Neurotrophin expression in the reproductively senescent forebrain is refractory to estrogen stimulation.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Neurobiology of Aging

• Publication date

  2001-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0197-4580(00)00230-XPMID 11182481
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer Disease: A Randomized Controlled Trial

  2000cited by this paper
• Estradiol Induces Differential Neuronal Phenotypes by Activating Estrogen Receptor α or β.

  2000cited by this paper
• Local and cortical effects of olfactory bulb lesions on trophic support and cholinergic function and their modulation by estrogen.

  2000cited by this paper
• Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study.

  2000cited by this paper
• Estradiol induces differential neuronal phenotypes by activating estrogen receptor alpha or beta.

  2000cited by this paper
• Estrogen-Induced Activation of the Mitogen-Activated Protein Kinase Cascade in the Cerebral Cortex of Estrogen Receptor-α Knock-Out Mice

  2000cited by this paper
• Neurotrophin signaling via Trks and p75.

  1999cited by this paper
• Estradiol Modulates bcl-2 in Cerebral Ischemia: A Potential Role for Estrogen Receptors

  1999cited by this paper
• Peptide antagonists of the human estrogen receptor.

  1999cited by this paper
• Granule Cells in Aging Rats Are Sexually Dimorphic in Their Response to Estradiol

  1999cited by this paper
• Novel mechanisms of estrogen action in the brain: new players in an old story.

  1999cited by this paper
• BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies.

  1999cited by this paper
• Estrogen-Induced Activation of Mitogen-Activated Protein Kinase in Cerebral Cortical Explants: Convergence of Estrogen and Neurotrophin Signaling Pathways

  1999cited by this paper
• Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta.

  1999cited by this paper
• Effects of aging and axotomy on the expression of neurotrophin receptors in primary sensory neurons

  1999cited by this paper
• Estradiol Protects against Ischemic Injury

  1998cited by this paper
• Expression and neuropeptidergic characterization of estrogen receptors (ERalpha and ERbeta) throughout the rat brain: anatomical evidence of distinct roles of each subtype.

  1998cited by this paper
• Neurotrophins prevent death and differentially affect tyrosine hydroxylase of adult rat nigrostriatal neurons in vivo.

  1998cited by this paper
• Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists.

  1998cited by this paper
• Age-related changes in human oestrogen receptor alpha function and levels in osteoblasts.

  1998cited by this paper
• Changes in neurotensin mRNA by estrogen in the female rat preoptic area during aging: an in situ hybridization histochemistry study.

  1998cited by this paper
• Evidence for the colocalization of estrogen receptor-beta mRNA and estrogen receptor-alpha immunoreactivity in neurons of the rat forebrain.

  1998cited by this paper
• Differential distribution and regulation of estrogen receptor-alpha and -beta mRNA within the female rat brain.

  1998cited by this paper
• Differential distribution and regulation of estrogen receptor-α and -β mRNA within the female rat brain

  1998cited by this paper
• Evidence of the Colocalization of Estrogen Receptor-β mRNA and Estrogen Receptor-α Immunoreactivity in Neurons of the Rat Forebrain.

  1998cited by this paper
• Differential Response of Estrogen Receptor α and Estrogen Receptor β to Partial Estrogen Agonists/Antagonists

  1998cited by this paper
• Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival

  1998cited by this paper
• NGF induces apoptosis in a human neuroblastoma cell line expressing the neurotrophin receptor p75NTR

  1998cited by this paper
• Quantification of a neurotrophin receptor from submilligram quantities of brain tissue using western blotting.

  1998cited by this paper
• The complete primary structure of human estrogen receptor beta (hER beta) and its heterodimerization with ER alpha in vivo and in vitro.

  1998cited by this paper
• Effects of estrogen replacement on choline acetyltransferase and trkA mRNA expression in the basal forebrain of aged rats.

  1998cited by this paper
• Influence of ovariectomy and estradiol treatment on calcium homeostasis during aging in rats.

  1997cited by this paper
• Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system.

  1997cited by this paper
• Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat.

  1997cited by this paper
• Steroid receptor coactivator-1 is a histone acetyltransferase

  1997cited by this paper
• Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors a and b

  1997cited by this paper
• Reciprocal changes in expression of mRNA for nerve growth factor and its receptors TrkA and LNGFR in brain of aged rats in relation to maze learning deficits

  1997cited by this paper
• Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta.

