IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Cell

• Publication date

  2018-05-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.cell.2018.02.055PMID 29576451PMCID PMC5935577
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Quality of TCR signaling encoded by differential enhancer affinities for the composite BATF-IRF4 transcription factor complex

  2017cited by this paper
• Differential roles of caspase-1 and caspase-11 in infection and inflammation

  2017cited by this paper
• Salmonella and the Inflammasome: Battle for Intracellular Dominance.

  2016cited by this paper
• Genetic functions of the NAIP family of inflammasome receptors for bacterial ligands in mice

  2016cited by this paper
• Transcriptional and Epigenetic Regulation of Innate Immune Cell Development by the Transcription Factor, Interferon Regulatory Factor-8

  2016cited by this paper
• IRF8 Transcription Factor Controls Survival and Function of Terminally Differentiated Conventional and Plasmacytoid Dendritic Cells, Respectively.

  2016cited by this paper
• Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

  2016cited by this paper
• NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo

  2016cited by this paper
• Single-cell analysis of mixed-lineage states leading to a binary cell fate choice

  2016cited by this paper
• Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

  2016cited by this paper
• The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation

  2016cited by this paper
• Intracellular innate immune surveillance devices in plants and animals

  2016cited by this paper
• Regulation of inflammasome activation

  2015cited by this paper
• Type I interferons in anticancer immunity

  2015cited by this paper
• Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

  2015cited by this paper
• Bacterial recognition pathways that lead to inflammasome activation

  2015cited by this paper
• The transcription factor IRF1 and guanylate-binding proteins target AIM2 inflammasome activation by Francisella infection

  2015cited by this paper
• Cutting Edge: Inflammasome Activation in Primary Human Macrophages Is Dependent on Flagellin

  2015cited by this paper
• The NAIP–NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus

  2015cited by this paper
• Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

  2015cited by this paper
• Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa.

  2014cited by this paper
• Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex

  2014cited by this paper
• Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

  2014cited by this paper
• Regulation of type I interferon responses

  2013cited by this paper
• Salmonella enterica Serovar Typhimurium Skills To Succeed in the Host: Virulence and Regulation

  2013cited by this paper
• Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

  2013cited by this paper
• Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation

  2013cited by this paper
• Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain

  2013cited by this paper
• The RIG-I-like receptor LGP2 controls CD8(+) T cell survival and fitness.

  2012cited by this paper
• Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges

  2012cited by this paper
• A Genomic Regulatory Element That Directs Assembly and Function of Immune-Specific AP-1–IRF Complexes

  2012cited by this paper
• Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

  2012cited by this paper
• Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

  2012cited by this paper
• Subversion of Host Recognition and Defense Systems by Francisella spp

  2012cited by this paper
• TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.

  2012cited by this paper
• Integrative Genomics Viewer

  2011cited by this paper
• Non-canonical inflammasome activation targets caspase-11

  2011cited by this paper
• The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

  2011cited by this paper
• Innate immune recognition of bacterial ligands by NAIPs dictates inflammasome specificity

  2011cited by this paper
• The N-Ethyl-N-Nitrosourea-Induced Goldenticket Mouse Mutant Reveals an Essential Function of Sting in the In Vivo Interferon Response to Listeria monocytogenes and Cyclic Dinucleotides

  2010cited by this paper
• A type VI secretion system of Pseudomonas aeruginosa targets a toxin to bacteria.

  2010cited by this paper
• Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis

  2010cited by this paper
• The AIM2 inflammasome is critical for innate immunity against Francisella tularensis

  2010cited by this paper
• Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella

  2010cited by this paper
• Burkholderia Type VI Secretion Systems Have Distinct Roles in Eukaryotic and Bacterial Cell Interactions

  2010cited by this paper
• Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

  2008cited by this paper
• Model-based Analysis of ChIP-Seq (MACS)

  2008cited by this paper
• Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

  2008cited by this paper
• The IRF family transcription factors in immunity and oncogenesis.

  2008cited by this paper
• GeneMANIA: a real-time multiple association network integration algorithm for predicting gene function

  2008cited by this paper
• The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8.

