Induction and specification of midbrain dopaminergic cells: focus on SHH, FGF8, and TGF-β

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Cell and Tissue Research

• Publication date

  2004-08-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00441-004-0916-4PMID 15322912
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transforming growth factor-beta(s) are essential for the development of midbrain dopaminergic neurons in vitro and in vivo.

  2003cited by this paper
• Sonic hedgehog and FGF8 collaborate to induce dopaminergic phenotypes in the Nurr1-overexpressing neural stem cell.

  2003cited by this paper
• Location and Size of Dopaminergic and Serotonergic Cell Populations Are Controlled by the Position of the Midbrain–Hindbrain Organizer

  2003cited by this paper
• Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a

  2003cited by this paper
• Elimination of serotonergic cells induces a marked increase in generation of dopaminergic neurons from mesencephalic precursors

  2003cited by this paper
• Transforming Growth Factor-βs Are Essential for the Development of Midbrain Dopaminergic Neurons In Vitro and In Vivo

  2003cited by this paper
• p57Kip2 cooperates with Nurr1 in developing dopamine cells

  2003cited by this paper
• Genetic Analysis of the Roles of Hh, FGF8, and Nodal Signaling during Catecholaminergic System Development in the Zebrafish Brain

  2003cited by this paper
• TGFβ induces GDNF responsiveness in neurons by recruitment of GFRα1 to the plasma membrane

  2002cited by this paper
• Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud.

  2002cited by this paper
• Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors

  2002cited by this paper
• A mitogen gradient of dorsal midline Wnts organizes growth in the CNS.

  2002cited by this paper
• Zebrafish smoothened functions in ventral neural tube specification and axon tract formation.

  2001cited by this paper
• spiel ohne grenzen/pou2 is required during establishment of the zebrafish midbrain-hindbrain boundary organizer.

  2001cited by this paper
• Sonic hedgehog and FGF8: inadequate signals for the differentiation of a dopamine phenotype in mouse and human neurons in culture.

  2001cited by this paper
• Hedgehog signaling in animal development: paradigms and principles.

  2001cited by this paper
• Extensive neuronal localization and neurotrophic function of fibroblast growth factor 8 in the nervous system.

  2001cited by this paper
• The Hedgehog and Wnt signalling pathways in cancer

  2001cited by this paper
• Fate of Midbrain Dopaminergic Neurons Controlled by the Engrailed Genes

  2001cited by this paper
• The status of Wnt signalling regulates neural and epidermal fates in the chick embryo

  2001cited by this paper
• Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.

  2000cited by this paper
• Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination

  2000cited by this paper
• Reduction of endogenous transforming growth factors β prevents ontogenetic neuron death

  2000cited by this paper
• Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice.

  2000cited by this paper
• Roles of Wnt proteins in neural development and maintenance.

  2000cited by this paper
• Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein.

  2000cited by this paper
• Control of Shh activity and signaling in the neural tube.

  2000cited by this paper
• Growth/Differentiation Factor-15/Macrophage Inhibitory Cytokine-1 Is a Novel Trophic Factor for Midbrain Dopaminergic Neurons In Vivo

  2000cited by this paper
• Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation.

  2000cited by this paper
• Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3

  2000cited by this paper
• Transcriptional control by the TGF‐β/Smad signaling system

  2000cited by this paper
• The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types

  2000cited by this paper
• Specification of dopaminergic and serotonergic neurons in the vertebrate CNS.

  1999cited by this paper
• Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo.

  1999cited by this paper
• Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis.

  1998cited by this paper
• Glial Cell Line-Derived Neurotrophic Factor Requires Transforming Growth Factor-β for Exerting Its Full Neurotrophic Potential on Peripheral and CNS Neurons

  1998cited by this paper
• Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish.

  1998cited by this paper
• In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex.

  1998cited by this paper
• Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system.