  1997cited by this paper
• Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action.

  1997cited by this paper
• A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease

  1997cited by this paper
• Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta.

  1997cited by this paper
• Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites.

  1997cited by this paper
• Brain-derived neurotrophic factor is reduced in Alzheimer's disease.

  1997cited by this paper
• Estrogen, cognition, and a woman's risk of Alzheimer's disease.

  1997cited by this paper
• Comparative distribution of estrogen receptor‐α and ‐β mRNA in the rat central nervous system

  1997cited by this paper
• Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease.

  1996cited by this paper
• Co-localization of high-affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease.

  1996cited by this paper
• Analysis of estrogen receptor transcriptional enhancement by a nuclear hormone receptor coactivator.

  1996cited by this paper
• Cloning of a novel receptor expressed in rat prostate and ovary.

  1996cited by this paper
• Estrogen increases GAP-43 (neuromodulin) mRNA in the preoptic area of aged rats.

  1996cited by this paper
• Target influence on aging of myelinated sensory nerve fibres.

  1996cited by this paper
• Regional specificity of alterations in NGF, BDNF and NT‐3 levels in Alzheimer's disease

  1996cited by this paper
• ERβ: Identification and characterization of a novel human estrogen receptor

  1996cited by this paper
• The effects of ovariectomy and estrogen replacement on trkA and choline acetyltransferase mRNA expression in the basal forebrain of the adult female Sprague-Dawley rat

  1996cited by this paper
• ER beta: identification and characterization of a novel human estrogen receptor.

  1996cited by this paper
• Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis

  1995cited by this paper
• The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats.

  1995cited by this paper
• Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor.

  1995cited by this paper
• Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

  1995cited by this paper
• Nerve growth factor in Alzheimer's disease: defective retrograde transport to nucleus basalis

  1995cited by this paper
• Estrogen replacement therapy and stroke.

  1995cited by this paper
• Highly selective effects of nerve growth factor, brain‐derived neurotrophic factor, and neurotrophin‐3 on intact and injured basal forebrain magnocellular neurons

  1994cited by this paper
• Reduced transport of [125I]nerve growth factor by cholinergic neurons and down-regulated TrkA expression in the medial septum of aged rats.

  1994cited by this paper
• Estrogen differentially regulates estrogen and nerve growth factor receptor mRNAs in adult sensory neurons

  1994cited by this paper
• Reciprocal regulation of estrogen and NGF receptors by their ligands in PC12 cells.

  1994cited by this paper
• Estrogen differentially regulates estrogen and nerve growth factor receptor mRNAs in adult sensory neurons.

  1994cited by this paper
• Induction of apoptosis by the low-affinity NGF receptor.

  1993cited by this paper
• Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness.

  1993cited by this paper
• Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions.

  1993cited by this paper
• Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer disease.

  1992cited by this paper
• Effects of estrogen and fimbria/fornix transection on p75NGFR and ChAT expression in the medial septum and diagonal band of Broca.

  1992cited by this paper
• Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain.

  1992cited by this paper
• Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain

  1992cited by this paper
• Differential expression of mRNAs for the NGF family of neurotrophic factors in the adult rat central olfactory system

  1991cited by this paper
• Receptor-mediated transport of human recombinant nerve growth factor from olfactory bulb to forebrain cholinergic nuclei.

  1991cited by this paper
• BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease.

  1991cited by this paper
• Cholinergic Neurons of the Nucleus basalis Express Elevated Levels of Nerve Growth Factor Receptor mRNA in Senile Dementia of the Alzheimer Type

  1990cited by this paper
• Comparison of age- and sex-related changes in cell nuclear estrogen-binding capacity and progestin receptor induction in the rat brain.

  1990cited by this paper
• trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

  1989cited by this paper
• Differential effects of aging on estrogen receptor dynamics in hypothalamus, pituitary and uterus of the C57BL/6J mouse.

  1989cited by this paper
• Reproductive senescence in female rats: a longitudinal study of individual differences in estrous cycles and behavior.

  1988cited by this paper
• Genomic organization of the human oestrogen receptor gene.

  1988cited by this paper
• Sequence and expression of human estrogen receptor complementary DNA.

  1986cited by this paper
• Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

  1986cited by this paper
• Altered estrogen action in the senescent rat uterus: a model for steroid resistance during aging.

