Cyclodextrins in pharmaceutical formulations II: solubilization, binding constant, and complexation efficiency.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Drug Discovery Today

• Publication date

  2016-02-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.drudis.2015.11.016PMID 26687191
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cyclodextrins in pharmaceutical formulations I: structure and physicochemical properties, formation of complexes, and types of complex.

  2016cited by this paper
• Interaction of fentanyl with various cyclodextrins in aqueous solutions

  2016cited by this paper
• Pharmacokinetics of cyclodextrins and drugs after oral and parenteral administration of drug/cyclodextrin complexes

  2016cited by this paper
• The effect of mechanical grinding on the formation, crystalline changes and dissolution behaviour of the inclusion complex of telmisartan and β-cyclodextrins.

  2015cited by this paper
• Influence of hydrophilic polymers on the complexation of carbamazepine with hydroxypropyl-β-cyclodextrin.

  2015cited by this paper
• Recent advances in cyclodextrin delivery techniques

  2015cited by this paper
• Cyclodextrin nanoassemblies: a promising tool for drug delivery.

  2015cited by this paper
• β-Cyclodextrin-dextran polymers for the solubilization of poorly soluble drugs.

  2014cited by this paper
• Background review for cyclodextrins used as excipients

  2014cited by this paper
• Mechanism of 2-hydropropyl-beta-cyclodextrin in the stabilization of frozen formulations.

  2014cited by this paper
• Quetiapine free base complexed with cyclodextrins to improve solubility for parenteral use.

  2013cited by this paper
• Cyclodextrin-water soluble polymer ternary complexes enhance the solubility and dissolution behaviour of poorly soluble drugs. Case example: itraconazole.

  2013cited by this paper
• Cyclodextrin-mediated enhancement of riboflavin solubility and corneal permeability.

  2013cited by this paper
• Excipient Selection In Parenteral Formulation Development

  2013cited by this paper
• Cyclodextrins.

  2013cited by this paper
• The effect of parenterally administered cyclodextrins on the pharmacokinetics of coadministered drugs.

  2012cited by this paper
• Long-Term Parenteral Administration of 2-Hydroxypropyl-β-Cyclodextrin Causes Bone Loss

  2012cited by this paper
• Cyclodextrins

  2008cited by this paper
• Cyclodextrins in drug delivery: An updated review

  2005cited by this paper
• Evaluation of cyclodextrin solubilization of drugs.

  2005cited by this paper
• Self-association of cyclodextrins and cyclodextrin complexes.

  2004cited by this paper
• The physicochemical characteristics and bioavailability of indomethacin from beta-cyclodextrin, hydroxyethyl-beta-cyclodextrin, and hydroxypropyl-beta-cyclodextrin complexes.

  2004cited by this paper
• When can cyclodextrins be considered for solubilization purposes?

  2003cited by this paper
• Cyclodextrins in Eye Drop Formulations

  2002cited by this paper
• Cyclodextrin complexes of salts of acidic drugs. Thermodynamic properties, structural features, and pharmaceutical applications.

  2001cited by this paper
• Drug/cyclodextrin/hydroxy acid multicomponent systems. Properties and pharmaceutical applications.

  2000cited by this paper
• Interaction of Hydroxy Acids with β-Cyclodextrin

  1999cited by this paper
• Solid-state β-cyclodextrin complexes containing indomethacin, ammonia and water. I. Formation studies

  1998cited by this paper
• Increasing the cyclodextrin complexation of drugs and drug biovailability through addition of water-soluble polymers.

  1998cited by this paper
• The Stability of Cyclodextrin Complexes in Solution.

  1997cited by this paper
• Cyclodextrins--enabling excipients: their present and future use in pharmaceuticals.

  1997cited by this paper
• Pharmaceutical applications of cyclodextrins. 2. In vivo drug delivery.

  1996cited by this paper
• Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization.