  1998cited by this paper
• Control of neural crest cell fate by the Wnt signalling pathway

  1998cited by this paper
• FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate.

  1998cited by this paper
• Positional cloning identifies zebrafish one-eyed pinhead as a permissive EGF-related ligand required during gastrulation.

  1998cited by this paper
• Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling

  1998cited by this paper
• Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1.

  1997cited by this paper
• The Pax protein Noi is required for commissural axon pathway formation in the rostral forebrain.

  1997cited by this paper
• Bone Morphogenetic Proteins: Neurotrophic Roles for Midbrain Dopaminergic Neurons and Implications of Astroglial Cells

  1997cited by this paper
• Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain.

  1997cited by this paper
• Inhibition of floor plate differentiation by Pax3: evidence from ectopic expression in transgenic mice.

  1996cited by this paper
• Expression of axial and sonic hedgehog in wildtype and midline defective zebrafish embryos.

  1996cited by this paper
• Midbrain development induced by FGF8 in the chick embryo

  1996cited by this paper
• Biochemical evidence that Patched is the Hedgehog receptor

  1996cited by this paper
• Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

  1996cited by this paper
• The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

  1996cited by this paper
• Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development

  1996cited by this paper
• Expression, localization, and function of transforming growth factor-beta s in embryonic chick spinal cord, hindbrain, and dorsal root ganglia.

  1996cited by this paper
• Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain.

  1996cited by this paper
• Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway.

  1996cited by this paper
• hedgehog is required for the proliferation and specification of ovarian somatic cells prior to egg chamber formation in Drosophila.

  1996cited by this paper
• Patterning the Vertebrate Neuraxis

  1996cited by this paper
• Diversity and Pattern in the Developing Spinal Cord

  1996cited by this paper
• Dual roles for patched in sequestering and transducing Hedgehog.

  1996cited by this paper
• Induction of dopaminergic neuron phenotype in the midbrain by Sonic hedgehog protein

  1995cited by this paper
• The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo.

  1995cited by this paper
• The product of hedgehog autoproteolytic cleavage active in local and long-range signalling

  1995cited by this paper
• Control of neuronal diversity by the floor plate: contact-mediated induction of midbrain dopaminergic neurons.

  1995cited by this paper
• Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo.

  1995cited by this paper
• Induction of midbrain dopaminergic neurons by Sonic hedgehog.

  1995cited by this paper
• A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth.

  1995cited by this paper
• Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation.

  1995cited by this paper
• TGF‐beta superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity.

  1995cited by this paper
• Autoproteolysis in hedgehog protein biogenesis.

  1994cited by this paper
• Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord.

  1994cited by this paper
• Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum.

  1994cited by this paper
• Involvement of androgen-induced growth factor (FGF-8) gene in mouse embryogenesis and morphogenesis.

  1994cited by this paper
• Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system.

  1994cited by this paper
• Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases.

  1994cited by this paper
• Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development.

  1994cited by this paper
• TGFβ2 and TGFβ3 are potent survival factors for midbrain dopaminergic neurons

  1994cited by this paper
• HNF-3 beta as a regulator of floor plate development.

  1994cited by this paper
• TGF beta 2 and TGF beta 3 are potent survival factors for midbrain dopaminergic neurons.

  1994cited by this paper
• Patterning of the embryonic avian midbrain after experimental inversions: a polarizing activity from the isthmus.

  1994cited by this paper
• HNF-3β as a regulator of floor plate development

  1994cited by this paper
• Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation.

  1993cited by this paper
• Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.

  1993cited by this paper
• A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos.

  1993cited by this paper
• Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds.

  1993cited by this paper
• Control of cell pattern in the neural tube: motor neuron induction by diffusible factors from notochord and floor plate.

  1993cited by this paper
• Sonic hedgehog mediates the polarizing activity of the ZPA.

  1993cited by this paper
• Dopamine D4 receptors elevated in schizophrenia

  1993cited by this paper
• Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells.

