Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Endocrinology

• Publication date

  2007-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/EN.2006-1231PMID 17204551PMCID PMC1890395
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• GPR39 signaling is stimulated by zinc ions but not by obestatin.

  2007cited by this paper
• Effects of obestatin on energy balance and growth hormone secretion in rodents.

  2007cited by this paper
• Normal food intake and body weight in mice lacking the G protein-coupled receptor GPR39.

  2007cited by this paper
• Neither intravenous nor intracerebroventricular administration of obestatin affects the secretion of GH, PRL, TSH and ACTH in rats.

  2007cited by this paper
• Obestatin acts in brain to inhibit thirst.

  2007cited by this paper
• Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status.

  2006cited by this paper
• Central obestatin administration does not modify either spontaneous or ghrelin-induced food intake in rats

  2006cited by this paper
• A negative feedback system between brain serotonin systems and plasma active ghrelin levels in mice.

  2006cited by this paper
• Vaccination against weight gain

  2006cited by this paper
• Lack of interaction between peripheral injection of CCK and obestatin in the regulation of gastric satiety signaling in rodents.

  2006cited by this paper
• Obestatin does not activate orphan G protein-coupled receptor GPR39.

  2006cited by this paper
• Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat

  2006cited by this paper
• Acylated ghrelin stimulates food intake in the fed and fasted states but desacylated ghrelin has no effect.

  2006cited by this paper
• Absence of ghrelin protects against early-onset obesity.

  2005cited by this paper
• Anti-ghrelin Spiegelmer NOX-B11 inhibits neurostimulatory and orexigenic effects of peripheral ghrelin in rats

  2005cited by this paper
• Endogenous ghrelin regulates episodic growth hormone (GH) secretion by amplifying GH Pulse amplitude: evidence from antagonism of the GH secretagogue-R1a receptor.

  2005cited by this paper
• Mice lacking ghrelin receptors resist the development of diet-induced obesity.

  2005cited by this paper
• Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake

  2005influential reference
• Feeding response to ghrelin agonist and antagonist in lean and obese Zucker rats.

  2004cited by this paper
• Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference.

  2004cited by this paper
• Interrelationship between the novel peptide ghrelin and somatostatin/growth hormone-releasing hormone in regulation of pulsatile growth hormone secretion.

  2003cited by this paper
• Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus.

  2003cited by this paper
• Deletion of Ghrelin Impairs neither Growth nor Appetite

  2003cited by this paper
• The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis.

  2003cited by this paper
• The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats.

  2002cited by this paper
• Ultradian rhythmicity of ghrelin secretion in relation with GH, feeding behavior, and sleep-wake patterns in rats.

  2002cited by this paper
• A role for ghrelin in the central regulation of feeding

  2001cited by this paper
• Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway.

  2001cited by this paper
• In vivo and in vitro Effects of Ghrelin/Motilin-Related Peptide on Growth Hormone Secretion in the Rat

  2001cited by this paper
• The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion.

  2000cited by this paper
• Ghrelin induces adiposity in rodents

  2000cited by this paper
• Co-Localization of Growth Hormone Secretagogue Receptor and NPY mRNA in the Arcuate Nucleus of the Rat

  1999cited by this paper
• Daily changes in hypothalamic gene expression of neuropeptide Y, galanin, proopiomelanocortin, and adipocyte leptin gene expression and secretion: effects of food restriction.

  1999cited by this paper
• Ghrelin is a growth-hormone-releasing acylated peptide from stomach

  1999cited by this paper
• Post-translational processing of proopiomelanocortin in the pituitary and in the brain.

  1997cited by this paper
• An enzyme immunoassay for rat growth hormone: validation and application to the determination of plasma levels and in vitro release.

  1997cited by this paper
• Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors.

  1997influential reference
• Galanin-containing neurons in the paraventricular nucleus: a neurochemical marker for fat ingestion and body weight gain.

  1994cited by this paper
• Diurnal Rhythm in Proopiomelanocortin mRNA in the Arcuate Nucleus of the Male Rat

  1994cited by this paper
• Further evidence that thyrotropin-releasing hormone participate in the regulation of growth hormone secretion in the rat.

  1986cited by this paper
• Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection.

  1986cited by this paper
• A chronometric approach to the study of feeding behavior.

