Lipidomic Profiles in Diabetes and Dementia

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Journal of Alzheimer's Disease

• Publication date

  2017-05-30

• Fields of study

  Medicine

• Identifiers
  DOI 10.3233/JAD-161215PMID 28582856
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Major changes in the sphingophospholipidome of HDL in non-diabetic patients with metabolic syndrome.

  2016cited by this paper
• Sphingolipid-Enriched Extracellular Vesicles and Alzheimer’s Disease: A Decade of Research

  2016cited by this paper
• Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural‐derived blood exosomes of preclinical Alzheimer's disease

  2015cited by this paper
• Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case‐control study

  2015cited by this paper
• Applications of mass spectrometry for cellular lipid analysis.

  2015cited by this paper
• Optimizing the lipidomics workflow for clinical studies—practical considerations

  2015cited by this paper
• Pathogenesis of Type 2 Diabetes Mellitus

  2015cited by this paper
• Ceramides - Lipotoxic Inducers of Metabolic Disorders.

  2015cited by this paper
• Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice*

  2014cited by this paper
• The Ether Lipid Precursor Hexadecylglycerol Stimulates the Release and Changes the Composition of Exosomes Derived from PC-3 Cells*

  2014cited by this paper
• Ultra-performance liquid chromatography-mass spectrometry as a sensitive and powerful technology in lipidomic applications.

  2014cited by this paper
• Global estimates of diabetes prevalence for 2013 and projections for 2035.

  2014cited by this paper
• Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

  2014cited by this paper
• Peripheral nervous system plasmalogens regulate Schwann cell differentiation and myelination.

  2014cited by this paper
• Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease.

  2014cited by this paper
• Plasma phospholipids identify antecedent memory impairment in older adults

  2014cited by this paper
• Lipidomics: potential role in risk prediction and therapeutic monitoring for diabetes and cardiovascular disease.

  2014cited by this paper
• Reduced skeletal muscle oxidative capacity and elevated ceramide but not diacylglycerol content in severe obesity

  2013cited by this paper
• Nonalcoholic fatty liver disease is associated with lower hepatic and erythrocyte ratios of phosphatidylcholine to phosphatidylethanolamine.

  2013cited by this paper
• Plasma Lipid Profiling Shows Similar Associations with Prediabetes and Type 2 Diabetes

  2013cited by this paper
• Molecular lipidomics of exosomes released by PC-3 prostate cancer cells.

  2013cited by this paper
• Plasmalogens Rescue Neuronal Cell Death through an Activation of AKT and ERK Survival Signaling

  2013cited by this paper
• Ceramides Contained in LDL Are Elevated in Type 2 Diabetes and Promote Inflammation and Skeletal Muscle Insulin Resistance

  2013cited by this paper
• Plasma ceramides are elevated in female children and adolescents with type 2 diabetes

  2013cited by this paper
• Plasma lipid profiling in a large population-based cohort[S]

  2013cited by this paper
• Plasma biomarkers for Alzheimer's disease: much needed but tough to find.

  2012cited by this paper
• Leptin signaling and Alzheimer's disease.

  2012cited by this paper
• Increased Ceramide in Brains with Alzheimer's and Other Neurodegenerative Diseases

  2012cited by this paper
• Serum ceramides increase the risk of Alzheimer disease

  2012cited by this paper
• Anti-inflammatory/anti-amyloidogenic effects of plasmalogens in lipopolysaccharide-induced neuroinflammation in adult mice

  2012cited by this paper
• Functions of plasmalogen lipids in health and disease.

  2012cited by this paper
• Aging-Related Changes in Blood-Brain Barrier Integrity and the Effect of Dietary Fat

  2012influential reference
• Direction-Selective Circuitry in Rat Retina Develops Independently of GABAergic, Cholinergic and Action Potential Activity

  2011cited by this paper
• Metabolomics in Early Alzheimer's Disease: Identification of Altered Plasma Sphingolipidome Using Shotgun Lipidomics

  2011cited by this paper
• Alzheimer's disease.

  2011cited by this paper
• Plasmalogens the neglected regulatory and scavenging lipid species.