  1986cited by this paper
• Estrogen binding in nuclear and cytosolic extracts from brain and pituitary of middle-aged female rats.

  1986cited by this paper
• Decreased estrogenic stimulation of RNA polymerase II in aged rat uteri is apparently due to reduced nuclear binding of receptor-estradiol complexes.

  1985cited by this paper
• Changes in concentrations of estradiol nuclear receptors in the preoptic area, medial basal hypothalamus, amygdala, and pituitary gland of middle-aged and old cycling rats.

  1984cited by this paper
• Estradiol-induced daily luteinizing hormone and prolactin surges in young and middle-aged rats: correlations with age-related changes in pituitary responsiveness and catecholamine turnover rates in microdissected brain areas.

  1984cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper
• Age-related changes in the concentrations of cytosol receptors for sex steroid hormones in the hypothalamus and pituitary gland of the rat.

  1981cited by this paper

• Sex Steroids and Brain-Derived Neurotrophic Factor Interactions in the Nervous System: A Comprehensive Review of Scientific Data

  2025cites this paper
• Peripheral, but not central, IGF-1 treatment attenuates stroke-induced cognitive impairment in middle-aged female Sprague Dawley rats: The gut as a therapeutic target

  2024cites this paper
• The aging ovary impairs acute stroke outcomes

  2023cites this paper
• Function of brain-derived neurotrophic factor in the hypothalamus: Implications for depression pathology

  2022cites this paper
• Intestinal epithelial stem cell transplants as a novel therapy for cerebrovascular stroke

  2022cites this paper
• Estrogen administration attenuates post-stroke depression by enhancing CREB/BDNF/TrkB signaling in the rat hippocampus

  2021cites this paper
• Sex differences in stroke outcome correspond to rapid and severe changes in gut permeability in adult Sprague-Dawley rats

  2021cites this paper
• Brain-derived neurotrophic factor (BDNF) expression and function in the mammalian reproductive Tract.

  2020cites this paper
• Optimized integration of fluoxetine and 7, 8-dihydroxyflavone as an efficient therapy for reversing depressive-like behavior in mice during the perimenopausal period.

  2020cites this paper
• Sex Differences in Stroke Outcome Are Associated With Constitutive Gut Dysbiosis and Stroke-induced Gut Permeability

  2020cites this paper
• Mir363-3p Treatment Attenuates Long-Term Cognitive Deficits Precipitated by an Ischemic Stroke in Middle-Aged Female Rats

  2020cites this paper
• DHEA restores central and peripheral BDNF levels in female castrated rats

  2020cites this paper
• Reproductive Senescence and Ischemic Stroke Remodel the Gut Microbiome and Modulate the Effects of Estrogen Treatment in Female Rats

  2019cites this paper
• Sex hormones and stroke: Beyond estrogens.

  2019cites this paper
• Infralimbic Estradiol Enhances Neuronal Excitability and Facilitates Extinction of Cocaine Seeking in Female Rats via a BDNF/TrkB Mechanism

  2019cites this paper
• Mir363-3p attenuates post-stroke depressive-like behaviors in middle-aged female rats.

  2019cites this paper
• Sex differences in miRNA as therapies for ischemic stroke.

  2019cites this paper
• MYCN-amplified neuroblastoma maintains an aggressive and undifferentiated phenotype by deregulation of estrogen and NGF signaling

  2018cites this paper
• Luteinizing Hormone Involvement in Aging Female Cognition: Not All Is Estrogen Loss

  2018cites this paper
• Astrocyte‐specific insulin‐like growth factor‐1 gene transfer in aging female rats improves stroke outcomes

  2017cites this paper
• Sex and the development of Alzheimer's disease

  2017cites this paper
• Mir363–3p improves ischemic stroke outcomes in female but not male rats

  2017cites this paper
• Effects of estrogen on cerebrovascular function: age-dependent shifts from beneficial to detrimental in small cerebral arteries of the rat.

  2016cites this paper
• Small Vessels-Big Problems : Novel Insights into Microvascular Mechanisms of Diseases Effects of estrogen on cerebrovascular function : age-dependent shifts from beneficial to detrimental in small cerebral arteries of the rat

  2016cites this paper
• Insulin-Like Growth Factor (IGF)-I Modulates Endothelial Blood-Brain Barrier Function in Ischemic Middle-Aged Female Rats.

