Vitamin C promotes wound healing through novel pleiotropic mechanisms

No abstract is available for this paper.

• Publication year

  2016

• Venue

  International Wound Journal

• Publication date

  2016-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/iwj.12484PMID 26290474PMCID PMC7949787
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2012influential reference
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• Basal and induced amounts of interleukin-6 mRNA decline progressively with age in human fibroblasts.

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  1994cited by this paper
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  1994cited by this paper
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  1989cited by this paper
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  1981cited by this paper
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  1975cited by this paper
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  1972cited by this paper

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