Dishevelled promotes axon differentiation by regulating atypical protein kinase C

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Nature Cell Biology

• Publication date

  2007-06-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ncb1603PMID 17558396
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Neuronal polarity].

  2008cited by this paper
• Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity.

  2006cited by this paper
• Wnt signals and frizzled activity orient anterior-posterior axon outgrowth in C. elegans.

  2006cited by this paper
• Wnt signaling establishes anteroposterior neuronal polarity and requires retromer in C. elegans

  2006cited by this paper
• Requirement of dendritic Akt degradation by the ubiquitin–proteasome system for neuronal polarity

  2006cited by this paper
• PAR-6–PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1

  2005cited by this paper
• Signalling in neural development: WNTS in the vertebrate nervous system: from patterning to neuronal connectivity

  2005cited by this paper
• Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development

  2005cited by this paper
• The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity

  2005cited by this paper
• Mammalian SAD Kinases Are Required for Neuronal Polarization

  2005cited by this paper
• Both the Establishment and the Maintenance of Neuronal Polarity Require Active Mechanisms: Critical Roles of GSK-3 and Its Upstream Regulators

  2005cited by this paper
• GSK-3β Regulates Phosphorylation of CRMP-2 and Neuronal Polarity

  2005cited by this paper
• Regulation of Lethal giant larvae by Dishevelled

  2005cited by this paper
• Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators.

  2005cited by this paper
• Centrosome localization determines neuronal polarity

  2005cited by this paper
• Role of the PAR-3–KIF3 complex in the establishment of neuronal polarity

  2004cited by this paper
• aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.

  2004cited by this paper
• Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity.

  2004cited by this paper
• Parsing the Polarity Code

  2004cited by this paper
• The Wnt signaling pathway in development and disease.

  2004cited by this paper
• Wnt signaling in axon guidance.

  2004cited by this paper
• Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.

  2004cited by this paper
• The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity

  2004cited by this paper
• Synaptogenesis: Wnt and TGF-β Take Centre Stage

  2003cited by this paper
• Anterior-Posterior Guidance of Commissural Axons by Wnt-Frizzled Signaling

  2003cited by this paper
• Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity

  2003cited by this paper
• Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity.

  2003cited by this paper
• Wnt-mediated axon guidance via the Drosophila Derailed receptor

  2003cited by this paper
• Synaptogenesis: Wnt and TGF-beta take centre stage.

  2003cited by this paper
• Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells.

  2003cited by this paper
• Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1.

  2002cited by this paper
• Efficient gene transfer into the embryonic mouse brain using in vivo electroporation.

  2001cited by this paper
• PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling

  2001cited by this paper
• A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

  2000cited by this paper
• Wnts as retrograde signals for axon and growth cone differentiation.

  2000cited by this paper
• Dishevelled-1 Regulates Microtubule Stability : A New Function Mediated by Glycogen Synthase Kinase-3 b

  2000cited by this paper
• The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

  2000cited by this paper
• The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape.

  2000cited by this paper
• The atypical protein kinase Cs

  2000cited by this paper
• Dishevelled-1 Regulates Microtubule Stability

  2000cited by this paper
• Mechanisms of Wnt signaling in development.

  1998cited by this paper
• Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium.

  1998cited by this paper
• Inhibition of GSK-3 β leading to the loss of phosphorylated MAP-1 B is an early event in axonal remodelling induced by WNT-7 a or lithium

  1998cited by this paper
• MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption.

  1997cited by this paper
• Mammalian homologues of C. elegans PAR-1 are asymmetrically localized in epithelial cells and may influence their polarity.

  1997cited by this paper
• Neuronal polarity.

  1994cited by this paper
• The establishment of polarity by hippocampal neurons in culture

  1988cited by this paper
• Experimentally induced alteration in the polarity of developing neurons

  1987cited by this paper

• Multi‐Omic Analysis of Glutamate Excitotoxicity in Primary Neuronal Cultures

  2025cites this paper
• Investigation of the synergistic effect of metformin and FX11 on PANC-1 cell lines

  2025cites this paper
• Mechanisms of brain overgrowth in autism spectrum disorder with macrocephaly

  2025cites this paper
• Microproteins Simba1 and Simba2 activate Wingless signaling during the reactivation of neural stem cells in Drosophila

  2025cites this paper
• A comprehensive review of hydrogel strategies for repairing peripheral nerve injuries

  2025cites this paper
• Small-Molecule Inhibitors in WNT Signalling Pathway for Targeted Cancer Therapy: Interplay between WNT, Autophagy and Apoptosis.

  2024cites this paper
• Wnt5a Promotes Axon Elongation in Coordination with the Wnt–Planar Cell Polarity Pathway

  2024cites this paper
• Transport of Golgi-localized β-catenin p-S47 by KIF11 or KIFC3 induces primary ciliogenesis

  2024cites this paper
• Down-regulation of PCBP2 suppresses the invasion and migration of trophoblasts via the WNT5A/ROR2 pathway in preeclampsia

  2024cites this paper
• Unlocking Hope: Therapeutic Advances and Approaches in Modulating the Wnt Pathway for Neurodegenerative Diseases

  2024cites this paper
• Wnt signaling in the tumor microenvironment: A driver of brain tumor dynamics.