  2007cited by this paper
• Type I interferon signaling is required for activation of the inflammasome during Francisella infection

  2007cited by this paper
• Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome

  2007cited by this paper
• Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity

  2006cited by this paper
• Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

  2006cited by this paper
• Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

  2006cited by this paper
• Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

  2006cited by this paper
• Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

  2006cited by this paper
• A global map of p53 transcription-factor binding sites in the human genome.

  2006cited by this paper
• Regulation of Legionella Phagosome Maturation and Infection through Flagellin and Host Ipaf*

  2006cited by this paper
• The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

  2006cited by this paper
• IRF-7 is the master regulator of type-I interferon-dependent immune responses

  2005cited by this paper
• Synergistic Activation of Interleukin-12 p35 Gene Transcription by Interferon Regulatory Factor-1 and Interferon Consensus Sequence-binding Protein*

  2004cited by this paper
• Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

  2004cited by this paper
• Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

  2003cited by this paper
• Distribution of NF-κB-binding sites across human chromosome 22

  2003cited by this paper
• Cytoscape: a software environment for integrated models of biomolecular interaction networks.

  2003cited by this paper
• Complex Formation of the Interferon (IFN) Consensus Sequence-binding Protein with IRF-1 Is Essential for Murine Macrophage IFN-γ-induced iNOS Gene Expression*

  2003cited by this paper
• An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis

  2003cited by this paper
• Distribution of NF-kappaB-binding sites across human chromosome 22.

  2003cited by this paper
• IRF‐8/ICSBP and IRF‐1 cooperatively stimulate mouse IL‐12 promoter activity in macrophages

  2002cited by this paper
• Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

  2002cited by this paper
• Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction.

  2000cited by this paper
• An IFN-γ-Inducible Transcription Factor, IFN Consensus Sequence Binding Protein (ICSBP), Stimulates IL-12 p40 Expression in Macrophages

  2000cited by this paper
• Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction

  2000cited by this paper
• Defective NK cell activity and Th1 response in IL-18-deficient mice.

  1998cited by this paper
• PU.1, Interferon Regulatory Factor 1, and Interferon Consensus Sequence-binding Protein Cooperate to Increase gp91 phox Expression*

  1998cited by this paper
• Interferons up-regulate STAT1, STAT2, and IRF family transcription factor gene expression in human peripheral blood mononuclear cells and macrophages.

  1997cited by this paper
• Phenotypic and functional characterization of mice that lack the type I receptor for IL-1.

  1997cited by this paper
• A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes

  1996cited by this paper
• Essential and non‐redundant roles of p48 (ISGF3γ) and IRF‐1 in both type I and type II interferon responses, as revealed by gene targeting studies

  1996cited by this paper
• Differential expression of interferon regulatory factor 1 (IRF-1), IRF-2, and interferon consensus sequence binding protein genes in lipopolysaccharide (LPS)-responsive and LPS-hyporesponsive macrophages

  1995cited by this paper
• Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family.

  1994cited by this paper
• Functional role of type I and type II interferons in antiviral defense.

  1994cited by this paper
• Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development.

  1993cited by this paper
• Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins

  1992cited by this paper
• An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes.

  1990cited by this paper
• Induction of endogenous IFN-α and IFN-β genes by a regulatory transcription factor, IRF-1

  1989cited by this paper
• Induction of endogenous IFN-alpha and IFN-beta genes by a regulatory transcription factor, IRF-1.

  1989cited by this paper
• Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes.

  1989cited by this paper

• PU.1 Inhibition Attenuates Neuroinflammation and Pyroptosis After Traumatic Brain Injury by Modulating Microglial Polarization.

  2026cites this paper
• Mechanism of IRF8 on osteocyte apoptosis in steroid-induced osteonecrosis of the femoral head

  2025cites this paper
• The critical role of the ZBP1-NINJ1 axis and IRF1/IRF9 in ethanol-induced cell death, PANoptosis, and alcohol-associated liver disease

  2025cites this paper
• Innate immune sensor NLRP3 drives PANoptosome formation and PANoptosis

  2025cites this paper
• Microglia-drive IRF8 upregulates complement pathway in Parkinson's disease.