  1980cited by this paper
• The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2001 by The Endocrine Society Endocrine Activities of Ghrelin, a Natural Growth Hormone Secretagogue (GHS), in Humans: Comparison and Interactions with Hexarelin, a Nonnatura

  year unknowncited by this paper

• The Mystery Actor in the Neuroendocrine Theater: Who Really Knows Obestatin? Central Focus on Hypothalamic–Pituitary Axes

  2025cites this paper
• Position Statement of the Polish Academy of Sciences’ Committee of Human Nutrition Science on the Principles for the Nutrition of Preschool Children (4–6 Years of Age) and Early School-Age Children (7–9 Years of Age)

  2023cites this paper
• Role of the Ghrelin System in Colitis and Hepatitis as Risk Factors for Inflammatory-Related Cancers

  2022cites this paper
• Brain Related Gut Peptides - A Review.

  2022cites this paper
• Diverse and Complementary Effects of Ghrelin and Obestatin

  2022cites this paper
• Brain-derived neurotrophic factor (BDNF) affects somatotrophic axis activity in sheep

  2021cites this paper
• Altered islet prohormone processing: A cause or consequence of diabetes?

  2021cites this paper
• Ghrelin Gene Deletion Alters Pulsatile Growth Hormone Secretion in Adult Female Mice

  2021cites this paper
• Relationship between ghrelin and obestatin levels and ghrelin/obestatin ratio in patients with asthma.

  2020cites this paper
• Obestatin and Its Fragments: A New Approach to the Regulation of Body Weight under Normal and Pathological Conditions

  2020cites this paper
• Central obestatin administration affect the LH and FSH secretory activity in peripubertal sheep.

  2020cites this paper
• Ghrelin, obestatin and the ghrelin/obestatin ratio as potential mediators for food intake among obese children: a case control study

  2020cites this paper
• Obestatin protects and reverses nonalcoholic fatty liver disease and its associated insulin resistance in rats via inhibition of food intake, enhancing hepatic adiponectin signaling, and blocking ghrelin acylation

  2019cites this paper
• Role of bioactive molecules and maternal immune cells in breast-milk in type 2 diabetes mellitus risk reduction

  2019cites this paper
• Obestatin Downregulating Aquaporin 2 Plasma Membrane Distribution Through a Short‐Term Regulatory Effect

  2019cites this paper
• The effect of orlistat and weight loss diet on plasma ghrelin and obestatin

  2018cites this paper
• Obestatin stimulates the somatotrophic axis activity in sheep.

  2018influential citation
• Investigating the Role of the Growth Hormone Secretagogue Receptor in Food-Motivated Behaviours

  2018cites this paper
• Biochemical properties and biological actions of obestatin and its relevence in type 2 diabetes

  2018cites this paper
• Age modifies the association between serum obestatin, appetite and nutritional status in maintenance hemodialysis patients

  2018cites this paper
• Serum obestatin level strongly correlates with lipoprotein subfractions in non-diabetic obese patients

  2018cites this paper
• The Effects of Hydroalcoholic Extract of Devil's Claw on Serum Levels of Obestatin and Body Weight in Male Rats

  2017cites this paper
• Obestatin controls skeletal muscle fiber-type determination

  2017cites this paper
• Clarifying the Ghrelin System’s Ability to Regulate Feeding Behaviours Despite Enigmatic Spatial Separation of the GHSR and Its Endogenous Ligand

  2017cites this paper
• Preclinical evidence of ghrelin as a therapeutic target in epilepsy

  2017cites this paper
• Regulation of GIP and Ghrelin in Healthy Subjects Fed on Sun-Dried Raisins: A Pilot Study with a Crossover Trial Design

  2017cites this paper
• Obestatin stimulates glucose-induced insulin secretion through ghrelin receptor GHS-R

  2017cites this paper
• Obestatin modulates ghrelin's effects on the basal and stimulated testosterone secretion by the testis of rat: an in vitro study.

  2017cites this paper
• Long-term obestatin treatment of mice type 2 diabetes increases insulin sensitivity and improves liver function

  2017cites this paper
• An ex vivo Perifusion Method for Quantitative Determination of Neuropeptide Release from Mouse Hypothalamic Explants.

  2017cites this paper
• Combination of Selective Immunoassays and Mass Spectrometry to Characterize Preproghrelin-Derived Peptides in Mouse Tissues

  2017cites this paper
• 15 Ghrelin , a Gastric Hormone with Diverse Functions

  2017cites this paper
• Low prevalence of obesity in Behçet's disease is associated with high obestatin level.