  2024cites this paper
• Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy

  2024cites this paper
• Advances in Understanding the Molecular Mechanisms of Neuronal Polarity

  2023cites this paper
• Aberrant centrosome biogenesis disrupts nephron and collecting duct progenitor growth and fate resulting in fibrocystic kidney disease.

  2023cites this paper
• Disheveled-1 Interacts with Claudin-5 and Contributes to Norrin-Induced Endothelial Barrier Restoration

  2023cites this paper
• A Role for Second Messengers in Axodendritic Neuronal Polarity

  2023cites this paper
• Identification of epigenetically regulated genes distinguishing intracranial from extracranial melanoma metastases.

  2023cites this paper
• G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders

  2023cites this paper
• Biomolecular Condensates defined by Receptor Independent Activator of G protein Signaling: Properties and Regulation

  2023cites this paper
• Aberrant centrosome biogenesis disrupts nephron progenitor cell renewal and fate resulting in fibrocystic kidney disease

  2023cites this paper
• Boosting Neurogenesis in the Adult Hippocampus Using Antidepressants and Mesenchymal Stem Cells

  2022cites this paper
• Directed mechanisms for apical dendrite development during neuronal polarization.

  2022cites this paper
• The Roles of Par3, Par6, and aPKC Polarity Proteins in Normal Neurodevelopment and in Neurodegenerative and Neuropsychiatric Disorders

  2022cites this paper
• Close association of polarization and LC3, a marker of autophagy, in axon determination in mouse hippocampal neurons.

  2022cites this paper
• Vertebrate Wnt5a - At the crossroads of cellular signalling.

  2021cites this paper
• FOXG1 Directly Suppresses Wnt5a During the Development of the Hippocampus

  2021cites this paper
• Local Wnt signalling in the asymmetric migrating vertebrate cells.

  2021cites this paper
• A nerve conduit filled with Wnt5a‐loaded fibrin hydrogels promotes peripheral nerve regeneration

  2021cites this paper
• Cdc42 Facilitates Axonogenesis by Enhancing Microtubule Stabilization in Primary Hippocampal Neurons

  2021cites this paper
• DELETION 1p36 SYNDROME

  2020cites this paper
• Development of neuronal polarity in vivo

  2020cites this paper
• Targeting the Wnt/β-catenin signaling pathway in cancer

  2020cites this paper
• Phenotypic and Molecular Cytogenetic Analysis of a Case of Monosomy 1p36 Syndrome due to Unbalanced Translocation

  2020cites this paper
• Thyroid hormone, gene expression, and Central Nervous System: Where we are.

  2020cites this paper
• Polymorphism and expression of the Dvl3 gene in the etiology of depressive disorder.

  2020cites this paper
• Phosphorylation and Proteolytic Cleavage of Notch in Canonical and Noncanonical Notch Signaling.

  2020cites this paper
• Orthosteric and allosteric modulation of human kinases: A mechanistic view.

  2020cites this paper
• Dysregulated Wnt Signalling in the Alzheimer’s Brain

  2020cites this paper
• Involvement of Wnt signaling in primary cilia assembly and disassembly

  2020cites this paper
• Intersection of two key signal integrators in the cell: activator of G-protein signaling 3 and dishevelled-2

  2020cites this paper
• Advances in defining signaling networks for the establishment of neuronal polarity.

  2020cites this paper
• Linking Cell Polarity to Cortical Development and Malformations

  2019cites this paper
• aPKC in neuronal differentiation, maturation and function

  2019cites this paper
• Transient Deregulation of Canonical Wnt Signaling in Developing Pyramidal Neurons Leads to Dendritic Defects and Impaired Behavior.

  2019cites this paper
• Neuronal Polarity: Positive and Negative Feedback Signals

  2019cites this paper
• Wnt5a promotes differentiation and development of adult‐born neurons in the hippocampus by noncanonical Wnt signaling

  2019cites this paper
• The ASD Living Biology: from cell proliferation to clinical phenotype

  2018cites this paper
• Interleukin-1 beta promotes neuronal differentiation through the Wnt5a/RhoA/JNK pathway in cortical neural precursor cells

  2018cites this paper
• PAR3–PAR6–atypical PKC polarity complex proteins in neuronal polarization

  2018cites this paper
• Motoneuron Wnts regulate neuromuscular junction development

  2018cites this paper
• NMDA receptors inhibit axonal outgrowth by inactivating Akt and activating GSK‐3&bgr; via calcineurin in cultured immature hippocampal neurons

  2018cites this paper
• Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity

  2018cites this paper
• Implication de la protéine Girdin dans la polarité apico-basale des cellules épithéliales chez Drosophila melanogaster

  2018cites this paper
• Placental CpG methylation of infants born extremely preterm predicts cognitive impairment later in life

  2018cites this paper
• Dishevelled: A masterful conductor of complex Wnt signals.