  2025cites this paper
• Cardiomyocyte pyroptosis inhibited by dental pulp-derived mesenchymal stem cells via the miR-19a-3p/IRF-8/MAPK pathway in ischemia–reperfusion

  2025cites this paper
• A potent NLRP3 inhibitor effective against both MCC950-sensitive and -resistant inflammation.

  2025cites this paper
• IRF8 and RUNX1 cooperatively regulate the senescence and damage of urine-derived renal progenitor cells by upregulating LINC01806.

  2025cites this paper
• Targeting innate immune sensors for therapeutic strategies in infectious diseases.

  2025cites this paper
• Regulation of cancer by inflammasomes: from inflammation to tumorigenesis

  2025cites this paper
• Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis.

  2025cites this paper
• Roles of NLRC4 inflammasome in neurological disorders: Mechanisms, implications, and therapeutic potential.

  2025cites this paper
• Signature Construction Associated with Tumor-Infiltrating Macrophages Identifies IRF8 as a Novel Biomarker for Immunotherapy in Advanced Gastric Cancer

  2025cites this paper
• Stress granule component protein TIA1 is a negative regulator of the noncanonical NLRP3 inflammasome

  2025cites this paper
• Zika virus inhibits cell death by inhibiting the expression of NLRP3 and A20

  2025cites this paper
• Regulation of ZFP36 by lncOlfr29 promotes inflammation through NLRP3

  2025cites this paper
• Inflammation in cancer: therapeutic opportunities from new insights

  2025cites this paper
• GSDMD-mediated pyroptosis: molecular mechanisms, diseases and therapeutic targets

  2025cites this paper
• Identification of an IRF8 gene in common carp (Cyprinus carpio. L) and its regulatory role in immune responses

  2025cites this paper
• The hypervirulent Type-1/Type-17 phenotype of Cryptococcus neoformans clinical isolates is specific to A/J mice

  2025cites this paper
• The Angiotensin II Receptor Neprilysin Inhibitor LCZ696 Inhibits the NLRP3 Inflammasome By Reducing Mitochondrial Dysfunction in Macrophages and Alleviates Dextran Sulfate Sodium-induced Colitis in a Mouse Model

  2024cites this paper
• The multiple roles of interferon regulatory factor family in health and disease

  2024cites this paper
• Recent Advances in NLRP3 Inflammasome in Corneal Diseases: Preclinical Insights and Therapeutic Implications.

  2024cites this paper
• Exploring the correlation between innate immune activation of inflammasome and regulation of pyroptosis after intracerebral hemorrhage: From mechanism to treatment.

  2024cites this paper
• NLRC4, inflammation and colorectal cancer (Review)

  2024cites this paper
• Atg16l2 augments Nlrc4 inflammasome activation by facilitating NAIPs–NLRC4 association

  2024cites this paper
• Classical apoptotic stimulus, staurosporine, induces lytic inflammatory cell death, PANoptosis

  2024cites this paper
• Defining PANoptosis: Biochemical and Mechanistic Evaluation of Innate Immune Cell Death Activation

  2024cites this paper
• Human NLRC4 expression promotes cancer survival and associates with type I interferon signaling and immune infiltration

  2024cites this paper
• The NLR family of innate immune and cell death sensors.

  2024cites this paper
• A palmitoylation–depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis

  2024influential citation
• Inflammasome diversity: exploring novel frontiers in the innate immune response.

  2024cites this paper
• Cell death.

  2024cites this paper
• TLR priming licenses NAIP inflammasome activation by immunoevasive ligands

  2024cites this paper
• CircMLH3 induces mononuclear macrophage pyroptosis in sepsis by sponging miR-590-3p to regulate TAK1 expression.

  2024cites this paper
• NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress

  2024cites this paper
• The NLRP3 molecule is responsible for mediating the pyroptosis of intestinal mucosa cells and plays a crucial role in salmonellosis enteritis in chicks.

