Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Cell Metabolism

• Publication date

  2018-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.cmet.2018.02.024PMID 29628419PMCID PMC5932208
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment

  2017cited by this paper
• Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up

  2017cited by this paper
• Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma.

  2016cited by this paper
• Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

  2016cited by this paper
• Image Analysis–based Assessment of PD-L1 and Tumor-Associated Immune Cells Density Supports Distinct Intratumoral Microenvironment Groups in Non–small Cell Lung Carcinoma Patients

  2016influential reference
• LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.

  2016cited by this paper
• In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer.

  2016cited by this paper
• In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype.

  2016cited by this paper
• Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy.

  2016cited by this paper
• From Krebs to clinic: glutamine metabolism to cancer therapy

  2016cited by this paper
• Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma.

  2016cited by this paper
• Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade.

  2016cited by this paper
• Serine and one-carbon metabolism in cancer

  2016cited by this paper
• Oxygen availability and metabolic adaptations

  2016cited by this paper
• Regulatory circuits of T cell function in cancer

  2016cited by this paper
• From Krebs to clinic: glutamine metabolism to cancer therapy

  2016cited by this paper
• Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy.

  2016influential reference
• Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy.

  2016cited by this paper
• Lung cancer: First-line immunotherapy in lung cancer — taking the first step

  2016cited by this paper
• Adoptive cell transfer as personalized immunotherapy for human cancer

  2015cited by this paper
• Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities.

  2015cited by this paper
• Investigational cancer drugs targeting cell metabolism in clinical development

  2015cited by this paper
• Genomic Classification of Cutaneous Melanoma.

  2015cited by this paper
• Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

  2015cited by this paper
• An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2

  2015cited by this paper
• Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression.

  2015cited by this paper
• Comprehensive molecular profiling of lung adenocarcinoma

  2014cited by this paper
• Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.

  2014cited by this paper
• Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions

  2014cited by this paper
• Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α

  2014cited by this paper
• A 12-Gene Set Predicts Survival Benefits from Adjuvant Chemotherapy in Non–Small Cell Lung Cancer Patients

  2013cited by this paper
• Metabolic targets for cancer therapy

  2013cited by this paper
• Oncology meets immunology: the cancer-immunity cycle.

  2013influential reference
• Co-Stimulation through 4-1BB/CD137 Improves the Expansion and Function of CD8+ Melanoma Tumor-Infiltrating Lymphocytes for Adoptive T-Cell Therapy

  2013cited by this paper
• BRAF Inhibition Is Associated with Enhanced Melanoma Antigen Expression and a More Favorable Tumor Microenvironment in Patients with Metastatic Melanoma

  2013cited by this paper
• Comprehensive genomic characterization of squamous cell lung cancers

  2012cited by this paper
• BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice

  2012cited by this paper
• A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue

  2012cited by this paper
• Oncogenic BRAF(V600E) Promotes Stromal Cell-Mediated Immunosuppression Via Induction of Interleukin-1 in Melanoma

  2012cited by this paper
• Hallmarks of cancer: the next generation.

  2011cited by this paper
• Warburg phenotype in renal cell carcinoma: High expression of glucose‐transporter 1 (GLUT‐1) correlates with low CD8+ T‐cell infiltration in the tumor

  2011cited by this paper
• Aerobic glycolysis: meeting the metabolic requirements of cell proliferation.

  2011cited by this paper
• Effect of Long-term Storage in TRIzol on Microarray-Based Gene Expression Profiling

  2010cited by this paper
• Transduction of Tumor-Specific T Cells with CXCR2 Chemokine Receptor Improves Migration to Tumor and Antitumor Immune Responses

  2010cited by this paper
• Clinical studies for improving radiotherapy with 2-deoxy-D-glucose: present status and future prospects.

  2009cited by this paper
• A method for lactate and pyruvate determination in filter-paper dried blood spots.

  2009cited by this paper
• Inhibitory effect of tumor cell-derived lactic acid on human T cells.

  2007cited by this paper
• 2-NBDG as a fluorescent indicator for direct glucose uptake measurement.

  2005cited by this paper
• Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma.

  2005cited by this paper
• Assay of Rab25 function in ovarian and breast cancers.

  2005cited by this paper
• A sensitive flow cytometry-based cytotoxic T-lymphocyte assay through detection of cleaved caspase 3 in target cells.

  2005cited by this paper
• Estimating the Occurrence of False Positives and False Negatives in Microarray Studies by Approximating and Partitioning the Empirical Distribution of P-values

  2003cited by this paper
• High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers.