  1992cited by this paper
• Relationship between Wnt-1 and En-2 expression domains during early development of normal and ectopic met-mesencephalon.

  1992cited by this paper
• Segment polarity genes and cell patterning within the Drosophila body segment.

  1991cited by this paper
• Localization and actions of transforming growth factor-beta s in the embryonic nervous system.

  1991cited by this paper
• Induction of a mesencephalic phenotype in the 2-day-old chick prosencephalon is preceded by the early expression of the homeobox gene en.

  1991cited by this paper
• The cellular environment controls the expression of engrailed-like protein in the cranial neuroepithelium of quail-chick chimeric embryos.

  1991cited by this paper
• Control of cell pattern in the developing nervous system: polarizing activity of the floor plate and notochord.

  1991cited by this paper
• The GLI-Kruppel family of human genes

  1988cited by this paper
• Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

  1988cited by this paper
• Identification of an amplified, highly expressed gene in a human glioma.

  1987cited by this paper
• Drugs, neurotransmitters, and schizophrenia.

  1974cited by this paper

• Elucidating Mechanisms of Hypomorphic WDR19-Related Kidney Failure

  2025cites this paper
• Stem Cell Therapy in Parkinson’s Disease: Advances in Regenerative Medicine and Clinical Applications

  2025cites this paper
• Three-dimensional midbrain organoids: a next-generation tool for Parkinson’s disease modelling and drug discovery

  2025cites this paper
• Differential roles of NR4A2 (NURR1) paralogs in the brain and behavior of zebrafish

  2024cites this paper
• A review article on the development of dopaminergic neurons and establishment of dopaminergic neuron–based in vitro models by using immortal cell lines or stem cells to study and treat Parkinson's disease

  2024cites this paper
• State of the Art in Sub-Phenotyping Midbrain Dopamine Neurons

  2024cites this paper
• MiR-210-5p promotes the differentiation of human induced pluripotent stem cells into dopaminergic neural precursors by targeting SMAD4 and SUFU and treats parkinsonian rats.

  2023cites this paper
• Application and prospects of high-throughput screening for in vitro neurogenesis

  2022cites this paper
• Progress in generating iPSC-derived dopaminergic neurons as accurate models of neurodegenerative disease

  2021cites this paper
• Replacing what’s lost: a new era of stem cell therapy for Parkinson’s disease

  2020cites this paper
• Autocrine and paracrine stimulation of dopamine secretion by human neural stem cells: Role BDNF and GDNF

  2020cites this paper
• The development of an in vitro culture system for the expansion of notochordal cell populations with retention of phenotype

  2019cites this paper
• Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene

  2019cites this paper
• Developmental mechanisms of intervertebral disc and vertebral column formation

  2017cites this paper
• TGF-β Family Signaling in Neural and Neuronal Differentiation, Development, and Function.

  2017cites this paper
• TGF- b Family Signaling in Neural and Neuronal Differentiation, Development, and Function

  2017cites this paper
• Embryonic development of selectively vulnerable neurons in Parkinson’s disease

  2017cites this paper
• A novel method to differentiate rat embryonic stem cells into dopaminergic neurons in vitro

  2017cites this paper
• Common pitfalls of stem cell differentiation: a guide to improving protocols for neurodegenerative disease models and research

  2016cites this paper
• Chemical conversion of mouse fibroblasts into functional dopaminergic neurons.

  2016cites this paper
• The loss of scents: do defects in olfactory sensory neuron development underlie human disease?

  2015cites this paper
• Role of TGF-β1 in the Behavior Disorders

  2015cites this paper
• Expression of functional recombinant human fibroblast growth factor 8b and its protective effects on MPP+-lesioned PC12 cells

  2015cites this paper
• Roles for the TGFβ Superfamily in the Development and Survival of Midbrain Dopaminergic Neurons

  2014cites this paper
• Molecular mechanisms of dopaminergic subset specification: fundamental aspects and clinical perspectives

  2014cites this paper
• Direct lineage reprogramming of mouse fibroblasts to functional midbrain dopaminergic neuronal progenitors.