  2024cites this paper
• Pyroptosis: the dawn of a new era in endometrial cancer treatment

  2023cites this paper
• PE12 interaction with TLR4 promotes intracellular survival of Mycobacterium tuberculosis by suppressing inflammatory response.

  2023cites this paper
• Control of Cell Death in Health and Disease.

  2023cites this paper
• Epigenetic and transcriptional control of gasdermins.

  2023cites this paper
• Regulated cell death pathways and their roles in homeostasis, infection, inflammation, and tumorigenesis

  2023cites this paper
• Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and NLRP12-PANoptosome activation and inflammatory cell death (PANoptosis)

  2023cites this paper
• Hypomethylated interferon regulatory factor 8 recruits activating protein-2α to attenuate porcine epidemic diarrhea virus infection in porcine jejunum

  2023cites this paper
• Inflammasomes: Mechanisms of Action and Involvement in Human Diseases

  2023cites this paper
• NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs.

  2023influential citation
• SaaS sRNA promotes Salmonella intestinal invasion via modulating MAPK inflammatory pathway

  2023cites this paper
• TLR priming licenses NAIP inflammasome activation by immunoevasive ligands

  2023cites this paper
• The effects of dimethyl fumarate on cytoplasmic LPS-induced noncanonical pyroptosis in periodontal ligament fibroblasts and dental pulp cells.

  2023cites this paper
• LNCGM1082-mediated NLRC4 activation drives resistance to bacterial infection

  2023cites this paper
• Pyroptosis, inflammasome, and gasdermins in tumor immunity

  2023cites this paper
• Genome-wide exploration of a pyroptosis-related gene module along with immune cell infiltration patterns in bronchopulmonary dysplasia

  2023cites this paper
• Modulation of Nod-like Receptor Expression in the Thymus during Early Pregnancy in Ewes

  2022cites this paper
• It’s All in the PAN: Crosstalk, Plasticity, Redundancies, Switches, and Interconnectedness Encompassed by PANoptosis Underlying the Totality of Cell Death-Associated Biological Effects

  2022cites this paper
• Talaromyces marneffei activates the AIM2-caspase-1/-4-GSDMD axis to induce pyroptosis in hepatocytes

  2022cites this paper
• The human inflammasomes.

  2022cites this paper
• Role of pyroptosis in inflammation and cancer

  2022cites this paper
• Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes

  2022cites this paper
• Nicotine in Combination with SARS-CoV-2 Affects Cells Viability, Inflammatory Response and Ultrastructural Integrity

  2022cites this paper
• IRF8: Mechanism of Action and Health Implications

  2022cites this paper
• Comprehensive analysis reveals potential hub genes and therapeutic drugs in an acquired lymphedema model

  2022cites this paper
• Determining distinct roles of IL-1α through generation of an IL-1α knockout mouse with no defect in IL-1β expression

  2022cites this paper
• Deacetylation of IRF8 inhibits iNOS expression and inflammation via SIRT1 in macrophages.

  2022cites this paper
• AIM2 and NLRC4-driven inflammasome activation in adult-onset Still’s disease and the preliminary therapeutic effect exploration of carboxyamidotriazole

  2022cites this paper
• NLRC4 Deficiency Leads to Enhanced Phosphorylation of MLKL and Necroptosis

  2022cites this paper
• Salmonella Infection Causes Hyperglycemia for Decreased GLP-1 Content by Enteroendocrine L Cells Pyroptosis in Pigs

  2022cites this paper
• Innate Sensors Trigger Regulated Cell Death to Combat Intracellular Infection.