  1996cited by this paper
• The Influence of water-soluble polymers and pH on hydroxypropyl-β-cyclodextrin complexation of drugs

  1996cited by this paper
• Effect of SBE4-β-CD, a sulfobutyl ether β-cyclodextrin, on the stability and solubility of O6-benzylguanine (NSC-637037) in aqueous solutions

  1995cited by this paper
• Theoretical studies on the structures of natural and alkylated cyclodextrins.

  1995cited by this paper
• Complexation of dihydroergotamine mesylate with cyclodextrin derivatives: Solubility and stability in aqueous solution

  1995cited by this paper
• A new pH-metric methodology for the determination of thermodynamic inclusion constants of guest/cyclodextrin complexes.

  1995cited by this paper
• The effect of water-soluble polymers on drug-cyclodextrin complexation

  1994cited by this paper
• Physical and chemical interactions between cellulose ethers and β-cyclodextrins

  1994cited by this paper
• Cyclodextrins in Pharmacy

  1993cited by this paper
• Cyclodextrin complexation of NSAIDSs: physicochemical characteristics

  1993cited by this paper
• Complexation of 6-ACYL-O-β-Cyclodextrin derivatives with steroids - effects of chain length and substitution degree

  1992cited by this paper
• Interaction of NSA with cyclodextrins and hydroxypropyl cyclodextrin derivatives

  1991cited by this paper
• New trends in cyclodextrins and derivatives

  1991cited by this paper
• The potential use of cyclodextrins in parenteral formulations.

  1989cited by this paper
• The Schardinger dextrins.

  1957cited by this paper

• Structurally Modified Cyclodextrins in Topical Nanotechnology: Advancing Barrier-Penetrating Drug Delivery Strategies for Psoriasis Management

  2026cites this paper
• Physicochemical characterization, cyclodextrin complexation, and protonation state-dependent receptor binding of selected tyrosine kinase inhibitors

  2026cites this paper
• Adsorption of Natural Essential Oils on Phyllosilicate and Cyclodextrin Surfaces by Molecular Modeling for Predicting Drug Delivery Systems

  2026cites this paper
• Influence of Ionization and the Addition of Cyclodextrins and Hydrophilic Excipients on the Solubility of Benzthiazide, Isoxicam, and Piroxicam

  2025cites this paper
• Study of Carvedilol–β-Cyclodextrin Derivatives Interactions

  2025cites this paper
• Comparative analysis of novel modified drug delivery systems for improving the oral bioavailability of water-insoluble tadalafil using copovidone, TPGS and hydroxypropyl-β-cyclodextrin.

  2025cites this paper
• β-Cyclodextrin: A key player in boosting the biocompatible anti-inflammatory potential of a novel thiazole derivative

  2025cites this paper
• Utilizing hydroxypropyl methylcellulose acetate succinate-based amorphous solid dispersions to enhance oral bioavailability and antifibrotic activity of Nintedanib.

  2025cites this paper
• Cyclodextrins as Modulators of Gut Microbiota: Pharmaceutical Applications and Impact on Intestinal Health

  2025cites this paper
• Formulation of Caffeine–Hydroxypropyl-β-Cyclodextrin Complex in Hydrogel for Skin Treatment

  2025cites this paper
• Supramolecular assembly of methylthiazole derivative with β-cyclodextrin for the improvement of anti-inflammation performances: Structural insights from NBO approach

  2025cites this paper
• A stable curcumin/β-cyclodextrin/ascorbic acid ternary inclusion complexes, docking studies, antimicrobial and anticancer assays

  2025cites this paper
• Improvement of anti-inflammation performance in the form of inclusion complexes of ethyl-(2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carbonyl)glycine with β-cyclodextrin

  2025cites this paper
• Targeting KEAP1-mediated IKKβ degradation strategy for colitis-associated colorectal carcinogenesis: The potential of xanthohumol.

  2025cites this paper
• Screening Cyclodextrin Complexes for Bisphenols with High Binding Performance Based on the Data-Driven Model.

