Oct4 is a critical regulator of stemness in head and neck squamous carcinoma cells

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Oncogene

• Publication date

  2014-06-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/onc.2014.174PMID 24954502
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007cited by this paper
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