  2018cites this paper
• Vangl2 regulates spermatid planar cell polarity through microtubule (MT)-based cytoskeleton in the rat testis

  2018cites this paper
• Wnt signalling in the development of axon, dendrites and synapses

  2018cites this paper
• Interconversion of inactive to active conformation of MARK2: Insights from molecular modeling and molecular dynamics simulation.

  2017cites this paper
• Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice

  2017cites this paper
• Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division

  2017cites this paper
• Rare Deleterious PARD3 Variants in the aPKC‐Binding Region are Implicated in the Pathogenesis of Human Cranial Neural Tube Defects Via Disrupting Apical Tight Junction Formation

  2017cites this paper
• Cell polarity and planar cell polarity (PCP) in spermatogenesis.

  2017influential citation
• The many postures of noncanonical Wnt signaling in development and diseases.

  2017cites this paper
• Dishevelled stability is positively regulated by PKCζ-mediated phosphorylation induced by Wnt agonists.

  2017cites this paper
• Planar cell polarity (PCP) proteins and spermatogenesis.

  2016cites this paper
• Neonicotinoid Insecticides Alter the Gene Expression Profile of Neuron-Enriched Cultures from Neonatal Rat Cerebellum

  2016cites this paper
• Wnt5a is essential for dendrite maintenance and cognitive functions in the adult brain

  2016influential citation
• Aberrant regulation of Wnt signaling in hepatocellular carcinoma

  2016cites this paper
• p300/β-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC)*

  2016cites this paper
• Wnt Signaling in Cartilage Development

  2016cites this paper
• Neural Differentiation of Human Adipose Tissue-Derived Stem Cells Involves Activation of the Wnt5a/JNK Signalling

  2015cites this paper
• WNT-5A: signaling and functions in health and disease

  2015cites this paper
• The ROR Receptor Family

  2015cites this paper
• Expression patterns of dishevelled-2 in different colon tissue segments in Hirschsprung's disease.

  2015cites this paper
• Insight into the role of Wnt5a-induced signaling in normal and cancer cells.

  2015cites this paper
• Wnt Signaling in Spinal Cord Injury

  2015cites this paper
• PAR-1 Kinase and Cell Polarity

  2015cites this paper
• Mechanical Tension Promotes the Osteogenic Differentiation of Rat Tendon-derived Stem Cells Through the Wnt5a/Wnt5b/JNK Signaling Pathway

  2015cites this paper
• Polarity Determinants in Dendritic Spine Development and Plasticity

  2015cites this paper
• Canonical and noncanonical Wnt signaling in neural stem/progenitor cells

  2015cites this paper
• Neuronal polarization in the developing cerebral cortex

  2015cites this paper
• Non-canonical WNT signalling in the lung.

  2015cites this paper
• A novel Wnt5a‐Frizzled4 signaling pathway mediates activity‐independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4

  2015cites this paper
• JB Review Non-canonical WNT signalling in the lung

  2015cites this paper
• Effects of T 208 E activating mutation on MARK 2 protein structure and dynamics : Modeling and simulation

  2014cites this paper
• Caspase-3 cleavage of dishevelled induces elimination of postsynaptic structures.

  2014cites this paper
• The best-laid plans go oft awry: synaptogenic growth factor signaling in neuropsychiatric disease

  2014cites this paper
• Protein Kinase A Rescues Microtubule Affinity-regulating Kinase 2-induced Microtubule Instability and Neurite Disruption by Phosphorylating Serine 409*

  2014cites this paper
• A morphologic and immunohistochemical analysis of gastric adenocarcinoma with regard to the presence of E-cadherin and localisation of β-catenin staining

  2014cites this paper
• Altered expression of atypical PKC and Ryk in the spinal cord of a mouse model of amyotrophic lateral sclerosis

  2014cites this paper
• Effects of T208E activating mutation on MARK2 protein structure and dynamics: Modeling and simulation

  2014cites this paper
• Regulation of neuronal polarity.

  2014cites this paper
• Evidence of functional distinction between WNT5A Isoform A and Isoform B in osteosarcoma cells

  2014cites this paper
• JIP1 Mediates Anterograde Transport of Rab10 Cargos during Neuronal Polarization

  2014cites this paper
• Wingless-type family member 3A triggers neuronal polarization via cross-activation of the insulin-like growth factor-1 receptor pathway

  2013cites this paper
• The cell polarity scaffold Lethal Giant Larvae regulates synapse morphology and function

  2013cites this paper
• Regulació de la Brain-specific Kinase 1 (BRSK1) neuronal per sulfàtid i modificacions post-traduccionals

  2013cites this paper
• Dishevelled Proteins Are Associated with Olfactory Sensory Neuron Presynaptic Terminals

  2013cites this paper
• Atypical Protein Kinase C and Par3 Are Required for Proteoglycan-Induced Axon Growth Inhibition

  2013cites this paper
• Expression of dishevelled gene in Hirschsprung's disease.

  2013cites this paper