diabetes Mellitus and Ischemic Heart Disease: The Role of Ion Channels

  2018cites this paper
• Neuronal nitric oxide synthase contributes to the normalization of blood pressure in medicated hypertensive patients.

  2018cites this paper
• Effects of Leptin on Hydrogen Peroxide Induced Contractions in Isolated Human Umbilical Artery

  2018cites this paper
• In vitro effects of hydrogen peroxide on rat uterine contraction before and during pregnancy

  2018cites this paper
• Metabolism of Docosahexaenoic Acid (DHA) Induces Pyroptosis in BV-2 Microglial Cells

  2018influential citation
• Changing the Channels: Nature's Remote Controlling in Health and Disease.

  2017cites this paper
• Chapter 7 – Hypertension

  2017cites this paper
• Potassium Channels in Regulation of Vascular Smooth Muscle Contraction and Growth.

  2017influential citation
• Regulation of Coronary Blood Flow.

  2017cites this paper
• Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.

  2017cites this paper
• CYP epoxygenase‐derived H2O2 is involved in the endothelium‐derived hyperpolarization (EDH) and relaxation of intrarenal arteries

  2017cites this paper
• Differential regulation of TRPV1 channels by H2O2: implications for diabetic microvascular dysfunction

  2016cites this paper
• Cardiac Response to Oxidative Stress Induced by Mitochondrial Dysfunction.

  2016cites this paper
• Reactive oxygen species facilitate the EDH response in arterioles by potentiating intracellular endothelial Ca2+ release

  2016cites this paper
• Homocysteine augments BK channel activity and decreases exocytosis of secretory granules in rat GH3 cells

  2016cites this paper
• Augmented oxidative stress and preserved vasoconstriction induced by hydrogen peroxide in coronary arteries in obesity: role of COX‐2

  2016cites this paper
• Insight Into Autonomic Dysfunctions With Novel Interventions: Focusing On Vascular Tone And Breathing Regulations

  2016cites this paper
• Contribution of KV1.5 Channel to Hydrogen Peroxide–Induced Human Arteriolar Dilation and Its Modulation by Coronary Artery Disease

  2016cites this paper
• Reactive Oxygen Species Modulation of Vascular Smooth Muscle Signaling by

  2016cites this paper
• Disease-Related Vascular Calcification Inflammatory Cytokines and Reactive Oxygen Species as Mediators of Chronic Kidney

  2015cites this paper
• Unveiling the Mechanism of Coronary Metabolic Vasodilation: Voltage-Gated Potassium Channels and Hydrogen Peroxide.

  2015cites this paper
• The effects of DPP-4 inhibitors on vascular endothelial function in diabetes

  2015influential citation
• Hydrogen peroxide activates store‐operated Ca2+ entry in coronary arteries

  2015influential citation
• Hyperoxic gassing with Tiron enhances bradykinin-induced endothelium-dependent and EDH-type relaxation through generation of hydrogen peroxide.

  2015cites this paper
• Sex differences in endothelial function in the porcine coronary artery

  2015cites this paper
• Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels

  2015cites this paper
• Tempol improves cutaneous thermal hyperemia through increasing nitric oxide bioavailability in young smokers.

  2014cites this paper
• Perivascular Fat and its Role in Vascular Disease, Insulin Resistance and Diabetes

  2014cites this paper
• Vasoplegia in septic shock: do we really fight the right enemy?

  2014cites this paper
• Mechanism underlying the anticontractile effect of perivascular adipose tissue

  2014cites this paper
• Hydrogen Peroxide Elicits Constriction of Skeletal Muscle Arterioles by Activating the Arachidonic Acid Pathway

  2014cites this paper
• Mitochondrial reactive oxygen species: A double edged sword in ischemia/reperfusion vs preconditioning

  2014cites this paper
• Hydrogen peroxide induces vasorelaxation by enhancing 4-aminopyridine-sensitive Kv currents through S-glutathionylation

  2014cites this paper
• A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries.

  2014cites this paper
• Vascular actions of oleamide in health and disease

  2013cites this paper
• Redox regulation of type Iα PKA in the heart

  2013cites this paper
• Quercetin relaxes rat tail main artery partly via a PKG‐mediated stimulation of KCa1.1 channels

  2013cites this paper
• Involvement of Large‐Conductance Ca2+‐Activated K+ Channels in both Nitric Oxide and Endothelium‐Derived Hyperpolarization‐Type Relaxation in Human Penile Small Arteries

  2013cites this paper
• Signaling pathways involved in the H2O2-induced vasoconstriction of rat coronary arteries.

  2013cites this paper
• Role of ion channels in coronary microcirculation: a review of the literature.

  2013cites this paper
• Antioxidants Condition Pleiotropic Vascular Responses to Exogenous H2O2: Role of Modulation of Vascular TP Receptors and the Heme Oxygenase System

  2013cites this paper
• Functional characterization of voltage-dependent Ca(2+) channels in mouse pulmonary arterial smooth muscle cells: divergent effect of ROS.