  2000cited by this paper

• From the Hallmarks of Cancer to the Survival System: A Paradigmatic Reconstruction of Oncological Theory through the Existential Crisis-Driven Survival (ECDS) Framework

  2026cites this paper
• Sperm-Specific Glyceraldehyde-3-Phosphate Dehydrogenase and Energy Metabolism in Melanoma Cells

  2026cites this paper
• Immunotherapy-driven remodeling of the tumor immune microenvironment: Spatiotemporal heterogeneity and multidimensional dynamics.

  2026cites this paper
• Metabolites as signalling molecules in the tumour immune microenvironment.

  2026cites this paper
• Lactylation in cancer: molecular mechanisms and advances in clinical study

  2026cites this paper
• CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting

  2026cites this paper
• The mechanism by which KAT2A increases the stability of CDC25A through acetylation to regulate glycolysis and mediate lung adenocarcinoma immune escape.

  2026cites this paper
• Histone lactylation increases CXCL1 expression for neutrophil infiltration and immune escape in pancreatic cancer.

  2026cites this paper
• Alkaline Phosphatase-Activated NIR-II AIEgens Nanosystem for Surgical and Postoperative Closed-Loop Therapy of Advanced Osteosarcoma.

  2026cites this paper
• Tumor microenvironment in gastric cancer immune tolerance and its therapeutic relevance in immunomodulation (Review)

  2026cites this paper
• Integrative single-cell atlas unveils heterogeneity and prognostic value of cancer-associated fibroblasts in gastric cancer

  2026cites this paper
• GLUT1 expression, lymphocyte distribution and CD3+ T-cell metabolic subsets as predictive markers of response to immunotherapy in advanced melanoma

  2026cites this paper
• Molecular Targets for Cancer Immunotherapy: Focusing on (Immune and Tumor) Cell-Derived Metabolites

  2026cites this paper
• Lactate-lactylation in tumor angiogenesis and progression: mechanisms, biomarker potential, and therapeutic implications

  2026cites this paper
• Machine Learning Characterization of Immunometabolism in the Tumor Microenvironment and Immunotherapy Responses in Bladder Cancer.

  2025cites this paper
• Impact of Sucrose Consumption on the Metabolic, Immune, and Redox Profile of Mice with Gestational Diabetes Mellitus

  2025cites this paper
• Protein lactylation in cancer and other pathologies: epigenetic regulation of glycolysis and its therapeutic perspectives.

  2025cites this paper
• Cell competition as an emerging mechanism and therapeutic target in cancer.

  2025cites this paper
• Energiehaushalt von malignen Melanomen: Tumorstoffwechsel erklärt Wachstum und Therapieresistenz

  2025cites this paper
• Lactate and lactylation in cancer

  2025cites this paper
• Therapeutic repurposing of old drugs to modulate the tumor immune microenvironment and enhance immunotherapy efficacy

  2025cites this paper
• Epithelial cell diversity and immune remodeling in bladder cancer progression: insights from single-cell transcriptomics

  2025cites this paper
• Cancer-associated fibroblasts promote EGFR-TKI resistance via the CTHRC1/glycolysis/H3K18la positive feedback loop

  2025cites this paper
• Suppression of Spry1 reduces HIF1α-dependent glycolysis and impairs angiogenesis in BRAF-mutant cutaneous melanoma

  2025cites this paper
• AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress

  2025cites this paper
• Unveiling immune resistance mechanisms in nasopharyngeal carcinoma and emerging targets for antitumor immune response: tertiary lymphoid structures

  2025cites this paper
• Ultrasmall lactoferrin/lipid multicompartmental nanomedicine-based reprogramming of glycolysis in triple-negative breast cancer via HDAC6/LDH axis enhances cancer immunotherapy

  2025cites this paper
• 6-Methoxyflavone inhibits glycolytic energy metabolism in HeLa cells

  2025cites this paper
• Integrative Single-Cell and Bulk RNA Sequencing Identifies a Glycolysis-Related Prognostic Signature for Predicting Prognosis in Pancreatic Cancer

  2025cites this paper
• D-mannose augments targeted radioligand-immunotherapy of prostate cancer by enhancing radiosensitivity and reshaping immune microenvironment

  2025cites this paper
• Unraveling the relapse-associated landscape and individualized therapy in stage I lung adenocarcinoma based on immune and mitochondrial metabolism hallmarks via multi-omics analyses

  2025cites this paper
• GLUT5 armouring enhances adoptive T-cell therapy anti-tumour activity under glucose-limiting conditions

  2025cites this paper
• Metabolic engineering to facilitate anti-tumor immunity.