  2016cites this paper
• The Role of Bdnf in 17β-Estradiol-Induced Facilitation of Extinction of Cocaine Seeking

  2016cites this paper
• Inflammation is increased with anxiety- and depression-like signs in a rat model of spinal cord injury.

  2016cites this paper
• Estrogen-IGF-1 interactions in neuroprotection: ischemic stroke as a case study.

  2015cites this paper
• Estrogen induced changes in uterine brain-derived neurotrophic factor and its receptors.

  2015cites this paper
• Estradiol modulation of neurotrophin receptor expression in female mouse basal forebrain cholinergic neurons in vivo.

  2015cites this paper
• Hormone replacement therapy-related changes in the early postmenopausal period (critical window): an in vivo brain proton magnetic resonance spectroscopy study.

  2014cites this paper
• Blood Brain Barrier and Neuroinflammation Are Critical Targets of IGF-1-Mediated Neuroprotection in Stroke for Middle-Aged Female Rats

  2014cites this paper
• Effects of age and sex on cerebrovascular function in the rat middle cerebral artery

  2014cites this paper
• Estrogen receptors and ischemic neuroprotection: who, what, where, and when?

  2013cites this paper
• The influence of aging and estradiol to progesterone ratio on rat macrophage phenotypic profile and NO and TNF-α production.

  2013cites this paper
• BDNF AND ANDROGEN INTERACTIONS IN SPINAL NEUROMUSCULAR SYSTEMS

  2013cites this paper
• Brain-derived neurotrophic factor and androgen interactions in spinal neuromuscular systems.

  2013cites this paper
• Interrelation between inflammation, thrombosis, and neuroprotection in cerebral ischemia

  2012cites this paper
• Estrogen and Cognitive Aging in Women: The Critical Period Hypothesis

  2012cites this paper
• Hormones and the Aging Brain

  2012cites this paper
• Neurodegenerative role of stress and glucocorticoid hormones through Alzheimer's disease Tau protein: a proteomic link between stress and brain pathology.

  2012cites this paper
• Interaction of Sex Steroid Hormones and Brain‐Derived Neurotrophic Factor‐Tyrosine Kinase B Signalling: Relevance to Schizophrenia and Depression

  2012cites this paper
• Role of estrogen receptor alpha and beta expression and signaling on cognitive function during aging

  2012cites this paper
• Sex hormones, aging, and Alzheimer's disease.

  2012cites this paper
• Age-related severity of focal ischemia in female rats is associated with impaired astrocyte function.

  2012cites this paper
• Age- and hormone-regulation of opioid peptides and synaptic proteins in the rat dorsal hippocampal formation.

  2011cites this paper
• Restorative effect of estrogen on basal forebrain cholinergic neurons

  2011influential citation
• Estrogen Enhances Neurogenesis and Behavioral Recovery after Stroke

  2011cites this paper
• Gene Expression and Signal Transduction Cascades Mediating Estrogen Effects on Memory

  2011cites this paper
• Electrical stimulation and testosterone differentially enhance expression of regeneration-associated genes.

  2010cites this paper
• Reproductive age modulates the impact of focal ischemia on the forebrain as well as the effects of estrogen treatment in female rats.

  2010influential citation
• Androgen regulates brain-derived neurotrophic factor in spinal motoneurons and their target musculature.

  2010cites this paper
• The neurotoxic effects of estrogen on ischemic stroke in older female rats is associated with age-dependent loss of IGF-1

  2010cites this paper
• The Neurotoxic Effects of Estrogen on Ischemic Stroke in Older Female Rats Is Associated with Age-Dependent Loss of Insulin-Like Growth Factor-1

  2010cites this paper
• Functional interactions between steroid hormones and neurotrophin BDNF.

  2010cites this paper
• A randomized controlled trial of add-back estrogen or placebo on cognition in men with prostate cancer receiving an antiandrogen and a gonadotropin-releasing hormone analog.

  2010influential citation
• A high cholesterol diet elevates hippocampal cytokine expression in an age and estrogen-dependent manner in female rats.

  2010cites this paper
• The critical period hypothesis of estrogen effects on cognition: Insights from basic research.

  2010cites this paper
• Progesterone inhibits estrogen‐mediated neuroprotection against excitotoxicity by down‐regulating estrogen receptor‐β

  2010cites this paper
• Sex differences in β-amyloid accumulation in 3xTg-AD mice: role of neonatal sex steroid hormone exposure.