  2013cites this paper
• Myocardial Ischemia and Infarction

  2013cites this paper
• Relationship of Oxidative Stress with Cardiovascular Disease

  2013cites this paper
• Exercise Training‐Enhanced, Endothelium‐Dependent Dilation Mediated by Altered Regulation of BKCa Channels in Collateral‐Dependent Porcine Coronary Arterioles

  2013cites this paper
• Consequências do consumo crônico de etanol sobre a reatividade e expressão dos componentes do sistema endotelinérgico em corpo cavernoso de rato

  2013cites this paper
• The effect of reactive oxygen species on the myogenic tone of rat ophthalmic arteries with and without endothelium

  2013cites this paper
• Contradictory Effects of Superoxide and Hydrogen Peroxide on KCa3.1 in Human Endothelial Cells

  2013cites this paper
• H2O2-Induced Dilation in Human Coronary Arterioles: Role of Protein Kinase G Dimerization and Large-Conductance Ca2+-Activated K+ Channel Activation

  2012cites this paper
• Role of a Changing Membrane Potential (Em) and Matching Blood Flow with Neuronal Activity

  2012cites this paper
• H 2 O 2 -Induced Dilation in Human Coronary Arterioles: Role of Protein Kinase G Dimerization and Large-Conductance Ca 2 (cid:1) -Activated K (cid:1) Channel Activation

  2012cites this paper
• Upregulation of endothelium-derived hyperpolarizing factor compensates for the loss of nitric oxide in mesenteric arteries of dahl salt-sensitive hypertensive rats

  2012cites this paper
• Hydrogen peroxide enhances vasodilatation by increasing dimerization of cGMP-dependent protein kinase type Iα.

  2012cites this paper
• Investigating the role of ion channels across the fetomaternal interface of the human placenta

  2012cites this paper
• Redox Balance in the Aging Microcirculation: New Friends, New Foes, and New Clinical Directions

  2012cites this paper
• The Contribution of d-Tubocurarine–sensitive and Apamin-sensitive K-channels to EDHF-mediated Relaxation of Mesenteric Arteries From eNOS−/− Mice

  2012cites this paper
• Interactive roles of hydrogen peroxide and calcium in the endothelial signaling network that underpins the EDHF phenomenon

  2012cites this paper
• Hydrogen peroxide as a mediator of vasorelaxation evoked by N-oleoylethanolamine and anandamide in rat small mesenteric arteries.

  2012cites this paper
• Ethanol induces vascular relaxation via redox-sensitive and nitric oxide-dependent pathways.

  2012cites this paper
• H₂O₂ lowers the cytosolic Ca²⁺ concentration via activation of cGMP-dependent protein kinase Iα.

  2012cites this paper
• Estudo da função em artérias de resistência de ratos pós-infarto do miocárdio.

  2012cites this paper
• Interactions between A2A adenosine receptor, hydrogen peroxide, and KATP channel in coronary reactive hyperemia

  2012cites this paper
• Vasomodulatory effect of novel peroxovanadate compounds on rat aorta: Role of rho kinase and nitric oxide/cGMP pathway.

  2011cites this paper
• Vazoactive Effects of Oxidative Stress Elicited by Hydrogen Peroxide in the 348 Human Umbilical Artery : An in Vitro Study 2 . Materials and Methods

  2011cites this paper
• H2O2 Is the Transferrable Factor Mediating Flow-Induced Dilation in Human Coronary Arterioles

  2011cites this paper
• Involvement of endothelial-derived relaxing factors in the regulation of cerebral blood flow

  2011cites this paper
• Endothelium-Derived Hyperpolarizing Factor and Vascular Function

  2011cites this paper
• Vazoactive Effects of Oxidative Stress Elicited by Hydrogen Peroxide in the Human Umbilical Artery: An in Vitro Study

  2011cites this paper
• Shear stress stimulates nitric oxide signaling in pulmonary arterial endothelial cells via a reduction in catalase activity: role of protein kinase C delta.

  2010cites this paper
• Superoxide differentially controls pulmonary and systemic vascular tone through multiple signalling pathways

  2010cites this paper
• Hydrogen peroxide as an endothelium-derived hyperpolarizing factor

  2010cites this paper
• IL-1b modulate the Ca 2+ -activated big-conductance K channels (BK) via reactive oxygen species in cultured rat aorta smooth muscle cells Yuan GaoYing YangQigang GuanXuefeng Pang •

  2010cites this paper
• Biphasic effects of H2O2 on BKCa channels

  2010cites this paper
• IL-1β modulate the Ca2+-activated big-conductance K channels (BK) via reactive oxygen species in cultured rat aorta smooth muscle cells

  2010influential citation
• Role of potassium channels in coronary vasodilation

  2010cites this paper
• Diabetes-associated Alterations in Volatile Anesthetic Actions on Contractile Response to Norepinephrine in Isolated Mesenteric Resistance Arteries

  2010cites this paper
• Relative contribution of eNOS and nNOS to endothelium-dependent vasodilation in the mouse aorta.

  2010cites this paper
• Modulation of endothelium-dependent arterial relaxation by inorganic arsenic and glucose

  2010cites this paper
• Enalapril Treatment Alters the Contribution of Epoxyeicosatrienoic Acids but Not Gap Junctions to Endothelium-Derived Hyperpolarizing Factor Activity in Mesenteric Arteries of Spontaneously Hypertensive Rats

  2009cites this paper
• Modulation of BKCa channel gating by endogenous signaling molecules.

  2009cites this paper
• Hydrogen peroxide down-regulates inositol 1,4,5-trisphosphate receptor content through proteasome activation.

  2009cites this paper
• Enhancement of BK(Ca) channel activity induced by hydrogen peroxide: involvement of lipid phosphatase activity of PTEN.

  2009cites this paper
• NADPH oxidases and angiotensin II receptor signaling.

  2009cites this paper