  2025cites this paper
• 4-Methylumbelliferone Modulates CAIX to Mitigate Hypoxia-Driven Dysregulation and Enhance PD-1 Immunotherapy in Lung Cancer

  2025cites this paper
• CUEDC1 promotes glycolytic metabolism reprogramming through the CUEDC1/CACNG4/PI3K axis to promote ER-positive breast cancer growth

  2025cites this paper
• Breaking Glycolysis Barriers to Immunotherapy with Nanomedicines

  2025cites this paper
• POU4F1 Promotes the Primary Resistance of Melanoma to Anti‐PD‐1 Therapy by Regulating Glycolysis Through METTL1‐Mediated m7G Methylation of PKM2

  2025cites this paper
• Immunometabolic Gatekeeping: Reconciling Peto’s & the T-cell Infiltration Prognostic Paradox

  2025cites this paper
• Turning cold tumors into hot tumors to ignite immunotherapy

  2025cites this paper
• Regulation of drug resistance in bladder urothelial carcinoma by tumor aerobic glycolysis

  2025cites this paper
• Targeting SRSF1 improves cancer immunotherapy by dually acting on CD8+T and tumor cells

  2025cites this paper
• Tumor-induced metabolic immunosuppression: Mechanisms and therapeutic targets.

  2025cites this paper
• Integration of multiple machine learning approaches develops a gene mutation-based classifier for accurate immunotherapy outcomes

  2025cites this paper
• Metabolism of Tryptophan, Glutamine, and Asparagine in Cancer Immunotherapy—Synergism or Mechanism of Resistance?

  2025cites this paper
• Glycolytic diversity drives immune complexity in cancer.

  2025cites this paper
• The Critical Role of Homing in TIL Therapy Success: From Biology to Clinical Application.

  2025cites this paper
• OPPORTUNITIES AND CHALLENGES FOR TARGETING CANCER METABOLISM.

  2025cites this paper
• Salvianolic acid B inhibits melanoma via dual modulation of glycolysis and NK/T cell immunity.

  2025cites this paper
• Spatiotemporal Heterogeneity of Tumor Glucose Metabolism Reprogramming: From Single-Cell Mechanisms to Precision Interventions

  2025cites this paper
• Metabolites as agents and targets for cancer immunotherapy

  2025cites this paper
• New onset diabetes predicts clinical outcomes in patients with pancreatic adenocarcinoma

  2025cites this paper
• An ultrasound-visualized methionine partitioning nano-modulator for enhanced immunotherapy against anti-PD-1 resistant tumors

  2025cites this paper
• Preoperative Maximum Standardized Uptake Value Emphasized in Explainable Machine Learning Model for Predicting the Risk of Recurrence in Resected Non–Small Cell Lung Cancer

  2025cites this paper
• Artificial Intelligence‐Guided Identification of IGFBP7 as a Critical Indicator in Lactic Metabolism Determines Immunotherapy Response in Stomach Adenocarcinoma

  2025cites this paper
• Immunogenomic cancer evolution: A framework to understand cancer immunosuppression.

  2025cites this paper
• The roles of enhancer, especially super-enhancer-driven genes in tumor metabolism and immunity.

  2025cites this paper
• Role of metabolic transformation in cancer immunotherapy resistance: molecular mechanisms and therapeutic implications

  2025cites this paper
• Comprehensive analysis of glycometabolism-related genes reveals PLOD2 as a prognostic biomarker and therapeutic target in gastric cancer

  2025cites this paper
• Radiotherapy-induced alterations in tumor microenvironment: metabolism and immunity

  2025cites this paper
• Unlocking T‐Cell Plasticity in the Tumor Microenvironment: Implications for Cancer Progression and Therapeutic Strategies

  2025cites this paper
• Bioinformatics prediction and experimental verification identify B4GALT1 as a diagnostic biomarker of glioblastoma.

  2025cites this paper
• Metabolism and Immune Suppressive Response in Liver Cancer

  2025cites this paper
• Metabolic adaptations in cancer progression.

  2025cites this paper
• Dihydroartemisinin inhibits histone lactylation through YAP1 to act as a 'hot' switch for 'cold' tumor in hepatocellular carcinoma.