  2010cites this paper
• BDNF variant Val66Met interacts with estrous cycle in the control of hippocampal function

  2010cites this paper
• The Ability of Oestradiol Administration to Regulate Protein Levels of Oestrogen Receptor Alpha in the Hippocampus and Prefrontal Cortex of Middle‐Aged Rats is Altered Following Long‐Term Ovarian Hormone Deprivation

  2009cites this paper
• The Effects of Alcohol and Age on Astrocytes In Female Rats Following an Inflammatory Stimulus

  2009cites this paper
• Estrous cycle regulates activation of hippocampal Akt, LIMK, and neurotrophin receptors in C57BL6 mice

  2009cites this paper
• Protective actions of sex steroid hormones in Alzheimer's disease.

  2009cites this paper
• Reproductive age-related changes in the blood brain barrier: expression of IgG and tight junction proteins.

  2009cites this paper
• Physiological Effects of Estradiol in the Mouse Hippocampal Formation

  2009cites this paper
• Estrogen therapy: is time of initiation critical for neuroprotection?

  2009cites this paper
• Action of estrogen on survival of basal forebrain cholinergic neurons: promoting amelioration.

  2009cites this paper
• Cognitive effects of hormonal therapy in older adults.

  2008cites this paper
• Estrous cycle regulates activation of hippocampal Akt, LIM kinase, and neurotrophin receptors in C57BL/6 mice.

  2008cites this paper
• Astrocytes from acyclic female rats exhibit lowered capacity for neuronal differentiation

  2008cites this paper
• Progesterone blocks estrogen neuroprotection from kainate in middle-aged female rats.

  2008cites this paper
• Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats.

  2008cites this paper
• Adverse effects of incorporating ketoprofen into established rodent studies.

  2008cites this paper
• Brain aging modulates the neuroprotective effects of estrogen on selective aspects of cognition in women: a critical review.

  2008cites this paper
• Uncovering the mechanisms of estrogen effects on hippocampal function.

  2008cites this paper
• Estrogen receptor-alpha overexpression suppresses 17beta-estradiol-mediated vascular endothelial growth factor expression and activation of survival kinases.

  2008cites this paper
• Hormones, the Brain, and Me

  2008cites this paper
• Estrogen, cognition and female ageing.

  2007cites this paper
• Tyrosine receptor kinase B (TrkB) protein expression in the human endometrium

  2007cites this paper
• Involvement of granulin in estrogen-induced neurogenesis in the adult rat hippocampus.

  2007cites this paper
• Novel perspectives for progesterone in hormone replacement therapy, with special reference to the nervous system.

  2007cites this paper
• The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings

  2007cites this paper
• Androgen regulates trkB immunolabeling in spinal motoneurons

  2007influential citation
• The Critical Period Hypothesis: Can It Explain Discrepancies in the Oestrogen‐Cognition Literature?

  2007cites this paper
• A high soy diet enhances neurotropin receptor and Bcl-XL gene expression in the brains of ovariectomized female rats.

  2007cites this paper
• Title : Novel perspectives for progesterone in HRT, with special reference to the nervous system

  2007cites this paper
• The clinical relevance of the relationship between estrogen and cognition in women.

  2007cites this paper
• Species and Sex Differences in Susceptibility to Olfactory Lesions Among the Mouse, Rat and Monkey Following an Intravenous Injection of Vincristine Sulphate

  2006cites this paper
• 17β-Estradiol Is Protective in Spinal Cord Injury in Post- and Pre-Menopausal Rats

  2006cites this paper
• Age-related changes in neuroprotection

  2006cites this paper
• Sex steroids as pleiotropic factors in the nervous system from brain development to brain ageing

  2006cites this paper
• Steroid receptor coregulator diversity: what can it mean for the stressed brain?

  2006cites this paper
• Guarding the blood-brain barrier: a role for estrogen in the etiology of neurodegenerative disease.

  2006cites this paper
• Novel Mechanisms for Estrogen-Induced Neuroprotection

  2006cites this paper
• Aging of Brain: Role of Estrogen

  2006cites this paper
• Estrogen and cognitive aging in women.

  2006cites this paper
• Estrogen-BDNF interactions: implications for neurodegenerative diseases.

  2006influential citation
• Temporal expression of IL-1β protein and mRNA in the brain after systemic LPS injection is affected by age and estrogen

  2006cites this paper