  2014cites this paper
• Overexpression of Mash 1 and Nurr 1 synergize to induce the Dopaminergic Neuron Phenotype during in vitro differentiation of Neural Stem Cells

  2014influential citation
• Co-delivery of Two Growth Factors From Combined PLGA and PLLA/PCL Microsphere Scaffolds for Spinal Cord Injury Repairs

  2014cites this paper
• Lentivirus-mediated delivery of sonic hedgehog into the striatum stimulates neuroregeneration in a rat model of Parkinson disease

  2014cites this paper
• Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome

  2014cites this paper
• Differentiation of human pluripotent stem cells to the neuronal dopaminergic fate

  2013cites this paper
• BMP and TGF-β pathway mediators are critical upstream regulators of Wnt signaling during midbrain dopamine differentiation in human pluripotent stem cells.

  2013cites this paper
• Cloning and bioinformatical analysis of the N-terminus of the sonic hedgehog gene

  2013cites this paper
• Heterozygous mutations in the FGF8, SHH and nodal/transforming growth factor beta pathways do not confer increased dopaminergic neuron vulnerability--a zebrafish study.

  2013cites this paper
• Characterisation of the role of canonical BMP-Smad 1/5/8 signalling in the development of ventral midbrain dopaminergic neurons

  2013cites this paper
• Cornelia de Lange Syndrome: NIPBL haploinsufficiency downregulates canonical Wnt pathway in zebrafish embryos and patients fibroblasts

  2013cites this paper
• Enhanced Production of Neuroprogenitors, Dopaminergic Neurons, and Identification of Target Genes by Overexpression of Sonic Hedgehog in Human Embryonic Stem Cells

  2012cites this paper
• Distribution and localization of fibroblast growth factor-8 in rat brain and nerve cells during neural stem/progenitor cell differentiation

  2012cites this paper
• Stromal factors SDF1α, sFRP1, and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells

  2012influential citation
• Differentiating human stem cells into neurons and glial cells for neural repair.

  2012cites this paper
• FGF signaling in neurogenesis and patterning of the developing midbrain and anterior hindbrain

  2012cites this paper
• Generación de neuronas dopaminérgicas a partir de células madre neurales mesencefálicas : nuevas contribuciones al desarrollo de terapia celular para la enfermedad de Parkinson

  2011cites this paper
• Maternal stress retards fetal development in mice with transcriptome-wide impact on gene expression profiles of the limb

  2011cites this paper
• The Use of Pluripotent Stem Cell for Personalized Cell Therapies against Neurological Disorders

  2011cites this paper
• Directing Differentiation of Embryonic Stem Cells Into Distinct Neuronal Subtypes

  2010cites this paper
• Expression of ventral diencephalon‐enriched genes in zebrafish

  2010cites this paper
• Ventral Mesencephalon Astrocytes Are More Efficient Than Those of Other Regions in Inducing Dopaminergic Neurons Through Higher Expression Level of TGF-β3

  2009cites this paper
• Development of Human Nervous Tissue upon Differentiation of Embryonic Stem Cells in Three‐Dimensional Culture

  2009cites this paper
• Ontogeny of substantia nigra dopamine neurons.

  2009cites this paper
• TGF-beta in dopamine neuron development, maintenance and neuroprotection.

  2009cites this paper
• Sonic Hedgehog and Neural Patterning

  2009cites this paper
• TGF-β in Dopamine Neuron Development, Maintenance and Neuroprotection

  2009cites this paper
• Birth, life and death of dopaminergic neurons in the substantia nigra.