  2017cites this paper
• Relation of plasma Obestatin levels with BMI and HOMA-IR in Syrian obese patients with type 2 diabetes

  2017cites this paper
• Eating and Feeding Disorders

  2017cites this paper
• The role of obestatin in Roux-en-Y gastric bypass surgery in the obese, type 2 diabetes Zucker rat.

  2016cites this paper
• The impact of laparoscopic sleeve gastrectomy on plasma obestatin and ghrelin levels.

  2016cites this paper
• Pretreatment with obestatin inhibits the development of acetic acid-induced colitis in rats

  2016cites this paper
• Obestatin and Ghrelin May Have a Complementary Function During Acute and Chronic Period in Mice.

  2016cites this paper
• [Ghrelin: a gastric hormone at the crossroad between growth and appetite regulation].

  2016cites this paper
• Impact de l'acide octanoïque alimentaire sur l'octanoylation de la Ghréline, chez le rat

  2016cites this paper
• New Insights in Anorexia Nervosa

  2016cites this paper
• Ghrelin‐related peptides do not modulate vasodilator nitric oxide production or superoxide levels in mouse systemic arteries

  2016cites this paper
• Revisiting the metabolism and physiological functions of caprylic acid (C8:0) with special focus on ghrelin octanoylation.

  2016cites this paper
• Risk Factors and Treatment for obesity Review Article

  2016cites this paper
• Neuroendocrine Regulation of Growth Hormone Secretion.

  2016cites this paper
• Obestatin as a key regulator of metabolism and cardiovascular function with emerging therapeutic potential for diabetes

  2016influential citation
• Hypothalamic regulation of body growth and appetite by ghrelin-derived peptides during balanced nutrition or undernutrition.

  2016cites this paper
• EFFECT OF TWELVE WEEKS COMBINED EXERCISE (AEROBIC- RESISTANCE) ON PLASMA LEVELS OF GHRELIN AND OBESTATIN IN OBESE ADOLESCENS

  2016cites this paper
• Maternal High-Fat Diet during Pregnancy and Lactation Influences Obestatin and Ghrelin Concentrations in Milk and Plasma of Wistar Rat Dams and Their Offspring

  2016cites this paper
• Fundamental structural and biochemical features for the obestatin/GPR39 system mitogenic action

  2016cites this paper
• Obestatin Accelerates the Healing of Acetic Acid-Induced Colitis in Rats

  2015cites this paper
• Maternal serum ratio of ghrelin to obestatin decreased in preeclampsia.

  2015cites this paper
• The effect of obestatin on anxiety-like behaviour in mice.

  2015cites this paper
• OBEZİTE İLE İNDÜKLENEN KARDİYAK HEMODİNAMİK DEĞİŞİMLER ÜZERİNE EGZERSİZ VE OBESTATİNİN KORUYUCU ROLÜ

  2015cites this paper
• Effect of Pilates Training on Plasma Levels of Ghrelin and Obestatin in Obese Older Men

  2015cites this paper
• Obestatin partially suppresses ghrelin stimulation of appetite in "high-responders" grass carp, Ctenopharyngodon idellus.

  2015cites this paper
• Estudio de envejecimiento de Mataró: Factores hormonales y genéticos que influyen en el envejecimiento

  2015cites this paper
• Erkeklerde Direnç Egzersizine Obestatin Cevabı

  2015cites this paper
• An early reduction in GH peak amplitude in preproghrelin-deficient male mice has a minor impact on linear growth.

  2014cites this paper
• Protection of MES23.5 dopaminergic cells by obestatin is mediated by proliferative rather than anti-apoptotic action

  2014cites this paper
• Ghrelin-Derived Peptides: A Link between Appetite/Reward, GH Axis, and Psychiatric Disorders?

  2014cites this paper
• The association between rs4684677 T/A polymorphism in preproghrelin gene and predisposition to autoimmune thyroid diseases in children*

  2014cites this paper
• Plasma Ghrelin Concentrations Are Negatively Correlated With Urine Albumin-to-Creatinine Ratio in Newly Diagnosed Type 2 Diabetes

  2014cites this paper
• Could the improvement of obesity-related co-morbidities depend on modified gut hormones secretion?