  2011cited by this paper
• Amyloid-β Forms Fibrils by Nucleated Conformational Conversion of Oligomers

  2011cited by this paper
• The Effects of a High-Energy Diet on Hippocampal Function and Blood-Brain Barrier Integrity in the Rat

  2010influential reference
• Alzheimer's disease.

  2010cited by this paper
• Membrane plasmalogen composition and cellular cholesterol regulation: a structure activity study

  2010cited by this paper
• Mammalian ceramide synthases

  2010cited by this paper
• GSK3: a possible link between beta amyloid peptide and tau protein.

  2010cited by this paper
• Membrane rafts in Alzheimer's disease beta-amyloid production.

  2010cited by this paper
• Ovalbumin-induced plasma interleukin-4 levels are reduced in ceramide kinase-deficient DO11.10 RAG1-/- mice

  2010cited by this paper
• Lipidomics reveals a remarkable diversity of lipids in human plasma1[S]

  2010cited by this paper
• Circulating plasmalogen levels and Alzheimer Disease Assessment Scale-Cognitive scores in Alzheimer patients.

  2010cited by this paper
• Sex Differences in High‐fat Diet‐induced Obesity, Metabolic Alterations and Learning, and Synaptic Plasticity Deficits in Mice

  2010cited by this paper
• Serum sphingomyelins and ceramides are early predictors of memory impairment.

  2010cited by this paper
• Plasmalogens in biological systems: their role in oxidative processes in biological membranes, their contribution to pathological processes and aging and plasmalogen analysis.

  2009cited by this paper
• A Variation in the Cerebroside Sulfotransferase Gene is Linked to Exercise-Modified Insulin Resistance and to Type 2 Diabetes

  2009cited by this paper
• Insulin Resistance Is Associated With Higher Intramyocellular Triglycerides in Type I but Not Type II Myocytes Concomitant With Higher Ceramide Content

  2009cited by this paper
• Mechanisms of Ceramide-Mediated Neurodegeneration

  2009cited by this paper
• Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance

  2009cited by this paper
• Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease

  2009cited by this paper
• A novel reciprocal and biphasic relationship between membrane cholesterol and β‐secretase activity in SH‐SY5Y cells and in human platelets

  2009cited by this paper
• The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics

  2009cited by this paper
• Hepatic Ceramide May Mediate Brain Insulin Resistance and Neurodegeneration in Type 2 Diabetes and Non-alcoholic Steatohepatitis

  2009cited by this paper
• Dyslipidemia in type 2 diabetes mellitus

  2009cited by this paper
• Defective insulin signaling pathway and increased glycogen synthase kinase‐3 activity in the brain of diabetic mice: Parallels with Alzheimer's disease and correction by insulin

  2008cited by this paper
• Adherence to Mediterranean diet and risk of developing diabetes: prospective cohort study

  2008cited by this paper
• Obesity and hypertriglyceridemia produce cognitive impairment.

  2008cited by this paper
• Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study.

  2008cited by this paper
• Journal of Neuroinflammation Neuro-inflammation Induced by Lipopolysaccharide Causes Cognitive Impairment through Enhancement of Beta-amyloid Generation

  2008cited by this paper
• Type 2 diabetes and risk of cognitive impairment and dementia

  2007cited by this paper
• Risk of dementia in diabetes mellitus: a systematic review.

  2006cited by this paper
• Mediterranean diet and risk for Alzheimer's disease

  2006cited by this paper
• The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis.

  2006cited by this paper
• Type 1 diabetes.

  2006cited by this paper
• Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

  2005cited by this paper
• A comprehensive classification system for lipids11 The evaluation of this manuscript was handled by the former Editor-in-Chief Trudy Forte. Published, JLR Papers in Press, February 16, 2005. DOI 10.1194/jlr.E400004-JLR200

  2005cited by this paper
• A comprehensive classification system for lipids 1

  2005cited by this paper
• Pathogenesis of type 2 diabetes mellitus.

  2005cited by this paper
• The role of inflammation in Alzheimer's disease.

