The chaperone protein HSP47: a platelet collagen binding protein that contributes to thrombosis and hemostasis

Essentials Heat shock protein 47 (HSP47), a collagen specific chaperone is present on the platelet surface. Collagen mediated platelet function was reduced following blockade or deletion of HSP47. GPVI receptor regulated signalling was reduced in HSP47 deficient platelets. Platelet HSP47 tethers to exposed collagen thus modulating thrombosis and hemostasis.

• Publication year

  2018

• Venue

  Journal of Thrombosis and Haemostasis

• Publication date

  2018-04-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/jth.13998PMID 29512284PMCID 6434988
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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