  2025cites this paper
• Synthesis and Properties of Chemically Modified Cyclodextrins as Drug Delivery Systems: An Update

  2025cites this paper
• Impact of Manganese Coordination and Cyclodextrin-Assisted Formulation on Thiabendazole Dissolution and Endothelial Cell Migration

  2025cites this paper
• Parenteral preparations for administration in the pediatric population: The challenges of excipients selection

  2025cites this paper
• Pharmacoinformatics in Drug-Excipient Interactions.

  2025cites this paper
• Cyclodextrins as Active Therapeutic Agents: Beyond Their Role as Excipients

  2025cites this paper
• Synergic Effect of Methyl-β-Cyclodextrin and Hydrophilic Polymers on Nepafenac Solubilization: Development of a 0.3% Ophthalmic Solution

  2025cites this paper
• Advances in metal-organic frameworks for cardiovascular therapy: from structural design to preclinical applications

  2025cites this paper
• Curcumin's niosomes coated with chitosan for the treatment of osteoarthritis: effect of cyclodextrin complexation.

  2025cites this paper
• Development of Low-Dose Disulfiram Rectal Suppository Intended for Application in Post-Treatment Lyme Disease Syndrome

  2025cites this paper
• Quantifying the bitter masking effect of drug-cyclodextrin complexation: NMR-ROESY mixing time approach.

  2024cites this paper
• A hyaluronic acid-modified cyclodextrin self-assembly system for the delivery of β-carotene in the treatment of dry eye disease.

  2024cites this paper
• Hydroxypropyl β Cyclodextrins Effects on Self-Assembly of Cyclic Peptide, Lanreotide Acetate, in Water and Subsequent Release rate from an in vitro Emulator of Subcutaneous Delivery.

  2024cites this paper
• Guest inclusion by native cyclodextrins in solid state and solutions: A review.

  2024cites this paper
• Cyclodextrins: Advances in Chemistry, Toxicology, and Multifaceted Applications

  2024cites this paper
• β-Cyclodextrin Derivatives Bind Aromatic Side Chains of the Cyclic Peptide Lanreotide.

  2024cites this paper
• Supramolecular deep eutectic solvents as green media for efficient extraction of tea polyphenols and its application in bio-active film.

  2024cites this paper
• The Mechanochemical and Supercritical Fluid Synthesis of β-Cyclodextrin-Hesperidin Inclusion Complex: A Comparison Green Chemistry versus Lyophilization

  2024cites this paper
• Pharmaceutical approaches for enhancing solubility and oral bioavailability of poorly soluble drugs.

  2024cites this paper
• Microwave, Ultrasound-Assisted, and Room Temperature One-Pot Synthesis of Silver and Gold Colloids Using Beta-Cyclodextrin as a Reducing and Capping Agent for SERS Applications

  2024cites this paper
• Advances in carrier-delivered small interfering RNA based therapeutics for treatment of neurodegenerative diseases.

  2024cites this paper
• Characterization and biological activity evaluation of water-soluble resveratrol complexes obtained by spray drying, ball milling and jet milling

  2024cites this paper
• Molecular recognition of aromatic carboxylic acids by cationic cyclodextrins

  2024cites this paper
• Thermodynamic investigation of biperiden hydrochloride and cyclodextrins supramolecular systems

  2024cites this paper
• Cyclodextrin in drug delivery: Exploring scaffolds, properties, and cutting-edge applications.

  2024cites this paper
• Host-Guest Complexes of Flavanone and 4′-Chloroflavanone with Naturals and Modified Cyclodextrin: A Calorimetric and Spectroscopy Investigations

  2024cites this paper
• A review on revolutionizing ophthalmic therapy: Unveiling the potential of chitosan, hyaluronic acid, cellulose, cyclodextrin, and poloxamer in eye disease treatments.

  2024cites this paper
• QbD Assisted Systematic Review for Optimizing the Selection of PVP as a Ternary Substance in Enhancing the Complexation Efficiency of Cyclodextrins: a Pilot Study

  2024cites this paper
• Evaluating solubility, stability, and inclusion complexation of oxyresveratrol with various β-cyclodextrin derivatives using advanced computational techniques and experimental validation

  2024cites this paper
• Comparative study of β-cyclodextrin and carboxymethyl-β-cyclodextrin as effective drug delivery systems for oxymetholone: Design, preparation, characterization, phase solubility and in vitro drug release studies

  2024cites this paper
• 17-β-Estradiol—β-Cyclodextrin Complex as an aqueous solution: Structural and Physicochemical Characterization supported by MM and QM calculations

  2024cites this paper
• Therapeutic potential and pharmacological mechanism of visnagin.