  2005cited by this paper
• Functions and biosynthesis of plasmalogens in health and disease.

  2004cited by this paper
• Plasmalogens: targets for oxidants and major lipophilic antioxidants.

  2004cited by this paper
• Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter.

  2004cited by this paper
• Role for neuronal insulin resistance in neurodegenerative diseases.

  2004cited by this paper
• Ceramide synthesis and metabolism as a target for cancer therapy.

  2004cited by this paper
• Triglycerides induce leptin resistance at the blood-brain barrier.

  2004influential reference
• Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes.

  2003cited by this paper
• Signaling events mediating activation of brain ethanolamine plasmalogen hydrolysis by ceramide.

  2003cited by this paper
• β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

  2003cited by this paper
• Novel Role for Apolipoprotein E in the Central Nervous System

  2003cited by this paper
• Selective lack of the C16:0 fatty acid isoform of sulfatide in pancreas of type II diabetic animal models

  2003cited by this paper
• Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts

  2003cited by this paper
• Anti-Inflammatory Drug Therapy Alters β-Amyloid Processing and Deposition in an Animal Model of Alzheimer's Disease

  2003cited by this paper
• Exclusively targeting β-secretase to lipid rafts by GPI-anchor addition up-regulates β-site processing of the amyloid precursor protein

  2003cited by this paper
• Deficiency in ethanolamine plasmalogen leads to altered cholesterol transport Published, JLR Papers in Press, November 4, 2002. DOI 10.1194/jlr.M200363-JLR200

  2003cited by this paper
• Exclusively targeting beta-secretase to lipid rafts byGPI-anchor addition up-regulates beta-site processing ofthe amyloid precursor protein

  2003cited by this paper
• Patients with Insulin-dependent Diabetes but not those with Non-insulin-dependent Diabetes have Anti-sulfatide Antibodies as Determined with a New ELISA Assay

  2002influential reference
• Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study.

  2002cited by this paper
• The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

  2002cited by this paper
• Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis

  2002influential reference
• Lipid rafts are enriched in arachidonic acid and plasmenylethanolamine and their composition is independent of caveolin-1 expression: a quantitative electrospray ionization/mass spectrometric analysis.

  2002cited by this paper
• Exosomes: composition, biogenesis and function

  2002cited by this paper
• Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry

  2001cited by this paper
• Insulin signalling and the regulation of glucose and lipid metabolism

  2001cited by this paper
• Serum cholesterol, APOE genotype, and the risk of Alzheimer’s disease: A population-based study of African Americans

  2000cited by this paper
• Ceramide Inhibits Protein Kinase B/Akt by Promoting Dephosphorylation of Serine 473*

  2000cited by this paper
• The glycosphingolipid sulfatide in the islets of Langerhans in rat pancreas is processed through recycling: possible involvement in insulin trafficking.

  2000cited by this paper

• Metabolome contribution to sex differences in the link between alcohol consumption and type 2 diabetes: a prospective analysis in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

  2026cites this paper
• Emerging role of the cardiac lipidome in the progression of heart failure.

  2025cites this paper
• Association of Dyslipidemia With Dermatological Manifestations in Patients With Type 2 Diabetes Mellitus

  2025cites this paper
• NRF2 deficiency is associated with synaptic alterations and ether-linked phospholipid imbalance in the hippocampus

  2025cites this paper
• Identification of characteristic lipids of Tan lamb and their potential health benefits.

  2025cites this paper
• EXPRESS: Metformin; Its Salutary Effects Beyond Diabetes Mellitus.

  2025cites this paper
• Microglial SCAP deficiency protects against diabetes-associated cognitive impairment through inhibiting NLRP3 inflammasome-mediated neuroinflammation.

  2024cites this paper
• Unveiling the Therapeutic Potential: Metabolomics Insights into Medicinal Plants and Their Antidiabetic Effects

  2024cites this paper
• Lipidomics profiling reveals distinct patterns of plasma sphingolipid alterations in Alzheimer’s disease and vascular dementia

  2023cites this paper
• APLICAÇÃO DA LIPIDÔMICA NA DOENÇA DE ALZHEIMER

  2023cites this paper
• Integrative metabolomics science in Alzheimer's disease: relevance and future perspectives.