  2014cites this paper
• Nutritional regulation of metabolic hormones implicated in the postnatal programming of obesity : the case of leptin and ghrelin

  2014cites this paper
• Ghrelin , Obestatin and Leptin in Childhood Obesity

  2014cites this paper
• Serum, urine, and saliva levels of ghrelin and obestatin pre- and post-treatment in pediatric epilepsy.

  2014cites this paper
• RELATIONSHIP BETWEEN GHRELIN AND OBESTATIN WITH SOME OF BODY COMPOSITION INDEXES IN 50-70 YEARS OLD ATHLETES AND NON-ATHLETES MEN

  2014cites this paper
• Regulatory neuropeptides (ghrelin, obestatin and nesfatin-1) levels in serum and reproductive tissues of female and male rats with fructose-induced metabolic syndrome.

  2014cites this paper
• Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in female primates and male/female mice.

  2014influential citation
• Neuromodulatory action of obestatin on the secretory activity of the hypothalamic - pituitary axis

  2014cites this paper
• Obestatin is associated to muscle strength, functional capacity and cognitive status in old women

  2013cites this paper
• Identification of GPR39 Receptor and Ghrelin Receptor in Thyroid Tissues in Paediatric Patients with Immune and Non-Immune Thyroid Diseases

  2013cites this paper
• Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight.

  2013cites this paper
• The Role of Obestatin in Glucose and Lipid Metabolism

  2013cites this paper
• Ghrelins, obestatin, nesfatin-1 and leptin levels in pregnant women with and without hyperemesis gravidarum.

  2013cites this paper
• Azioni biologiche e metaboliche di obestatin, un peptide della famiglia del gene ghrelin

  2013cites this paper
• Obestatin receptor in energy homeostasis and obesity pathogenesis.

  2013cites this paper
• Effect of in ovo ghrelin administration on hatching results and post-hatching performance of broiler chickens

  2013cites this paper
• Obestatin does not modify weight and nutritional behaviour but is associated with metabolic syndrome in old women

  2013cites this paper
• Obestatin: A new metabolic player in the pancreas and white adipose tissue

  2013cites this paper
• Obestatin Receptor in Energy Homeostasis and Obesity Pathogenesis

  2013cites this paper
• Effect of intraperitoneal administration of ghrelin on some of serum biochemical indices in geese

  2013cites this paper
• Ghrelin as a GH-releasing factor.

  2013cites this paper
• Association of Serum Obestatin Concentration with Hypothyroidism and Hyperthyroidism

  2013cites this paper
• The ghrelin axis--does it have an appetite for cancer progression?

  2012cites this paper
• The Effect of a Single Circuit-Resistance and Aerobic Exercise on Plasma Obestatin Levels in Well-Trained Females

  2012cites this paper
• Actions of Agonists and Antagonists of the ghrelin/GHS-R Pathway on GH Secretion, Appetite, and cFos Activity

  2012cites this paper
• Impact of intracerebroventricular obestatin on plasma acyl ghrelin, des-acyl ghrelin and nesfatin-1 levels, and on gastric emptying in rats.

  2012cites this paper
• A Natural Variant of Obestatin, Q90L, Inhibits Ghrelin's Action on Food Intake and GH Secretion and Targets NPY and GHRH Neurons in Mice

  2012cites this paper
• Ghrelin and Obestatin in Infants, Lactating Mothers and Breast Milk

  2012cites this paper
• Ghrelin and obestatin in thyroid dysfunction.

  2012cites this paper
• The Obestatin/GPR39 System Is Up-regulated by Muscle Injury and Functions as an Autocrine Regenerative System*

  2012cites this paper
• Circulating obestatin is increased in patients with cardiorenal syndrome and positively correlated with vasopressin.

  2012cites this paper
• The function and mechanisms of action of ghrelin and obestatin in ovarian cancer

  2012influential citation
• Ghrelin, a Gastric Hormone with Diverse Functions

  2012cites this paper
• Ghrelin and obestatin in thyroid dysfunction Ghrelina i obestatyna w zaburzeniach czynności tarczycy

  2012cites this paper
• Changes in serum obestatin, preptin and ghrelins in patients with Gestational Diabetes Mellitus.

  2012cites this paper
• Rôles des peptides dérivés de la préproghréline dans le contrôle de la sécrétion de GH et du comportement alimentaire

  2012cites this paper