  2022cites this paper
• The Roles of Monocytes and Macrophages in Behçet’s Disease With Focus on M1 and M2 Polarization

  2022cites this paper
• Host Cells Actively Resist Porcine Reproductive and Respiratory Syndrome Virus Infection via the IRF8-MicroRNA-10a-SRP14 Regulatory Pathway

  2022cites this paper
• SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation

  2021cites this paper
• Dysbiosis From a Microbial and Host Perspective Relative to Oral Health and Disease

  2021cites this paper
• Inflammasome Activation in Ankylosing Spondylitis Is Associated With Gut Dysbiosis

  2021cites this paper
• High IRF8 expression correlates with CD8 T cell infiltration and is a predictive biomarker of therapy response in ER-negative breast cancer

  2021cites this paper
• Point Mutation Specific Antibodies in B-Cell and T-Cell Lymphomas and Leukemias: Targeting IDH2, KRAS, BRAF and Other Biomarkers RHOA, IRF8, MYD88, ID3, NRAS, SF3B1 and EZH2

  2021cites this paper
• PU.1 and IRF8 Modulate Activation of NLRP3 Inflammasome via Regulating Its Expression in Human Macrophages

  2021cites this paper
• Select hyperactivating NLRP3 ligands enhance the TH1- and TH17-inducing potential of human type 2 conventional dendritic cells

  2021cites this paper
• Bacterial outer membrane vesicles and host cell death signaling.

  2021cites this paper
• Differential mRNA and miRNA Profiles Reveal the Potential Roles of Genes and miRNAs Involved in LPS Infection in Chicken Macrophages

  2021cites this paper
• Inflammasomes in Alveolar Bone Loss

  2021cites this paper
• TLR and IKK Complex–Mediated Innate Immune Signaling Inhibits Stress Granule Assembly

  2021cites this paper
• Hierarchical Cell Death Program Disrupts the Intracellular Niche Required for Burkholderia thailandensis Pathogenesis

  2021influential citation
• Updating the NLRC4 Inflammasome: from Bacterial Infections to Autoimmunity and Cancer

  2021cites this paper
• Pattern recognition receptors in health and diseases

  2021cites this paper
• Preexisting mycobacterial infection modulates Candida albicans-driven pyroptosis

  2021cites this paper
• IRF8 Impacts Self‐Renewal of Hematopoietic Stem Cells by Regulating TLR9 Signaling Pathway of Innate Immune Cells

  2021cites this paper
• Hepatic interferon regulatory factor 8 expression mediates liver ischemia/reperfusion injury in mice.

  2021cites this paper
• AIM2 forms a complex with Pyrin and ZBP1 to drive PANoptosis and host defense

  2021cites this paper
• Programming inflammatory cell death for therapy.

  2021cites this paper
• Cutting Edge: Caspase-8 Is a Linchpin in Caspase-3 and Gasdermin D Activation to Control Cell Death, Cytokine Release, and Host Defense during Influenza A Virus Infection

  2021cites this paper
• ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis.

  2021influential citation
• The transcriptional activity profile of inhibitor apoptosis protein encoding genes in colon cancer patients

  2021cites this paper
• RNA-Seq analysis identifies novel roles for the primary cilia gene SPAG17 and the SOX9 locus non-coding RNAs in systemic sclerosis

  2021cites this paper
• An all-in-one adjuvanted therapeutic cancer vaccine targeting dendritic cell cytosol induces long-lived tumor suppression through NLRC4 inflammasome activation.

  2021cites this paper
• A novel pyroptosis-related gene signature to predict outcomes in laryngeal squamous cell carcinoma

  2021cites this paper
• Advances in Understanding Activation and Function of the NLRC4 Inflammasome

  2021cites this paper
• Role of NLRs in the Regulation of Type I Interferon Signaling, Host Defense and Tolerance to Inflammation

  2021influential citation
• Brd4 regulates NLRC4 inflammasome activation by facilitating IRF8-mediated transcription of Naips

  2021cites this paper
• Tumor Suppressor Protein p53 and Inhibitor of Apoptosis Proteins in Colorectal Cancer—A Promising Signaling Network for Therapeutic Interventions

  2021cites this paper
• The nonreceptor tyrosine kinase SYK induces autoinflammatory osteomyelitis in a mouse model of chronic recurrent multifocal osteomyelitis

  2020influential citation
• Molecular Mechanisms of Salmonella Effector Proteins: A Comprehensive Review

  2020cites this paper