  2025cites this paper
• Disrupting tumor homeostasis with an autoamplificatory nanoinducer to augment pyroptosis for efficient immunotherapy.

  2025cites this paper
• Generation of personalized whole tumor cells vaccine for pyroptosis-enhanced anticancer immunity via Cu2-xSe photothermal activation under NIR irradiation.

  2025cites this paper
• Persistent accumulation of therapy-induced senescent cells: an obstacle to long-term cancer treatment efficacy

  2025cites this paper
• Mitochondrial metabolism and cancer therapeutic innovation

  2025cites this paper
• Pan‐cancer analysis and oncogenic implications of MGAM and MGAM2: Toward precision oncology and drug repurposing in colorectal cancer

  2025cites this paper
• Sonodynamic therapy augmented by glycolysis inhibition: a novel metabolic reprogramming strategy for enhanced osteosarcoma treatment

  2025cites this paper
• Reprogramming of cancer metabolism via photoresponsive nano-PROTAC enhances pyroptosis-mediated immunotherapy

  2025cites this paper
• Inhibition of DDX3 modulates immune signaling in aggressive breast cancers.

  2025cites this paper
• Tumor Intrinsic METTL5 Modulates ATF4 Translation to Prevent T Cell‐Induced Ferroptosis in Ovarian Cancer

  2025cites this paper
• Metabolite to Modifier: Lactate and Lactylation in the Evolution of Tumors

  2025cites this paper
• Targeting tumor-draining lymph node to overcome resistance to cancer immunotherapy: an update

  2025cites this paper
• Reprogramming neural-tumor crosstalk: emerging therapeutic dimensions and targeting strategies

  2025cites this paper
• Cervical cancer molecular subtype identification and prognosis classification by a metabolism-related gene expression

  2025cites this paper
• Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

  2025cites this paper
• Dysregulated mitochondrial dynamics in cancer: Unlocking new strategies to combat drug resistance.

  2025cites this paper
• Recent advances in nanotechnology for metabolic cancer therapy

  2025cites this paper
• Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

  2024cites this paper
• Exploring the impact of circRNAs on cancer glycolysis: Insights into tumor progression and therapeutic strategies

  2024cites this paper
• GPC3-targeted CAR-T cells expressing GLUT1 or AGK exhibit enhanced antitumor activity against hepatocellular carcinoma

  2024cites this paper
• A signature of seven hypoxia-related lncRNAs is a potential biomarker for predicting the prognosis of melanoma.

  2024cites this paper
• Glycolysis inhibition affects proliferation and cytotoxicity of Vγ9Vδ2 T cells expanded for adoptive cell therapy.

  2024cites this paper
• Dihydroartemisinin breaks the positive feedback loop of YAP1 and GLUT1-mediated aerobic glycolysis to boost the CD8+ effector T cells in hepatocellular carcinoma.

  2024cites this paper
• 肿瘤微环境中细胞代谢相互作用的研究进展

  2024cites this paper
• Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties

  2024cites this paper
• Cancer cell metabolism and antitumour immunity

  2024cites this paper
• A Novel Gene Signature Based on Immune Cell Infiltration Landscape Predicts Prognosis in Lung Adenocarcinoma Patients.

  2024cites this paper
• Enhancing NSCLC recurrence prediction with PET/CT habitat imaging, ctDNA, and integrative radiogenomics-blood insights

  2024cites this paper
• Biomarkers for response to TIL therapy: a comprehensive review

  2024cites this paper
• Abnormal changes in metabolites caused by m6A methylation modification: The leading factors that induce the formation of immunosuppressive tumor microenvironment and their promising potential for clinical application

  2024cites this paper
• The interplay between metabolic adaptations and diet in cancer immunotherapy.

  2024cites this paper
• Distinctive multicellular immunosuppressive hubs confer different intervention strategies for left- and right-sided colon cancers

  2024cites this paper
• Nasopharyngeal carcinoma: current views on the tumor microenvironment's impact on drug resistance and clinical outcomes

  2024cites this paper
• RETRACTED ARTICLE: Effect of radiotherapy on head and neck cancer tissues in patients receiving radiotherapy: a bioinformatics analysis-based study

  2024cites this paper
• Decreased LDHB expression in breast tumor cells causes NK cell activation and promotes tumor progression

  2024cites this paper
• Pathway‐based stratification of gliomas uncovers four subtypes with different TME characteristics and prognosis

  2024cites this paper
• Immunosurveillance encounters cancer metabolism

  2024cites this paper