  2009cites this paper
• Signals Involved in Neural Differentiation of Human Embryonic Stem Cells

  2009cites this paper
• Dopaminergic differentiation of human neural stem cells mediated by co‐cultured rat striatal brain slices

  2008cites this paper
• The Hedgehog gene family of the cnidarian, Nematostella vectensis, and implications for understanding metazoan Hedgehog pathway evolution.

  2008cites this paper
• Dopaminergic neurons derived from BG01V2, a variant of human embryonic stem cell line BG01

  2008influential citation
• Generation of Dopaminergic Neurons from Human Embryonic Stem Cells

  2008cites this paper
• Preliminary evidence for a modulation of fetal dopaminergic development by maternal immune activation during pregnancy.

  2008cites this paper
• Neural stem cell engineering: directed differentiation of adult and embryonic stem cells into neurons.

  2008cites this paper
• Enhanced neurogenesis from neural progenitor cells with G1/S‐phase cell cycle arrest is mediated by transforming growth factor β1

  2008cites this paper
• Blood vessel growth in primate retinal development : relationship of retinal maturation with choriocapillaris growth and a role for TGF-β in the retina.

  2008cites this paper
• Generation of Dopaminergic Neurons from Human Embryonic Stem Cells

  2008cites this paper
• Current advances in the treatment of Parkinson's disease with stem cells.

  2007cites this paper
• Transcriptional repressor and activator activities of SMA-9 contribute differentially to BMP-related signaling outputs.

  2007cites this paper
• Concise Review: Therapeutic Strategies for Parkinson Disease Based on the Modulation of Adult Neurogenesis

  2007cites this paper
• TGF-beta in neural stem cells and in tumors of the central nervous system

  2007cites this paper
• Bdnf gene is a downstream target of Nurr1 transcription factor in rat midbrain neurons in vitro

  2007cites this paper
• Survival of DA neurons is independent of CREM upregulation in absence of CREB

  2006cites this paper
• Transforming Growth Factor β Is Required for Differentiation of Mouse Mesencephalic Progenitors into Dopaminergic Neurons In Vitro and In Vivo: Ectopic Induction in Dorsal Mesencephalon

  2006cites this paper
• Development of dopaminergic neurons in the mammalian brain

  2006cites this paper
• Differential regulation of tyrosine hydroxylase expression by sonic hedgehog

  2006cites this paper
• Stable expression of a neuronal dopaminergic progenitor phenotype in cell lines derived from human amniotic fluid cells

  2006influential citation
• Strategies to unravel molecular codes essential for the development of meso‐diencephalic dopaminergic neurons

  2006influential citation
• Murine embryonic EGF-responsive ventral mesencephalic neurospheres display distinct regional specification and promote survival of dopaminergic neurons.

  2006cites this paper
• Estrogen and the development and protection of nigrostriatal dopaminergic neurons: concerted action of a multitude of signals, protective molecules, and growth factors.

  2006cites this paper
• Enhanced sensitivity and stability in two‐color in situ hybridization by means of a novel chromagenic substrate combination

  2006cites this paper
• Neurogenic niche modulation by activated microglia: transforming growth factor β increases neurogenesis in the adult dentate gyrus

  2006influential citation
• The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease.

  2005cites this paper
• Emerging roles for TGF-beta1 in nervous system development.

  2005cites this paper
• Emerging roles for TGF‐β1 in nervous system development

  2005cites this paper
• The floor plate: multiple cells, multiple signals

  2005cites this paper
• Purified mouse dopamine neurons thrive and function after transplantation into brain but require novel glial factors for survival in culture.

  2005cites this paper
• Factors involved in the determination of the neurotransmitter phenotype of developing neurons of the CNS: applications in cell replacement treatment for Parkinson's disease.

  2005cites this paper
• Purified mouse dopamine neurons thrive and function after transplantation into brain but require novel glial factors for survival in culture.

  2005influential citation
• UvA-DARE (Digital Academic Repository) Embryonic development of selectively vulnerable neurons in Parkinson's disease

  year unknowncites this paper