  2024cites this paper
• Host–Guest Interaction Study of Olmesartan Medoxomil with β-Cyclodextrin Derivatives

  2024cites this paper
• Systematic Study of Different Types of Interactions in α-, β- and γ-Cyclodextrin: Quantum Chemical Investigation

  2024cites this paper
• Development of Oral Tablets of Nebivolol with Improved Dissolution Properties, Based on Its Combinations with Cyclodextrins

  2024cites this paper
• Cyclodextrin encapsulation enabling the anticancer repositioning of disulfiram: Preparation, analytical and in vitro biological characterization of the inclusion complexes.

  2024cites this paper
• Synthesis and bioevaluation of water-soluble β-cyclodextrin–diterpene acid conjugates

  2024cites this paper
• Exploring Cyclodextrin-Based Nanosponges as Drug Delivery Systems: Understanding the Physicochemical Factors Influencing Drug Loading and Release Kinetics

  2024cites this paper
• Thrombotic microenvironment responsive crosslinking cyclodextrin metal-organic framework nanocarriers for precise targeting and thrombolysis.

  2024cites this paper
• Development of a Hydroxypropyl-β-Cyclodextrin-Based Liquid Formulation for the Oral Administration of Propranolol in Pediatric Therapy

  2023cites this paper
• Innovative Technology of the Self-Emulsifying Drug Delivery System of the Anticonvulsant Galodif

  2023cites this paper
• Improved Topical Ophthalmic Natamycin Suspension for the Treatment of Fungal Keratitis

  2023cites this paper
• QSPR models for complexation performance of α-cyclodextrin and β-cyclodextrin complexes by norm indices

  2023cites this paper
• The green synthesis and applications of biological metal-organic frameworks for targeted drug delivery and tumor treatments.

  2023cites this paper
• Active and Intelligent Packaging: A Review of the Possible Application of Cyclodextrins in Food Storage and Safety Indicators

  2023cites this paper
• Natural biomass-derived carbon dots as a potent solubilizer with high biocompatibility and enhanced antioxidant activity

  2023cites this paper
• Supramolecular chitin-based hydrogels with self-adapting and fast-degradation properties for enhancing wound healing.

  2023cites this paper
• Effects of a Standardized Hydrogenated Extract of Curcumin (Curowhite™) on Melanogenesis: A Pilot Study

  2023cites this paper
• Optimization of Delivery and Bioavailability of Encapsulated Caffeic Acid

  2023cites this paper
• Drug complexes: Perspective from Academic Research and Pharmaceutical Market

  2023cites this paper
• Anomalous Properties of Cyclodextrins and Their Complexes in Aqueous Solutions

  2023cites this paper
• A Review of Applications of Solid-State Nuclear Magnetic Resonance (ssNMR) for the Analysis of Cyclodextrin-Including Systems

  2023cites this paper
• An Overview of Taste-Masking Technologies: Approaches, Application, and Assessment Methods

  2023cites this paper
• Solubility Enhancement and Inhalation Delivery of Cyclodextrin-Based Inclusion Complex of Delamanid for Pulmonary Tuberculosis Treatment

  2023cites this paper
• Cyclodextrin-based ocular drug delivery systems: A comprehensive review

  2023cites this paper
• Three Birds, One Excipient: Development of an Improved pH, Isotonic, and Buffered Ketamine Formulation for Subcutaneous Injection

  2022influential citation
• Antifungal Combination Eye Drops for Fungal Keratitis Treatment

  2022cites this paper
• AN ADDUCT: 5-FLUOROURACIL INCORPORATED β-CD INCLUSION COMPLEX FOR SOLUBILITY AND STABILITY ENHANCEMENT IN DOSAGE FORMS