  2023cites this paper
• The roles of dietary lipids and lipidomics in gut-brain axis in type 2 diabetes mellitus

  2023cites this paper
• The Changes of Lipidomic Profiles Reveal Therapeutic Effects of Exenatide in Patients With Type 2 Diabetes

  2022cites this paper
• Ethnic disparities attributed to the manifestation in and response to type 2 diabetes: insights from metabolomics

  2022cites this paper
• Metabolomics in gestational diabetes mellitus: A review.

  2022cites this paper
• Lipidomic Alterations in the Cerebral Cortex and White Matter in Sporadic Alzheimer’s Disease

  2022cites this paper
• Occult hypoperfusion and changes of systemic lipid levels after severe trauma: an analysis in a standardized porcine polytrauma model

  2022cites this paper
• Metformin and the risk of dementia based on an analysis of 396,332 participants

  2022cites this paper
• Targeted Lipidomics To Measure Phospholipids and Sphingomyelins in Plasma: A Pilot Study To Understand the Impact of Race/Ethnicity in Alzheimer's Disease.

  2022cites this paper
• Chemical Derivatization-Aided High Resolution Mass Spectrometry for Shotgun Lipidome Analysis.

  2021cites this paper
• Plasma lipidomics profile in pregnancy and gestational diabetes risk: a prospective study in a multiracial/ethnic cohort

  2021cites this paper
• Lipids: biomarkers of healthy aging

  2021cites this paper
• Effects of Lifestyle Intervention in Tissue-Specific Lipidomic Profile of Formerly Obese Mice

  2021cites this paper
• Prevalence of Dyslipidemia in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study

  2021cites this paper
• High-throughput liquid chromatography mass-spectrometry-driven lipidomics discover metabolic biomarkers and pathways as promising targets to reveal the therapeutic effects of the Shenqi pill

  2020cites this paper
• Editorial: Back to the Future: On the Road Towards Precision Psychiatry

  2020cites this paper
• Lipid alterations in human frontal cortex in ALS‐FTLD‐TDP43 proteinopathy spectrum are partly related to peroxisome impairment

  2020cites this paper
• The Lipidome Fingerprint of Longevity

  2020cites this paper
• Plasma lipidomic profiles and risk of diabetes: two prospective cohorts of HIV-infected and HIV-uninfected individuals

  2020cites this paper
• Untargeted lipidomics reveals progression of early Alzheimer’s disease in APP/PS1 transgenic mice

  2020cites this paper
• Exceptional human longevity is associated with a specific plasma phenotype of ether lipids

  2019cites this paper
• Redox Biology Exceptional human longevity is associated with a speci fi c plasma phenotype of ether lipids

  2019cites this paper
• The current and future perspectives of zinc oxide nanoparticles in the treatment of diabetes mellitus.

  2019cites this paper
• Metabolomics for Investigating Physiological and Pathophysiological Processes.

  2019cites this paper
• Clinical and pathophysiological aspects of nonalcoholic fatty liver disease in bariatric surgery

  2019cites this paper
• Metformin and the Risk of Dementia in Type 2 Diabetes Patients

  2019cites this paper
• Lipidomic Profiling Links the Fanconi Anemia Pathway to Glycosphingolipid Metabolism in Head and Neck Cancer Cells

  2018cites this paper
• Plasma Lipidomic Profiling and Risk of Type 2 Diabetes in the PREDIMED Trial

  2018cites this paper
• Lipidomics Reveals a Tissue-Specific Fingerprint

  2018cites this paper
• Blood-Based Lipidomics Approach to Evaluate Biomarkers Associated With Response to Olanzapine, Risperidone, and Quetiapine Treatment in Schizophrenia Patients

  2018cites this paper
• Polyphenol-enriched extract of Rosa rugosa Thunb regulates lipid metabolism in diabetic rats by activation of AMPK pathway.

  2018cites this paper
• Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies

  2018cites this paper
• Understanding the Link between Dementia and Diabetes

  2017cites this paper