level viremia at <50 copies/ml, the latter sees it as a central task to eliminate the virus from all body compartments with a plasma HIV RNA count of <1 copy/ml. In addition, the reservoir is significantly smaller in elite controllers with decreased concentration of HIV DNA. Viral reservoir is simply different areas of the body where viral copies hide quietly and undetected and are unable to be treated until they are stimulated or activated to reproduce. Anatomical reservoirs include the gastrointestinal tract (GIT), lymphoid tissue and the central nervous system (CNS). These compartments may harbour unique long-lived latently infected cells, and penetration of cART may be limited at these sites. What are the phenotypic characteristics of functional cure? First is the undetectable or very low noninfective levels of the virus (<50 copies/ml) though some authors suggested <75 copies/ml for six months [109], and second is a normal range of CD4 cell count when cART is discontinued. Although cART have tremen‐ dously improved the lives of individuals with HIV, they come with significant side effects, perhaps not the ideal functional cure which would get HIV-infected patients to the point where cART are no longer needed to keep their infections under control.
Oxidative Stress, Redox Regulation and Elite Controllers of HIV Infection: Towards a Functional Cure
Published 2015 in Unknown venue
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- Publication year
2015
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Unknown venue
- Publication date
2015-09-02
- Fields of study
Biology, Medicine, Chemistry
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Semantic Scholar
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