  2022cites this paper
• Inclusion Complex Formation between Sulfadiazine and Various Modified Β-Cyclodextrins and Characterization of the Complexes

  2022cites this paper
• Inclusion Complex between Local Anesthetic/2-hydroxypropyl-β-cyclodextrin in Stealth Liposome

  2022influential citation
• Oxygen Bioavailability is a Rate-Limited Factor in Phytosterols Bioconversion Using a Cyclodextrin-Resting Cell System

  2022cites this paper
• Improvement in Solubility–Permeability Interplay of Psoralens from Brosimum gaudichaudii Plant Extract upon Complexation with Hydroxypropyl-β-cyclodextrin

  2022cites this paper
• Cyclodextrin-based delivery systems in parenteral formulations: a critical update review.

  2022cites this paper
• In silico formulation prediction of drug/cyclodextrin/polymer ternary complexes by machine learning and molecular modeling techniques.

  2022cites this paper
• Preparation and characterization of an oridonin and γ-cyclodextrin complex

  2022cites this paper
• Functionality-related characteristics of hydroxypropyl-β-cyclodextrin for the complexation

  2022cites this paper
• Synthesis and Characterization of Cyclodextrin-Based Scaffold Incorporating Ciprofloxacin Antibacterial Agent for Skin Infection Prevention

  2022cites this paper
• Inclusion complexes of 3-(3-(2-chlorophenyl)prop-2-enoyl)-4-hydroxycoumarin with 2-hydroxypropyl-(-cyclodextrin: solubility and antimicrobial activity

  2022cites this paper
• Cyclodextrin inclusion complex of a multi-component natural product by hot-melt extrusion

  2022cites this paper
• Cyclodextrin-Based Delivery Systems and Hydroxycinnamic Acids: Interactions and Effects on Crucial Parameters Influencing Oral Bioavailability—A Review

  2022cites this paper
• Testing the Protective Effects of Sulfobutylether-Βeta-Cyclodextrin (SBECD) and Sugammadex against Chlorpromazine-Induced Acute Toxicity in SH-SY5Y Cell Line and in NMRI Mice

  2022cites this paper
• Influence of pH, β-Cyclodextrin, and Metal Ions on the Solubility and Stability of the Medicinally Competent Isoxazole Derivative of Curcumin: A Photophysical Study.

  2021cites this paper
• Characterization and evaluation of inclusion complexes between astaxanthin esters with different molecular structures and hydroxypropyl-β-cyclodextrin

  2021cites this paper
• HP-β-CD for the formulation of IgG and Ig-based biotherapeutics.

  2021cites this paper
• Novel Water Soluble Sterile Natamycin Formulation (Natasol) for Fungal Keratitis.

  2021cites this paper
• Thermodynamic investigation of water evaporation process from α-cyclodextrin hydrates

  2021cites this paper
• Structural, physicochemical and biological characterization of chloramphenicol multicomponent complexes

  2021cites this paper
• Particle Size Reduction Techniques of Pharmaceutical Compounds for the Enhancement of Their Dissolution Rate and Bioavailability

  2021cites this paper
• Insights to the phase solubility diagrams of flurbiprofen with inclusion complex

  2021cites this paper
• Important Roles of Oligo- and Polysaccharides against SARS-CoV-2: Recent Advances

  2021cites this paper
• Integrated computer-aided formulation design: A case study of andrographolide/ cyclodextrin ternary formulation

  2021cites this paper
• Microbial amylolytic enzymes in foods: Technological importance of the Bacillus genus

  2021cites this paper
• Cyclodextrin Based Nanoparticles For Improved Solubility and Drug Delivery

  2021influential citation
• Application of Molecular Dynamics Simulations in the Analysis of Cyclodextrin Complexes

  2021cites this paper
• Simultaneous determination of cyclodextrin stability constants as a function of pH and temperature – A tool for drug formulation and process design

  2021cites this paper
• Mass Spectrometric Evaluation of β-Cyclodextrins as Potential Hosts for Titanocene Dichloride

  2021cites this paper